Gingival RecessionNCT07526259
Comparative Evaluation of Novel 3D Tunneling Technique Versus Modified Coronally Advanced Tunnel (MCAT) With Connective Tissue Graft in the Management of Multiple RT2 Gingival Recession
A study testing Root coverage in people with Gingival Recession, run by Cairo University at 1 site in Egypt.
Trial summary
Defects associated with severe interdental hard and soft tissue loss are challenging to the periodontist, mainly due to the increased avascular surface and the reduced interproximal periosteal bed. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Gingival Recession
- What is being tested?
- Root coverage
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 36 participants
- Where
- 1 siteEgypt
- Study dates
- 10 May 2025to 10 May 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Buccal and lingual multiple adjacent recession defects classified as Cairo et al RT2.
- Age ≥18 years
- Full mouth plaque index score less than 20% O'Leary et al. 1972
- Patients with healthy systemic condition
- Clinical indication and/or patient request for root coverage
Who cannot join
- Patients with systemically compromised health
- Periodontal surgical treatment during the previous 24 months in the involved site
- Pregnant or lactating mothers
- Smokers
- Non-compliant patients
- Restored teeth
- Non-carious cervical lesion
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Cairo University
Cairo, AlManial, 11562
Riham O Professor, PHD, +201001405748, riham.omar@dentistry.cu.edu.eg
Omar A Ashour, PHD, +201115537575, omarmahmoud@dentistry.cu.edu.eg
About this study
Official title: Comparative Evaluation of Novel 3D Tunneling Technique Versus Modified Coronally Advanced Tunnel (MCAT) With Connective Tissue Graft in the Management of Multiple RT2 Gingival Recession: A Randomized Controlled Trial
Defects associated with severe interdental hard and soft tissue loss are challenging to the periodontist, mainly due to the increased avascular surface and the reduced interproximal periosteal bed. Reports on the surgical techniques used to address recession type 2 or 3 defects mostly showed statistics on the mid-facial root coverage that yielded outcomes that do not encompass coverage of the interdental exposed root surface which highlights areas of controversy in their use for papilla reconstruction. Several case reports and clinical studies have shown encouraging results, but the long-term data are not available in the literature yet. The novel 3D tunneling (3DT) method achieved significant clinical improvement with long term stability in a recent case series. However, additional research is needed to validate 3DT for its routine clinical use. Moreover, the 3DT method achieved a decrease in the lingual recession depth which should be pointed out that the technique also addresses lingual recession.
- Conditions
- Gingival Recession
- Being tested
- Root coverage
- Medical subject headings
- Gingival Recession
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Root coverageProcedure or surgery
The novel 3D tunneling (3DT) method achieved significant clinical improvement with long term stability in a recent case series. However, additional research is needed to validate 3DT for its routine clinical use.
| Study group | Role | What they receive |
|---|---|---|
| Modified coronally advanced tunnel (MCAT) | Active comparator | Not described Receives: Procedure: Root coverage |
| novel 3D tunneling (3DT) | Experimental | Not described Receives: Procedure: Root coverage |
What is being measured
The primary outcome is the main question the study is designed to answer.
Gingival recession depth
Measured: From enrollment to the end of treatment at 1 year
Secondary outcomes (8)
Gingival recession depth lingual
Measured: From enrollment to the end of treatment at 1 year
Clinical attachment level (CAL) buccal and lingual
Measured: From enrollment to the end of treatment at 1 year
Periodontal probing depth (PPD) buccal and lingual
Measured: From enrollment to the end of treatment at 1 year
Width of keratinized tissue (KTW)
Measured: From enrollment to the end of treatment at 1 year
Papilla tip to contact point distance
Measured: From enrollment to the end of treatment at 1 year
Mean root coverage
Measured: From enrollment to the end of treatment at 1 year
Root coverage esthetic score (RES)
The RES system evaluates five variables 1 year following surgery: GM, marginal tissue contour (MTC), soft tissue texture (STT), MGJ alignment, and gingival color (GC).
GM. Zero points = failure of root coverage (gingival margin apical or equal to the baseline recession); 3 points = partial root coverage; 6 points = CRC.
MTC. Zero points = irregular gingival margin (does not follow the CEJ); 1 point = proper marginal contour/scalloped gingival margin (follows the CEJ).
STT. Zero points = scar formation and/or keloid-like appearance; 1 point = absence of scar or keloid formation.
MGJ. Zero points = MGJ not aligned with the MGJ of adjacent teeth; 1 point = MGJ aligned with the MGJ of adjacent teeth.
GC. Zero points = color of tissue varies from gingival color at adjacent teeth; 1 point = normal color and integration with the adjacent soft tissues.
Thus, the ideal esthetic score is 10.
Measured: From enrollment to the end of treatment at 1 year
Post operative pain using Visual analogue scale (VAS)
Pain score will be reported by the patient directly through Visual Analogue Scale (VAS) score (between 0 and 10.0: no pain, 1: minimal pain, 5: moderate pain, 10: severe pain) will be recorded at day 3, day 7, and day 14.
Measured: From enrollment to the end of treatment at 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Apr 2026
- Study start10 May 2025
- Primary completion10 Jan 2027 (estimated)
- Study completion10 May 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Gingival RecessionStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 36 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Lobna Magdy Mohamed Saber Moawad, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07526259
- Sponsor's protocol ID
- P-E-R-3-3-2
- Status last verified
- Apr 2026
- First submitted
- 30 Mar 2026
- Last updated
- 13 Apr 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Kazarian E, Inozemtseva K, Lebedeva E. A Novel 3D Tunneling (3DT) Surgical Technique for the Treatment of Gingival Recessions with Reconstruction of the Deficient Interdental Papilla and Interproximal Attachment Regeneration: A Case Series. Int J Periodontics Restorative Dent. 2025 Jan 24;45(1):31-45. doi: 10.11607/prd.6960.
PubMed 38198432
Study at a glance
From the registry record, last updated by the sponsor on 13 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Evaluation of Novel 3D Tunneling Technique Versus Modified Coronally Advanced Tunnel (MCAT) With Connective Tissue Graft in the Management of Multiple RT2 Gingival Recession: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07526259
- Acronym / sponsor ID
- P-E-R-3-3-2
- Conditions
- Gingival Recession
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 36 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 10 May 2025 (actual)
- Primary completion
- 10 Jan 2027 (estimated)
- Study completion
- 10 May 2027 (estimated)
- First posted
- 13 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Defects associated with severe interdental hard and soft tissue loss are challenging to the periodontist, mainly due to the increased avascular surface and the reduced interproximal periosteal bed. Reports on the surgical techniques used to address recession type 2 or 3 defects mostly showed statistics on the mid-facial root coverage that yielded outcomes that do not encompass coverage of the interdental exposed root surface which highlights areas of controversy in their use for papilla reconstruction. Several case reports and clinical studies have shown encouraging results, but the long-term data are not available in the literature yet. The novel 3D tunneling (3DT) method achieved significant clinical improvement with long term stability in a recent case series. However, additional research is needed to validate 3DT for its routine clinical use. Moreover, the 3DT method achieved a decrease in the lingual recession depth which should be pointed out that the technique also addresses lingual recession.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Modified coronally advanced tunnel (MCAT) | Active comparator | Procedure: Root coverage |
| novel 3D tunneling (3DT) | Experimental | Procedure: Root coverage |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Buccal and lingual multiple adjacent recession defects classified as Cairo et al RT2.
- Age ≥18 years
- Full mouth plaque index score less than 20% O'Leary et al. 1972
- Patients with healthy systemic condition
- Clinical indication and/or patient request for root coverage
Key exclusion criteria (7 listed)
- Patients with systemically compromised health
- Periodontal surgical treatment during the previous 24 months in the involved site
- Pregnant or lactating mothers
- Smokers
- Non-compliant patients
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Root coverageThe novel 3D tunneling (3DT) method achieved significant clinical improvement with long term stability in a recent case series. However, additional research is needed to validate 3DT for its routine clinical use. | Procedure or surgery | Modified coronally advanced tunnel (MCAT), novel 3D tunneling (3DT) |
Primary outcome
Gingival recession depth
Time frame: From enrollment to the end of treatment at 1 year
8 secondary outcomes
Gingival recession depth lingual
Time frame: From enrollment to the end of treatment at 1 year
Clinical attachment level (CAL) buccal and lingual
Time frame: From enrollment to the end of treatment at 1 year
Periodontal probing depth (PPD) buccal and lingual
Time frame: From enrollment to the end of treatment at 1 year
Width of keratinized tissue (KTW)
Time frame: From enrollment to the end of treatment at 1 year
Papilla tip to contact point distance
Time frame: From enrollment to the end of treatment at 1 year
Mean root coverage
Time frame: From enrollment to the end of treatment at 1 year
Root coverage esthetic score (RES)
Time frame: From enrollment to the end of treatment at 1 year
Post operative pain using Visual analogue scale (VAS)
Time frame: From enrollment to the end of treatment at 1 year
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Apr 2026.
- Background: PubMed 38198432Kazarian E, Inozemtseva K, Lebedeva E. A Novel 3D Tunneling (3DT) Surgical Technique for the Treatment of Gingival Recessions with Reconstruction of the Deficient Interdental Papilla and Interproximal Attachment Regeneration: A Case Series. Int J Periodontics Restorative Dent. 2025 Jan 24;45(1):31-45. doi: 10.11607/prd.6960.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Root coverage in people with Gingival Recession, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 13 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Gingival recession depth (time frame: From enrollment to the end of treatment at 1 year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07526259, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Apr 2026.