Healthy Adult ParticipantstRNSlangNCT07554105
Effect of Transcranial Random Noise Stimulation on the Performance in Language Tasks
A study testing transcranial random noise stimulation in people with Healthy Adult Participants, run by Adrian Guggisberg at 1 site in Switzerland.
Trial summary
Language is an essential part of daily life, enabling us to communicate, understand others, read, and learn. Certain brain injuries can disrupt these abilities, and current treatments do not always lead to a full recovery. Read more about this study
- Who is it for?
- Ages 18 to 90 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy Adult Participants
- What is being tested?
- transcranial random noise stimulation
- Type of treatment
- Medical device
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 90 participants
- Where
- 1 siteSwitzerland
- Study dates
- 17 Mar 2026to 31 Dec 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 90 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Age: 18-35 years or 60-90 years
- Native French speakers
- Right handed
- Willing and able to provide informed consent
- Normal or corrected-to-normal vision and hearing
Who cannot join
- History of neurological or psychiatric disease
- Regular consumption of benzodiazepines, neuroleptics, or psychoactive drugs
- Major language deficit, developmental language disorder, arthropathies and other mechanical language impairments
- Inability to understand or follow study procedures
- Contraindications to brain stimulation, such as
- History of epilepsy or severe migraine
Show all 10Show fewer
- Pacemaker or other active implants
- Metallic objects in the head
- Skull breach such as craniotomy
- Pregnancy
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Switzerland1 site, 1 recruiting
- Recruiting
Division of Neurorehabilitation, University Hospital of Geneva
Geneva, Canton of Geneva, 1211
Adrian G Guggisberg, MD, +41223723700, adrian.guggisberg@hcuge.ch
Adrian G Guggisberg, MD
About this study
Language is an essential part of daily life, enabling us to communicate, understand others, read, and learn. Certain brain injuries can disrupt these abilities, and current treatments do not always lead to a full recovery. To improve future therapeutic approaches, it is necessary to better understand how the brain processes language and how its activity can be modulated.
This study aims to evaluate the effects of a non-invasive brain stimulation technique called transcranial random noise stimulation. This method involves applying a very weak electrical current to the scalp to modulate the activity of brain regions involved in language. It is commonly used in research and is considered safe when administered in accordance with current guidelines.
Read more
Healthy adult volunteers will participate in this study. Each participant will take part in two sessions spaced about a week apart. During one session, active stimulation will be used, and during the other, placebo stimulation will be used. Placebo stimulation resembles the actual stimulation but has no active effect. Neither the participants nor the researchers will know which type of stimulation is being used during each session.
During the sessions, participants will perform various language tasks, and their brain activity will be recorded using an electroencephalogram (EEG), a painless method.
This study does not provide any direct benefit to participants. The risks are low and limited to temporary sensations, such as a tingling sensation on the scalp. The results will provide a better understanding of how the brain processes language and could eventually contribute to the development of new rehabilitation approaches.
- Conditions
- Healthy Adult Participants
- Being tested
- transcranial random noise stimulation, sham stimulation
- Keywords
- language, tRNS
- Medical subject headings
- Language
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
transcranial random noise stimulationDevice
active HD-tRNS
sham stimulationDevice
current will be ramped up for 30 seconds and then switched of, to mimic the subjective sensation of tRNS.
| Study group | Role | What they receive |
|---|---|---|
| Younger adults | Other | age 15-35 years Receives: Device: transcranial random noise stimulation; Device: sham stimulation |
| Elderly adults | Other | age 60-90 years Receives: Device: transcranial random noise stimulation; Device: sham stimulation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Composite score
composite behavioural score reflecting overall language performance across four language domains (phonological, semantic, morphosyntactic, and reading)
Measured: Periprocedural
Secondary outcomes (5)
Phonological processing
pseudoword reading task: accuracy (% correct) and response latency (ms)
Measured: Periprocedural
Semantic processing
semantic fluency task: number of correct words produced within 1 min
Measured: Periprocedural
Morphosyntactic processing
grammaticality judgment task: accuracy (% correct) and response latency (ms)
Measured: Periprocedural
Reading speed
International reading speed test IReST: Reading time (s), words per minute, and error count
Measured: Periprocedural
Sustained attention
d2-R: standard concentration performance score and error rate (control measure)
Measured: Periprocedural
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Apr 2026
- Study start17 Mar 2026
- Primary completion30 Sep 2027 (estimated)
- Study completion31 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Healthy Adult ParticipantsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 90 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Adrian Guggisberg
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Adrian Guggisberg, University Hospital, Geneva
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07554105
- Sponsor's protocol ID
- 2026-D0001
- Acronym
- tRNSlang
- Status last verified
- Apr 2026
- First submitted
- 10 Apr 2026
- Last updated
- 28 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: EEG and behavioral data
Study at a glance
From the registry record, last updated by the sponsor on 28 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Transcranial Random Noise Stimulation on the Performance in Language Tasks
- ClinicalTrials.gov ID
- NCT07554105
- Acronym / sponsor ID
- tRNSlang / 2026-D0001
- Conditions
- Healthy Adult Participants
- Keywords
- language, tRNS
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 90 participants (estimated)
- Lead sponsor
- Adrian GuggisbergUniversity, hospital or other
- Study start
- 17 Mar 2026 (actual)
- Primary completion
- 30 Sep 2027 (estimated)
- Study completion
- 31 Dec 2027 (estimated)
- First posted
- 28 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Language is an essential part of daily life, enabling us to communicate, understand others, read, and learn. Certain brain injuries can disrupt these abilities, and current treatments do not always lead to a full recovery. To improve future therapeutic approaches, it is necessary to better understand how the brain processes language and how its activity can be modulated.
This study aims to evaluate the effects of a non-invasive brain stimulation technique called transcranial random noise stimulation. This method involves applying a very weak electrical current to the scalp to modulate the activity of brain regions involved in language. It is commonly used in research and is considered safe when administered in accordance with current guidelines.
Healthy adult volunteers will participate in this study. Each participant will take part in two sessions spaced about a week apart. During one session, active stimulation will be used, and during the other, placebo stimulation will be used. Placebo stimulation resembles the actual stimulation but has no active effect. Neither the participants nor the researchers will know which type of stimulation is being used during each session.
During the sessions, participants will perform various language tasks, and their brain activity will be recorded using an electroencephalogram (EEG), a painless method.
This study does not provide any direct benefit to participants. The risks are low and limited to temporary sensations, such as a tingling sensation on the scalp. The results will provide a better understanding of how the brain processes language and could eventually contribute to the development of new rehabilitation approaches.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Younger adults | Other | Device: transcranial random noise stimulation, Device: sham stimulationage 15-35 years |
| Elderly adults | Other | Device: transcranial random noise stimulation, Device: sham stimulationage 60-90 years |
Who may qualify
- Ages
- 18 to 90 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Age: 18-35 years or 60-90 years
- Native French speakers
- Right handed
- Willing and able to provide informed consent
- Normal or corrected-to-normal vision and hearing
Key exclusion criteria (10 listed)
- History of neurological or psychiatric disease
- Regular consumption of benzodiazepines, neuroleptics, or psychoactive drugs
- Major language deficit, developmental language disorder, arthropathies and other mechanical language impairments
- Inability to understand or follow study procedures
- Contraindications to brain stimulation, such as
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| transcranial random noise stimulationactive HD-tRNS | Device | Elderly adults, Younger adults |
| sham stimulationcurrent will be ramped up for 30 seconds and then switched of, to mimic the subjective sensation of tRNS. | Device | Elderly adults, Younger adults |
Primary outcome
Composite score
Time frame: Periprocedural
composite behavioural score reflecting overall language performance across four language domains (phonological, semantic, morphosyntactic, and reading)
5 secondary outcomes
Phonological processing
Time frame: Periprocedural
Semantic processing
Time frame: Periprocedural
Morphosyntactic processing
Time frame: Periprocedural
Reading speed
Time frame: Periprocedural
Sustained attention
Time frame: Periprocedural
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Apr 2026.
- Individual participant dataSharing planned: Yes. EEG and behavioral data
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing transcranial random noise stimulation in people with Healthy Adult Participants, run by Adrian Guggisberg at 1 site in Switzerland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 28 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Switzerland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Adrian Guggisberg, MD (+41223723700, adrian.guggisberg@hug.ch), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Composite score (time frame: Periprocedural). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Apr 2026.