Aging ProblemsVAMP-AgingNCT07563725
Vascular Aging and Microcirculation: Physiological Aspects of Vascular Aging in the Elderly Population (VAMP-Aging)
An observational study of Aging Problems, run by National Institute of Cardiology, Laranjeiras, Brazil at 1 site in Brazil.
Trial summary
Rising life expectancy worldwide challenges public health due to increased cardiovascular disease linked to vascular aging, where microvascular dysfunction serves as an early indicator of system-wide inflammation, or "inflammaging". Read more about this study
- Who is it for?
- Ages 60 to 100 yearsHealthy volunteers can take part
- Conditions the study is for
- Aging Problems
- What is being tested?
- Laser Speckle Contrast Imaging, Handgrip Dynamometry (Muscle Strength) and Sit-to-Stand Test (5-Times Sit-to-Stand - 5STS)
- How many people
- 62 participants
- Where
- 1 siteBrazil
- Study dates
- 4 Nov 2026to Dec 2029
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 to 100 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: An observational, cross-sectional study will be conducted, including volunteers aged ≥ 60 years, divided into two groups: elderly (60-80 years) and very elderly (>80). Young volunteers aged between 20 and 40 years, already participants in previous studies, whose demographic and microcirculation data are in the research laboratory's database, will be included as controls. Data from the control group will be obtained from an institutional database, respecting confidentiality and anonymization, in accordance with current ethical standards.
Who may be able to join
- Absence of symptoms and history of cardiovascular and cerebrovascular diseases.
- Baseline blood pressure levels within the normal range (< 140/90 mmHg, according to WHO criteria) and absence of use of antihypertensive medications.
Who cannot join
- Diabetes Mellitus: Fasting blood glucose ≥ 126 mg/dL or use of hypoglycemic agents.
- Smoking: Active or quit less than 5 years ago.
- Inflammatory Diseases: Autoimmune diseases, active neoplasms, or acute infectious processes.
- Surgery or trauma in the last 60 days.
- Renal Dysfunction: Chronic renal failure (estimated by eGFR < 60 mL/min/1.73m²).
- Medication Use: Chronic use of corticosteroids, immunosuppressants, or drugs with direct action on vascular reactivity (e.g., continuous use of nitrates).
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Rising life expectancy worldwide challenges public health due to increased cardiovascular disease linked to vascular aging, where microvascular dysfunction serves as an early indicator of system-wide inflammation, or "inflammaging". The proposed study aims to validate non-invasive, high-resolution techniques, such as Laser Speckle Contrast Imaging, to identify early endothelial senescence biomarkers and map their correlation with metabolic, inflammatory, and anthropometric profiles to advance personalized, preventive translational medicine.
Read the detailed description
An observational, cross-sectional study will be conducted, including volunteers aged ≥ 60 years, divided into two groups: elderly (60-80 years) and very elderly (>80). Young volunteers aged between 20 and 40 years, already participants in previous studies, whose demographic and microcirculation data are in the research laboratory's database, will be included as controls. Data from the control group will be obtained from an institutional database, respecting confidentiality and anonymization, in accordance with current ethical standards.
- Conditions
- Aging Problems
- Being tested
- Laser Speckle Contrast Imaging, Handgrip Dynamometry (Muscle Strength), Sit-to-Stand Test (5-Times Sit-to-Stand - 5STS), Single-Leg Balance Test, Assessment of Global Cognitive Function
- Keywords
- microcirculation, Laser Speckle Contrast Imaging, vascular aging
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Laser Speckle Contrast ImagingDiagnostic test
Investigation of Systemic Endothelial Microvascular Function
Handgrip Dynamometry (Muscle Strength)Diagnostic test
Serving as a marker of systemic muscle strength and sarcopenia.
Sit-to-Stand Test (5-Times Sit-to-Stand - 5STS)Diagnostic test
This test will assess the strength and power of the lower limbs.
Single-Leg Balance TestDiagnostic test
Failure to maintain the position (to stand on one leg) for at least 10 seconds will be correlated as a marker of frailty and risk of falls.
Assessment of Global Cognitive FunctionDiagnostic test
Overall cognitive function will be assessed using the Mini-Mental State Examination.
| Study group | Role | What they receive |
|---|---|---|
| elderly (60-80 years) | Evaluation of systemic microcirculation Receives: Diagnostic Test: Laser Speckle Contrast Imaging; Diagnostic Test: Handgrip Dynamometry (Muscle Strength); Diagnostic Test: Sit-to-Stand Test (5-Times Sit-to-Stand - 5STS); Diagnostic Test: Single-Leg Balance Test; Diagnostic Test: Assessment of Global Cognitive Function | |
| very elderly (>80) | Evaluation of systemic microcirculation Receives: Diagnostic Test: Laser Speckle Contrast Imaging; Diagnostic Test: Handgrip Dynamometry (Muscle Strength); Diagnostic Test: Sit-to-Stand Test (5-Times Sit-to-Stand - 5STS); Diagnostic Test: Single-Leg Balance Test; Diagnostic Test: Assessment of Global Cognitive Function |
What is being measured
The primary outcome is the main question the study is designed to answer.
Systemic (cutaneous) microcirculatory reactivity.
To analyze structural and functional changes in the microcirculation in different ages groups, with emphasis on microvascular endothelial senescence.
Measured: up to 20 minutes
Secondary outcomes (1)
Muscle Strength
Handgrip Dynamometry Maximum isometric strength will be assessed using a manual hydraulic dynamometer.
Measured: up to 10 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 May 2026
- Study start4 Nov 2026 (estimated)
- Primary completionDec 2029 (estimated)
- Study completionDec 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Aging ProblemsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 62 participants (estimated)
Sponsor and investigators
- Lead sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Eduardo Tibirica, MD, PhD, National Institute of Cardiology, Laranjeiras, Brazil
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07563725
- Sponsor's protocol ID
- VAMP-Aging
- Acronym
- VAMP-Aging
- Status last verified
- Nov 2026
- First submitted
- 22 Apr 2026
- Last updated
- 4 Nov 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 4 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Vascular Aging and Microcirculation: Physiological Aspects of Vascular Aging in the Elderly Population (VAMP-Aging)
- ClinicalTrials.gov ID
- NCT07563725
- Acronym / sponsor ID
- VAMP-Aging / VAMP-Aging
- Conditions
- Aging Problems
- Keywords
- microcirculation, Laser Speckle Contrast Imaging, vascular aging
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 62 participants (estimated)
- Lead sponsor
- National Institute of Cardiology, Laranjeiras, BrazilOther government
- Study start
- 4 Nov 2026 (estimated)
- Primary completion
- Dec 2029 (estimated)
- Study completion
- Dec 2029 (estimated)
- First posted
- 4 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Rising life expectancy worldwide challenges public health due to increased cardiovascular disease linked to vascular aging, where microvascular dysfunction serves as an early indicator of system-wide inflammation, or "inflammaging". The proposed study aims to validate non-invasive, high-resolution techniques, such as Laser Speckle Contrast Imaging, to identify early endothelial senescence biomarkers and map their correlation with metabolic, inflammatory, and anthropometric profiles to advance personalized, preventive translational medicine.
Detailed description
An observational, cross-sectional study will be conducted, including volunteers aged ≥ 60 years, divided into two groups: elderly (60-80 years) and very elderly (>80). Young volunteers aged between 20 and 40 years, already participants in previous studies, whose demographic and microcirculation data are in the research laboratory's database, will be included as controls. Data from the control group will be obtained from an institutional database, respecting confidentiality and anonymization, in accordance with current ethical standards.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| elderly (60-80 years) | – | Diagnostic Test: Laser Speckle Contrast Imaging, Diagnostic Test: Handgrip Dynamometry (Muscle Strength), Diagnostic Test: Sit-to-Stand Test (5-Times Sit-to-Stand - 5STS), Diagnostic Test: Single-Leg Balance Test, Diagnostic Test: Assessment of Global Cognitive FunctionEvaluation of systemic microcirculation |
| very elderly (>80) | – | Diagnostic Test: Laser Speckle Contrast Imaging, Diagnostic Test: Handgrip Dynamometry (Muscle Strength), Diagnostic Test: Sit-to-Stand Test (5-Times Sit-to-Stand - 5STS), Diagnostic Test: Single-Leg Balance Test, Diagnostic Test: Assessment of Global Cognitive FunctionEvaluation of systemic microcirculation |
Who may qualify
- Ages
- 60 to 100 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- An observational, cross-sectional study will be conducted, including volunteers aged ≥ 60 years, divided into two groups: elderly (60-80 years) and very elderly (>80). Young volunteers aged between 20 and 40 years, already participants in previous studies, whose demographic and microcirculation data are in the research laboratory's database, will be included as controls. Data from the control group will be obtained from an institutional database, respecting confidentiality and anonymization, in accordance with current ethical standards.
Key inclusion criteria (2 listed)
- Absence of symptoms and history of cardiovascular and cerebrovascular diseases.
- Baseline blood pressure levels within the normal range (< 140/90 mmHg, according to WHO criteria) and absence of use of antihypertensive medications.
Key exclusion criteria (6 listed)
- Diabetes Mellitus: Fasting blood glucose ≥ 126 mg/dL or use of hypoglycemic agents.
- Smoking: Active or quit less than 5 years ago.
- Inflammatory Diseases: Autoimmune diseases, active neoplasms, or acute infectious processes.
- Surgery or trauma in the last 60 days.
- Renal Dysfunction: Chronic renal failure (estimated by eGFR < 60 mL/min/1.73m²).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Laser Speckle Contrast ImagingInvestigation of Systemic Endothelial Microvascular Function | Diagnostic test | elderly (60-80 years), very elderly (>80) |
| Handgrip Dynamometry (Muscle Strength)Serving as a marker of systemic muscle strength and sarcopenia. | Diagnostic test | elderly (60-80 years), very elderly (>80) |
| Sit-to-Stand Test (5-Times Sit-to-Stand - 5STS)This test will assess the strength and power of the lower limbs. | Diagnostic test | elderly (60-80 years), very elderly (>80) |
| Single-Leg Balance TestFailure to maintain the position (to stand on one leg) for at least 10 seconds will be correlated as a marker of frailty and risk of falls. | Diagnostic test | elderly (60-80 years), very elderly (>80) |
| Assessment of Global Cognitive FunctionOverall cognitive function will be assessed using the Mini-Mental State Examination. | Diagnostic test | elderly (60-80 years), very elderly (>80) |
Primary outcome
Systemic (cutaneous) microcirculatory reactivity.
Time frame: up to 20 minutes
To analyze structural and functional changes in the microcirculation in different ages groups, with emphasis on microvascular endothelial senescence.
1 secondary outcome
Muscle Strength
Time frame: up to 10 minutes
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Nov 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Aging Problems, run by National Institute of Cardiology, Laranjeiras, Brazil at 1 site in Brazil.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 4 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Brazil. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Eduardo Tibirica, MD, PhD (+55-21-99914-6075, etibi@uol.com.br), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Systemic (cutaneous) microcirculatory reactivity. (time frame: up to 20 minutes). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Nov 2026.