Cardiac Surgery SubjectsNCT07531602
Effect of PEEP on Cardiac Function
A study testing EIT Guided PEEP Trial in people with Cardiac Surgery Subjects, run by Beth Israel Deaconess Medical Center at 1 site in United States.
Trial summary
The purpose of this single-center, prospective study is to evaluate the physiologic effect of changes in PEEP on biventricular mechanics and RV-pulmonary arterial (RV-PA) coupling in adult patients undergoing cardiac surgery. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Cardiac Surgery Subjects
- What is being tested?
- EIT Guided PEEP Trial
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 28 participants
- Where
- 1 siteUnited States
- Study dates
- 17 Jun 2026to 30 Oct 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- 1. Age ≥ 18 years
- 2. Scheduled to undergo cardiac surgery requiring general anesthesia
- 3. Planned use of intraoperative transesophageal echocardiography (TEE) as part of routine clinical care
- 4. Planned placement of a pulmonary artery catheter as part of clinical care (Pulmonary artery catheter placement will be performed solely based on clinical judgment by the treating anesthesia and surgical teams. At our institution, pulmonary artery catheters are routinely placed in cardiac surgery patients with clinical indications including:
- preoperative pulmonary hypertension (e.g., estimated PCWP >20 mmHg or elevated filling pressures on preoperative echocardiography),
- right ventricular dysfunction or suspected RV failure (preoperative visual TTE assessment),
Show all 9Show fewer
- significant cardiopulmonary comorbidity,
- or anticipated complex, prolonged, or high-acuity cardiac surgery. The research team will not influence decisions regarding catheter placement. Only patients already scheduled to receive a clinically indicated pulmonary artery catheter will be eligible for enrollment.)
- 5. Able and willing to provide written informed consent prior to surgery
Who cannot join
- 1. Significant arrhythmia (e.g., atrial fibrillation with uncontrolled ventricular response or other rhythm disturbances) that would interfere with reliable pressure waveform or echocardiographic measurements.
- 2. Severe valvular disease where protocol-related PEEP changes may pose unacceptable hemodynamic risk, as determined by the clinical team.
- 3. Significant chronic lung disease or other pulmonary pathology where PEEP adjustments may be unsafe (e.g., severe COPD with dynamic hyperinflation, bullous lung disease), at the discretion of the anesthesia team.
- 4. Contraindication to changes in PEEP, including inability to tolerate the planned PEEP titration due to hemodynamic instability or clinician concern.
- 5. Any contraindication to TEE (if clinically required TEE is not performed or is contraindicated, the subject will not be eligible)
- 6. Investigator or clinical team discretion (e.g., safety concerns, inability to obtain reliable measurements, or conflict with other perioperative research protocols)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02115
About this study
Official title: The Effect of Positive End-Expiratory Pressure on Biventricular Mechanics in the Perioperative Setting
The purpose of this single-center, prospective study is to evaluate the physiologic effect of changes in PEEP on biventricular mechanics and RV-pulmonary arterial (RV-PA) coupling in adult patients undergoing cardiac surgery.
Read the detailed description
Positive end-expiratory pressure (PEEP) is a critical modality of mechanical ventilation but has important and often underappreciated effects on biventricular mechanics. PEEP is frequently selected based primarily on respiratory mechanics and oxygenation targets; however, increasing intrathoracic pressure may reduce RV preload by elevating right atrial pressure, while increasing transpulmonary pressure may increase RV afterload by compressing intra-alveolar pulmonary vessels and redistributing pulmonary blood flow. This is important specifically in the context of cardiac surgery where right ventricular (RV) function plays a critical role in determining postoperative morbidity and mortality. Perioperative RV dysfunction has been consistently associated with adverse outcomes, including prolonged vasopressor and inotrope requirements, difficulty weaning from cardiopulmonary bypass, longer intensive care unit stays, and increased mortality.
Right ventricular-pulmonary arterial (RV-PA) coupling provides a physiologically integrated assessment of RV performance by quantifying the relationship between RV contractility and afterload. Animal studies have shown that incremental PEEP increases can impair biventricular mechanics and precipitate RV-PA uncoupling. However, these physiologic effects have not been systematically characterized in the perioperative setting in the cardiac surgery population. This protocol seeks to address this knowledge gap by systematically evaluating biventricular mechanics and RV-PA coupling across varying PEEP levels in a controlled setting, using tools already employed in routine cardiac surgical care (pulmonary artery catheter and intraoperative TEE).
The overarching goal of this proposal is to define how perioperative positive end-expiratory pressure alters biventricular mechanics and right ventricular-pulmonary arterial coupling, to inform physiologically guided, RV-protective ventilatory strategies during cardiac surgery.
- Conditions
- Cardiac Surgery Subjects
- Being tested
- EIT Guided PEEP Trial
- Keywords
- PEEP Titration, Mechanical Ventilation, Coronary Artery Disease, Right Ventricular Impairment
- Medical subject headings
- Coronary Artery Disease, Heart Failure
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
EIT Guided PEEP TrialProcedure or surgery
Electrical impedance tomography (EIT) will be used to guide identification of "optimal PEEP" based on lung mechanics. After induction of anesthesia and initiation of controlled mechanical ventilation, EIT data will be collected during a brief standardized PEEP titration maneuver to assess lung recruitment and overdistension.
| Study group | Role | What they receive |
|---|---|---|
| Optimized PEEP Group | Experimental | These are patients undergoing cardiac surgery who will undergo an incremental/decremental PEEP trial using Electrical Impedance Tomography (EIT). Receives: Procedure: EIT Guided PEEP Trial |
What is being measured
The primary outcome is the main question the study is designed to answer.
Right ventricle-pulmonary artery coupling (Ees/Ea)
Right ventricle-pulmonary artery (RV-PA) coupling ratio (Ees/Ea) assessed using simultaneous transesophageal echocardiography and hemodynamic monitoring at four predefined PEEP levels (optimal PEEP + 5 cmH₂O, optimal PEEP, optimal PEEP - 5 cmH₂O, and PEEP 0 cmH₂O [baseline]) during a standardized stepwise PEEP titration sequence.
Measured: During the standardized PEEP titration sequence after induction of anesthesia and before surgical intervention (approximately 20-25 minutes)
Secondary outcomes (12)
Right ventricular end-diastolic volume at predefined PEEP levels
Three-dimensional right ventricular end-diastolic volume (RVEDV) measured by transesophageal echocardiography at four predefined PEEP levels (optimal PEEP + 5 cmH₂O, optimal PEEP, optimal PEEP - 5 cmH₂O, and PEEP 0 cmH₂O [baseline]).
Measured: During PEEP titration sequence (approximately 20-25 minutes after induction of anesthesia and prior to surgical incision)
Right ventricular end-systolic volume at predefined PEEP levels
Three-dimensional right ventricular end-systolic volume (RVESV) assessed by three-dimensional transesophageal echocardiography at four predefined PEEP levels (optimal PEEP + 5 cmH₂O, optimal PEEP, optimal PEEP - 5 cmH₂O, and PEEP 0 cmH₂O [baseline]).
Measured: During standardized PEEP titration sequence after induction of anesthesia and prior to surgical incision (approximately 20-25 minutes)
Right ventricular stroke volume at predefined PEEP levels
Right ventricular stroke volume derived from three-dimensional transesophageal echocardiography at four predefined PEEP levels (optimal PEEP + 5 cmH₂O, optimal PEEP, optimal PEEP - 5 cmH₂O, and PEEP 0 cmH₂O [baseline]).
Measured: During standardized PEEP titration sequence after induction of anesthesia and prior to surgical incision (approximately 20-25 minutes)
Right ventricular end-diastolic pressure at predefined PEEP levels
Right ventricular end-diastolic pressure measured via pulmonary artery catheter at four predefined PEEP levels (optimal PEEP + 5 cmH₂O, optimal PEEP, optimal PEEP - 5 cmH₂O, and PEEP 0 cmH₂O [baseline]).
Measured: During standardized PEEP titration sequence after induction of anesthesia and prior to surgical incision (approximately 20-25 minutes)
Right ventricular end-systolic pressure at predefined PEEP levels
Right ventricular end-systolic pressure estimated using waveform-based calculation methods from pulmonary artery catheter data at four predefined PEEP levels (optimal PEEP + 5 cmH₂O, optimal PEEP, optimal PEEP - 5 cmH₂O, and PEEP 0 cmH₂O [baseline]).
Measured: During standardized PEEP titration sequence after induction of anesthesia and prior to surgical incision (approximately 20-25 minutes)
Pulmonary artery systolic pressure at predefined PEEP levels
Pulmonary artery systolic pressure measured via pulmonary artery catheter at four predefined PEEP levels (optimal PEEP + 5 cmH₂O, optimal PEEP, optimal PEEP - 5 cmH₂O, and PEEP 0 cmH₂O [baseline]).
Measured: During standardized PEEP titration sequence after induction of anesthesia and prior to surgical incision (approximately 20-25 minutes)
Mean pulmonary artery pressure at predefined PEEP levels
Mean pulmonary artery pressure measured via pulmonary artery catheter at four predefined PEEP levels (optimal PEEP + 5 cmH₂O, optimal PEEP, optimal PEEP - 5 cmH₂O, and PEEP 0 cmH₂O [baseline]).
Measured: During standardized PEEP titration sequence after induction of anesthesia and prior to surgical incision (approximately 20-25 minutes)
Right ventricular end-systolic elastance at predefined PEEP levels
Right ventricular end-systolic elastance (Ees) derived using single-beat pressure-volume analysis at four predefined PEEP levels (optimal PEEP + 5 cmH₂O, optimal PEEP, optimal PEEP - 5 cmH₂O, and PEEP 0 cmH₂O [baseline]).
Measured: During standardized PEEP titration sequence after induction of anesthesia and prior to surgical incision (approximately 20-25 minutes)
Effective arterial elastance at predefined PEEP levels
Effective arterial elastance (Ea) derived from pressure-volume analysis at four predefined PEEP levels (optimal PEEP + 5 cmH₂O, optimal PEEP, optimal PEEP - 5 cmH₂O, and PEEP 0 cmH₂O [baseline]).
Measured: During standardized PEEP titration sequence after induction of anesthesia and prior to surgical incision (approximately 20-25 minutes)
Three-dimensional right ventricular ejection fraction
Three-dimensional right ventricular ejection fraction (3D RVEF) assessed by transesophageal echocardiography at four predefined PEEP levels (optimal PEEP + 5 cmH₂O, optimal PEEP, optimal PEEP - 5 cmH₂O, and PEEP 0 cmH₂O [baseline]) during a standardized stepwise PEEP titration sequence.
Measured: During standardized PEEP titration sequence after induction of anesthesia and prior to surgical incision (approximately 20-25 minutes)
Left ventricular ejection fraction at predefined PEEP levels
Three-dimensional left ventricular ejection fraction (LVEF) assessed by transesophageal echocardiography at four predefined PEEP levels (optimal PEEP + 5 cmH₂O, optimal PEEP, optimal PEEP - 5 cmH₂O, and PEEP 0 cmH₂O [baseline]).
Measured: During standardized PEEP titration sequence after induction of anesthesia and prior to surgical incision (approximately 20-25 minutes)
Left ventricular stroke volume at predefined PEEP levels
Left ventricular stroke volume derived from echocardiographic measurements at four predefined PEEP levels (optimal PEEP + 5 cmH₂O, optimal PEEP, optimal PEEP - 5 cmH₂O, and PEEP 0 cmH₂O [baseline]).
Measured: During standardized PEEP titration sequence after induction of anesthesia and prior to surgical incision (approximately 20-25 minutes)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Apr 2026
- Study start17 Jun 2026
- Primary completion30 Jul 2028 (estimated)
- Study completion30 Oct 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (6)Papers the sponsor has linked to this study.
- Other trials for Cardiac Surgery SubjectsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 28 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Beth Israel Deaconess Medical Center
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Vahid Kiarad, Beth Israel Deaconess Medical Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07531602
- Sponsor's protocol ID
- 2026P000077
- Status last verified
- Jun 2026
- First submitted
- 9 Apr 2026
- Last updated
- 1 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Bellofiore A, Vanderpool R, Brewis MJ, Peacock AJ, Chesler NC. A novel single-beat approach to assess right ventricular systolic function. J Appl Physiol (1985). 2018 Feb 1;124(2):283-290. doi: 10.1152/japplphysiol.00258.2017. Epub 2017 Oct 12.
PubMed 29025899Araos J, Glocker F, Owyang CG, Teran F, Kim J, Nieman G, Heerdt PM. Biventricular Response to Positive End-expiratory Pressure in Swine: Assessment Based on Beat-to-beat Pressure Waveform Analysis. Anesthesiology. 2025 Apr 1;142(4):767-769. doi: 10.1097/ALN.0000000000005363. Epub 2025 Feb 13. No abstract available.
PubMed 39946198Wood G, Madsen TL, Kim WY, Lyhne MD. Increasing Levels of Positive End-expiratory Pressure Cause Stepwise Biventricular Stroke Work Reduction in a Porcine Model. Anesthesiology. 2024 Feb 1;140(2):240-250. doi: 10.1097/ALN.0000000000004821.
PubMed 37905995Acosta P, Santisbon E, Varon J. "The use of positive end-expiratory pressure in mechanical ventilation". Crit Care Clin. 2007 Apr;23(2):251-61, x. doi: 10.1016/j.ccc.2006.12.012.
PubMed 17368169Ahmed U, Mahmood F, Nicoara A, Kiarad V. Right Ventricular Function and Echocardiographic Pressure-Volume Loops: Overview and Perioperative Clinical Implications. J Cardiothorac Vasc Anesth. 2025 Oct;39(10):2857-2865. doi: 10.1053/j.jvca.2025.05.019. Epub 2025 May 17.
PubMed 40483247Kiarad V, Mahmood F, Hedayat M, Yunus R, Nicoara A, Liu D, Chu L, Senthilnathan V, Kai M, Khabbaz K. Intraoperative right ventricular end-systolic pressure-volume loop analysis in patients undergoing cardiac surgery: A proof-of-concept methodology. JTCVS Open. 2024 Sep 26;22:225-234. doi: 10.1016/j.xjon.2024.09.020. eCollection 2024 Dec.
PubMed 39780800
Study at a glance
From the registry record, last updated by the sponsor on 1 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Positive End-Expiratory Pressure on Biventricular Mechanics in the Perioperative Setting
- ClinicalTrials.gov ID
- NCT07531602
- Acronym / sponsor ID
- 2026P000077
- Conditions
- Cardiac Surgery Subjects
- Keywords
- PEEP Titration, Mechanical Ventilation, Coronary Artery Disease, Right Ventricular Impairment
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 28 participants (estimated)
- Lead sponsor
- Beth Israel Deaconess Medical CenterUniversity, hospital or other
- Study start
- 17 Jun 2026 (actual)
- Primary completion
- 30 Jul 2028 (estimated)
- Study completion
- 30 Oct 2028 (estimated)
- First posted
- 15 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this single-center, prospective study is to evaluate the physiologic effect of changes in PEEP on biventricular mechanics and RV-pulmonary arterial (RV-PA) coupling in adult patients undergoing cardiac surgery.
Detailed description
Positive end-expiratory pressure (PEEP) is a critical modality of mechanical ventilation but has important and often underappreciated effects on biventricular mechanics. PEEP is frequently selected based primarily on respiratory mechanics and oxygenation targets; however, increasing intrathoracic pressure may reduce RV preload by elevating right atrial pressure, while increasing transpulmonary pressure may increase RV afterload by compressing intra-alveolar pulmonary vessels and redistributing pulmonary blood flow. This is important specifically in the context of cardiac surgery where right ventricular (RV) function plays a critical role in determining postoperative morbidity and mortality. Perioperative RV dysfunction has been consistently associated with adverse outcomes, including prolonged vasopressor and inotrope requirements, difficulty weaning from cardiopulmonary bypass, longer intensive care unit stays, and increased mortality.
Right ventricular-pulmonary arterial (RV-PA) coupling provides a physiologically integrated assessment of RV performance by quantifying the relationship between RV contractility and afterload. Animal studies have shown that incremental PEEP increases can impair biventricular mechanics and precipitate RV-PA uncoupling. However, these physiologic effects have not been systematically characterized in the perioperative setting in the cardiac surgery population. This protocol seeks to address this knowledge gap by systematically evaluating biventricular mechanics and RV-PA coupling across varying PEEP levels in a controlled setting, using tools already employed in routine cardiac surgical care (pulmonary artery catheter and intraoperative TEE).
The overarching goal of this proposal is to define how perioperative positive end-expiratory pressure alters biventricular mechanics and right ventricular-pulmonary arterial coupling, to inform physiologically guided, RV-protective ventilatory strategies during cardiac surgery.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Optimized PEEP Group | Experimental | Procedure: EIT Guided PEEP TrialThese are patients undergoing cardiac surgery who will undergo an incremental/decremental PEEP trial using Electrical Impedance Tomography (EIT). |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (9 listed)
- 1. Age ≥ 18 years
- 2. Scheduled to undergo cardiac surgery requiring general anesthesia
- 3. Planned use of intraoperative transesophageal echocardiography (TEE) as part of routine clinical care
- 4. Planned placement of a pulmonary artery catheter as part of clinical care (Pulmonary artery catheter placement will be performed solely based on clinical judgment by the treating anesthesia and surgical teams. At our institution, pulmonary artery catheters are routinely placed in cardiac surgery patients with clinical indications including:
- 5. Able and willing to provide written informed consent prior to surgery
Key exclusion criteria (6 listed)
- 1. Significant arrhythmia (e.g., atrial fibrillation with uncontrolled ventricular response or other rhythm disturbances) that would interfere with reliable pressure waveform or echocardiographic measurements.
- 2. Severe valvular disease where protocol-related PEEP changes may pose unacceptable hemodynamic risk, as determined by the clinical team.
- 3. Significant chronic lung disease or other pulmonary pathology where PEEP adjustments may be unsafe (e.g., severe COPD with dynamic hyperinflation, bullous lung disease), at the discretion of the anesthesia team.
- 4. Contraindication to changes in PEEP, including inability to tolerate the planned PEEP titration due to hemodynamic instability or clinician concern.
- 5. Any contraindication to TEE (if clinically required TEE is not performed or is contraindicated, the subject will not be eligible)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| EIT Guided PEEP TrialElectrical impedance tomography (EIT) will be used to guide identification of "optimal PEEP" based on lung mechanics. After induction of anesthesia and initiation of controlled mechanical ventilation, EIT data will be collected during a brief standardized PEEP titration maneuver to assess lung recruitment and overdistension. | Procedure or surgery | Optimized PEEP Group |
Primary outcome
Right ventricle-pulmonary artery coupling (Ees/Ea)
Time frame: During the standardized PEEP titration sequence after induction of anesthesia and before surgical intervention (approximately 20-25 minutes)
Right ventricle-pulmonary artery (RV-PA) coupling ratio (Ees/Ea) assessed using simultaneous transesophageal echocardiography and hemodynamic monitoring at four predefined PEEP levels (optimal PEEP + 5 cmH₂O, optimal PEEP, optimal PEEP - 5 cmH₂O, and PEEP 0 cmH₂O [baseline]) during a standardized stepwise PEEP titration sequence.
12 secondary outcomes
Right ventricular end-diastolic volume at predefined PEEP levels
Time frame: During PEEP titration sequence (approximately 20-25 minutes after induction of anesthesia and prior to surgical incision)
Right ventricular end-systolic volume at predefined PEEP levels
Time frame: During standardized PEEP titration sequence after induction of anesthesia and prior to surgical incision (approximately 20-25 minutes)
Right ventricular stroke volume at predefined PEEP levels
Time frame: During standardized PEEP titration sequence after induction of anesthesia and prior to surgical incision (approximately 20-25 minutes)
Right ventricular end-diastolic pressure at predefined PEEP levels
Time frame: During standardized PEEP titration sequence after induction of anesthesia and prior to surgical incision (approximately 20-25 minutes)
Right ventricular end-systolic pressure at predefined PEEP levels
Time frame: During standardized PEEP titration sequence after induction of anesthesia and prior to surgical incision (approximately 20-25 minutes)
Pulmonary artery systolic pressure at predefined PEEP levels
Time frame: During standardized PEEP titration sequence after induction of anesthesia and prior to surgical incision (approximately 20-25 minutes)
Mean pulmonary artery pressure at predefined PEEP levels
Time frame: During standardized PEEP titration sequence after induction of anesthesia and prior to surgical incision (approximately 20-25 minutes)
Right ventricular end-systolic elastance at predefined PEEP levels
Time frame: During standardized PEEP titration sequence after induction of anesthesia and prior to surgical incision (approximately 20-25 minutes)
Effective arterial elastance at predefined PEEP levels
Time frame: During standardized PEEP titration sequence after induction of anesthesia and prior to surgical incision (approximately 20-25 minutes)
Three-dimensional right ventricular ejection fraction
Time frame: During standardized PEEP titration sequence after induction of anesthesia and prior to surgical incision (approximately 20-25 minutes)
Left ventricular ejection fraction at predefined PEEP levels
Time frame: During standardized PEEP titration sequence after induction of anesthesia and prior to surgical incision (approximately 20-25 minutes)
Left ventricular stroke volume at predefined PEEP levels
Time frame: During standardized PEEP titration sequence after induction of anesthesia and prior to surgical incision (approximately 20-25 minutes)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Jul 2026.
- Background: PubMed 29025899Bellofiore A, Vanderpool R, Brewis MJ, Peacock AJ, Chesler NC. A novel single-beat approach to assess right ventricular systolic function. J Appl Physiol (1985). 2018 Feb 1;124(2):283-290. doi: 10.1152/japplphysiol.00258.2017. Epub 2017 Oct 12.
- Background: PubMed 39946198Araos J, Glocker F, Owyang CG, Teran F, Kim J, Nieman G, Heerdt PM. Biventricular Response to Positive End-expiratory Pressure in Swine: Assessment Based on Beat-to-beat Pressure Waveform Analysis. Anesthesiology. 2025 Apr 1;142(4):767-769. doi: 10.1097/ALN.0000000000005363. Epub 2025 Feb 13. No abstract available.
- Background: PubMed 37905995Wood G, Madsen TL, Kim WY, Lyhne MD. Increasing Levels of Positive End-expiratory Pressure Cause Stepwise Biventricular Stroke Work Reduction in a Porcine Model. Anesthesiology. 2024 Feb 1;140(2):240-250. doi: 10.1097/ALN.0000000000004821.
- Background: PubMed 17368169Acosta P, Santisbon E, Varon J. "The use of positive end-expiratory pressure in mechanical ventilation". Crit Care Clin. 2007 Apr;23(2):251-61, x. doi: 10.1016/j.ccc.2006.12.012.
- Background: PubMed 40483247Ahmed U, Mahmood F, Nicoara A, Kiarad V. Right Ventricular Function and Echocardiographic Pressure-Volume Loops: Overview and Perioperative Clinical Implications. J Cardiothorac Vasc Anesth. 2025 Oct;39(10):2857-2865. doi: 10.1053/j.jvca.2025.05.019. Epub 2025 May 17.
- Background: PubMed 39780800Kiarad V, Mahmood F, Hedayat M, Yunus R, Nicoara A, Liu D, Chu L, Senthilnathan V, Kai M, Khabbaz K. Intraoperative right ventricular end-systolic pressure-volume loop analysis in patients undergoing cardiac surgery: A proof-of-concept methodology. JTCVS Open. 2024 Sep 26;22:225-234. doi: 10.1016/j.xjon.2024.09.020. eCollection 2024 Dec.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing EIT Guided PEEP Trial in people with Cardiac Surgery Subjects, run by Beth Israel Deaconess Medical Center at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 1 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Right ventricle-pulmonary artery coupling (Ees/Ea) (time frame: During the standardized PEEP titration sequence after induction of anesthesia and before surgical intervention (approximately 20-25 minutes)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07531602, which also lists 6 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Jul 2026.