Liver CirrhosisThrombosisNCT07560202
Portal Vein Thrombosis in Liver Cirrhosis: Clinical Characteristics, Radiological Patterns, and Predictors
An observational study of Liver Cirrhosis and Portal Vein Thrombosis, run by Elham Ahmed Hassan at 1 site in Egypt.
Trial summary
Portal vein thrombosis (PVT) is a common complication in patients with liver cirrhosis and is associated with increased morbidity due to worsening portal hypertension and hepatic decompensation. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Liver Cirrhosis, Portal Vein Thrombosis
- What is being tested?
- Abdominal US, Doppler US and abdominal multi-slice computed tomography (MSCT) with contrast was performed
- How many people
- 240 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jun 2025to 1 May 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult patients with liver cirrhosis
Who may be able to join
- Adult patients with liver cirrhosis
Who cannot join
- Patients with non-hepatic hemostatic disorders, active bacterial sepsis, renal dysfunction, peripheral or hepatic venous thrombosis, recent splenectomy, liver transplantation, antiplatelet or anticoagulant therapy or contraceptive pills were excluded.
Trial locations and contacts
1 site in 1 country.
About this study
Portal vein thrombosis (PVT) is a common complication in patients with liver cirrhosis and is associated with increased morbidity due to worsening portal hypertension and hepatic decompensation. The clinical presentation and radiological patterns of PVT vary widely, and the factors predicting its development remain incompletely understood.
This observational study will include adult patients (≥18 years) with established liver cirrhosis who are admitted to the Department of Gastroenterology and Tropical Medicine, Al-Rajhi Liver Hospital, Assiut University. Eligible participants will undergo routine screening for PVT using Doppler ultrasonography, with confirmation by contrast-enhanced computed tomography when indicated.
Read more
The study aims to evaluate the clinical characteristics, laboratory parameters, and radiological features of PVT. Cases of PVT will be classified according to extent (partial or complete) and anatomical location (main portal vein, right branch, left branch, or combined involvement). Clinical and laboratory data will be analyzed to identify potential predictors associated with the development and severity of PVT.
The findings of this study are expected to improve understanding of the risk factors and radiological patterns of PVT in cirrhotic patients, contributing to better risk stratification and clinical management.
- Conditions
- Liver Cirrhosis, Portal Vein Thrombosis
- Being tested
- Abdominal US, Doppler US and abdominal multi-slice computed tomography (MSCT) with contrast was performed
- Keywords
- Portal vein thrombosis, liver cirrhosis, D-dimer
- Medical subject headings
- Liver Cirrhosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Abdominal US, Doppler US and abdominal multi-slice computed tomography (MSCT) with contrast was performedDiagnostic test
to assess portal circulation, portosystemic collaterals, the presence of PVT, ascites and HCC.
| Study group | Role | What they receive |
|---|---|---|
| Group 1 (Patients): with PVT, Group 2 (Controls): without PVT | Not described Receives: Diagnostic Test: Abdominal US, Doppler US and abdominal multi-slice computed tomography (MSCT) with contrast was performed |
What is being measured
The primary outcome is the main question the study is designed to answer.
Prevalence of Portal Vein Thrombosis (PVT)
Proportion of cirrhotic patients diagnosed with portal vein thrombosis based on Doppler ultrasonography with confirmation by contrast-enhanced CT when indicated.
Measured: At baseline (during study enrollment period)
Predictors of Portal Vein Thrombosis
Identification of clinical, laboratory, and radiological factors associated with the presence of PVT in cirrhotic patients
Measured: Baseline assessment
Secondary outcomes (2)
Radiological Pattern of PVT
Distribution of portal vein thrombosis according to:
Extent (partial vs complete) Anatomical location (main portal vein, right branch, left branch, or combined involvement)
Measured: At time of PVT diagnosis
Association Between PVT Type and Clinical Parameters
Correlation between type of PVT (partial vs complete) and clinical/laboratory characteristics of patients.
Measured: At time of diagnosis
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 May 2026
- Study start1 Jun 2025
- Primary completion1 Jan 2026
- Study completion1 May 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Liver CirrhosisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Enrolment
- 240 participants (actual)
Sponsor and investigators
- Lead sponsor
- Elham Ahmed Hassan
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Elham Ahmed Hassan, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07560202
- Sponsor's protocol ID
- AUN-PVT-LC-2026
- Acronym
- Thrombosis
- Status last verified
- Apr 2026
- First submitted
- 24 Apr 2026
- Last updated
- 1 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: I do not have specific consent from participants to share individual-level data.
Study at a glance
From the registry record, last updated by the sponsor on 1 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Portal Vein Thrombosis in Liver Cirrhosis: Clinical Characteristics, Radiological Patterns, and Predictors
- ClinicalTrials.gov ID
- NCT07560202
- Acronym / sponsor ID
- Thrombosis / AUN-PVT-LC-2026
- Conditions
- Liver Cirrhosis, Portal Vein Thrombosis
- Keywords
- Portal vein thrombosis, liver cirrhosis, D-dimer
- Study type
- Observational
- Recruitment status
- Active, not recruiting
- Enrolment
- 240 participants (actual)
- Lead sponsor
- Elham Ahmed HassanUniversity, hospital or other
- Study start
- 1 Jun 2025 (actual)
- Primary completion
- 1 Jan 2026 (actual)
- Study completion
- 1 May 2026 (estimated)
- First posted
- 1 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Portal vein thrombosis (PVT) is a common complication in patients with liver cirrhosis and is associated with increased morbidity due to worsening portal hypertension and hepatic decompensation. The clinical presentation and radiological patterns of PVT vary widely, and the factors predicting its development remain incompletely understood.
This observational study will include adult patients (≥18 years) with established liver cirrhosis who are admitted to the Department of Gastroenterology and Tropical Medicine, Al-Rajhi Liver Hospital, Assiut University. Eligible participants will undergo routine screening for PVT using Doppler ultrasonography, with confirmation by contrast-enhanced computed tomography when indicated.
The study aims to evaluate the clinical characteristics, laboratory parameters, and radiological features of PVT. Cases of PVT will be classified according to extent (partial or complete) and anatomical location (main portal vein, right branch, left branch, or combined involvement). Clinical and laboratory data will be analyzed to identify potential predictors associated with the development and severity of PVT.
The findings of this study are expected to improve understanding of the risk factors and radiological patterns of PVT in cirrhotic patients, contributing to better risk stratification and clinical management.
Study design
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Group 1 (Patients): with PVT, Group 2 (Controls): without PVT | – | Diagnostic Test: Abdominal US, Doppler US and abdominal multi-slice computed tomography (MSCT) with contrast was performed |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult patients with liver cirrhosis
Key inclusion criteria (1 listed)
- Adult patients with liver cirrhosis
Key exclusion criteria (1 listed)
- Patients with non-hepatic hemostatic disorders, active bacterial sepsis, renal dysfunction, peripheral or hepatic venous thrombosis, recent splenectomy, liver transplantation, antiplatelet or anticoagulant therapy or contraceptive pills were excluded.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Abdominal US, Doppler US and abdominal multi-slice computed tomography (MSCT) with contrast was performedto assess portal circulation, portosystemic collaterals, the presence of PVT, ascites and HCC. | Diagnostic test | Group 1 (Patients): with PVT, Group 2 (Controls): without PVT |
Primary outcome
Prevalence of Portal Vein Thrombosis (PVT)
Time frame: At baseline (during study enrollment period)
Proportion of cirrhotic patients diagnosed with portal vein thrombosis based on Doppler ultrasonography with confirmation by contrast-enhanced CT when indicated.
Predictors of Portal Vein Thrombosis
Time frame: Baseline assessment
Identification of clinical, laboratory, and radiological factors associated with the presence of PVT in cirrhotic patients
2 secondary outcomes
Radiological Pattern of PVT
Time frame: At time of PVT diagnosis
Association Between PVT Type and Clinical Parameters
Time frame: At time of diagnosis
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 May 2026.
- Individual participant dataSharing planned: No. I do not have specific consent from participants to share individual-level data.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Liver Cirrhosis and Portal Vein Thrombosis, run by Elham Ahmed Hassan at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 1 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Prevalence of Portal Vein Thrombosis (PVT) (time frame: At baseline (during study enrollment period)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 May 2026.