Skin Barrier FunctionNCT07561242
Clinical Observational Study on Changes in Skin Physiological Parameters Following Ablative and Non-Ablative Fractional Laser Treatment at Different Doses
An observational study of Skin Barrier Function and Wound Healing, run by ChinaNorm at 1 site in China.
Trial summary
This clinical observational study investigates the dose-response relationship between laser energy intensity and skin damage/repair by applying different parameter sets of fractional ablative (CO2) and non-ablative (M22) lasers to the inner forearms of approximately 20 healthy Chinese female volunteers (aged 18-60… Read more about this study
- Who is it for?
- Ages 18 to 60 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Skin Barrier Function, Wound Healing
- What is being tested?
- Ablative Fractional Carbon Dioxide Laser and Non-ablative Fractional Laser (1565 nm)
- Type of treatment
- Surgery or procedure
- How many people
- 20 participants
- Where
- 1 siteChina
- Study dates
- 21 Mar 2026to 30 Apr 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- Women only
- Healthy volunteers accepted
- Adult
Study population: Approximately 20 healthy Chinese female volunteers, aged 18-60 years with Fitzpatrick skin phototypes III, IV, or V. This population will serve as participants in a self-controlled, observational study to model laser-induced skin injury. Each participant will receive both ablative (CO2) and non-ablative (M22) fractional laser exposures with varying parameters on their inner forearms to observe the dynamic physiological response and recovery process.
Who may be able to join
- Female Chinese study participants aged 18 to 60 years (inclusive).
- Fitzpatrick skin phototypes III, IV, or V.
- Willing to receive non-ablative fractional laser (M22) and ablative fractional laser (CO2) irradiation on the test sites during the study.
- No primary or secondary lesions (such as scars, ulcers, vesicles, tattoos) on the test sites.
- Has not participated in any other studies involving the test area (forearms) in the past 2 months.
- Agrees not to use skin-whitening products on the test area during the study period.
Show all 9Show fewer
- In good general health at the time of the study.
- Volunteers to participate and signs the informed consent form and photo release authorization.
- Willing to comply with all requirements of the study.
Who cannot join
- Study participants with skin diseases or skin allergies in the test area.
- Presence of moderate to severe inflammatory skin diseases (e.g., active eczema, acute photosensitive dermatitis, etc.) on the test sites within the past 4 weeks, or those who require treatment with oral or topical corticosteroids or immunosuppressants for skin conditions.
- On the day of the visit, the investigator judges the presence of significant diffuse erythema, desquamation, or exudation in the test area that may significantly affect skin color measurement.
- The investigator assesses that the participant is currently suffering from a stable or progressively worsening disease.
- Participant is planning for pregnancy, is pregnant, or is breastfeeding (applicable to female participants only).
- Participant with immunodeficiency.
Show all 13Show fewer
- Participant has a history of photosensitivity or photoallergy.
- Participant has a history of skin cancer or malignant melanoma.
- Presence of significant scars, tattoos, surgical incisions, or pigmented lesions (e.g., prominent birthmarks) in the test area that may affect assessment, and in the investigator's judgment, would impede normal imaging or scoring.
- Has used high-potency active products containing high concentrations of retinoic acid/retinol, alpha hydroxy acids, salicylic acid, etc., on the test area frequently (≥3 times per week) for an extended period (≥4 weeks) within the past 3 months, which, in the investigator's judgment, may significantly affect skin texture or barrier status.
- History of moderate to severe sun exposure (e.g., prolonged outdoor work, travel to seaside/high altitude) within the past 4 weeks, resulting in significant tanning or sunburn in the test area that, in the investigator's judgment, may interfere with study-related readings.
- Participation in other clinical or consumer testing projects involving the skin condition of the test area within the past 4 weeks.
- Presence of significant mental or cognitive impairment affecting compliance, and the investigator considers the participant unable to understand the study procedures or complete the tests as required.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
China1 site, 1 recruiting
- Recruiting
Shanghai China-norm Quality Technical Service Co., Ltd.
Shanghai, Shanghai Municipality, 200072
Wenqu Tang, 13585634612, tangwenqu@china-norm.com
About this study
This clinical observational study investigates the dose-response relationship between laser energy intensity and skin damage/repair by applying different parameter sets of fractional ablative (CO2) and non-ablative (M22) lasers to the inner forearms of approximately 20 healthy Chinese female volunteers (aged 18-60, Fitzpatrick skin types III-V) in a single-center, self-controlled design. Each participant receives both laser types on contralateral arms, with four distinct energy/density combinations per laser applied to separate test areas, and the dynamic skin responses are evaluated at baseline, immediately post-treatment, and at 30 minutes, 1, 2, 3, 4 hours, 7 days, and 10 days thereafter through clinical assessments (edema, erythema, etc.), standardized photography, high-frequency ultrasound (Dermascan), and objective instrumental measurements of skin color (Chromameter CM26dG), melanin/hemoglobin (Mexameter MX18), and barrier function (TEWL via Vapometer). The collected data will be analyzed using descriptive and comparative statistical methods to characterize the acute injury and recovery profiles, aiming to establish a foundational model for future post-procedure cosmetic intervention research.
- Conditions
- Skin Barrier Function, Wound Healing
- Being tested
- Ablative Fractional Carbon Dioxide Laser, Non-ablative Fractional Laser (1565 nm)
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Ablative Fractional Carbon Dioxide LaserProcedure or surgery
This intervention involves the application of ablative fractional laser using a carbon dioxide (CO₂) laser system. Four distinct parameter combinations will be used on four separate test areas (each 1.5cm x 1.5cm) on the participant's inner forearm. The varied parameters include different settings for energy (mJ), spot spacing, and density. The procedure creates microscopic columns of thermal injury in the skin to study the acute tissue response and subsequent healing process. The specific device and parameters are part of the study protocol and are not being evaluated for a new indication.
Non-ablative Fractional Laser (1565 nm)Procedure or surgery
This intervention involves the application of non-ablative fractional laser using a 1565 nm wavelength laser system (e.g., M22 ResurFX). Four distinct parameter combinations will be used on four separate test areas (each 1.5cm x 1.5cm) on the participant's inner forearm. The varied parameters include different settings for energy (mJ) and density. The procedure delivers focused photothermal energy to the dermis without disrupting the epidermis, aiming to study the sub-surface tissue response and recovery dynamics. The specific device and parameters are part of the study protocol and are not being evaluated for a new indication.
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Composite Clinical Skin Damage Score as Assessed by Clinician
Measured: From baseline (immediately before laser exposure) to 10 days post-exposure. Assessments are conducted at baseline (T0), immediately post-exposure (Timm), and 30 minutes, 1, 2, 3, 4 hours, 7 days (T7d), and 10 days (T10d) post-exposure.
Secondary outcomes (3)
Change in Skin Color Parameters (L, a, b*, ITA°) measured by Chromameter CM26dG
Measured: From baseline (immediately before laser exposure) to 10 days post-exposure. Assessments are conducted at baseline (T0), immediately post-exposure (Timm), and 30 minutes, 1, 2, 3, 4 hours, 7 days (T7d), and 10 days (T10d) post-exposure.
Change in Melanin and Hemoglobin Index measured by Mexameter MX18
Measured: From baseline (immediately before laser exposure) to 10 days post-exposure. Assessments are conducted at baseline (T0), immediately post-exposure (Timm), and 30 minutes, 1, 2, 3, 4 hours, 7 days (T7d), and 10 days (T10d) post-exposure.
Change in Transepidermal Water Loss (TEWL) measured by Vapometer
Measured: From baseline (immediately before laser exposure) to 10 days post-exposure. Assessments are conducted at baseline (T0), immediately post-exposure (Timm), and 30 minutes, 1, 2, 3, 4 hours, 7 days (T7d), and 10 days (T10d) post-exposure.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 May 2026
- Study start21 Mar 2026
- Primary completion30 Apr 2026 (estimated)
- Study completion30 Apr 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Skin Barrier FunctionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Prospective
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- ChinaNorm
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07561242
- Sponsor's protocol ID
- R26000004
- Status last verified
- Apr 2026
- First submitted
- 13 Apr 2026
- Last updated
- 1 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 1 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical Observational Study on Changes in Skin Physiological Parameters Following Ablative and Non-Ablative Fractional Laser Treatment at Different Doses
- ClinicalTrials.gov ID
- NCT07561242
- Acronym / sponsor ID
- R26000004
- Conditions
- Skin Barrier Function, Wound Healing
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- ChinaNormIndustry (pharma, biotech, devices)
- Study start
- 21 Mar 2026 (actual)
- Primary completion
- 30 Apr 2026 (estimated)
- Study completion
- 30 Apr 2026 (estimated)
- First posted
- 1 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This clinical observational study investigates the dose-response relationship between laser energy intensity and skin damage/repair by applying different parameter sets of fractional ablative (CO2) and non-ablative (M22) lasers to the inner forearms of approximately 20 healthy Chinese female volunteers (aged 18-60, Fitzpatrick skin types III-V) in a single-center, self-controlled design. Each participant receives both laser types on contralateral arms, with four distinct energy/density combinations per laser applied to separate test areas, and the dynamic skin responses are evaluated at baseline, immediately post-treatment, and at 30 minutes, 1, 2, 3, 4 hours, 7 days, and 10 days thereafter through clinical assessments (edema, erythema, etc.), standardized photography, high-frequency ultrasound (Dermascan), and objective instrumental measurements of skin color (Chromameter CM26dG), melanin/hemoglobin (Mexameter MX18), and barrier function (TEWL via Vapometer). The collected data will be analyzed using descriptive and comparative statistical methods to characterize the acute injury and recovery profiles, aiming to establish a foundational model for future post-procedure cosmetic intervention research.
Study design
- Observational model
- Other
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 to 60 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- Approximately 20 healthy Chinese female volunteers, aged 18-60 years with Fitzpatrick skin phototypes III, IV, or V. This population will serve as participants in a self-controlled, observational study to model laser-induced skin injury. Each participant will receive both ablative (CO2) and non-ablative (M22) fractional laser exposures with varying parameters on their inner forearms to observe the dynamic physiological response and recovery process.
Key inclusion criteria (9 listed)
- Female Chinese study participants aged 18 to 60 years (inclusive).
- Fitzpatrick skin phototypes III, IV, or V.
- Willing to receive non-ablative fractional laser (M22) and ablative fractional laser (CO2) irradiation on the test sites during the study.
- No primary or secondary lesions (such as scars, ulcers, vesicles, tattoos) on the test sites.
- Has not participated in any other studies involving the test area (forearms) in the past 2 months.
Key exclusion criteria (13 listed)
- Study participants with skin diseases or skin allergies in the test area.
- Presence of moderate to severe inflammatory skin diseases (e.g., active eczema, acute photosensitive dermatitis, etc.) on the test sites within the past 4 weeks, or those who require treatment with oral or topical corticosteroids or immunosuppressants for skin conditions.
- On the day of the visit, the investigator judges the presence of significant diffuse erythema, desquamation, or exudation in the test area that may significantly affect skin color measurement.
- The investigator assesses that the participant is currently suffering from a stable or progressively worsening disease.
- Participant is planning for pregnancy, is pregnant, or is breastfeeding (applicable to female participants only).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Ablative Fractional Carbon Dioxide LaserThis intervention involves the application of ablative fractional laser using a carbon dioxide (CO₂) laser system. Four distinct parameter combinations will be used on four separate test areas (each 1.5cm x 1.5cm) on the participant's inner forearm. The varied parameters include different settings for energy (mJ), spot spacing, and density. The procedure creates microscopic columns of thermal injury in the skin to study the acute tissue response and subsequent healing process. The specific device and parameters are part of the study protocol and are not being evaluated for a new indication. | Procedure or surgery | – |
| Non-ablative Fractional Laser (1565 nm)This intervention involves the application of non-ablative fractional laser using a 1565 nm wavelength laser system (e.g., M22 ResurFX). Four distinct parameter combinations will be used on four separate test areas (each 1.5cm x 1.5cm) on the participant's inner forearm. The varied parameters include different settings for energy (mJ) and density. The procedure delivers focused photothermal energy to the dermis without disrupting the epidermis, aiming to study the sub-surface tissue response and recovery dynamics. The specific device and parameters are part of the study protocol and are not being evaluated for a new indication. | Procedure or surgery | – |
Primary outcome
Change in Composite Clinical Skin Damage Score as Assessed by Clinician
Time frame: From baseline (immediately before laser exposure) to 10 days post-exposure. Assessments are conducted at baseline (T0), immediately post-exposure (Timm), and 30 minutes, 1, 2, 3, 4 hours, 7 days (T7d), and 10 days (T10d) post-exposure.
3 secondary outcomes
Change in Skin Color Parameters (L, a, b*, ITA°) measured by Chromameter CM26dG
Time frame: From baseline (immediately before laser exposure) to 10 days post-exposure. Assessments are conducted at baseline (T0), immediately post-exposure (Timm), and 30 minutes, 1, 2, 3, 4 hours, 7 days (T7d), and 10 days (T10d) post-exposure.
Change in Melanin and Hemoglobin Index measured by Mexameter MX18
Time frame: From baseline (immediately before laser exposure) to 10 days post-exposure. Assessments are conducted at baseline (T0), immediately post-exposure (Timm), and 30 minutes, 1, 2, 3, 4 hours, 7 days (T7d), and 10 days (T10d) post-exposure.
Change in Transepidermal Water Loss (TEWL) measured by Vapometer
Time frame: From baseline (immediately before laser exposure) to 10 days post-exposure. Assessments are conducted at baseline (T0), immediately post-exposure (Timm), and 30 minutes, 1, 2, 3, 4 hours, 7 days (T7d), and 10 days (T10d) post-exposure.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 May 2026.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Skin Barrier Function and Wound Healing, run by ChinaNorm at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 1 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Yanwen Jiang (13501700841, jiangyanwen@china-norm.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Composite Clinical Skin Damage Score as Assessed by Clinician (time frame: From baseline (immediately before laser exposure) to 10 days post-exposure. Assessments are conducted at baseline (T0), immediately post-exposure (Timm), and 30 minutes, 1, 2, 3, 4 hours, 7 days (T7d), and 10 days (T10d) post-exposure.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 May 2026; AzTrials last refreshed its copy on 31 Oct 2026.