Dental ImplantNCT07536451
Low-Level Diode Laser Therapy on the Acceleration of Osseointegration Around Delayed Dental Implant
A study testing Dental implant + LLDL and Dental implant in people with Dental Implant, run by Hams Hamed Abdelrahman at 1 site in Egypt.
Trial summary
Good quality soft tissue determines the possibility not only to obtain full primary wound closure during the bone defect reconstruction, but also assures effective implant treatment and stability of peri-implant condition.Moreover, it is very important to assure the proper emergence profile of the implant supported… Read more about this study
- Who is it for?
- Ages 20 to 50 years
- Conditions the study is for
- Dental Implant
- What is being tested?
- Dental implant + LLDL and Dental implant
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jun 2024to 1 Oct 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 50 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Patients are systemically medically free.
- Ability to maintain good oral hygiene as evidenced in recall visits.
- Sufficient mesiodistal and interocclusal space and have an intact buccal bone contours which does not require bone augmentation procedures.
- Adequate bone quality.
- Keratinized tissue ≥ 2mm.
- Thickness of the gingiva ≥ 1 mm.
Who cannot join
- Presence of any systemic disease that could influence the outcome of the therapy.
- Presence of any risk factor e.g.; smoker, pregnant, lactating patients or any disease affect bone healing.
- Previous history of periodontal surgical treatment in quadrant selected for the study.
- Restorations or caries in the area to be treated and non-vital tooth.
- Adjacent teeth are tilted or rotated.
- Patients taking medications known to cause affect bone quality.
- Traumatic occlusion or Para-functional habits such as clenching or bruxism.
- Participation in other clinical trials.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Efficacy of Low-Level Diode Laser Therapy on the Acceleration of Osseointegration and Mucosal Phenotype Around Delayed Dental Implant: A Randomized Controlled Clinical Trial
Good quality soft tissue determines the possibility not only to obtain full primary wound closure during the bone defect reconstruction, but also assures effective implant treatment and stability of peri-implant condition.Moreover, it is very important to assure the proper emergence profile of the implant supported restorations, which give the opportunity to achieve the highest aesthetic appearance. In the long-term, the correct width and thickness of the attached keratinized tissue is the key point to ensure the stable position of the mucosal line around the implant's neck. The promising outcomes of laser on soft and hard tissue have been demonstrating in a variety of studies. Therefore, the aim of this clinical study is to evaluate the efficacy of LLDLT on enhancing osseointegration and on the peri-implant mucosal tissue around delayed dental implants.
- Conditions
- Dental Implant
- Being tested
- Dental implant + LLDL, Dental implant
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Dental implant + LLDLOther
implant placement in the posterior areas and implants will be placed with application of LLDL. Preparation of the alveolus for delayed dental implant placement will be done and LLDL application according to manufacturer instructions
Dental implantOther
It includes ten patients seeking for implant placement at the posterior areas and those patients will be received their implants only without application of LLDL .
| Study group | Role | What they receive |
|---|---|---|
| With laser | Experimental | Not described Receives: Other: Dental implant + LLDL |
| Without laser | Active comparator | Not described Receives: Other: Dental implant |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in marginal bone loss
To assess the change in marginal bone loss, the linear distance from a fixed reference point-typically the implant shoulder or CEJ-to the highest level of bone-to-tooth/implant contact is measured.
Measured: 2 weeks, 1month, 2 months, and 6 months
Change in in implant stability
Ostell device will be used to assess implant stability
Measured: Immediately after surgery, 2 months and 6months postoperative.
Secondary outcomes (1)
Change in bone density
Radiographic examination of the patients will be done firstly pre-operative then at six months follow-up period post-operative by using CBCT device
Measured: 2 weeks, 1month, 2 months, and 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Apr 2026
- Study start1 Jun 2024
- Primary completion1 Oct 2025
- Study completion1 Oct 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Dental ImplantStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 20 participants (actual)
Sponsor and investigators
- Lead sponsor
- Hams Hamed Abdelrahman
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Hams Hamed Abdelrahman, Alexandria University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07536451
- Sponsor's protocol ID
- KFSIRB200-116
- Status last verified
- Apr 2026
- First submitted
- 11 Apr 2026
- Last updated
- 17 Apr 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 17 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Efficacy of Low-Level Diode Laser Therapy on the Acceleration of Osseointegration and Mucosal Phenotype Around Delayed Dental Implant: A Randomized Controlled Clinical Trial
- ClinicalTrials.gov ID
- NCT07536451
- Acronym / sponsor ID
- KFSIRB200-116
- Conditions
- Dental Implant
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 20 participants (actual)
- Lead sponsor
- Hams Hamed AbdelrahmanUniversity, hospital or other
- Study start
- 1 Jun 2024 (actual)
- Primary completion
- 1 Oct 2025 (actual)
- Study completion
- 1 Oct 2025 (actual)
- First posted
- 17 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Good quality soft tissue determines the possibility not only to obtain full primary wound closure during the bone defect reconstruction, but also assures effective implant treatment and stability of peri-implant condition.Moreover, it is very important to assure the proper emergence profile of the implant supported restorations, which give the opportunity to achieve the highest aesthetic appearance. In the long-term, the correct width and thickness of the attached keratinized tissue is the key point to ensure the stable position of the mucosal line around the implant's neck. The promising outcomes of laser on soft and hard tissue have been demonstrating in a variety of studies. Therefore, the aim of this clinical study is to evaluate the efficacy of LLDLT on enhancing osseointegration and on the peri-implant mucosal tissue around delayed dental implants.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| With laser | Experimental | Other: Dental implant + LLDL |
| Without laser | Active comparator | Other: Dental implant |
Who may qualify
- Ages
- 20 to 50 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Patients are systemically medically free.
- Ability to maintain good oral hygiene as evidenced in recall visits.
- Sufficient mesiodistal and interocclusal space and have an intact buccal bone contours which does not require bone augmentation procedures.
- Adequate bone quality.
- Keratinized tissue ≥ 2mm.
Key exclusion criteria (8 listed)
- Presence of any systemic disease that could influence the outcome of the therapy.
- Presence of any risk factor e.g.; smoker, pregnant, lactating patients or any disease affect bone healing.
- Previous history of periodontal surgical treatment in quadrant selected for the study.
- Restorations or caries in the area to be treated and non-vital tooth.
- Adjacent teeth are tilted or rotated.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Dental implant + LLDLimplant placement in the posterior areas and implants will be placed with application of LLDL. Preparation of the alveolus for delayed dental implant placement will be done and LLDL application according to manufacturer instructions | Other | With laser |
| Dental implantIt includes ten patients seeking for implant placement at the posterior areas and those patients will be received their implants only without application of LLDL . | Other | Without laser |
Primary outcome
Change in marginal bone loss
Time frame: 2 weeks, 1month, 2 months, and 6 months
To assess the change in marginal bone loss, the linear distance from a fixed reference point-typically the implant shoulder or CEJ-to the highest level of bone-to-tooth/implant contact is measured.
Change in in implant stability
Time frame: Immediately after surgery, 2 months and 6months postoperative.
Ostell device will be used to assess implant stability
1 secondary outcome
Change in bone density
Time frame: 2 weeks, 1month, 2 months, and 6 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Apr 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Dental implant + LLDL and Dental implant in people with Dental Implant, run by Hams Hamed Abdelrahman at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 17 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in marginal bone loss (time frame: 2 weeks, 1month, 2 months, and 6 months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Apr 2026.