ThyroidectomyNCT07522983
RECURRENT LARYNGEAL INJURY WHILE USING LIGASURE Versus CONVENTIONAL KNOT TYING IN TOTAL THYROIDECTOMY
A study testing tie and knot and Ligasure in people with Thyroidectomy, run by Gulab Devi Hospital at 1 site in Pakistan.
Trial summary
To compare the frequency of recurrent laryngeal injury during total thyroidectomy when utilizing the LigaSure technique against conventional knot tying. Read more about this study
- Who is it for?
- Ages 18 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Thyroidectomy
- What is being tested?
- tie and knot and Ligasure
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 120 participants
- Where
- 1 sitePakistan
- Study dates
- 7 Jul 2025to 25 Mar 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Aged: 18 to 60 years
- Both Gender
- Patients undergoing total thyroidectomy
- Normal IDL
- No Hoarseness of voice
Who cannot join
- Patients requiring re-operation, including completion thyroidectomy.
- Patients undergoing concurrent procedures such as cervical lymphadenectomy or parathyroidectomy.
- Patient having previous neck surgery
- Patient having neck radiation
- Thyroidectomy for thyroid malignancy
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
Gulab Devi Hospital Ferozpur Road Lahore
Lahore, Punjab Province, 54600
About this study
Official title: INCIDENCE OF RECURRENT LARYNGEAL INJURY WHILE USING LIGASURE IN TOTAL THYROIDECTOMY AS COMPARED TO CONVENTIONAL KNOT TYING
To compare the frequency of recurrent laryngeal injury during total thyroidectomy when utilizing the LigaSure technique against conventional knot tying.
- Conditions
- Thyroidectomy
- Being tested
- tie and knot, Ligasure
- Keywords
- Thyroid gland, Multi nodular goiter
- Medical subject headings
- Thyroid Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
tie and knotProcedure or surgery
Also called Group conventional vessel sealing
patients designated for total thyroidectomy with tie and knot hemostasis
LigasureProcedure or surgery
Also called Ligasure vessel sealing
Ligasure for hemostasis
| Study group | Role | What they receive |
|---|---|---|
| Group knot tying | Experimental | Group A will consist of patients designated for total thyroidectomy with tie and knot hemostasis Receives: Procedure: tie and knot |
| Group ligasure | Experimental | Group B will comprise patients scheduled for total thyroidectomy using Ligasure for hemostasis Receives: Procedure: Ligasure |
What is being measured
The primary outcome is the main question the study is designed to answer.
Recurrent laryngeal nerve injury
Patients will be admitted to the hospital ward and assessed for recurrent laryngeal injury as per the operational definition during their stay.
Measured: 3 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Apr 2026
- Study start7 Jul 2025
- Primary completion7 Jan 2026
- Study completion25 Mar 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for ThyroidectomyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Screening
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 120 participants (actual)
Sponsor and investigators
- Lead sponsor
- Gulab Devi Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mudassar Malik, Gulab Devi Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07522983
- Sponsor's protocol ID
- AAMC/IRB/EA242025
- Status last verified
- Apr 2026
- First submitted
- 26 Mar 2026
- Last updated
- 13 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 13 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- INCIDENCE OF RECURRENT LARYNGEAL INJURY WHILE USING LIGASURE IN TOTAL THYROIDECTOMY AS COMPARED TO CONVENTIONAL KNOT TYING
- ClinicalTrials.gov ID
- NCT07522983
- Acronym / sponsor ID
- AAMC/IRB/EA242025
- Conditions
- Thyroidectomy
- Keywords
- Thyroid gland, Multi nodular goiter
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 120 participants (actual)
- Lead sponsor
- Gulab Devi HospitalUniversity, hospital or other
- Study start
- 7 Jul 2025 (actual)
- Primary completion
- 7 Jan 2026 (actual)
- Study completion
- 25 Mar 2026 (actual)
- First posted
- 13 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To compare the frequency of recurrent laryngeal injury during total thyroidectomy when utilizing the LigaSure technique against conventional knot tying.
Study design
- Primary purpose
- Screening
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group knot tying | Experimental | Procedure: tie and knotGroup A will consist of patients designated for total thyroidectomy with tie and knot hemostasis |
| Group ligasure | Experimental | Procedure: LigasureGroup B will comprise patients scheduled for total thyroidectomy using Ligasure for hemostasis |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Aged: 18 to 60 years
- Both Gender
- Patients undergoing total thyroidectomy
- Normal IDL
- No Hoarseness of voice
Key exclusion criteria (5 listed)
- Patients requiring re-operation, including completion thyroidectomy.
- Patients undergoing concurrent procedures such as cervical lymphadenectomy or parathyroidectomy.
- Patient having previous neck surgery
- Patient having neck radiation
- Thyroidectomy for thyroid malignancy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| tie and knotAlso: Group conventional vessel sealingpatients designated for total thyroidectomy with tie and knot hemostasis | Procedure or surgery | Group knot tying |
| LigasureAlso: Ligasure vessel sealingLigasure for hemostasis | Procedure or surgery | Group ligasure |
Primary outcome
Recurrent laryngeal nerve injury
Time frame: 3 days
Patients will be admitted to the hospital ward and assessed for recurrent laryngeal injury as per the operational definition during their stay.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Apr 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing tie and knot and Ligasure in people with Thyroidectomy, run by Gulab Devi Hospital at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Recurrent laryngeal nerve injury (time frame: 3 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Apr 2026.