Autonomic Nervous System DiseaseAutonomicNCT07536997
Resonance Breathing and Postural Resonance: Acute Modulation of Autonomic and Hemodynamic Responses Via Arterial Baroreflex Mechanisms
A study testing Resonance Breathing and Postural Resonance in people with Autonomic Nervous System Disease, run by Beijing Sport University at 1 site in China.
Trial summary
This randomized crossover study compared the acute autonomic and hemodynamic responses to three experimental conditions: control, resonance breathing (RB), and postural resonance (PR), in healthy young adults. Each participant completed all three sessions in randomized order, separated by a 5-day washout period. Read more about this study
- Who is it for?
- Ages 18 to 30 yearsHealthy volunteers can take part
- Conditions the study is for
- Autonomic Nervous System Disease
- What is being tested?
- Resonance Breathing and Postural Resonance
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteChina
- Study dates
- 1 May 2024to 10 Apr 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- 18-30 years old
Who cannot join
- No history of systematic professional sports training; Right-hand dominance (as assessed by the Edinburgh Handedness Inventory). Participants were excluded from the study if they had any of the following: Smoking, chronic alcohol consumption, or the use of psychotropic drugs or other substances affecting the nervous system; Irregular menstrual cycle; History of peripheral neuropathy or other autonomic nervous system disorders; Pre-existing cardiovascular diseases or abnormal electrocardiograms (ECG); Use of hormonal contraceptives; Uncontrolled hypertension or hypotension; Recent major life stressors; Regular practice of meditation or participation in psychotherapy; Presence of any movement disorders or inability to comprehend the experimental instructions.
Trial locations and contacts
1 site in 1 country.
China1 site
No. 11, Gongyi Road, Dongcheng District, Beijing
Beijing, Dongcheng, 100010
About this study
This randomized crossover study compared the acute autonomic and hemodynamic responses to three experimental conditions: control, resonance breathing (RB), and postural resonance (PR), in healthy young adults. Each participant completed all three sessions in randomized order, separated by a 5-day washout period. Each session included a 15-minute baseline and a 15-minute assigned condition, followed by a post-condition stress protocol consisting of a 2-minute mental arithmetic task (MAT), 5 minutes of seated rest, a 2-minute cold pressor test (CPT), and a final 5-minute recovery period. Skin sympathetic nerve activity (SKNA) and heart rate variability (HRV) were recorded continuously throughout each session, including the stress tasks and recovery periods. Blood pressure (BP) was measured intermittently at the protocol-specified time points, and pulse wave velocity (PWV) was measured at the time points specified in the study protocol.
- Conditions
- Autonomic Nervous System Disease
- Being tested
- Resonance Breathing, Postural Resonance
- Keywords
- Arterial baroreflex, Autonomic nervous system, Skin sympathetic nerve activity, Blood pressure, Resonance intervention
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Resonance BreathingBehavioural
A structured intervention focusing on resonance breathing ( slow, rhythmic breathing at spontaneous resonance frequency ) . The protocol aims to acutely modulate autonomic nervous system activity and hemodynamic responses via stimulation of the arterial baroreflex.
Postural ResonanceBehavioural
A structured intervention focusing on postural resonance alignment. The protocol aims to acutely modulate autonomic nervous system activity and hemodynamic responses via stimulation of the arterial baroreflex. Sessions include guided breathing practice, postural adjustment, and feedback on breathing mechanics
| Study group | Role | What they receive |
|---|---|---|
| Intervention Arm | Experimental | Participants receive structured Resonance Breathing and Postural Resonance training aimed at modulating baroreflex function, autonomic balance, and hemodynamic responses. All measurements are conducted at baseline and following intervention. Receives: Behavioral: Resonance Breathing; Behavioral: Postural Resonance |
What is being measured
The primary outcome is the main question the study is designed to answer.
Skin sympathetic nerve activity
Skin sympathetic nerve activity (SKNA) was recorded non-invasively from the chest wall using a dedicated SKNA monitoring system. SKNA was continuously recorded during all three experimental conditions (control, resonance breathing, and postural resonance), including the 15-minute baseline, 15-minute assigned condition, 2-minute mental arithmetic task (MAT), 5-minute seated rest between tasks, 2-minute cold pressor test (CPT), and final 5-minute recovery period. SKNA was assessed across the protocol-defined phases to characterize changes in sympathetic activity.
Measured: During each session: 15-minute baseline, 15-minute assigned condition, 2-minute MAT, 5-minute inter-task seated rest, 2-minute CPT, and final 5-minute recovery.
Heart Rate Variability (HRV) Responses During Post-Condition Stress Tasks
Heart rate variability (HRV) was derived from continuous cardiac recordings collected during all three experimental conditions (control, resonance breathing, and postural resonance). Recordings covered the 15-minute baseline, 15-minute assigned condition, 2-minute mental arithmetic task (MAT), 5-minute seated rest between tasks, 2-minute cold pressor test (CPT), and final 5-minute recovery period. HRV measures were evaluated across the protocol-defined phases to characterize cardiac autonomic responses.
Measured: During each session: 15-minute baseline, 15-minute assigned condition, 2-minute MAT, 5-minute inter-task seated rest, 2-minute CPT, and final 5-minute recovery.
Secondary outcomes (2)
Changes in Resting Systolic and Diastolic Blood Pressure
Resting systolic and diastolic blood pressure were measured in a seated position using a validated automated sphygmomanometer. Measurements were collected at baseline (pre-intervention) and immediately post-intervention, to evaluate acute hemodynamic changes following the resonance breathing and postural resonance intervention.
Measured: Baseline (pre-intervention) and immediately post-intervention (within 5 minutes of intervention completion)
Changes in Pulse Wave Velocity (PWV)
Pulse wave velocity (PWV), a non-invasive marker of arterial stiffness, was assessed using a validated vascular screening device. Measurements were obtained at baseline (pre-intervention) and immediately post-intervention, to evaluate acute changes in arterial function following the intervention.
Measured: Baseline (pre-intervention) and immediately post-intervention (within 5 minutes of intervention completion)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Apr 2026
- Study start1 May 2024
- Primary completion15 Jun 2024
- Study completion10 Apr 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Autonomic Nervous System DiseaseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Beijing Sport University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07536997
- Sponsor's protocol ID
- 2023091801
- Other IDs
- 23-50 and 24-30
- Acronym
- Autonomic
- Status last verified
- Apr 2024
- First submitted
- 12 Apr 2026
- Last updated
- 2 Nov 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 2 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Resonance Breathing and Postural Resonance: Acute Modulation of Autonomic and Hemodynamic Responses Via Arterial Baroreflex Mechanisms
- ClinicalTrials.gov ID
- NCT07536997
- Acronym / sponsor ID
- Autonomic / 2023091801
- Conditions
- Autonomic Nervous System Disease
- Keywords
- Arterial baroreflex, Autonomic nervous system, Skin sympathetic nerve activity, Blood pressure, Resonance intervention
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Beijing Sport UniversityUniversity, hospital or other
- Study start
- 1 May 2024 (actual)
- Primary completion
- 15 Jun 2024 (actual)
- Study completion
- 10 Apr 2026 (actual)
- First posted
- 17 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized crossover study compared the acute autonomic and hemodynamic responses to three experimental conditions: control, resonance breathing (RB), and postural resonance (PR), in healthy young adults. Each participant completed all three sessions in randomized order, separated by a 5-day washout period. Each session included a 15-minute baseline and a 15-minute assigned condition, followed by a post-condition stress protocol consisting of a 2-minute mental arithmetic task (MAT), 5 minutes of seated rest, a 2-minute cold pressor test (CPT), and a final 5-minute recovery period. Skin sympathetic nerve activity (SKNA) and heart rate variability (HRV) were recorded continuously throughout each session, including the stress tasks and recovery periods. Blood pressure (BP) was measured intermittently at the protocol-specified time points, and pulse wave velocity (PWV) was measured at the time points specified in the study protocol.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Intervention Arm | Experimental | Behavioral: Resonance Breathing, Behavioral: Postural ResonanceParticipants receive structured Resonance Breathing and Postural Resonance training aimed at modulating baroreflex function, autonomic balance, and hemodynamic responses. All measurements are conducted at baseline and following intervention. |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- 18-30 years old
Key exclusion criteria (1 listed)
- No history of systematic professional sports training; Right-hand dominance (as assessed by the Edinburgh Handedness Inventory). Participants were excluded from the study if they had any of the following: Smoking, chronic alcohol consumption, or the use of psychotropic drugs or other substances affecting the nervous system; Irregular menstrual cycle; History of peripheral neuropathy or other autonomic nervous system disorders; Pre-existing cardiovascular diseases or abnormal electrocardiograms (ECG); Use of hormonal contraceptives; Uncontrolled hypertension or hypotension; Recent major life stressors; Regular practice of meditation or participation in psychotherapy; Presence of any movement disorders or inability to comprehend the experimental instructions.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Resonance BreathingA structured intervention focusing on resonance breathing ( slow, rhythmic breathing at spontaneous resonance frequency ) . The protocol aims to acutely modulate autonomic nervous system activity and hemodynamic responses via stimulation of the arterial baroreflex. | Behavioural | Intervention Arm |
| Postural ResonanceA structured intervention focusing on postural resonance alignment. The protocol aims to acutely modulate autonomic nervous system activity and hemodynamic responses via stimulation of the arterial baroreflex. Sessions include guided breathing practice, postural adjustment, and feedback on breathing mechanics | Behavioural | Intervention Arm |
Primary outcome
Skin sympathetic nerve activity
Time frame: During each session: 15-minute baseline, 15-minute assigned condition, 2-minute MAT, 5-minute inter-task seated rest, 2-minute CPT, and final 5-minute recovery.
Skin sympathetic nerve activity (SKNA) was recorded non-invasively from the chest wall using a dedicated SKNA monitoring system. SKNA was continuously recorded during all three experimental conditions (control, resonance breathing, and postural resonance), including the 15-minute baseline, 15-minute assigned condition, 2-minute mental arithmetic task (MAT), 5-minute seated rest between tasks, 2-minute cold pressor test (CPT), and final 5-minute recovery period. SKNA was assessed across the protocol-defined phases to characterize changes in sympathetic activity.
Heart Rate Variability (HRV) Responses During Post-Condition Stress Tasks
Time frame: During each session: 15-minute baseline, 15-minute assigned condition, 2-minute MAT, 5-minute inter-task seated rest, 2-minute CPT, and final 5-minute recovery.
Heart rate variability (HRV) was derived from continuous cardiac recordings collected during all three experimental conditions (control, resonance breathing, and postural resonance). Recordings covered the 15-minute baseline, 15-minute assigned condition, 2-minute mental arithmetic task (MAT), 5-minute seated rest between tasks, 2-minute cold pressor test (CPT), and final 5-minute recovery period. HRV measures were evaluated across the protocol-defined phases to characterize cardiac autonomic responses.
2 secondary outcomes
Changes in Resting Systolic and Diastolic Blood Pressure
Time frame: Baseline (pre-intervention) and immediately post-intervention (within 5 minutes of intervention completion)
Changes in Pulse Wave Velocity (PWV)
Time frame: Baseline (pre-intervention) and immediately post-intervention (within 5 minutes of intervention completion)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Nov 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Resonance Breathing and Postural Resonance in people with Autonomic Nervous System Disease, run by Beijing Sport University at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Skin sympathetic nerve activity (time frame: During each session: 15-minute baseline, 15-minute assigned condition, 2-minute MAT, 5-minute inter-task seated rest, 2-minute CPT, and final 5-minute recovery.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Nov 2026.