Climate Change Heat StressNCT07538778
Assessment of Climate Change Related Heat Stress Among Workers in Upper Egypt : Impact of Intervention Program on Physiological Responses
A study testing Heat Stress Awareness Program (HSAP) and no traing in people with Climate Change Heat Stress, run by Assiut University.
Trial summary
Climate change has a significant impact on human health and productivity at work. According to the Intergovernmental Panel on Climate Change (IPCC) and the United Nations, climate change is one of the most significant global challenges of the 21st century. Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- Climate Change Heat Stress
- What is being tested?
- Heat Stress Awareness Program (HSAP) and no traing
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 84 participants
- Where
- No sites listed yet
- Study dates
- Apr 2026to Sep 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Age >18 years old
- Both sex
- workers with a duration of work more than one year.
- Workers exposed to hot environmental conditions during daily work.
Who cannot join
- Workers with severe chronic medical conditions that may independently affect heat tolerance (e.g., advanced cardiac, renal, or endocrine disorders).
- Workers not regularly engaged in outdoor fieldwork (administrative or indoor workers).
- Workers who refused to participate or withdrew from the study.
About this study
Climate change has a significant impact on human health and productivity at work. According to the Intergovernmental Panel on Climate Change (IPCC) and the United Nations, climate change is one of the most significant global challenges of the 21st century. It is defined by the United Nations Framework Convention on Climate Change (UNFCCC) as "a change in climate that is directly or indirectly attributable to human activity that alters the composition of the global atmosphere and that is in addition to the natural climate variability observed over comparable time periods".
Climate change has led to a significant increase in global average temperatures; temperatures on average have increased by about 1.1°C since pre-industrial times . In addition, the intensity, frequency, and duration of heatwaves have been rapidly increasing around the globe . Nineteen out of the 20 warmest years on record have occurred since 2000.
Read more
Occupational exposure associated with rising temperatures and climate change has become a concern to the health and safety, productivity, and social well-being of the world's diversified workforce. As a result, the 2030 Sustainable Development Goals (SDGs) are focused on ensuring healthy lifestyles, promoting wellbeing, ensuring decent employment and work capacity, and combating the effects of climate change on all sectors of development. Climate change continues to pose an immediate and long-term threat to human survival around the world; hence, the global agenda to promote humanity's well-being by combating rising temperatures and the impacts of climate change, as stated in the Sustainable Development Goals (SDG 13).
In tropical regions in low-and middle-income countries, rural populations often work in hot climates, live in dwellings that are not thermally efficient, and are unable to access fans or air conditioners. Laboring in high heat increases the risk of heat-related injuries and illnesses. Egypt is especially vulnerable to climate change due to its geographic location and reliance on climate sensitive economic sectors.
Exposure to heat can cause a range of adverse health effects including damage to major organs and even death if the core temperature of the body exceeds 42 °C .
Working people's exposure to hot environments to heat-related health effects such respiratory, heart, and renal illnesses. Even in healthy people, heat stress has the potential to produce acute kidney damage through volume depletion. Numerous heat-related symptoms, including exhaustion, headaches, muscle cramps, weakness, nausea, vomiting, tachycardia, hyperventilation, and chest pain that may be mild or severe depending on severity, ataxia, hypotension, syncope, and momentary changes in mental status, can all be signs of heat stress.
It is possible that in some cases the asymptomatic rise in serum creatinine levels represents a dehydration-related decrease in renal perfusion without structural injury or that the rise in the creatinine level does not represent a true fall in the estimated glomerular filtration rate (eGFR). However, there is concern that changes in the creatinine level during the work shift may represent injury to the kidneys, which, if repetitive, could confer a predisposition to chronic kidney disease
- Conditions
- Climate Change Heat Stress
- Being tested
- Heat Stress Awareness Program (HSAP), no traing
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Heat Stress Awareness Program (HSAP)Behavioural
The HSAP consisted of training and medical monitoring of enrolled employees. The program will be conducted before hot session and reevaluation will be conducted after end of hot session
no traingBehavioural
worker not recives any health education
| Study group | Role | What they receive |
|---|---|---|
| Heat Stress Awareness Program | Active comparator | Not described Receives: Behavioral: Heat Stress Awareness Program (HSAP) |
| control group | Placebo comparator | Not described Receives: Behavioral: no traing |
What is being measured
The primary outcome is the main question the study is designed to answer.
change in self-reported heat-related illness (HRI) symptoms during work
change in self-reported heat-related illness (HRI) symptoms during work .number of workers who have heat-related illness before and after intervention program
Measured: baseline and 3 months after intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Apr 2026
- Study startApr 2026 (estimated)
- Primary completionApr 2027 (estimated)
- Study completionSep 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Climate Change Heat StressStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 84 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Alaa Bazied Dardir mohamed, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07538778
- Sponsor's protocol ID
- Climate Change Heat Stress
- Status last verified
- Apr 2026
- First submitted
- 14 Mar 2026
- Last updated
- 20 Apr 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Assessment of Climate Change Related Heat Stress Among Workers in Upper Egypt : Impact of Intervention Program on Physiological Responses
- ClinicalTrials.gov ID
- NCT07538778
- Acronym / sponsor ID
- Climate Change Heat Stress
- Conditions
- Climate Change Heat Stress
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 84 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- Apr 2026 (estimated)
- Primary completion
- Apr 2027 (estimated)
- Study completion
- Sep 2027 (estimated)
- First posted
- 20 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Climate change has a significant impact on human health and productivity at work. According to the Intergovernmental Panel on Climate Change (IPCC) and the United Nations, climate change is one of the most significant global challenges of the 21st century. It is defined by the United Nations Framework Convention on Climate Change (UNFCCC) as "a change in climate that is directly or indirectly attributable to human activity that alters the composition of the global atmosphere and that is in addition to the natural climate variability observed over comparable time periods".
Climate change has led to a significant increase in global average temperatures; temperatures on average have increased by about 1.1°C since pre-industrial times . In addition, the intensity, frequency, and duration of heatwaves have been rapidly increasing around the globe . Nineteen out of the 20 warmest years on record have occurred since 2000.
Occupational exposure associated with rising temperatures and climate change has become a concern to the health and safety, productivity, and social well-being of the world's diversified workforce. As a result, the 2030 Sustainable Development Goals (SDGs) are focused on ensuring healthy lifestyles, promoting wellbeing, ensuring decent employment and work capacity, and combating the effects of climate change on all sectors of development. Climate change continues to pose an immediate and long-term threat to human survival around the world; hence, the global agenda to promote humanity's well-being by combating rising temperatures and the impacts of climate change, as stated in the Sustainable Development Goals (SDG 13).
In tropical regions in low-and middle-income countries, rural populations often work in hot climates, live in dwellings that are not thermally efficient, and are unable to access fans or air conditioners. Laboring in high heat increases the risk of heat-related injuries and illnesses. Egypt is especially vulnerable to climate change due to its geographic location and reliance on climate sensitive economic sectors.
Exposure to heat can cause a range of adverse health effects including damage to major organs and even death if the core temperature of the body exceeds 42 °C .
Working people's exposure to hot environments to heat-related health effects such respiratory, heart, and renal illnesses. Even in healthy people, heat stress has the potential to produce acute kidney damage through volume depletion. Numerous heat-related symptoms, including exhaustion, headaches, muscle cramps, weakness, nausea, vomiting, tachycardia, hyperventilation, and chest pain that may be mild or severe depending on severity, ataxia, hypotension, syncope, and momentary changes in mental status, can all be signs of heat stress.
It is possible that in some cases the asymptomatic rise in serum creatinine levels represents a dehydration-related decrease in renal perfusion without structural injury or that the rise in the creatinine level does not represent a true fall in the estimated glomerular filtration rate (eGFR). However, there is concern that changes in the creatinine level during the work shift may represent injury to the kidneys, which, if repetitive, could confer a predisposition to chronic kidney disease
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Heat Stress Awareness Program | Active comparator | Behavioral: Heat Stress Awareness Program (HSAP) |
| control group | Placebo comparator | Behavioral: no traing |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Age >18 years old
- Both sex
- workers with a duration of work more than one year.
- Workers exposed to hot environmental conditions during daily work.
Key exclusion criteria (3 listed)
- Workers with severe chronic medical conditions that may independently affect heat tolerance (e.g., advanced cardiac, renal, or endocrine disorders).
- Workers not regularly engaged in outdoor fieldwork (administrative or indoor workers).
- Workers who refused to participate or withdrew from the study.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Heat Stress Awareness Program (HSAP)The HSAP consisted of training and medical monitoring of enrolled employees. The program will be conducted before hot session and reevaluation will be conducted after end of hot session | Behavioural | Heat Stress Awareness Program |
| no traingworker not recives any health education | Behavioural | control group |
Primary outcome
change in self-reported heat-related illness (HRI) symptoms during work
Time frame: baseline and 3 months after intervention
change in self-reported heat-related illness (HRI) symptoms during work .number of workers who have heat-related illness before and after intervention program
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Apr 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
A study testing Heat Stress Awareness Program (HSAP) and no traing in people with Climate Change Heat Stress, run by Assiut University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 20 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
change in self-reported heat-related illness (HRI) symptoms during work (time frame: baseline and 3 months after intervention). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Apr 2026.