MRI, Functional MRINCT07539506
Cross Modal Correlation of EEG and MRI Functional Connectivity: An Investigative Study
A study testing EEG in people with MRI, Functional MRI, run by Assaf-Harofeh Medical Center at 1 site in Israel.
Trial summary
Cross modal correlation of EEG and MRI functional connectivity: An Investigative Study. Correlating EEG Analysis with Brain Network Connectivity in Functional MRI. The primary aim of this study is to correlate correlation of MRI and EEG. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- MRI, Functional MRI
- What is being tested?
- EEG
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 1,500 participants
- Where
- 1 siteIsrael
- Study dates
- 2 Apr 2024to 31 Jan 2030
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Male or females aged 18 years or older.
- Performed a brain MRI at the Sagol Center MRI Unit, at the Shamir Medical Center
- Able to cooperate in an EEG evaluation
- Can read and sign the informed consent.
Who cannot join
- Any scalp/bone abnormality incompatible with the EEG electrodes
- Any known allergy to metals.
- Inability to cooperate with simple instructions.
- Inability to read and sign the informed consent.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Israel1 site, 1 recruiting
- Recruiting
The Sagol Center for Hyperbaric Medicine and Research Shamir Medical Center (Assaf Harofeh)
Zrifin, 70300
Shai Efrati, Prof, 972-8-9779393, efratishai@outlook.com
About this study
Cross modal correlation of EEG and MRI functional connectivity: An Investigative Study. Correlating EEG Analysis with Brain Network Connectivity in Functional MRI. The primary aim of this study is to correlate correlation of MRI and EEG.
Read the detailed description
Cross modal correlation of EEG and MRI functional connectivity: An Investigative Study. Correlating EEG Analysis with Brain Network Connectivity in fMRI. The primary aim of this study is to correlate correlation of MRI and EEG. The expected study duration is approximately 24 months (first patient in to last patient out). Estimated Enrolment: 1500 Subjects.
The aim of this study is to correlate between fMRI and EEG. Overall, the integration of AI into the study of correlations between EEG and fMRI for brain network analysis holds great promise for advancing our understanding of brain function.
Upon consent, eligible participants will be invited for EEG evaluation. EEG will be obtained using a dry electrodes headset. Correlation between fMRI and EEG connectivity for each EEG frequency band across different configurations (brain atlas, EEG connectivity measure).
EEG data will undergo pre-processing of filtering, electrical line noise removal, artifact removal and down sampling. EEG analysis for each state, comprising within and between participant data, will include frequency analysis (peak frequency and relative power), oscillations (proportions of the activity of the alpha, beta, theta, and delta bands) and power spectra distribution. Functional connectivity analysis will be performed including functional coupling.
For evoked response potentials analysis, data will be segmented to trials/epochs. Bad trials will be excluded from analysis. Included trials data will be averaged. Event-related synchronization (ERS) / desynchronization (ERD) will be evaluated.
- Conditions
- MRI, Functional MRI
- Being tested
- EEG
- Keywords
- Fmri, EEG
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
EEGDiagnostic test
EEG uses small sensors paced on the scalp to record the brain's electrical activity.
| Study group | Role | What they receive |
|---|---|---|
| Electroencephalography (EEG) | Other | EEG excels in capturing rapid changes in neural activity, making it ideal for investigating the dynamic nature of brain networks. It can detect millisecond-level fluctuations in electrical brain signals, allowing precise timing of neural events and interactions between brain regions. Receives: Diagnostic Test: EEG |
What is being measured
The primary outcome is the main question the study is designed to answer.
Correlation of fMRI and EEG functional connectivity.
Examines how brain connectivity patterns measured by fMRI (blood-flow activity) relate to connectivity patterns measured by EEG (electrical activity).
Measured: The expected study duration is approximately 24 months (first patient in to last patient out)
Secondary outcomes (2)
Correlation between EEG to anatomical MRI findings
Investigates how electrical brain activity (EEG) corresponds to structural brain features or abnormalities seen on anatomical MRI.
Measured: The expected study duration is approximately 24 months (first patient in to last patient out)
Correlation between EEG to clinical diagnosis, cognitive and physical parameters.
Explores how EEG findings relate to a patient's medical diagnosis, cognitive functioning (e.g., memory, attention), and physical/neurological condition.
Measured: The expected study duration is approximately 24 months (first patient in to last patient out)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Apr 2026
- Study start2 Apr 2024
- Primary completion31 Jan 2030 (estimated)
- Study completion31 Jan 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for MRI, Functional MRIStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 1,500 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assaf-Harofeh Medical Center
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Shay Efrati, Assaf-Harofeh Medical Center
- Investigators
- Shai Efrati, MD, Principal investigator, Study Principal Investigator
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07539506
- Sponsor's protocol ID
- 0287-23-ASF
- Status last verified
- Apr 2026
- First submitted
- 25 Feb 2026
- Last updated
- 22 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 22 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Cross Modal Correlation of EEG and MRI Functional Connectivity: An Investigative Study
- ClinicalTrials.gov ID
- NCT07539506
- Acronym / sponsor ID
- 0287-23-ASF
- Conditions
- MRI, Functional MRI
- Keywords
- Fmri, EEG
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 1,500 participants (estimated)
- Lead sponsor
- Assaf-Harofeh Medical CenterOther government
- Study start
- 2 Apr 2024 (actual)
- Primary completion
- 31 Jan 2030 (estimated)
- Study completion
- 31 Jan 2030 (estimated)
- First posted
- 20 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Cross modal correlation of EEG and MRI functional connectivity: An Investigative Study. Correlating EEG Analysis with Brain Network Connectivity in Functional MRI. The primary aim of this study is to correlate correlation of MRI and EEG.
Detailed description
Cross modal correlation of EEG and MRI functional connectivity: An Investigative Study. Correlating EEG Analysis with Brain Network Connectivity in fMRI. The primary aim of this study is to correlate correlation of MRI and EEG. The expected study duration is approximately 24 months (first patient in to last patient out). Estimated Enrolment: 1500 Subjects.
The aim of this study is to correlate between fMRI and EEG. Overall, the integration of AI into the study of correlations between EEG and fMRI for brain network analysis holds great promise for advancing our understanding of brain function.
Upon consent, eligible participants will be invited for EEG evaluation. EEG will be obtained using a dry electrodes headset. Correlation between fMRI and EEG connectivity for each EEG frequency band across different configurations (brain atlas, EEG connectivity measure).
EEG data will undergo pre-processing of filtering, electrical line noise removal, artifact removal and down sampling. EEG analysis for each state, comprising within and between participant data, will include frequency analysis (peak frequency and relative power), oscillations (proportions of the activity of the alpha, beta, theta, and delta bands) and power spectra distribution. Functional connectivity analysis will be performed including functional coupling.
For evoked response potentials analysis, data will be segmented to trials/epochs. Bad trials will be excluded from analysis. Included trials data will be averaged. Event-related synchronization (ERS) / desynchronization (ERD) will be evaluated.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Electroencephalography (EEG) | Other | Diagnostic Test: EEGEEG excels in capturing rapid changes in neural activity, making it ideal for investigating the dynamic nature of brain networks. It can detect millisecond-level fluctuations in electrical brain signals, allowing precise timing of neural events and interactions between brain regions. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Male or females aged 18 years or older.
- Performed a brain MRI at the Sagol Center MRI Unit, at the Shamir Medical Center
- Able to cooperate in an EEG evaluation
- Can read and sign the informed consent.
Key exclusion criteria (4 listed)
- Any scalp/bone abnormality incompatible with the EEG electrodes
- Any known allergy to metals.
- Inability to cooperate with simple instructions.
- Inability to read and sign the informed consent.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| EEGEEG uses small sensors paced on the scalp to record the brain's electrical activity. | Diagnostic test | Electroencephalography (EEG) |
Primary outcome
Correlation of fMRI and EEG functional connectivity.
Time frame: The expected study duration is approximately 24 months (first patient in to last patient out)
Examines how brain connectivity patterns measured by fMRI (blood-flow activity) relate to connectivity patterns measured by EEG (electrical activity).
2 secondary outcomes
Correlation between EEG to anatomical MRI findings
Time frame: The expected study duration is approximately 24 months (first patient in to last patient out)
Correlation between EEG to clinical diagnosis, cognitive and physical parameters.
Time frame: The expected study duration is approximately 24 months (first patient in to last patient out)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Apr 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Shai Efrati, MD principal investigator
Study Principal Investigator
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing EEG in people with MRI, Functional MRI, run by Assaf-Harofeh Medical Center at 1 site in Israel.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 22 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Israel. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Shai Efrati, MD (972509212866, efratishai@outlook.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Correlation of fMRI and EEG functional connectivity. (time frame: The expected study duration is approximately 24 months (first patient in to last patient out)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Apr 2026.