Athletic PerformanceNCT07555288
Sideritis Supplementation and Performance
A study testing 950 mg of Sideritis Scardica (SidTea+) extract one hour pre-exercise in people with Athletic Performance, run by University of Thessaly at 1 site in Greece.
Trial summary
The purpose of this study is to examine the effect of sideritis consumption on physiological and performance indicators in adult subjects and compare it with the control trial. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Athletic Performance
- What is being tested?
- 950 mg of Sideritis Scardica (SidTea+) extract one hour pre-exercise
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 12 participants
- Where
- 1 siteGreece
- Study dates
- 25 Apr 2026to 30 Jun 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy Individuals aged 18-40 years
Who cannot join
- Musculoskeletal Injury
- Dietary supplements
- Medication
Trial locations and contacts
1 site in 1 country.
Greece1 site
Exercise Biochemistry, Physiology and Nutrition Laboratory, Department of Physical Education and Sport Science, University of Thessaly
Trikala, Thessaly, 42150
About this study
Official title: The Effect of Sideritis as Supplement on Performance
The purpose of this study is to examine the effect of sideritis consumption on physiological and performance indicators in adult subjects and compare it with the control trial.
Read the detailed description
Significance of the Study:
There is currently no evidence supporting an improvement in athletic performance following the use of sideritis. Despite existing studies showing that the mechanism through which sideritis acts is almost identical to that of other supplements that have been found to enhance athletic performance, direct evidence for its effectiveness remains lacking.
Methodology:
Initially, the participants of the study will visit the laboratory in order to be informed about the exercise research protocol. During the first visit, the participants will perform a maximal oxygen uptake (VO₂max) test on a treadmill using the RAMP protocol. In this specific method for determining maximal oxygen uptake, the treadmill speed will increase by 1 km/h every minute. Thus, the participants will reach exhaustion gradually.
The participants will visit the laboratory two more times in order to perform the exercise protocols. One hour before each session, each participant will receive a dietary supplement, which will contain either 950 mg of sideritis or a specific dosage of a neutral substance (placebo). The selection of supplements will be random, as the study will be conducted using a double-blind design. This means that neither the participants nor the researcher will know which type of supplement has been consumed prior to the exercise protocol. The exercise protocol will consist of 60 minutes of treadmill running at an intensity of 70-75% of VO₂max, which has been individually determined for each participant based on the prior VO₂max test. During these 60 minutes, a gas exchange mask will be used to determine that participants are running at the specified intensity. After the 60 minutes, participants will wear the mask again and will run at a higher intensity (90-95% VO₂max) until exhaustion (Time to Exhaustion). Before each exercise protocol, and at 15, 30, 45, and 60 minutes during exercise, as well as immediately after completion, capillary blood samples will be collected to assess lactate and glucose levels. Additionally, body composition measurements will be conducted using the BIA method. Participants' dietary intake will also be recorded for the day prior to the VO₂max test, as well as for the days preceding the exercise protocol sessions. This recording will be conducted in order to determine whether any participant has consumed sideritis through their diet prior to the protocol.
Statistical Analysis
A 2-way repeated measures ANOVA will be performed. The statistical program SPSS 26 will be used.
- Conditions
- Athletic Performance
- Being tested
- 950 mg of Sideritis Scardica (SidTea+) extract one hour pre-exercise, 950 mg of placebo one hour pre-exercise
- Keywords
- sideritis, Extract, Performance, Blood lactate, Blood Glusose
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
950 mg of Sideritis Scardica (SidTea+) extract one hour pre-exerciseDietary supplement
950 mg of Sideritis Scardica (SidTea+) extract one hour pre-exercise during exercise day
950 mg of placebo one hour pre-exerciseDietary supplement
950 mg of placebo one hour pre-exercise during exercise day
| Study group | Role | What they receive |
|---|---|---|
| Sideritis Scardica (SidTea+) extract | Experimental | Sideritis Scardica (SidTea+) extract will be administered to participants in this arm. Receives: Dietary Supplement: 950 mg of Sideritis Scardica (SidTea+) extract one hour pre-exercise |
| Placebo Supplementation | Placebo comparator | Placebo will be administered to participants in this arm. Receives: Dietary Supplement: 950 mg of placebo one hour pre-exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Blood lactate
Blood lactate concentration will be estimated using an analyzer.
Measured: Change from baseline to 15, 30, 45, 60 minutes during exercise and immediately post-exercise
Change in mean respiratory quotient during exercise
The mean respiratory quotient during exercise will be measured using a gas analyzer
Measured: Mean respiratory quotient will be measured during 60 minute of exercise
Change in mean oxygen consumption during exercise
Mean oxygen consumption during exercise will be measured using a gas analyzer
Measured: Mean oxygen consumption will be measured during 60 minute of exercise
Change in mean Heart rate during exercise
Mean heart rate during exercise will be measured using a heart rate monitor
Measured: Mean heart rate will be measured during 60 minute of exercise
Change in time to exhaustion
Time to exhaustion will be estimated using an electronic timer
Measured: The time to exhaustion will be measured immediately after 60 minute of exercise
Change in Glucose concentration
Glucose concentration will be estimated using an analyzer.
Measured: Change from baseline to 15, 30, 45, 60 minutes during exercise and immediately post-exercise
Change in heart rate
Heart rate will be estimated using monitor units.
Measured: Change from baseline to 15, 30, 45, 60 minutes during exercise and immediately post-exercise
Change in oxygen consumption
Oxygen consumption will be estimated using gas analyzer
Measured: Change from baseline to 15, 30, 45, 60 minutes during exercise and immediately post-exercise
Change in respiratory quotient
Respiratory quotient will be estimated using gas analyzer
Measured: Change from baseline to 15, 30, 45, 60 minutes during exercise and immediately post-exercise
Secondary outcomes (5)
Body weight
Body weight will be estimated using beam balance scale
Measured: Baseline
Body fat (%)
Body fat will be measured by bioelectrical impedance analysis
Measured: Baseline
Resting Heart Rate
Resting heart rate will be measured using a heart rate sensor
Measured: Baseline
Diastolic and systolic blood pressure
Diastolic and systolic blood pressure will be measured using a manual sphygmomanometer
Measured: Baseline
Maximal oxygen consumption (VO2max)
VO2max will be measured using an automated open-circuit spirometer
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Apr 2026
- Study start25 Apr 2026
- Primary completion25 May 2026
- Study completion30 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Athletic PerformanceStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 12 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Thessaly
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Athanasios Z. Jamurtas, University of Thessaly
- Investigators
- Athanasios Z Jamurtas, Professor, Study director, University of Thessaly
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07555288
- Sponsor's protocol ID
- UTH_DPESS_SID_PER
- Status last verified
- Apr 2026
- First submitted
- 21 Apr 2026
- Last updated
- 13 Oct 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Papanikolaou K, Kouloridas K, Rosvoglou A, Gatsas A, Georgakouli K, Deli CK, Draganidis D, Argyropoulou A, Michailidis D, Fatouros IG, Jamurtas AZ. Characterization of the Sideritis scardica Extract SidTea+TM and Its Effect on Physiological Profile, Metabolic Health and Redox Biomarkers in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Molecules. 2024 Mar 1;29(5):1113. doi: 10.3390/molecules29051113.
PubMed 38474625
Study at a glance
From the registry record, last updated by the sponsor on 13 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Sideritis as Supplement on Performance
- ClinicalTrials.gov ID
- NCT07555288
- Acronym / sponsor ID
- UTH_DPESS_SID_PER
- Conditions
- Athletic Performance
- Keywords
- sideritis, Extract, Performance, Blood lactate, Blood Glusose
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 12 participants (actual)
- Lead sponsor
- University of ThessalyUniversity, hospital or other
- Study start
- 25 Apr 2026 (actual)
- Primary completion
- 25 May 2026 (actual)
- Study completion
- 30 Jun 2026 (actual)
- First posted
- 29 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to examine the effect of sideritis consumption on physiological and performance indicators in adult subjects and compare it with the control trial.
Detailed description
Significance of the Study:
There is currently no evidence supporting an improvement in athletic performance following the use of sideritis. Despite existing studies showing that the mechanism through which sideritis acts is almost identical to that of other supplements that have been found to enhance athletic performance, direct evidence for its effectiveness remains lacking.
Methodology:
Initially, the participants of the study will visit the laboratory in order to be informed about the exercise research protocol. During the first visit, the participants will perform a maximal oxygen uptake (VO₂max) test on a treadmill using the RAMP protocol. In this specific method for determining maximal oxygen uptake, the treadmill speed will increase by 1 km/h every minute. Thus, the participants will reach exhaustion gradually.
The participants will visit the laboratory two more times in order to perform the exercise protocols. One hour before each session, each participant will receive a dietary supplement, which will contain either 950 mg of sideritis or a specific dosage of a neutral substance (placebo). The selection of supplements will be random, as the study will be conducted using a double-blind design. This means that neither the participants nor the researcher will know which type of supplement has been consumed prior to the exercise protocol. The exercise protocol will consist of 60 minutes of treadmill running at an intensity of 70-75% of VO₂max, which has been individually determined for each participant based on the prior VO₂max test. During these 60 minutes, a gas exchange mask will be used to determine that participants are running at the specified intensity. After the 60 minutes, participants will wear the mask again and will run at a higher intensity (90-95% VO₂max) until exhaustion (Time to Exhaustion). Before each exercise protocol, and at 15, 30, 45, and 60 minutes during exercise, as well as immediately after completion, capillary blood samples will be collected to assess lactate and glucose levels. Additionally, body composition measurements will be conducted using the BIA method. Participants' dietary intake will also be recorded for the day prior to the VO₂max test, as well as for the days preceding the exercise protocol sessions. This recording will be conducted in order to determine whether any participant has consumed sideritis through their diet prior to the protocol.
Statistical Analysis
A 2-way repeated measures ANOVA will be performed. The statistical program SPSS 26 will be used.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Sideritis Scardica (SidTea+) extract | Experimental | Dietary Supplement: 950 mg of Sideritis Scardica (SidTea+) extract one hour pre-exerciseSideritis Scardica (SidTea+) extract will be administered to participants in this arm. |
| Placebo Supplementation | Placebo comparator | Dietary Supplement: 950 mg of placebo one hour pre-exercisePlacebo will be administered to participants in this arm. |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Healthy Individuals aged 18-40 years
Key exclusion criteria (3 listed)
- Musculoskeletal Injury
- Dietary supplements
- Medication
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| 950 mg of Sideritis Scardica (SidTea+) extract one hour pre-exercise950 mg of Sideritis Scardica (SidTea+) extract one hour pre-exercise during exercise day | Dietary supplement | Sideritis Scardica (SidTea+) extract |
| 950 mg of placebo one hour pre-exercise950 mg of placebo one hour pre-exercise during exercise day | Dietary supplement | Placebo Supplementation |
Primary outcome
Change in Blood lactate
Time frame: Change from baseline to 15, 30, 45, 60 minutes during exercise and immediately post-exercise
Blood lactate concentration will be estimated using an analyzer.
Change in mean respiratory quotient during exercise
Time frame: Mean respiratory quotient will be measured during 60 minute of exercise
The mean respiratory quotient during exercise will be measured using a gas analyzer
Change in mean oxygen consumption during exercise
Time frame: Mean oxygen consumption will be measured during 60 minute of exercise
Mean oxygen consumption during exercise will be measured using a gas analyzer
Change in mean Heart rate during exercise
Time frame: Mean heart rate will be measured during 60 minute of exercise
Mean heart rate during exercise will be measured using a heart rate monitor
Change in time to exhaustion
Time frame: The time to exhaustion will be measured immediately after 60 minute of exercise
Time to exhaustion will be estimated using an electronic timer
Change in Glucose concentration
Time frame: Change from baseline to 15, 30, 45, 60 minutes during exercise and immediately post-exercise
Glucose concentration will be estimated using an analyzer.
Change in heart rate
Time frame: Change from baseline to 15, 30, 45, 60 minutes during exercise and immediately post-exercise
Heart rate will be estimated using monitor units.
Change in oxygen consumption
Time frame: Change from baseline to 15, 30, 45, 60 minutes during exercise and immediately post-exercise
Oxygen consumption will be estimated using gas analyzer
Change in respiratory quotient
Time frame: Change from baseline to 15, 30, 45, 60 minutes during exercise and immediately post-exercise
Respiratory quotient will be estimated using gas analyzer
5 secondary outcomes
Body weight
Time frame: Baseline
Body fat (%)
Time frame: Baseline
Resting Heart Rate
Time frame: Baseline
Diastolic and systolic blood pressure
Time frame: Baseline
Maximal oxygen consumption (VO2max)
Time frame: Baseline
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Oct 2026.
- Background: PubMed 38474625Papanikolaou K, Kouloridas K, Rosvoglou A, Gatsas A, Georgakouli K, Deli CK, Draganidis D, Argyropoulou A, Michailidis D, Fatouros IG, Jamurtas AZ. Characterization of the Sideritis scardica Extract SidTea+TM and Its Effect on Physiological Profile, Metabolic Health and Redox Biomarkers in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Molecules. 2024 Mar 1;29(5):1113. doi: 10.3390/molecules29051113.
- Individual participant dataSharing planned: No
Related trials for Athletic Performance
Active, not recruiting
Effects of Blood Flow Restriction Training on Physical Function, Muscle Adaptations, and Performance in Roller Skaters
Athletic Performance Enhancement
Recruiting
UCLA Magnesium Formulation Athlete Study
Athletic Performance, Recovery
Active, not recruitingObservational study
Physiological and Performance Characteristics of HYROX Athletes
Physical Fitness, Athletic Performance
Not yet recruiting
Delayed Morning Training, Sleep, and Change-of-Direction Performance in Badminton Athletes
Sleep Duration, Athletic Performance
Active, not recruiting
Weighted-Vest Versus Bodyweight Plyometric Training in Youth Female Soccer Players
Healthy, Athletic Performance
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Athanasios Z Jamurtas, Professor study director
University of Thessaly
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing 950 mg of Sideritis Scardica (SidTea+) extract one hour pre-exercise in people with Athletic Performance, run by University of Thessaly at 1 site in Greece.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Greece. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Blood lactate (time frame: Change from baseline to 15, 30, 45, 60 minutes during exercise and immediately post-exercise). The study lists 9 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07555288, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Oct 2026.