Colorectal CancerNCT07559825
Early-Onset Colorectal Cancer Patients Too Young for Screening
An observational study of Colorectal Cancer, run by Methodist Health System at 1 site in United States.
Trial summary
This is a population-based retrospective study using the Surveillance, Epidemiology, and End Results (SEER) registry and National Cancer Data Base (NCDB) to look at colorectal cancer (CRC) patients younger than 35 and comparing them against CRC patients older than 35 years of age. Read more about this study
- Who is it for?
- Ages 35 years and older
- Conditions the study is for
- Colorectal Cancer
- What is being tested?
- Colorectal cancer
- How many people
- 100 participants
- Where
- 1 siteUnited States
- Study dates
- 31 Jan 2020to Jan 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 35 years and older
- All sexes
- Adult, Older adult
Study population: This is a population-based retrospective study using the Surveillance, Epidemiology, and End Results (SEER) registry and National Cancer Data Base (NCDB) to look at colorectal cancer (CRC) patients younger than 35 and comparing them against CRC patients older than 35 years of age.
Who may be able to join
- Colorectal cancer
Who cannot join
- No Colorectal cancer
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Methodist Dallas Medical Center- Clinical Research Institute
Dallas, Texas, 75203
Colette Ngo Ndjom, 214-947-1289, ClinicalResearch@mhd.com
Kavya Mankulangara, 214-947-4604, ClinicalResearch@mhd.com
About this study
Official title: Early-Onset Colorectal Cancer Patients Too Young for Screening: Outcomes and Treatment Patterns
This is a population-based retrospective study using the Surveillance, Epidemiology, and End Results (SEER) registry and National Cancer Data Base (NCDB) to look at colorectal cancer (CRC) patients younger than 35 and comparing them against CRC patients older than 35 years of age.
Read the detailed description
Specifically, investigator want to investigate the effect of having a diagnosis of CRC before the age of 35 years on:disease stage at presentation, insurance status at diagnosis, treatment patterns by stage, and adjusted cancer-specific survival. The hypothesis is that patients younger than 35 years of age with CRC will present with more advanced disease at diagnosis but will have longer survival overall through more aggressive therapy.
- Conditions
- Colorectal Cancer
- Being tested
- Colorectal cancer
- Medical subject headings
- Colorectal Neoplasms
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Colorectal cancerOther
CRC is a disease that is often associated with older adults (<50 years). CRC remains the second most common cause of cancer death in males and the third most common cancer death in women. Despite this, CRC incidence has steadily declined in older adults; however, there is a concerning rise of incidence of colorectal cancer in young patients. The incidence of CRC in men and women under the age of 50 steadily increased 2.1 percent per year from 1992 through 2012.
| Study group | Role | What they receive |
|---|---|---|
| colorectal cancer (CRC) patients younger than 35 | The hypothesis is that patients younger than 35 years of age with CRC will present with more advanced disease at diagnosis but will have longer survival overall through more aggressive therapy. Receives: Other: Colorectal cancer |
What is being measured
The primary outcome is the main question the study is designed to answer.
Age
colorectal cancer (CRC) patients younger than 35 years and comparing them against CRC patients older than 35 years of age.
Measured: 20 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Apr 2026
- Study start31 Jan 2020
- Primary completionJan 2027 (estimated)
- Study completionJan 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Colorectal CancerStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Retrospective
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Methodist Health System
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Rohan Jeyarajah, MD, Principal investigator, Methodist Health System
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07559825
- Sponsor's protocol ID
- 036.HBP.2020.R
- Status last verified
- Jan 2026
- First submitted
- 18 Mar 2026
- Last updated
- 30 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The data attained will be de-identified prior to sharing via presentation and/or publication in relevant research mediums.
Study at a glance
From the registry record, last updated by the sponsor on 30 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Early-Onset Colorectal Cancer Patients Too Young for Screening: Outcomes and Treatment Patterns
- ClinicalTrials.gov ID
- NCT07559825
- Acronym / sponsor ID
- 036.HBP.2020.R
- Conditions
- Colorectal Cancer
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Methodist Health SystemUniversity, hospital or other
- Study start
- 31 Jan 2020 (actual)
- Primary completion
- Jan 2027 (estimated)
- Study completion
- Jan 2028 (estimated)
- First posted
- 30 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is a population-based retrospective study using the Surveillance, Epidemiology, and End Results (SEER) registry and National Cancer Data Base (NCDB) to look at colorectal cancer (CRC) patients younger than 35 and comparing them against CRC patients older than 35 years of age.
Detailed description
Specifically, investigator want to investigate the effect of having a diagnosis of CRC before the age of 35 years on:disease stage at presentation, insurance status at diagnosis, treatment patterns by stage, and adjusted cancer-specific survival. The hypothesis is that patients younger than 35 years of age with CRC will present with more advanced disease at diagnosis but will have longer survival overall through more aggressive therapy.
Study design
- Observational model
- Case only
- Time perspective
- Retrospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| colorectal cancer (CRC) patients younger than 35 | – | Other: Colorectal cancerThe hypothesis is that patients younger than 35 years of age with CRC will present with more advanced disease at diagnosis but will have longer survival overall through more aggressive therapy. |
Who may qualify
- Ages
- 35 years and older
- Sex
- All
- Age groups
- Adult, Older adult
- Study population
- This is a population-based retrospective study using the Surveillance, Epidemiology, and End Results (SEER) registry and National Cancer Data Base (NCDB) to look at colorectal cancer (CRC) patients younger than 35 and comparing them against CRC patients older than 35 years of age.
Key inclusion criteria (1 listed)
- Colorectal cancer
Key exclusion criteria (1 listed)
- No Colorectal cancer
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Colorectal cancerCRC is a disease that is often associated with older adults (<50 years). CRC remains the second most common cause of cancer death in males and the third most common cancer death in women. Despite this, CRC incidence has steadily declined in older adults; however, there is a concerning rise of incidence of colorectal cancer in young patients. The incidence of CRC in men and women under the age of 50 steadily increased 2.1 percent per year from 1992 through 2012. | Other | colorectal cancer (CRC) patients younger than 35 |
Primary outcome
Age
Time frame: 20 years
colorectal cancer (CRC) patients younger than 35 years and comparing them against CRC patients older than 35 years of age.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Apr 2026.
- Individual participant dataSharing planned: Yes. The data attained will be de-identified prior to sharing via presentation and/or publication in relevant research mediums.
Related trials for Colorectal Cancer
Not yet recruitingPhase 1
Hepatic Artery Infusion of Carfilzomib in Participants With Liver Metastatic Disease Previously Treated With Hepatic Artery Infusion Pump Therapy
Colorectal Neoplasms, Neoplasms
Active, not recruiting
Streamlined Geriatric and Oncological Evaluation Based On IC Technology
Breast Cancer, Comorbidities and Coexisting Conditions
RecruitingObservational study
Pre- and On-treatment Multi-omics Profiling of Locally Advanced Rectal Cancer
Rectal Neoplasms
Enrolling by invitationObservational study
Natural History Study of Early Life Exposures in Agriculture (ELEA)
Prostate Cancer, Leukemia
RecruitingPhase 2
Tislelizumab in People With Colorectal Cancer
Colorectal Cancer
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Rohan Jeyarajah, MD principal investigator
Methodist Health System
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Colorectal Cancer, run by Methodist Health System at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 30 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Crystee Cooper, DHEd (214-947-1280, ClinicalResearch@mhd.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Age (time frame: 20 years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Apr 2026.