SurgeryPEARLNCT07525323
EMG ss AMG In Robotic/Laparoscopic Surgery
A study testing AMG device and EMG in people with Surgery, run by Mayo Clinic at 1 site in United States.
Trial summary
The purpose of this study is to compare the mean cumulative weight-based/time-corrected rocuronium dose administered in patients undergoing robotic- or laparoscopic- assisted surgery using either acceleromyography or electromyography. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Surgery
- What is being tested?
- AMG device and EMG
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 400 participants
- Where
- 1 siteUnited States
- Study dates
- 31 Dec 2026to 31 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age > or = 18 years old
- Patients willing to participate and provide an integrated, informed consent
- Patients undergoing elective laparoscopic- or robotic-assisted surgical procedures
- Anticipated surgery duration < 300 minutes Exclusion Criteria
- Patients with disorders, such as stroke, carpal tunnel syndrome, broken wrist with nerve damage, Dupuytren contracture, or any similar wrist injury.
- Patients with systemic neuromuscular diseases such as myasthenia gravis.
- Patients having surgery that would involve prepping the arm into the sterile field.
- Patients with chronic kidney disease (eGFR <60).
Who cannot join
None listed.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: The Impact Of Electromyography Vs Acceleromyography On The Management Of Neuromuscular Block During Robotic And Laparoscopic Surgery: A Randomized Controlled Trial
The purpose of this study is to compare the mean cumulative weight-based/time-corrected rocuronium dose administered in patients undergoing robotic- or laparoscopic- assisted surgery using either acceleromyography or electromyography.
- Conditions
- Surgery
- Being tested
- AMG device, EMG
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
AMG deviceDevice
The anesthesia team will use an AMG device to monitor neuromuscular block
EMGDevice
The anesthesia team will use an EMG device to monitor neuromuscular block
| Study group | Role | What they receive |
|---|---|---|
| AMG | Experimental | The anesthesia team will manage the level of block based on AMG values Receives: Device: AMG device |
| EMG | Active comparator | The anesthesia team will manage the level of block based on EMG values Receives: Device: EMG |
What is being measured
The primary outcome is the main question the study is designed to answer.
Cumulative rocuronium dose
Weight- and time-adjusted mean cumulative rocuronium dose between the AMG and EMG groups
Measured: Perioperative/Periprocedural
Secondary outcomes (4)
Mean sugammadex dose
Mean sugammadex dose between the two groups
Measured: Perioperative/Periprocedural
Number of rocuronium administrations
Number of rocuronium administrations throughout the case,
Measured: Perioperative/Periprocedural
Frequency of placing a peripheral nerve stimulator
Frequency of placing a peripheral nerve stimulator
Measured: Perioperative/Periprocedural
Depth of neuromuscular block prior to sugammadex administration
Depth of neuromuscular block prior to sugammadex administration
Measured: Perioperative/Periprocedural
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Apr 2026
- Study start31 Dec 2026 (estimated)
- Primary completion31 Dec 2026 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for SurgeryStudies of the same condition, open and under way.
- More trials run by Mayo ClinicThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 400 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Mayo Clinic
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, J. Ross Renew, M.D., Mayo Clinic
- Investigators
- Johnathan Renew, Principal investigator, Mayo Clinic
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07525323
- Sponsor's protocol ID
- 25-014604
- Acronym
- PEARL
- Status last verified
- Oct 2026
- First submitted
- 30 Mar 2026
- Last updated
- 19 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 19 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Impact Of Electromyography Vs Acceleromyography On The Management Of Neuromuscular Block During Robotic And Laparoscopic Surgery: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07525323
- Acronym / sponsor ID
- PEARL / 25-014604
- Conditions
- Surgery
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 400 participants (estimated)
- Lead sponsor
- Mayo ClinicUniversity, hospital or other
- Study start
- 31 Dec 2026 (estimated)
- Primary completion
- 31 Dec 2026 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 13 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to compare the mean cumulative weight-based/time-corrected rocuronium dose administered in patients undergoing robotic- or laparoscopic- assisted surgery using either acceleromyography or electromyography.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| AMG | Experimental | Device: AMG deviceThe anesthesia team will manage the level of block based on AMG values |
| EMG | Active comparator | Device: EMGThe anesthesia team will manage the level of block based on EMG values |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- Age > or = 18 years old
- Patients willing to participate and provide an integrated, informed consent
- Patients undergoing elective laparoscopic- or robotic-assisted surgical procedures
- Anticipated surgery duration < 300 minutes Exclusion Criteria
- Patients with disorders, such as stroke, carpal tunnel syndrome, broken wrist with nerve damage, Dupuytren contracture, or any similar wrist injury.
Key exclusion criteria (0 listed)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| AMG deviceThe anesthesia team will use an AMG device to monitor neuromuscular block | Device | AMG |
| EMGThe anesthesia team will use an EMG device to monitor neuromuscular block | Device | EMG |
Primary outcome
Cumulative rocuronium dose
Time frame: Perioperative/Periprocedural
Weight- and time-adjusted mean cumulative rocuronium dose between the AMG and EMG groups
4 secondary outcomes
Mean sugammadex dose
Time frame: Perioperative/Periprocedural
Number of rocuronium administrations
Time frame: Perioperative/Periprocedural
Frequency of placing a peripheral nerve stimulator
Time frame: Perioperative/Periprocedural
Depth of neuromuscular block prior to sugammadex administration
Time frame: Perioperative/Periprocedural
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Oct 2026.
- Mayo Clinic Clinical TrialsLink provided by the sponsor.
- Individual participant dataSharing planned: No
Related trials for Surgery
RecruitingPhase 4
Anrikefon-based Patient-controlled Intravenous Analgesia Following Laparoscopic Surgery
Laparoscopic Surgery, Visceral Pain, Postoperative
RecruitingPhase 1
Study of Preoperative Radiation Therapy in Participants With Resectable Recurrent Abdominal Adrenocortical Carcinoma
Adrenocortical Carcinoma (ACC), Recurrent Adrenocortical Carcinoma (ACC)
Not yet recruitingObservational study
Arterial Stiffness During Negative Pressure Wound Therapy for Abdominal Wall Wounds
Postoperative Abdominal Wall Wound Complications, Surgical Wound Infection
Recruiting
Safety and Performance of a Pelvic Floor Mesh Implant for Laparoscopic Sacrocolpopexy (ProGYNious)
Pelvic Organ Prolapse (POP), Synthetic Mesh
Active, not recruitingPhase 2
Treating Muscle-invasive Bladder Cancer With A Non-surgical Method Consisting of Anti-PD-1 Therapy and Chemoradiation
Muscle-Invasive Bladder Carcinoma, Programmed Cell Death Protein 1 Inhibitor
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Johnathan Renew principal investigator
Mayo Clinic
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing AMG device and EMG in people with Surgery, run by Mayo Clinic at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 19 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Cumulative rocuronium dose (time frame: Perioperative/Periprocedural). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Oct 2026.