Impacted Mandibular Third MolarDEXA-TMSNCT07538375
Effectiveness of Dexamethasone Injection for Reducing Pain After Third Molar Surgery
A study testing Dexamethasone in people with Impacted Mandibular Third Molar and Postoperative Pain, run by 28 Military Dental Centre Lahore at 1 site in Pakistan.
Trial summary
This randomized clinical trial aims to evaluate the effectiveness of dexamethasone injection in reducing postoperative pain after surgical removal of impacted mandibular third molars. Read more about this study
- Who is it for?
- Ages 20 to 40 years
- Conditions the study is for
- Impacted Mandibular Third Molar, Postoperative Pain
- What is being tested?
- Dexamethasone
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 70 participants
- Where
- 1 sitePakistan
- Study dates
- 1 Dec 2025to 30 May 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 40 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Patients aged 20 to 40 years
- Patients with at least one impacted mandibular third molar (Class A or B, Class I or II) including mesioangular, horizontal, vertical, or distoangular impactions according to Pell and Gregory classification confirmed by panoramic radiograph
- Patients with no systemic disease (e.g., diabetes mellitus, hypertension, ischemic heart disease)
- Patients of either gender
Who cannot join
- Patients who have used analgesics or related drugs within 15 days prior to surgery
- Pregnant patients
- Patients with known allergy to corticosteroids
- Patients with tooth associated with cyst, tumor, or trauma
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effectiveness of Dexamethasone Injection on Postoperative Pain After Impacted Third Molar Surgery Assessed Using Visual Analog Scale
This randomized clinical trial aims to evaluate the effectiveness of dexamethasone injection in reducing postoperative pain after surgical removal of impacted mandibular third molars. Patients are divided into two groups: one receiving standard local anesthesia, and the other receiving an additional dexamethasone injection postoperatively. Pain levels are assessed using the Visual Analogue Scale (VAS) at 24, 48, and 72 hours after surgery. The study is conducted at 28 Military Dental Centre, Lahore.
Read the detailed description
Impacted mandibular third molar surgery is commonly associated with postoperative pain, which can affect patient comfort and recovery. Corticosteroids such as dexamethasone have anti-inflammatory properties and may reduce postoperative pain and swelling.
This randomized clinical trial is designed to compare postoperative pain levels in patients undergoing third molar surgery with and without the administration of dexamethasone. Patients are randomly allocated into two groups. Group 1 receives standard inferior alveolar nerve block using 2% lignocaine with epinephrine. Group 2 receives an additional 1 ml (8 mg) dexamethasone injection in the buccal vestibule after completion of surgery.
Pain is assessed using the Visual Analogue Scale (VAS) at 24, 48, and 72 hours postoperatively. All patients are prescribed the same postoperative analgesic regimen. The primary outcome is the difference in mean pain scores between the two groups. Data analysis is performed using SPSS, and statistical significance is set at p < 0.05.
- Being tested
- Dexamethasone
- Keywords
- Dexamethasone, Third Molar Surgery, Impacted Tooth, Postoperative pain, Visual analogue scale
- Medical subject headings
- Pain, Postoperative, Tooth, Impacted
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
DexamethasoneDrug
Dexamethasone 8 mg (1 ml) was administered via buccal vestibular injection immediately after surgical removal of impacted mandibular third molars.
| Study group | Role | What they receive |
|---|---|---|
| Dexamethasone Group | Experimental | Dexamethasone 8 mg (1 ml) was administered via buccal vestibular injection immediately after surgical removal of impacted mandibular third molars. Receives: Drug: Dexamethasone |
| Control Group | No intervention | Participants will receive standard postoperative care without dexamethasone following surgical removal of impacted mandibular third molars. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Postoperative pain intensity
Postoperative pain will be assessed using a 10-point Visual Analog Scale (VAS), where 0 indicates no pain and 10 indicates worst possible pain, following surgical removal of impacted mandibular third molars.
Measured: 24 hours, 48 hours, and 72 hours postoperatively
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Apr 2026
- Study start1 Dec 2025
- Primary completion15 May 2026 (estimated)
- Study completion30 May 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Impacted Mandibular Third MolarStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomly assigned into two parallel groups: one group will receive dexamethasone injection and the other group will receive standard postoperative care without dexamethasone following surgical removal of impacted mandibular third molars.
- Masking
- None (open label)
- Enrolment
- 70 participants (actual)
Sponsor and investigators
- Lead sponsor
- 28 Military Dental Centre Lahore
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Maryam Umar, 28 Military Dental Centre Lahore
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07538375
- Sponsor's protocol ID
- MDC-LHR-DEXA-2025
- Acronym
- DEXA-TMS
- Status last verified
- Apr 2026
- First submitted
- 12 Apr 2026
- Last updated
- 20 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effectiveness of Dexamethasone Injection on Postoperative Pain After Impacted Third Molar Surgery Assessed Using Visual Analog Scale
- ClinicalTrials.gov ID
- NCT07538375
- Acronym / sponsor ID
- DEXA-TMS / MDC-LHR-DEXA-2025
- Keywords
- Dexamethasone, Third Molar Surgery, Impacted Tooth, Postoperative pain, Visual analogue scale
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 70 participants (actual)
- Lead sponsor
- 28 Military Dental Centre LahoreOther government
- Study start
- 1 Dec 2025 (actual)
- Primary completion
- 15 May 2026 (estimated)
- Study completion
- 30 May 2026 (estimated)
- First posted
- 20 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized clinical trial aims to evaluate the effectiveness of dexamethasone injection in reducing postoperative pain after surgical removal of impacted mandibular third molars. Patients are divided into two groups: one receiving standard local anesthesia, and the other receiving an additional dexamethasone injection postoperatively. Pain levels are assessed using the Visual Analogue Scale (VAS) at 24, 48, and 72 hours after surgery. The study is conducted at 28 Military Dental Centre, Lahore.
Detailed description
Impacted mandibular third molar surgery is commonly associated with postoperative pain, which can affect patient comfort and recovery. Corticosteroids such as dexamethasone have anti-inflammatory properties and may reduce postoperative pain and swelling.
This randomized clinical trial is designed to compare postoperative pain levels in patients undergoing third molar surgery with and without the administration of dexamethasone. Patients are randomly allocated into two groups. Group 1 receives standard inferior alveolar nerve block using 2% lignocaine with epinephrine. Group 2 receives an additional 1 ml (8 mg) dexamethasone injection in the buccal vestibule after completion of surgery.
Pain is assessed using the Visual Analogue Scale (VAS) at 24, 48, and 72 hours postoperatively. All patients are prescribed the same postoperative analgesic regimen. The primary outcome is the difference in mean pain scores between the two groups. Data analysis is performed using SPSS, and statistical significance is set at p < 0.05.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Participants will be randomly assigned into two parallel groups: one group will receive dexamethasone injection and the other group will receive standard postoperative care without dexamethasone following surgical removal of impacted mandibular third molars.
| Arm | Type | Receives |
|---|---|---|
| Dexamethasone Group | Experimental | Drug: DexamethasoneDexamethasone 8 mg (1 ml) was administered via buccal vestibular injection immediately after surgical removal of impacted mandibular third molars. |
| Control Group | No intervention | –Participants will receive standard postoperative care without dexamethasone following surgical removal of impacted mandibular third molars. |
Who may qualify
- Ages
- 20 to 40 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Patients aged 20 to 40 years
- Patients with at least one impacted mandibular third molar (Class A or B, Class I or II) including mesioangular, horizontal, vertical, or distoangular impactions according to Pell and Gregory classification confirmed by panoramic radiograph
- Patients with no systemic disease (e.g., diabetes mellitus, hypertension, ischemic heart disease)
- Patients of either gender
Key exclusion criteria (4 listed)
- Patients who have used analgesics or related drugs within 15 days prior to surgery
- Pregnant patients
- Patients with known allergy to corticosteroids
- Patients with tooth associated with cyst, tumor, or trauma
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| DexamethasoneDexamethasone 8 mg (1 ml) was administered via buccal vestibular injection immediately after surgical removal of impacted mandibular third molars. | Drug | Dexamethasone Group |
Primary outcome
Postoperative pain intensity
Time frame: 24 hours, 48 hours, and 72 hours postoperatively
Postoperative pain will be assessed using a 10-point Visual Analog Scale (VAS), where 0 indicates no pain and 10 indicates worst possible pain, following surgical removal of impacted mandibular third molars.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Apr 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Dexamethasone in people with Impacted Mandibular Third Molar and Postoperative Pain, run by 28 Military Dental Centre Lahore at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 20 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Postoperative pain intensity (time frame: 24 hours, 48 hours, and 72 hours postoperatively). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Apr 2026.