PnesNCT07526467
Video-EEG Semiological Patterns in PNES
An observational study of Pnes, run by Tepecik Training and Research Hospital at 1 site in Turkey (Türkiye).
Trial summary
This retrospective observational study evaluates semiological and electroclinical characteristics of psychogenic nonepileptic seizures (PNES) in adult patients who underwent video-EEG monitoring. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Pnes
- How many people
- 50 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Sep 2025to 1 Apr 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: This study population consists of adult patients diagnosed with psychogenic nonepileptic seizures (PNES) who underwent long-term video-EEG monitoring in a tertiary epilepsy center. All included patients had at least one recorded PNES event and sufficient clinical data available for retrospective analysis. Patients were identified through medical records and video-EEG databases, and no interventions were performed as part of the study.
Who may be able to join
- Adults aged 18 years and older Diagnosis of psychogenic nonepileptic seizures (PNES) confirmed by video-EEG monitoring Availability of complete video-EEG recordings capturing at least one typical event Availability of sufficient clinical and demographic data in medical records for retrospective evaluation
Who cannot join
- Patients younger than 18 years Incomplete or poor-quality video-EEG recordings Absence of recorded typical PNES events during video-EEG monitoring Insufficient clinical documentation for retrospective analysis
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Distinct Semiological Clusters of Psychogenic Non-Epileptic Seizures Identified by Video-EEG Monitoring
This retrospective observational study evaluates semiological and electroclinical characteristics of psychogenic nonepileptic seizures (PNES) in adult patients who underwent video-EEG monitoring. The study aims to identify distinct semiological patterns and classify PNES events based on observable ictal features recorded during video-EEG monitoring.
Read the detailed description
Psychogenic nonepileptic seizures (PNES) are paroxysmal events that resemble epileptic seizures but are not associated with ictal epileptiform activity on electroencephalography (EEG). Video-EEG monitoring is the gold standard for diagnosis.
In this retrospective observational study, video-EEG recordings and clinical data of 52 adult patients diagnosed with PNES were reviewed. Semiological features observed during recorded events were systematically evaluated and coded as binary variables.
Hierarchical cluster analysis (Ward's method with squared Euclidean distance) was used to identify semiological patterns. The aim was to define clinically meaningful clusters of PNES events and to describe their demographic and clinical correlates.
- Conditions
- Pnes
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| patients | patients with pnes underwent video eeg monitoring |
What is being measured
The primary outcome is the main question the study is designed to answer.
Semiological cluster classification of PNES events
Classification of PNES events into semiological clusters (pauci-kinetic, hyperkinetic, hyperventilation-eye closure) based on ictal features identified during video-EEG monitoring.
Measured: Baseline (retrospective video-EEG analysis)
Secondary outcomes (1)
pnes events
Eye closure during PNES events Hyperventilation during PNES events Abrupt onset of PNES events Abrupt termination of PNES events Hyperkinetic motor activity Presence or absence of excessive motor activity (e.g., thrashing movements). Tremor during PNES events Dystonic posturing Axial extension Axial immobility Pelvic thrusting Presence or absence of pelvic thrusting.
Measured: baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Apr 2026
- Study start1 Sep 2025
- Primary completion1 Dec 2025
- Study completion1 Apr 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for PnesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Retrospective
- Enrolment
- 50 participants (actual)
Sponsor and investigators
- Lead sponsor
- Tepecik Training and Research Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Irem Fatma Uludag, Tepecik Training and Research Hospital
- Investigators
- irem fatma uludag, Principal investigator, Tepecik EAH
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07526467
- Sponsor's protocol ID
- semenaveeg
- Status last verified
- Apr 2026
- First submitted
- 6 Apr 2026
- Last updated
- 13 Apr 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 13 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Distinct Semiological Clusters of Psychogenic Non-Epileptic Seizures Identified by Video-EEG Monitoring
- ClinicalTrials.gov ID
- NCT07526467
- Acronym / sponsor ID
- semenaveeg
- Conditions
- Pnes
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 50 participants (actual)
- Lead sponsor
- Tepecik Training and Research HospitalUniversity, hospital or other
- Study start
- 1 Sep 2025 (actual)
- Primary completion
- 1 Dec 2025 (actual)
- Study completion
- 1 Apr 2026 (actual)
- First posted
- 13 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This retrospective observational study evaluates semiological and electroclinical characteristics of psychogenic nonepileptic seizures (PNES) in adult patients who underwent video-EEG monitoring. The study aims to identify distinct semiological patterns and classify PNES events based on observable ictal features recorded during video-EEG monitoring.
Detailed description
Psychogenic nonepileptic seizures (PNES) are paroxysmal events that resemble epileptic seizures but are not associated with ictal epileptiform activity on electroencephalography (EEG). Video-EEG monitoring is the gold standard for diagnosis.
In this retrospective observational study, video-EEG recordings and clinical data of 52 adult patients diagnosed with PNES were reviewed. Semiological features observed during recorded events were systematically evaluated and coded as binary variables.
Hierarchical cluster analysis (Ward's method with squared Euclidean distance) was used to identify semiological patterns. The aim was to define clinically meaningful clusters of PNES events and to describe their demographic and clinical correlates.
Study design
- Observational model
- Case only
- Time perspective
- Retrospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| patients | – | –patients with pnes underwent video eeg monitoring |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- This study population consists of adult patients diagnosed with psychogenic nonepileptic seizures (PNES) who underwent long-term video-EEG monitoring in a tertiary epilepsy center. All included patients had at least one recorded PNES event and sufficient clinical data available for retrospective analysis. Patients were identified through medical records and video-EEG databases, and no interventions were performed as part of the study.
Key inclusion criteria (1 listed)
- Adults aged 18 years and older Diagnosis of psychogenic nonepileptic seizures (PNES) confirmed by video-EEG monitoring Availability of complete video-EEG recordings capturing at least one typical event Availability of sufficient clinical and demographic data in medical records for retrospective evaluation
Key exclusion criteria (1 listed)
- Patients younger than 18 years Incomplete or poor-quality video-EEG recordings Absence of recorded typical PNES events during video-EEG monitoring Insufficient clinical documentation for retrospective analysis
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Semiological cluster classification of PNES events
Time frame: Baseline (retrospective video-EEG analysis)
Classification of PNES events into semiological clusters (pauci-kinetic, hyperkinetic, hyperventilation-eye closure) based on ictal features identified during video-EEG monitoring.
1 secondary outcome
pnes events
Time frame: baseline
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Apr 2026.
- Individual participant dataSharing planned: No
Related trials for Pnes
Recruiting
Retraining and Control Therapy (ReACT): Sense of Control and Symptom Expectations as Targets of a Treatment for PNES
Convulsion, Non-Epileptic
Recruiting
Retraining and Control Therapy (ReACT) R33 Phase
Convulsion, Non-Epileptic
Recruiting
Cognitive Rehabilitation for Veterans With PNES
Psychogenic Nonepileptic Seizures (PNES)
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
irem fatma uludag principal investigator
Tepecik EAH
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Pnes, run by Tepecik Training and Research Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Semiological cluster classification of PNES events (time frame: Baseline (retrospective video-EEG analysis)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Apr 2026.