Upper Tract Urothelial CarcinomaNCT07557563
Flexible Ureterorenoscopy for Surveillance of Upper Tract Urothelial Carcinoma
A study testing Flexible ureterorenoscopy in people with Upper Tract Urothelial Carcinoma, run by Chinese University of Hong Kong at 1 site in Hong Kong.
Trial summary
It is a prospective single-arm pilot study to investigate the safety and feasibility of flexible ureteroscopy under local anaesthesia. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Upper Tract Urothelial Carcinoma
- What is being tested?
- Flexible ureterorenoscopy
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 10 participants
- Where
- 1 siteHong Kong
- Study dates
- 1 Oct 2025to 31 Mar 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Aged 18 years or older
- Capable of giving informed consent
- Having undergone an kidney-sparing surgery (endoscopic operation or segmental ureterectomy)
Who cannot join
- Allergy to transurethral lidocaine jelly
- On anticoagulation or anti-platelet medication with contraindications for cessation prior to the procedure
- Structural abnormalities in the upper urinary tract on the intended side of examination
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Hong Kong1 site, 1 recruiting
- Recruiting
Prince of Wales Hospital
Hong Kong
Jeremy Yuen-Chun TEOH, FRCS(Ed), 35052625, jeremyteoh@surgery.cuhk.edu.hk
About this study
Official title: Flexible Ureterorenoscopy for Surveillance of Upper Tract Urothelial Carcinoma - A Pilot Study
It is a prospective single-arm pilot study to investigate the safety and feasibility of flexible ureteroscopy under local anaesthesia.
Read the detailed description
All consecutive patients who have undergone kidney-sparing surgery for managing upper tract urothelial carcinoma will be screened for study eligibility. Surveillance flexible ureteroscopy of the upper urinary tract under local anaesthesia in an ambulatory care setting. The peri-operative outcomes, patient reported outcomes, complication and cost-effectiveness analysis will be evaluated.
- Conditions
- Upper Tract Urothelial Carcinoma
- Being tested
- Flexible ureterorenoscopy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Flexible ureterorenoscopyOther
Flexible ureterorenoscopy for Surveillance of UTUC under local anaesthesia
| Study group | Role | What they receive |
|---|---|---|
| Treatment Arm | Experimental | Flexible ureterorenoscopy for Surveillance of UTUC under local anaesthesia Receives: Other: Flexible ureterorenoscopy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Procedure success rate
The procedure is completed successfully.
Measured: Immediately postoperatively
Secondary outcomes (2)
Complication rate
Assessed by Clavien Dindo Classification
Measured: On day 30
Readmission rate
Assessed by readmission to hospital after discharge
Measured: On Day 30
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Apr 2026
- Study start1 Oct 2025
- Primary completion31 Dec 2027 (estimated)
- Study completion31 Mar 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Upper Tract Urothelial CarcinomaStudies of the same condition, open and under way.
- More trials run by Chinese University of Hong KongThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 10 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Chinese University of Hong Kong
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Jeremy Yuen Chun TEOH, Chinese University of Hong Kong
- Investigators
- Yuen Chun Jeremy TEOH, MD, Principal investigator, Chinese University of Hong Kong
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07557563
- Sponsor's protocol ID
- CRE-2024.432
- Status last verified
- Oct 2026
- First submitted
- 22 Apr 2026
- Last updated
- 27 Oct 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Flexible Ureterorenoscopy for Surveillance of Upper Tract Urothelial Carcinoma - A Pilot Study
- ClinicalTrials.gov ID
- NCT07557563
- Acronym / sponsor ID
- CRE-2024.432
- Conditions
- Upper Tract Urothelial Carcinoma
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 10 participants (estimated)
- Lead sponsor
- Chinese University of Hong KongUniversity, hospital or other
- Study start
- 1 Oct 2025 (actual)
- Primary completion
- 31 Dec 2027 (estimated)
- Study completion
- 31 Mar 2028 (estimated)
- First posted
- 29 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
It is a prospective single-arm pilot study to investigate the safety and feasibility of flexible ureteroscopy under local anaesthesia.
Detailed description
All consecutive patients who have undergone kidney-sparing surgery for managing upper tract urothelial carcinoma will be screened for study eligibility. Surveillance flexible ureteroscopy of the upper urinary tract under local anaesthesia in an ambulatory care setting. The peri-operative outcomes, patient reported outcomes, complication and cost-effectiveness analysis will be evaluated.
Study design
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Treatment Arm | Experimental | Other: Flexible ureterorenoscopyFlexible ureterorenoscopy for Surveillance of UTUC under local anaesthesia |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Aged 18 years or older
- Capable of giving informed consent
- Having undergone an kidney-sparing surgery (endoscopic operation or segmental ureterectomy)
Key exclusion criteria (3 listed)
- Allergy to transurethral lidocaine jelly
- On anticoagulation or anti-platelet medication with contraindications for cessation prior to the procedure
- Structural abnormalities in the upper urinary tract on the intended side of examination
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Flexible ureterorenoscopyFlexible ureterorenoscopy for Surveillance of UTUC under local anaesthesia | Other | Treatment Arm |
Primary outcome
Procedure success rate
Time frame: Immediately postoperatively
The procedure is completed successfully.
2 secondary outcomes
Complication rate
Time frame: On day 30
Readmission rate
Time frame: On Day 30
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Yuen Chun Jeremy TEOH, MD principal investigator
Chinese University of Hong Kong
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Flexible ureterorenoscopy in people with Upper Tract Urothelial Carcinoma, run by Chinese University of Hong Kong at 1 site in Hong Kong.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 27 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Hong Kong. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ho Ming Chris WONG, MBChB (35052625, chriswong@surgery.cuhk.edu.hk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Procedure success rate (time frame: Immediately postoperatively). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Oct 2026.