Elevated Pulmonary Artery PressureNCT07535398
Telerehabilitation in Patients With Elevated Pulmonary Artery Pressure
A study testing Synchronous Telerehabilitation and Breathing and Posture Exercises in people with Elevated Pulmonary Artery Pressure, run by Marmara University at 1 site in Turkey (Türkiye).
Trial summary
The goal of this clinical trial is to learn if synchronous telerehabilitation is effective in patients with elevated pulmonary artery pressure identified by echocardiography (systolic pulmonary artery pressure ≥50 mmHg). Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Elevated Pulmonary Artery Pressure
- What is being tested?
- Synchronous Telerehabilitation and Breathing and Posture Exercises
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 12 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- Apr 2026to Aug 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults aged 18 to 65 years
- Elevated pulmonary artery pressure identified by echocardiography, defined as systolic pulmonary artery pressure (sPAP) of 50 mmHg or higher
- Clinically stable and receiving medical treatment under cardiology follow-up World Health Organization functional class I or II
- New York Heart Association (NYHA) functional class I or II
- Living with a caregiver, family member, or another person who can provide assistance if needed
- Access to the internet and adequate visual, cognitive, and functional ability to participate in videoconference-based sessions
- Willing to participate and able to provide informed consent
Who cannot join
- Requirement for oxygen therapy
- Musculoskeletal problems limiting participation in exercise
- Ongoing treatment for psychiatric or psychological disorders
- Cognitive impairment based on Mini-Mental State Examination findings
- Severe chronic obstructive pulmonary disease (COPD)
- Other significant cardiac disease that may interfere with participation or assessment
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Tokat Gaziosmanpaşa University
Tokat Province
Mehmet Armağan, 00903562521616, mehmetarm@gmail.com
About this study
Official title: The Effectiveness of Telerehabilitation in Patients With Elevated Pulmonary Artery Pressure
The goal of this clinical trial is to learn if synchronous telerehabilitation is effective in patients with elevated pulmonary artery pressure identified by echocardiography (systolic pulmonary artery pressure ≥50 mmHg). It will also evaluate the effects of telerehabilitation on exercise capacity, dyspnea, fatigue, functional status, and quality of life. The main questions it aims to answer are:
Does synchronous telerehabilitation improve exercise and functional capacity in these patients? Does synchronous telerehabilitation improve dyspnea, fatigue, psychological status, and quality of life?
Read more
Researchers will compare synchronous telerehabilitation with breathing and posture exercises to see if telerehabilitation provides greater clinical and functional benefit.
Participants will:
Be randomly assigned to one of 2 groups Follow an 8-week program, 3 times per week, for 30 minutes per session Perform aerobic, endurance, and strengthening exercises by synchronous telerehabilitation, or breathing and posture exercises in the control group Complete assessments before and after treatment
Read the detailed description
Pulmonary hypertension is associated with impaired cardiopulmonary function, reduced aerobic capacity, decreased oxygen consumption, and exercise intolerance. Dyspnea, fatigue, reduced physical activity, and limitations in daily activities negatively affect functional status, psychological well-being, and quality of life in this patient population. Exercise-based rehabilitation has been reported to improve functional capacity, exercise performance, and overall well-being in patients with pulmonary vascular disease, despite earlier concerns that exercise might worsen symptoms in these patients.
Telerehabilitation refers to the delivery of rehabilitation services through telecommunication technologies. Synchronous telerehabilitation is based on real-time interaction between the clinician and the patient and may be a useful, accessible, and safe alternative when attendance at center-based rehabilitation is difficult. Previous studies have shown beneficial effects of exercise-based telerehabilitation in cardiopulmonary populations; however, evidence regarding synchronous telerehabilitation in patients with elevated pulmonary artery pressure remains limited.
The aim of this study is to investigate the effectiveness of a synchronous telerehabilitation program in patients with elevated pulmonary artery pressure identified by echocardiography, defined as systolic pulmonary artery pressure (sPAP) of 50 mmHg or higher. Participants will be randomly assigned to either a synchronous telerehabilitation group or a control group. The telerehabilitation group will receive a supervised program including aerobic, endurance, and strengthening exercises, while the control group will perform breathing and posture exercises. Both groups will participate in the program 3 days per week, 30 minutes per session, for 8 weeks. At the end of the 8-week period, participants in the control group who wish to continue may be offered the synchronous rehabilitation program.
The study will evaluate the effects of the intervention on cardiopulmonary and functional outcomes, including dyspnea, fatigue, physical activity level, psychological status, pulmonary function, exercise capacity, functional capacity, and quality of life. Assessments will be performed before and after the intervention period using standardized outcome measures.
The findings of this study may help clarify the role of synchronous telerehabilitation as an accessible rehabilitation strategy for patients with elevated pulmonary artery pressure, particularly for individuals who have difficulty accessing in-person rehabilitation services. Given the limited evidence in this specific population, this study is expected to contribute clinically relevant data regarding the effectiveness of remote exercise-based rehabilitation.
- Conditions
- Elevated Pulmonary Artery Pressure
- Being tested
- Synchronous Telerehabilitation, Breathing and Posture Exercises
- Keywords
- Elevated pulmonary artery pressure, pulmonary hypertension, synchronous telerehabilitation, exercise capacity, pulmonary function, quality of life
- Medical subject headings
- Hypertension, Pulmonary
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Synchronous TelerehabilitationBehavioural
A supervised synchronous telerehabilitation program delivered via videoconferencing, including aerobic, endurance, and strengthening exercises for 8 weeks, 3 times per week, 30 minutes per session. The program will be individualized based on participant tolerance and clinical findings, with monitoring of symptoms and physiologic responses during exercise.
Breathing and Posture ExercisesBehavioural
A control intervention consisting of breathing exercises, positions to relieve breathing discomfort, breathing control techniques, energy conservation strategies, and posture exercises, performed for 8 weeks, together with routine care and weekly motivational follow-up.
| Study group | Role | What they receive |
|---|---|---|
| Synchronous Telerehabilitation Group | Experimental | Participants with elevated pulmonary artery pressure identified by echocardiography (systolic pulmonary artery pressure ≥50 mmHg) who meet the study eligibility criteria will receive an 8-week synchronous telerehabilitation program. The program will be delivered 3 days per week, 30 minutes per session, under real-time physiotherapist supervision. The intervention will include aerobic, endurance, and strengthening exercises. Exercise intensity and progression will be individualized according to clinical status, baseline adaptation, and cardiopulmonary exercise test findings. Hemodynamic parameters, oxygen saturation, dyspnea, and fatigue will be monitored during sessions. Receives: Behavioral: Synchronous Telerehabilitation |
| Control Group | Active comparator | Participants with elevated pulmonary artery pressure identified by echocardiography (systolic pulmonary artery pressure ≥50 mmHg) who meet the study eligibility criteria will perform breathing and posture exercises for 8 weeks. Participants in this group will continue routine care and receive weekly motivational follow-up by a physiotherapist. At the end of the study period, participants in the control group may be offered the exercise program if they wish to continue. Receives: Behavioral: Breathing and Posture Exercises |
What is being measured
The primary outcome is the main question the study is designed to answer.
Exercise Capacity
Change in 6-minute walk distance assessed by the 6-minute walk test to evaluate functional capacity.
Measured: Baseline and at 8 weeks
Dyspnea severity measured by the Modified Borg Dyspnea Scale
Change in dyspnea severity assessed using the Modified Borg Dyspnea Scale. The Modified Borg Dyspnea Scale is a subjective rating scale used to assess the severity of dyspnea at rest and/or during activity. Scores range from 0 to 10, with higher scores indicating greater dyspnea severity and a worse outcome.
Measured: Baseline and at 8 weeks
Secondary outcomes (6)
Fatigue severity measured by the Fatigue Severity Scale
Change in fatigue severity assessed using the Fatigue Severity Scale. The Fatigue Severity Scale is a 9-item patient-reported outcome measure assessing the severity and impact of fatigue. Each item is scored from 1 to 7. Total score can be calculated as the sum of all items, ranging from 9 to 63, or as the mean item score, ranging from 1 to 7. Higher scores indicate greater fatigue severity and a worse outcome.
Measured: Baseline and at 8 weeks
Physical activity level
Change in physical activity level assessed using the International Physical Activity Questionnaire-Short Form.
Measured: Baseline and at 8 weeks
Anxiety and depression measured by the Hospital Anxiety and Depression Scale
Change in anxiety and depression levellevel assessed using the Hospital Anxiety and Depression Scale. The Hospital Anxiety and Depression Scale is a 14-item self-report questionnaire developed to assess psychological distress in patients with physical health problems. It consists of 2 subscales, anxiety and depression, with 7 items in each subscale. Each item is scored from 0 to 3. Total scores range from 0 to 42, with higher scores indicating worse psychological status and a worse outcome.
Measured: Baseline and at 8 weeks
Pulmonary function parameters
Change in pulmonary function parameters including forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), FEV1/FVC ratio.
Measured: Baseline and at 8 weeks
Quality of life measured by the Short Form-36 (SF-36)
Change in health-related quality of life assessed using the Short Form-36 questionnaire. The 36-Item Short Form Survey (SF-36) is a validated self-report questionnaire used to assess health-related quality of life. It includes 8 domains: physical functioning, bodily pain, general health perception, role limitations due to physical problems, role limitations due to emotional problems, social functioning, mental health, and vitality. Scores range from 0 to 100, with higher scores indicating better health-related quality of life and a better outcome.
Measured: Baseline and at 8 weeks
Independence in activities of daily living measured by the Barthel Index
Change in functional independence in activities of daily living assessed using the Barthel Index. The Barthel Index is a standardized measure used to assess independence in activities of daily living. Scores range from 0 to 100, with higher scores indicating greater independence in daily activities and a better outcome. A score of 100 indicates full independence, while lower scores indicate increasing levels of dependency.
Measured: Baseline and at 8 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Apr 2026
- Study startApr 2026 (estimated)
- Primary completionJun 2026 (estimated)
- Study completionAug 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Elevated Pulmonary Artery PressureStudies of the same condition, open and under way.
- More trials run by Marmara UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomly assigned to either a synchronous telerehabilitation group or a control group. The synchronous telerehabilitation group will receive aerobic, endurance, and strengthening exercises, while the control group will perform breathing and posture exercises. Both groups will participate in the program 3 days per week, 30 minutes per session, for 8 weeks.
- Masking
- None (open label)
- Enrolment
- 12 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Marmara University
- Sponsor type
- University, hospital or other
- Collaborators
- Tokat Gaziosmanpasa University
- Responsible party
- Principal investigator, Aysel Yildiz, Marmara University
- Investigators
- Aysel Yıldız Özer, PhD, Study director, Marmara University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07535398
- Sponsor's protocol ID
- 09.2024.165
- Status last verified
- Apr 2026
- First submitted
- 10 Apr 2026
- Last updated
- 29 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 29 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effectiveness of Telerehabilitation in Patients With Elevated Pulmonary Artery Pressure
- ClinicalTrials.gov ID
- NCT07535398
- Acronym / sponsor ID
- 09.2024.165
- Conditions
- Elevated Pulmonary Artery Pressure
- Keywords
- Elevated pulmonary artery pressure, pulmonary hypertension, synchronous telerehabilitation, exercise capacity, pulmonary function, quality of life
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 12 participants (estimated)
- Lead sponsor
- Marmara UniversityUniversity, hospital or other
- Collaborators
- Tokat Gaziosmanpasa University
- Study start
- Apr 2026 (estimated)
- Primary completion
- Jun 2026 (estimated)
- Study completion
- Aug 2026 (estimated)
- First posted
- 17 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to learn if synchronous telerehabilitation is effective in patients with elevated pulmonary artery pressure identified by echocardiography (systolic pulmonary artery pressure ≥50 mmHg). It will also evaluate the effects of telerehabilitation on exercise capacity, dyspnea, fatigue, functional status, and quality of life. The main questions it aims to answer are:
Does synchronous telerehabilitation improve exercise and functional capacity in these patients? Does synchronous telerehabilitation improve dyspnea, fatigue, psychological status, and quality of life?
Researchers will compare synchronous telerehabilitation with breathing and posture exercises to see if telerehabilitation provides greater clinical and functional benefit.
Participants will:
Be randomly assigned to one of 2 groups Follow an 8-week program, 3 times per week, for 30 minutes per session Perform aerobic, endurance, and strengthening exercises by synchronous telerehabilitation, or breathing and posture exercises in the control group Complete assessments before and after treatment
Detailed description
Pulmonary hypertension is associated with impaired cardiopulmonary function, reduced aerobic capacity, decreased oxygen consumption, and exercise intolerance. Dyspnea, fatigue, reduced physical activity, and limitations in daily activities negatively affect functional status, psychological well-being, and quality of life in this patient population. Exercise-based rehabilitation has been reported to improve functional capacity, exercise performance, and overall well-being in patients with pulmonary vascular disease, despite earlier concerns that exercise might worsen symptoms in these patients.
Telerehabilitation refers to the delivery of rehabilitation services through telecommunication technologies. Synchronous telerehabilitation is based on real-time interaction between the clinician and the patient and may be a useful, accessible, and safe alternative when attendance at center-based rehabilitation is difficult. Previous studies have shown beneficial effects of exercise-based telerehabilitation in cardiopulmonary populations; however, evidence regarding synchronous telerehabilitation in patients with elevated pulmonary artery pressure remains limited.
The aim of this study is to investigate the effectiveness of a synchronous telerehabilitation program in patients with elevated pulmonary artery pressure identified by echocardiography, defined as systolic pulmonary artery pressure (sPAP) of 50 mmHg or higher. Participants will be randomly assigned to either a synchronous telerehabilitation group or a control group. The telerehabilitation group will receive a supervised program including aerobic, endurance, and strengthening exercises, while the control group will perform breathing and posture exercises. Both groups will participate in the program 3 days per week, 30 minutes per session, for 8 weeks. At the end of the 8-week period, participants in the control group who wish to continue may be offered the synchronous rehabilitation program.
The study will evaluate the effects of the intervention on cardiopulmonary and functional outcomes, including dyspnea, fatigue, physical activity level, psychological status, pulmonary function, exercise capacity, functional capacity, and quality of life. Assessments will be performed before and after the intervention period using standardized outcome measures.
The findings of this study may help clarify the role of synchronous telerehabilitation as an accessible rehabilitation strategy for patients with elevated pulmonary artery pressure, particularly for individuals who have difficulty accessing in-person rehabilitation services. Given the limited evidence in this specific population, this study is expected to contribute clinically relevant data regarding the effectiveness of remote exercise-based rehabilitation.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Participants will be randomly assigned to either a synchronous telerehabilitation group or a control group. The synchronous telerehabilitation group will receive aerobic, endurance, and strengthening exercises, while the control group will perform breathing and posture exercises. Both groups will participate in the program 3 days per week, 30 minutes per session, for 8 weeks.
| Arm | Type | Receives |
|---|---|---|
| Synchronous Telerehabilitation Group | Experimental | Behavioral: Synchronous TelerehabilitationParticipants with elevated pulmonary artery pressure identified by echocardiography (systolic pulmonary artery pressure ≥50 mmHg) who meet the study eligibility criteria will receive an 8-week synchronous telerehabilitation program. The program will be delivered 3 days per week, 30 minutes per session, under real-time physiotherapist supervision. The intervention will include aerobic, endurance, and strengthening exercises. Exercise intensity and progression will be individualized according to clinical status, baseline adaptation, and cardiopulmonary exercise test findings. Hemodynamic parameters, oxygen saturation, dyspnea, and fatigue will be monitored during sessions. |
| Control Group | Active comparator | Behavioral: Breathing and Posture ExercisesParticipants with elevated pulmonary artery pressure identified by echocardiography (systolic pulmonary artery pressure ≥50 mmHg) who meet the study eligibility criteria will perform breathing and posture exercises for 8 weeks. Participants in this group will continue routine care and receive weekly motivational follow-up by a physiotherapist. At the end of the study period, participants in the control group may be offered the exercise program if they wish to continue. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- Adults aged 18 to 65 years
- Elevated pulmonary artery pressure identified by echocardiography, defined as systolic pulmonary artery pressure (sPAP) of 50 mmHg or higher
- Clinically stable and receiving medical treatment under cardiology follow-up World Health Organization functional class I or II
- New York Heart Association (NYHA) functional class I or II
- Living with a caregiver, family member, or another person who can provide assistance if needed
Key exclusion criteria (6 listed)
- Requirement for oxygen therapy
- Musculoskeletal problems limiting participation in exercise
- Ongoing treatment for psychiatric or psychological disorders
- Cognitive impairment based on Mini-Mental State Examination findings
- Severe chronic obstructive pulmonary disease (COPD)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Synchronous TelerehabilitationA supervised synchronous telerehabilitation program delivered via videoconferencing, including aerobic, endurance, and strengthening exercises for 8 weeks, 3 times per week, 30 minutes per session. The program will be individualized based on participant tolerance and clinical findings, with monitoring of symptoms and physiologic responses during exercise. | Behavioural | Synchronous Telerehabilitation Group |
| Breathing and Posture ExercisesA control intervention consisting of breathing exercises, positions to relieve breathing discomfort, breathing control techniques, energy conservation strategies, and posture exercises, performed for 8 weeks, together with routine care and weekly motivational follow-up. | Behavioural | Control Group |
Primary outcome
Exercise Capacity
Time frame: Baseline and at 8 weeks
Change in 6-minute walk distance assessed by the 6-minute walk test to evaluate functional capacity.
Dyspnea severity measured by the Modified Borg Dyspnea Scale
Time frame: Baseline and at 8 weeks
Change in dyspnea severity assessed using the Modified Borg Dyspnea Scale. The Modified Borg Dyspnea Scale is a subjective rating scale used to assess the severity of dyspnea at rest and/or during activity. Scores range from 0 to 10, with higher scores indicating greater dyspnea severity and a worse outcome.
6 secondary outcomes
Fatigue severity measured by the Fatigue Severity Scale
Time frame: Baseline and at 8 weeks
Physical activity level
Time frame: Baseline and at 8 weeks
Anxiety and depression measured by the Hospital Anxiety and Depression Scale
Time frame: Baseline and at 8 weeks
Pulmonary function parameters
Time frame: Baseline and at 8 weeks
Quality of life measured by the Short Form-36 (SF-36)
Time frame: Baseline and at 8 weeks
Independence in activities of daily living measured by the Barthel Index
Time frame: Baseline and at 8 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Apr 2026.
- Individual participant dataSharing planned: Undecided
Related trials for Elevated Pulmonary Artery Pressure
Recruiting
WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department
Acute Hypoxic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
Not yet recruitingObservational study
The Cardiovascular Effects of Patent Foramen Ovale in Hypoxia
Patent Foramen Ovale (PFO), High Altitude Pulmonary Edema
RecruitingObservational study
The FOCUS-ADHF Registry
Acute Heart Failure With Reduced Ejection Fraction, Decompensation; Heart, Congestive
Enrolling by invitation
Non-contrast Enhanced Cardiac Magnetic Resonance Imaging in the Diagnosis and Classification of Pulmonary Hypertension
Pulmonary Hypertension, Elevated Mean Pulmonary Arterial Pressure
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Aysel Yıldız Özer, PhD study director
Marmara University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Synchronous Telerehabilitation and Breathing and Posture Exercises in people with Elevated Pulmonary Artery Pressure, run by Marmara University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 29 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Mehmet Armağan Physiotherapist, Msc (00903562521616, mehmetarm@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Exercise Capacity (time frame: Baseline and at 8 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Apr 2026.