PeriodontitisNCT07536204
Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis
An observational study of Periodontitis and Periodontal Diseases, run by University of Chile at 1 site in Chile.
Trial summary
The goal of this observational study is to examine JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis). Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Periodontitis, Periodontal Diseases, Periodontal Inflammation
- How many people
- 30 participants
- Where
- 1 siteChile
- Study dates
- 1 Jun 2023to 31 Mar 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Adults from the northern area of Santiago, Chile
Who may be able to join
- Adults
- Sistemically healthy
Who cannot join
- Active Maliganancy
- History of radiation to the head-neck region
- Chemotherapy or radiation within the last 5 years
- History of hepatitis B/C or HIV infection
- Autoimmune diseases
- Diagnosis of diabetes
Show all 13Show fewer
- Pregnancy or lactation
- More than 3 hospitalizations over the last 3 years
- Use of systemic antibiotics over the last 3 months
- Use of systemic corticosteroids or immunosuppressants over the last 3 months
- Use of cytokine therapy over the last 3 months
- Use of large doses of pre/probiotic supplements over the last 3 months
- Smoke more than 10 cigarettes per day
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Chile1 site, 1 recruiting
- Recruiting
Faculty of Dentistry, University of Chile
Santiago, Metropolitan Region
Nicolas Dutzan, DDS, PhD, +56934037995, ndutzan@uchile.cl
About this study
Official title: Unraveling the Role of JAK1 and JAK2 Pathway in Periodontitis: Drivers of Immunopathology and Possible Therapeutic Targets
The goal of this observational study is to examine JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis). The main question it aims to answer is:
Is the JAK1/2 pathway overactivated in periodontitis compared to health?
Participants with healthy gingiva and periodontitis will donate gingival tissue to study the JAK1/2 pathway. All participants wil receive diagnosis and treatment of the gingival condition.
Read the detailed description
The goal of this observational study is to examine JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis). The main question it aims to answer is:
Is the JAK1/2 pathway overactivated in periodontitis compared to health?
A secondary outcome will be to describe the histological areas, such as epithelium or lamina propria, where the JAK1/2 pathway will be activated including the different subpopulation of cells.
The protocol include one visit where the gingival biopsies are taken.
Participants with healthy gingiva and periodontitis will donate gingival tissue to study the JAK1/2 pathway. All participants will receive diagnosis and treatment of the gingival condition.
- Conditions
- Periodontitis, Periodontal Diseases, Periodontal Inflammation, Gingival Diseases, Periodontal Attachment Loss
- Keywords
- JAK1, JAK2, Periodontitis, Gingiva, Inflammation
- Medical subject headings
- Periodontitis, Periodontal Diseases, Gingival Diseases, Periodontal Attachment Loss, Inflammation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Healthy gingiva | Adults without gingival inflammation diagnosed by a clinical exam | |
| Periodontits | Adults with periodontitis diagnosed by a clinical exam |
What is being measured
The primary outcome is the main question the study is designed to answer.
JAK1/2 pathway activation in gingival tissues
The activation of the JAK1/2 pathway will be evaluated by the phophorilation of JAK1/2 in the gingival tissues determined by western blot. Patients will be categorizied as 0, 1, 2.
0 = no phosphorilation
- = mild phosphorilation
- = intense phosphorilation
Measured: Day 1
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Apr 2026
- Study start1 Jun 2023
- Primary completion31 Mar 2027 (estimated)
- Study completion31 Mar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for PeriodontitisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Chile
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07536204
- Sponsor's protocol ID
- 2023/11
- Other IDs
- 1231350
- Status last verified
- Mar 2026
- First submitted
- 19 Mar 2026
- Last updated
- 17 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 17 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Unraveling the Role of JAK1 and JAK2 Pathway in Periodontitis: Drivers of Immunopathology and Possible Therapeutic Targets
- ClinicalTrials.gov ID
- NCT07536204
- Acronym / sponsor ID
- 2023/11
- Conditions
- Periodontitis, Periodontal Diseases, Periodontal Inflammation, Gingival Diseases, Periodontal Attachment Loss
- Keywords
- JAK1, JAK2, Periodontitis, Gingiva, Inflammation
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- University of ChileUniversity, hospital or other
- Study start
- 1 Jun 2023 (actual)
- Primary completion
- 31 Mar 2027 (estimated)
- Study completion
- 31 Mar 2027 (estimated)
- First posted
- 17 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this observational study is to examine JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis). The main question it aims to answer is:
Is the JAK1/2 pathway overactivated in periodontitis compared to health?
Participants with healthy gingiva and periodontitis will donate gingival tissue to study the JAK1/2 pathway. All participants wil receive diagnosis and treatment of the gingival condition.
Detailed description
The goal of this observational study is to examine JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis). The main question it aims to answer is:
Is the JAK1/2 pathway overactivated in periodontitis compared to health?
A secondary outcome will be to describe the histological areas, such as epithelium or lamina propria, where the JAK1/2 pathway will be activated including the different subpopulation of cells.
The protocol include one visit where the gingival biopsies are taken.
Participants with healthy gingiva and periodontitis will donate gingival tissue to study the JAK1/2 pathway. All participants will receive diagnosis and treatment of the gingival condition.
Study design
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Healthy gingiva | – | –Adults without gingival inflammation diagnosed by a clinical exam |
| Periodontits | – | –Adults with periodontitis diagnosed by a clinical exam |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Adults from the northern area of Santiago, Chile
Key inclusion criteria (2 listed)
- Adults
- Sistemically healthy
Key exclusion criteria (13 listed)
- Active Maliganancy
- History of radiation to the head-neck region
- Chemotherapy or radiation within the last 5 years
- History of hepatitis B/C or HIV infection
- Autoimmune diseases
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
JAK1/2 pathway activation in gingival tissues
Time frame: Day 1
The activation of the JAK1/2 pathway will be evaluated by the phophorilation of JAK1/2 in the gingival tissues determined by western blot. Patients will be categorizied as 0, 1, 2. 0 = no phosphorilation 1. = mild phosphorilation 2. = intense phosphorilation
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Apr 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Periodontitis and Periodontal Diseases, run by University of Chile at 1 site in Chile.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 17 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Chile. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Nicolas Dutzan, DDS, PhD (+56934037995, ndutzan@uchile.cl), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
JAK1/2 pathway activation in gingival tissues (time frame: Day 1). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Apr 2026.