Inguinal Hernia BilateralNCT07522853

M-TAPA vs OSTAP for Postoperative Analgesia in Laparoscopic Inguinal Hernia

A study testing Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA), Oblique Subcostal Transversus Abdominis Plane Block (OSTAP) and Standard Analgesia use (paracetamol, contramal) in people with Inguinal Hernia Bilateral and Postoperative Pain, run by Dr. Lutfi Kirdar Kartal Training and Research Hospital at 1 site in Turkey (Türkiye).

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

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Trial summary

This randomized controlled trial aims to compare the postoperative analgesic efficacy of M-TAPA block and OSTAP block in patients undergoing laparoscopic inguinal hernia repair. Pain scores, analgesic consumption, and patient satisfaction will be evaluated. Read more about this study

Who is it for?: Ages 18 to 65 years
Conditions the study is for: Inguinal Hernia Bilateral, Postoperative Pain
What is being tested?: Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA), Oblique Subcostal Transversus Abdominis Plane Block (OSTAP) and Standard Analgesia use (paracetamol, contramal)
Type of treatment: Surgery or procedure
Could I receive a placebo?: No, everyone receives an active treatment
How many people: 90 participants
Where: 1 siteTurkey (Türkiye)
Study dates: 8 Apr 2025to 20 Sep 2025
Phase: Interventional
Are there results?: None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 to 65 years
All sexes
No healthy volunteers
Adult, Older adult

Who may be able to join

Patients aged between 18 and 65 years
American Society of Anesthesiologists (ASA) physical status I-II
Scheduled for elective laparoscopic inguinal hernia repair (TEP technique)
Ability to understand and use the Visual Analog Scale (VAS)
Provided written informed consent

Who cannot join

Refusal to participate or inability to provide informed consent
Age under 18 or over 65 years
ASA physical status ≥ III
Coagulopathy (including abnormal INR, thrombocytopenia, or platelet dysfunction)
Infection at the injection site
Known allergy or hypersensitivity to study medications (local anesthetics, NSAIDs, opioids)

Show all 10Show fewer

Chronic opioid use (longer than 4 weeks)
Use of psychiatric medications affecting pain perception
Inability to cooperate or communicate effectively
Requirement for postoperative intensive care

Trial locations and contacts

1 site in 1 country.

Turkey (Türkiye)1 site

Kartal Dr. Lütfi Kırdar City Hospital
Istanbul

Other trials in Turkey (Türkiye)

About this study

Official title: Laparoscopic Inguinal Hernia Surgery Patients: Comparison of Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA) and Oblique Subcostal TAP Block for Postoperative Analgesia

Read the detailed description

Prospective, randomized, single-blind, controlled study including 90 patients undergoing elective laparoscopic inguinal hernia repair. Patients will be randomized into three groups: M-TAPA, OSTAP, and control. Postoperative pain scores (VAS), analgesic consumption, time to first analgesic requirement, and patient satisfaction will be assessed over 24 hours.

Conditions: Inguinal Hernia Bilateral, Postoperative Pain
Being tested: Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA), Oblique Subcostal Transversus Abdominis Plane Block (OSTAP), Standard Analgesia use (paracetamol, contramal)
Keywords: MTAPA, OSTAP, Postoperative pain, TAP Block, VAS Score
Medical subject headings: Pain, Postoperative

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA)Procedure or surgery
Ultrasound-guided bilateral M-TAPA block performed with 20 mL of 0.25% bupivacaine per side
Oblique Subcostal Transversus Abdominis Plane Block (OSTAP)Procedure or surgery
Ultrasound-guided bilateral OSTAP block performed with 20 mL of 0.25% bupivacaine per side
Standard Analgesia use (paracetamol, contramal)Other
Patients received standard postoperative analgesia without regional block

Study groups in NCT07522853
Study group	Role	What they receive
M-TAPA	Experimental	Bilateral M-TAPA block applied after surgery Receives: Procedure: Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA)
OSTAP	Experimental	Bilateral OSTAP block applied after surgery Receives: Procedure: Oblique Subcostal Transversus Abdominis Plane Block (OSTAP)
CONTROL	Other	No block applied and standart analgesia procedure Receives: Other: Standard Analgesia use (paracetamol, contramal)

What is being measured

The primary outcome is the main question the study is designed to answer.

Total analgesic consumption in 24 hours
Total amount of dexketoprofen consumed in the first 24 hours after surgery
Measured: 24 hours postoperative

Secondary outcomes (5)

Postoperative Pain Intensity (VAS Score)
Postoperative pain intensity assessed using the Visual Analog Scale (VAS, 0-10), where 0 indicates no pain and 10 indicates worst imaginable pain.
Measured: 0 (15 minutes), 2, 4, 8, 12, 16, and 24 hours postoperative
Time to First Analgesic Requirement
Time from the end of surgery to the first request for analgesic medication
Measured: Within 24 hours postoperative
Tramadol Consumption
Total amount of tramadol administered within the first 24 hours after surgery.
Measured: 24 hours postoperative
Patient Satisfaction Score
Patient satisfaction assessed using a Likert scale evaluating overall satisfaction with postoperative pain management
Measured: 24 hours postoperative
Incidence of Postoperative Nausea and Vomiting
Incidence of nausea and vomiting observed during the first 24 hours after surgery.
Measured: 24 hours postoperative

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

8 Apr 202520 Sep 2025

First posted13 Apr 2026
Study start8 Apr 2025
Primary completion20 Sep 2025
Study completion20 Sep 2025

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Other trials for Inguinal Hernia BilateralStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Treatment
Allocation: Randomised
Intervention model: Parallel groups
Masking: Single blind
Who is masked: Participant
Enrolment: 90 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT07522853
Sponsor's protocol ID: 2025-KAEK-43
Status last verified: Apr 2026
First submitted: 4 Apr 2026
Last updated: 13 Apr 2026
Results posted: No
FDA-regulated drug: No
FDA-regulated device: No
Individual data sharing: No: Individual participant data (IPD) will not be shared due to patient confidentiality, ethical considerations, and institutional regulations.

Want to know more?

The sponsor has not listed a contact. The official record may have more details.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See locations

Recruiting
Watchful Waiting Versus Immediate Repair for Occult Contralateral Inguinal Hernias.
Inguinal Hernia Bilateral, Inguinal Hernia Unilateral
Recruiting
Ultrasound-guided Quadratus Lumborum Block Versus Erector Spinae Plane Block for Postoperative Analgesia in Children Undergoing Elective Open Lower Abdominal Surgeries
Bilateral Inguinal Hernia Repair, Open Upper Abdominal Surgeries
RecruitingPhase 1
Reversing InGuinal Hernia Trial: The Evaluation of Sex Hormones to Reverse Inguinal Hernias in Males
Inguinal Hernia Unilateral, Inguinal Hernia Bilateral
Not yet recruiting
Bilateral vs Unilateral Inguinal Hernia Repairs With an Asymptomatic Inguinal Hernia in Bilateral Hernias
Inguinal Hernia Bilateral

All Inguinal Hernia Bilateral trials

Study at a glance

From the registry record, last updated by the sponsor on 13 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Laparoscopic Inguinal Hernia Surgery Patients: Comparison of Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA) and Oblique Subcostal TAP Block for Postoperative Analgesia
ClinicalTrials.gov ID: NCT07522853
Acronym / sponsor ID: 2025-KAEK-43
Conditions: Inguinal Hernia Bilateral, Postoperative Pain
Keywords: MTAPA, OSTAP, Postoperative pain, TAP Block, VAS Score
Study type: Interventional
Recruitment status: Completed
Enrolment: 90 participants (actual)
Lead sponsor: Dr. Lutfi Kirdar Kartal Training and Research HospitalOther government
Study start: 8 Apr 2025 (actual)
Primary completion: 20 Sep 2025 (actual)
Study completion: 20 Sep 2025 (actual)
First posted: 13 Apr 2026 (actual)
Results: Not posted in the source record

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

Detailed description

Study design

Primary purpose: Treatment
Allocation: Randomised
Intervention model: Parallel groups
Masking: Single blind (participant)
Number of arms: 3

Arm	Type	Receives
M-TAPA	Experimental	Procedure: Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA)Bilateral M-TAPA block applied after surgery
OSTAP	Experimental	Procedure: Oblique Subcostal Transversus Abdominis Plane Block (OSTAP)Bilateral OSTAP block applied after surgery
CONTROL	Other	Other: Standard Analgesia use (paracetamol, contramal)No block applied and standart analgesia procedure

Who may qualify

Ages: 18 to 65 years
Sex: All
Healthy volunteers: Not accepted
Age groups: Adult, Older adult

Key inclusion criteria (5 listed)

Patients aged between 18 and 65 years
American Society of Anesthesiologists (ASA) physical status I-II
Scheduled for elective laparoscopic inguinal hernia repair (TEP technique)
Ability to understand and use the Visual Analog Scale (VAS)
Provided written informed consent

Key exclusion criteria (10 listed)

Refusal to participate or inability to provide informed consent
Age under 18 or over 65 years
ASA physical status ≥ III
Coagulopathy (including abnormal INR, thrombocytopenia, or platelet dysfunction)
Infection at the injection site

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA)Ultrasound-guided bilateral M-TAPA block performed with 20 mL of 0.25% bupivacaine per side	Procedure or surgery	M-TAPA
Oblique Subcostal Transversus Abdominis Plane Block (OSTAP)Ultrasound-guided bilateral OSTAP block performed with 20 mL of 0.25% bupivacaine per side	Procedure or surgery	OSTAP
Standard Analgesia use (paracetamol, contramal)Patients received standard postoperative analgesia without regional block	Other	CONTROL

Primary outcome

Total analgesic consumption in 24 hours
Time frame: 24 hours postoperative
Total amount of dexketoprofen consumed in the first 24 hours after surgery

5 secondary outcomes

Postoperative Pain Intensity (VAS Score)
Time frame: 0 (15 minutes), 2, 4, 8, 12, 16, and 24 hours postoperative
Time to First Analgesic Requirement
Time frame: Within 24 hours postoperative
Tramadol Consumption
Time frame: 24 hours postoperative
Patient Satisfaction Score
Time frame: 24 hours postoperative
Incidence of Postoperative Nausea and Vomiting
Time frame: 24 hours postoperative

Results and safety

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 13 Apr 2026.
Individual participant dataSharing planned: No. Individual participant data (IPD) will not be shared due to patient confidentiality, ethical considerations, and institutional regulations.

Related trials for Inguinal Hernia Bilateral

Recruiting
Watchful Waiting Versus Immediate Repair for Occult Contralateral Inguinal Hernias.
Inguinal Hernia Bilateral, Inguinal Hernia Unilateral
Recruiting
Ultrasound-guided Quadratus Lumborum Block Versus Erector Spinae Plane Block for Postoperative Analgesia in Children Undergoing Elective Open Lower Abdominal Surgeries
Bilateral Inguinal Hernia Repair, Open Upper Abdominal Surgeries
RecruitingPhase 1
Reversing InGuinal Hernia Trial: The Evaluation of Sex Hormones to Reverse Inguinal Hernias in Males
Inguinal Hernia Unilateral, Inguinal Hernia Bilateral
Not yet recruiting
Bilateral vs Unilateral Inguinal Hernia Repairs With an Asymptomatic Inguinal Hernia in Bilateral Hernias
Inguinal Hernia Bilateral

Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.

Tahsin Simsek, MD principal investigator

Dr. Lutfi Kirdar Kartal Training and Research Hospital

1 site in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 13 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Total analgesic consumption in 24 hours (time frame: 24 hours postoperative). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07522853.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Apr 2026.