Abdominal HypertensionWSACSNCT07563842
Updated Abdominal Compartment Society Consensus Definitions
An observational study of Abdominal Hypertension and Abdominal Compartment Syndrome, run by Medical University of Lublin at 1 site in Poland.
Trial summary
An international team of experts is working on a project called updated WSACS consensus definitions. The goals of this study are to: 1. To generate expert consensus on the definitions and classification of IAH and ACS. 2. To generate expert consensus on definitions regarding the pathophysiology of IAH and ACS. 3. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Abdominal Hypertension, Abdominal Compartment Syndrome
- What is being tested?
- Delphi study
- How many people
- 60 participants
- Where
- 1 sitePoland
- Study dates
- 13 Oct 2025to 31 Jul 2026
- How long will I take part?
- 6 Months
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Inclusion Criteria: Panellists will be identified based on either of the following criteria At least 5 years of clinical experience as a staff member in Anesthesiology, Surgery or Intensive Care Medicine with involvement in care of patients with postoperative complications Author of at least one publication (observational studies or randomised controlled trials) on intra-abdominal hypertension or abdominal compartment syndrome. For patients and public involvement Individuals who have either personally experienced IAH or ACS following surgery or ICU within the last 5 years or, primary caregivers of such patients will be recruited as patient care representatives. Proficiency in English is required. To mitigate potential bias, patient care representatives mustn't maintain a professional or advisory relationship with the steering committee or panellists. Co-authors from previous WSACS survey published in 2024, former or current WSACS ambassadors, representative from WSES, ESAIC, ES
Who may be able to join
None listed.
Who cannot join
- None
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Expert Consensus On Definitions And Management Of Intra-Abdominal Hypertension And Abdominal Compartment Syndrome
An international team of experts is working on a project called updated WSACS consensus definitions. The goals of this study are to:
- To generate expert consensus on the definitions and classification of IAH and ACS.
- To generate expert consensus on definitions regarding the pathophysiology of IAH and ACS.
- To generate consensus on definitions regarding the methods of measurement of intra-abdominal pressure (IAP).
Read the detailed description
Intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are frequently encountered in critically ill or injured patients and remain associated with significant morbidity and mortality. IAH is defined as a sustained increase in intra-abdominal pressure (IAP) equal to or above 12 mmHg. It is diagnosed in approximately one-third of mixed medical and surgical intensive care unit (ICU) patients at admission and develops in about half during the first week of ICU stay. IAH has consistently been shown to be an independent predictor of adverse outcomes, including multi-organ dysfunction and death.
Following the original consensus definitions and subsequent guideline updates by the Abdominal Compartment Society (WSACS), the understanding and management of IAH and ACS have evolved substantially. While surgical etiologies such as trauma and ruptured abdominal aortic aneurysm were historically predominant, more recent data highlight that IAH and ACS frequently occur in medical ICU populations as well. Contributing factors include excessive fluid resuscitation, massive transfusion, venous congestion, and capillary leak, which can lead to secondary IAH and subsequent organ failure even in the absence of direct abdominal pathology.
Despite the availability of consensus guidelines and an improved understanding of the pathophysiology, it remains unclear whether prevention or active treatment of IAH directly improves patient outcomes. Furthermore, there is growing recognition of the need to refine the definitions, measurement techniques, and classification systems for IAH and ACS to reflect current clinical knowledge and practice across diverse healthcare settings.
The WSACS - The Abdominal Compartment Society - previously published comprehensive consensus definitions and recommendations in 2013. Since then, new research has provided additional insights into epidemiology, measurement technologies, classification systems, and the broader clinical implications of IAH and ACS. A recent global survey among healthcare professionals identified emerging areas of uncertainty and priority topics for definition updates.
In response, this study will conduct an international modified Delphi process to achieve expert consensus on updated definitions and clinical practice statements for IAH and ACS. The Delphi method will systematically collect and refine expert opinions over several iterative rounds, with the goal of reaching agreement on revised definitions, measurement approaches, pathophysiological frameworks, and classification criteria.
The outcome of this Delphi process will be a set of updated, evidence-informed, and globally endorsed definitions and recommendations for IAH, ACS, and the open abdomen. These consensus statements aim to harmonize terminology, support clinical decision-making, guide future research, and ultimately improve patient care. The target audience includes physicians, surgeons, intensivists, anesthesiologists, nurses, and policymakers involved in the management of critically ill or injured patients across both high- and low-to-middle-income countries.
- Being tested
- Delphi study
- Keywords
- abdominal hypertension, abdominal compartment syndrome, definitions, pathophysiology, measurement, intra-abdominal pressure, intra-abdominal volume
- Medical subject headings
- Intra-Abdominal Hypertension
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Delphi studyOther
structured interview via online survey
| Study group | Role | What they receive |
|---|---|---|
| Panelist | Not described Receives: Other: Delphi study |
What is being measured
The primary outcome is the main question the study is designed to answer.
Level of consensus on definitions of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS)
Proportion of predefined definition statements for IAH and ACS reaching consensus among expert panellists, measured using a structured Delphi process. Consensus is defined a priori as ≥80% agreement on a 5-point Likert scale (ratings of 4-5 indicating agreement). Outcomes will include:
Number and percentage of statements reaching consensus Median and interquartile range (IQR) of Likert scores per statement Stability of responses across Delphi rounds
Measured: 3-6 months
Secondary outcomes (2)
Level of consensus on pathophysiological concepts of IAH and ACS
Proportion of predefined pathophysiological statements related to IAH and ACS reaching consensus among expert panellists using a Delphi process. Consensus is defined as ≥80% agreement on a 5-point Likert scale. Outcomes will include:
Number and percentage of statements reaching consensus Median and IQR of Likert scores per statement Changes in agreement across Delphi rounds
Measured: 3-6 months
Level of consensus on measurement methods for intra-abdominal pressure (IAP)
Proportion of predefined statements regarding IAP measurement techniques reaching consensus among expert panellists using a Delphi process. Consensus is defined as ≥80% agreement on a 5-point Likert scale. Outcomes will include:
Number and percentage of statements reaching consensus Median and IQR of Likert scores per statement Agreement trends across Delphi rounds
Measured: 3-6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 May 2026
- Study start13 Oct 2025
- Primary completion31 Jul 2026 (estimated)
- Study completion31 Jul 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (27)Papers the sponsor has linked to this study.
- Other trials for Abdominal HypertensionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 60 participants (estimated)
- Target duration
- 6 Months
Sponsor and investigators
- Lead sponsor
- Medical University of Lublin
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Manu Malbrain, Medical University of Lublin
- Investigators
- Prashant Nasa, MD, Principal investigator, The Royal Wolverhampton NHS Trust Wolverhampton, UK
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07563842
- Sponsor's protocol ID
- MUL2025WSACS001
- Other IDs
- PROSPERO CRD420251167137
- Acronym
- WSACS
- Status last verified
- Apr 2026
- First submitted
- 8 Jan 2026
- Last updated
- 4 May 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: The IPD is available to investigators and can be shared with appropriate requests.
Publications
Alhazzani W, Lewis K, Jaeschke R, Rochwerg B, Moller MH, Evans L, Wilson KC, Patel S, Coopersmith CM, Cecconi M, Guyatt G, Akl EA. Conflicts of interest disclosure forms and management in critical care clinical practice guidelines. Intensive Care Med. 2018 Oct;44(10):1691-1698. doi: 10.1007/s00134-018-5367-6. Epub 2018 Sep 27.
PubMed 30264380Traversy G, Barnieh L, Akl EA, Allan GM, Brouwers M, Ganache I, Grundy Q, Guyatt GH, Kelsall D, Leng G, Moore A, Persaud N, Schunemann HJ, Straus S, Thombs BD, Rodin R, Tonelli M. Managing conflicts of interest in the development of health guidelines. CMAJ. 2021 Jan 11;193(2):E49-E54. doi: 10.1503/cmaj.200651. No abstract available.
PubMed 33431547Schunemann HJ, Al-Ansary LA, Forland F, Kersten S, Komulainen J, Kopp IB, Macbeth F, Phillips SM, Robbins C, van der Wees P, Qaseem A; Board of Trustees of the Guidelines International Network. Guidelines International Network: Principles for Disclosure of Interests and Management of Conflicts in Guidelines. Ann Intern Med. 2015 Oct 6;163(7):548-53. doi: 10.7326/M14-1885.
PubMed 26436619Gattrell WT, Logullo P, van Zuuren EJ, Price A, Hughes EL, Blazey P, Winchester CC, Tovey D, Goldman K, Hungin AP, Harrison N. ACCORD (ACcurate COnsensus Reporting Document): A reporting guideline for consensus methods in biomedicine developed via a modified Delphi. PLoS Med. 2024 Jan 23;21(1):e1004326. doi: 10.1371/journal.pmed.1004326. eCollection 2024 Jan.
PubMed 38261576Nasa P, Jain R, Juneja D. Delphi methodology in healthcare research: How to decide its appropriateness. World J Methodol. 2021 Jul 20;11(4):116-129. doi: 10.5662/wjm.v11.i4.116. eCollection 2021 Jul 20.
PubMed 34322364Nasa P, Azoulay E, Khanna AK, Jain R, Gupta S, Javeri Y, Juneja D, Rangappa P, Sundararajan K, Alhazzani W, Antonelli M, Arabi YM, Bakker J, Brochard LJ, Deane AM, Du B, Einav S, Esteban A, Gajic O, Galvagno SM Jr, Guerin C, Jaber S, Khilnani GC, Koh Y, Lascarrou JB, Machado FR, Malbrain MLNG, Mancebo J, McCurdy MT, McGrath BA, Mehta S, Mekontso-Dessap A, Mer M, Nurok M, Park PK, Pelosi P, Peter JV, Phua J, Pilcher DV, Piquilloud L, Schellongowski P, Schultz MJ, Shankar-Hari M, Singh S, Sorbello M, Tiruvoipati R, Udy AA, Welte T, Myatra SN. Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method. Crit Care. 2021 Mar 16;25(1):106. doi: 10.1186/s13054-021-03491-y.
PubMed 33726819Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hrobjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021 Mar 29;372:n71. doi: 10.1136/bmj.n71.
PubMed 33782057Nasa P, Wise RD, Smit M, Acosta S, D'Amours S, Beaubien-Souligny W, Bodnar Z, Coccolini F, Dangayach NS, Dabrowski W, Duchesne J, Ejike JC, Augustin G, De Keulenaer B, Kirkpatrick AW, Khanna AK, Kimball E, Koratala A, Lee RK, Leppaniemi A, Lerma EV, Marmolejo V, Meraz-Munoz A, Myatra SN, Niven D, Olvera C, Ordonez C, Petro C, Pereira BM, Ronco C, Regli A, Roberts DJ, Rola P, Rosen M, Shrestha GS, Sugrue M, Velez JCQ, Wald R, De Waele J, Reintam Blaser A, Malbrain MLNG. International cross-sectional survey on current and updated definitions of intra-abdominal hypertension and abdominal compartment syndrome. World J Emerg Surg. 2024 Nov 29;19(1):39. doi: 10.1186/s13017-024-00564-5.
PubMed 39609850Roberts DJ, Zygun DA, Kirkpatrick AW, Ball CG, Faris PD, Bobrovitz N, Robertson HL, Stelfox HT. A protocol for a scoping and qualitative study to identify and evaluate indications for damage control surgery and damage control interventions in civilian trauma patients. BMJ Open. 2014 Jul 7;4(7):e005634. doi: 10.1136/bmjopen-2014-005634.
PubMed 25001397Higa G, Friese R, O'Keeffe T, Wynne J, Bowlby P, Ziemba M, Latifi R, Kulvatunyou N, Rhee P. Damage control laparotomy: a vital tool once overused. J Trauma. 2010 Jul;69(1):53-9. doi: 10.1097/TA.0b013e3181e293b4.
PubMed 20622578Miller RS, Morris JA Jr, Diaz JJ Jr, Herring MB, May AK. Complications after 344 damage-control open celiotomies. J Trauma. 2005 Dec;59(6):1365-71; discussion 1371-4. doi: 10.1097/01.ta.0000196004.49422.af.
PubMed 16394910van Brunschot S, Schut AJ, Bouwense SA, Besselink MG, Bakker OJ, van Goor H, Hofker S, Gooszen HG, Boermeester MA, van Santvoort HC; Dutch Pancreatitis Study Group. Abdominal compartment syndrome in acute pancreatitis: a systematic review. Pancreas. 2014 Jul;43(5):665-74. doi: 10.1097/MPA.0000000000000108.
PubMed 24921201Strang SG, Van Lieshout EM, Breederveld RS, Van Waes OJ. A systematic review on intra-abdominal pressure in severely burned patients. Burns. 2014 Feb;40(1):9-16. doi: 10.1016/j.burns.2013.07.001. Epub 2013 Sep 17.
PubMed 24050978Karkos CD, Menexes GC, Patelis N, Kalogirou TE, Giagtzidis IT, Harkin DW. A systematic review and meta-analysis of abdominal compartment syndrome after endovascular repair of ruptured abdominal aortic aneurysms. J Vasc Surg. 2014 Mar;59(3):829-42. doi: 10.1016/j.jvs.2013.11.085. Epub 2014 Jan 16.
PubMed 24439324Malbrain ML, Chiumello D, Cesana BM, Reintam Blaser A, Starkopf J, Sugrue M, Pelosi P, Severgnini P, Hernandez G, Brienza N, Kirkpatrick AW, Schachtrupp A, Kempchen J, Estenssoro E, Vidal MG, De Laet I, De Keulenaer BL; WAKE-Up! Investigators. A systematic review and individual patient data meta-analysis on intra-abdominal hypertension in critically ill patients: the wake-up project. World initiative on Abdominal Hypertension Epidemiology, a Unifying Project (WAKE-Up!). Minerva Anestesiol. 2014 Mar;80(3):293-306. Epub 2013 Dec 12.
PubMed 24603146
Study at a glance
From the registry record, last updated by the sponsor on 4 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Expert Consensus On Definitions And Management Of Intra-Abdominal Hypertension And Abdominal Compartment Syndrome
- ClinicalTrials.gov ID
- NCT07563842
- Acronym / sponsor ID
- WSACS / MUL2025WSACS001
- Keywords
- abdominal hypertension, abdominal compartment syndrome, definitions, pathophysiology, measurement, intra-abdominal pressure, intra-abdominal volume
- Study type
- Observational
- Recruitment status
- Enrolling by invitation
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Medical University of LublinUniversity, hospital or other
- Study start
- 13 Oct 2025 (actual)
- Primary completion
- 31 Jul 2026 (estimated)
- Study completion
- 31 Jul 2026 (estimated)
- First posted
- 4 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
An international team of experts is working on a project called updated WSACS consensus definitions. The goals of this study are to:
- To generate expert consensus on the definitions and classification of IAH and ACS.
- To generate expert consensus on definitions regarding the pathophysiology of IAH and ACS.
- To generate consensus on definitions regarding the methods of measurement of intra-abdominal pressure (IAP).
Detailed description
Intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are frequently encountered in critically ill or injured patients and remain associated with significant morbidity and mortality. IAH is defined as a sustained increase in intra-abdominal pressure (IAP) equal to or above 12 mmHg. It is diagnosed in approximately one-third of mixed medical and surgical intensive care unit (ICU) patients at admission and develops in about half during the first week of ICU stay. IAH has consistently been shown to be an independent predictor of adverse outcomes, including multi-organ dysfunction and death.
Following the original consensus definitions and subsequent guideline updates by the Abdominal Compartment Society (WSACS), the understanding and management of IAH and ACS have evolved substantially. While surgical etiologies such as trauma and ruptured abdominal aortic aneurysm were historically predominant, more recent data highlight that IAH and ACS frequently occur in medical ICU populations as well. Contributing factors include excessive fluid resuscitation, massive transfusion, venous congestion, and capillary leak, which can lead to secondary IAH and subsequent organ failure even in the absence of direct abdominal pathology.
Despite the availability of consensus guidelines and an improved understanding of the pathophysiology, it remains unclear whether prevention or active treatment of IAH directly improves patient outcomes. Furthermore, there is growing recognition of the need to refine the definitions, measurement techniques, and classification systems for IAH and ACS to reflect current clinical knowledge and practice across diverse healthcare settings.
The WSACS - The Abdominal Compartment Society - previously published comprehensive consensus definitions and recommendations in 2013. Since then, new research has provided additional insights into epidemiology, measurement technologies, classification systems, and the broader clinical implications of IAH and ACS. A recent global survey among healthcare professionals identified emerging areas of uncertainty and priority topics for definition updates.
In response, this study will conduct an international modified Delphi process to achieve expert consensus on updated definitions and clinical practice statements for IAH and ACS. The Delphi method will systematically collect and refine expert opinions over several iterative rounds, with the goal of reaching agreement on revised definitions, measurement approaches, pathophysiological frameworks, and classification criteria.
The outcome of this Delphi process will be a set of updated, evidence-informed, and globally endorsed definitions and recommendations for IAH, ACS, and the open abdomen. These consensus statements aim to harmonize terminology, support clinical decision-making, guide future research, and ultimately improve patient care. The target audience includes physicians, surgeons, intensivists, anesthesiologists, nurses, and policymakers involved in the management of critically ill or injured patients across both high- and low-to-middle-income countries.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 6 Months
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Panelist | – | Other: Delphi study |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Inclusion Criteria: Panellists will be identified based on either of the following criteria At least 5 years of clinical experience as a staff member in Anesthesiology, Surgery or Intensive Care Medicine with involvement in care of patients with postoperative complications Author of at least one publication (observational studies or randomised controlled trials) on intra-abdominal hypertension or abdominal compartment syndrome. For patients and public involvement Individuals who have either personally experienced IAH or ACS following surgery or ICU within the last 5 years or, primary caregivers of such patients will be recruited as patient care representatives. Proficiency in English is required. To mitigate potential bias, patient care representatives mustn't maintain a professional or advisory relationship with the steering committee or panellists. Co-authors from previous WSACS survey published in 2024, former or current WSACS ambassadors, representative from WSES, ESAIC, ES
Key inclusion criteria (0 listed)
Key exclusion criteria (1 listed)
- None
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Delphi studystructured interview via online survey | Other | Panelist |
Primary outcome
Level of consensus on definitions of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS)
Time frame: 3-6 months
Proportion of predefined definition statements for IAH and ACS reaching consensus among expert panellists, measured using a structured Delphi process. Consensus is defined a priori as ≥80% agreement on a 5-point Likert scale (ratings of 4-5 indicating agreement). Outcomes will include: Number and percentage of statements reaching consensus Median and interquartile range (IQR) of Likert scores per statement Stability of responses across Delphi rounds
2 secondary outcomes
Level of consensus on pathophysiological concepts of IAH and ACS
Time frame: 3-6 months
Level of consensus on measurement methods for intra-abdominal pressure (IAP)
Time frame: 3-6 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 May 2026.
- Background: PubMed 30264380Alhazzani W, Lewis K, Jaeschke R, Rochwerg B, Moller MH, Evans L, Wilson KC, Patel S, Coopersmith CM, Cecconi M, Guyatt G, Akl EA. Conflicts of interest disclosure forms and management in critical care clinical practice guidelines. Intensive Care Med. 2018 Oct;44(10):1691-1698. doi: 10.1007/s00134-018-5367-6. Epub 2018 Sep 27.
- Background: PubMed 33431547Traversy G, Barnieh L, Akl EA, Allan GM, Brouwers M, Ganache I, Grundy Q, Guyatt GH, Kelsall D, Leng G, Moore A, Persaud N, Schunemann HJ, Straus S, Thombs BD, Rodin R, Tonelli M. Managing conflicts of interest in the development of health guidelines. CMAJ. 2021 Jan 11;193(2):E49-E54. doi: 10.1503/cmaj.200651. No abstract available.
- Background: PubMed 26436619Schunemann HJ, Al-Ansary LA, Forland F, Kersten S, Komulainen J, Kopp IB, Macbeth F, Phillips SM, Robbins C, van der Wees P, Qaseem A; Board of Trustees of the Guidelines International Network. Guidelines International Network: Principles for Disclosure of Interests and Management of Conflicts in Guidelines. Ann Intern Med. 2015 Oct 6;163(7):548-53. doi: 10.7326/M14-1885.
- Background: PubMed 38261576Gattrell WT, Logullo P, van Zuuren EJ, Price A, Hughes EL, Blazey P, Winchester CC, Tovey D, Goldman K, Hungin AP, Harrison N. ACCORD (ACcurate COnsensus Reporting Document): A reporting guideline for consensus methods in biomedicine developed via a modified Delphi. PLoS Med. 2024 Jan 23;21(1):e1004326. doi: 10.1371/journal.pmed.1004326. eCollection 2024 Jan.
- Background: PubMed 34322364Nasa P, Jain R, Juneja D. Delphi methodology in healthcare research: How to decide its appropriateness. World J Methodol. 2021 Jul 20;11(4):116-129. doi: 10.5662/wjm.v11.i4.116. eCollection 2021 Jul 20.
- Background: PubMed 33726819Nasa P, Azoulay E, Khanna AK, Jain R, Gupta S, Javeri Y, Juneja D, Rangappa P, Sundararajan K, Alhazzani W, Antonelli M, Arabi YM, Bakker J, Brochard LJ, Deane AM, Du B, Einav S, Esteban A, Gajic O, Galvagno SM Jr, Guerin C, Jaber S, Khilnani GC, Koh Y, Lascarrou JB, Machado FR, Malbrain MLNG, Mancebo J, McCurdy MT, McGrath BA, Mehta S, Mekontso-Dessap A, Mer M, Nurok M, Park PK, Pelosi P, Peter JV, Phua J, Pilcher DV, Piquilloud L, Schellongowski P, Schultz MJ, Shankar-Hari M, Singh S, Sorbello M, Tiruvoipati R, Udy AA, Welte T, Myatra SN. Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method. Crit Care. 2021 Mar 16;25(1):106. doi: 10.1186/s13054-021-03491-y.
- Background: PubMed 33782057Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hrobjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021 Mar 29;372:n71. doi: 10.1136/bmj.n71.
- Background: PubMed 39609850Nasa P, Wise RD, Smit M, Acosta S, D'Amours S, Beaubien-Souligny W, Bodnar Z, Coccolini F, Dangayach NS, Dabrowski W, Duchesne J, Ejike JC, Augustin G, De Keulenaer B, Kirkpatrick AW, Khanna AK, Kimball E, Koratala A, Lee RK, Leppaniemi A, Lerma EV, Marmolejo V, Meraz-Munoz A, Myatra SN, Niven D, Olvera C, Ordonez C, Petro C, Pereira BM, Ronco C, Regli A, Roberts DJ, Rola P, Rosen M, Shrestha GS, Sugrue M, Velez JCQ, Wald R, De Waele J, Reintam Blaser A, Malbrain MLNG. International cross-sectional survey on current and updated definitions of intra-abdominal hypertension and abdominal compartment syndrome. World J Emerg Surg. 2024 Nov 29;19(1):39. doi: 10.1186/s13017-024-00564-5.
- Background: PubMed 25001397Roberts DJ, Zygun DA, Kirkpatrick AW, Ball CG, Faris PD, Bobrovitz N, Robertson HL, Stelfox HT. A protocol for a scoping and qualitative study to identify and evaluate indications for damage control surgery and damage control interventions in civilian trauma patients. BMJ Open. 2014 Jul 7;4(7):e005634. doi: 10.1136/bmjopen-2014-005634.
- Background: PubMed 20622578Higa G, Friese R, O'Keeffe T, Wynne J, Bowlby P, Ziemba M, Latifi R, Kulvatunyou N, Rhee P. Damage control laparotomy: a vital tool once overused. J Trauma. 2010 Jul;69(1):53-9. doi: 10.1097/TA.0b013e3181e293b4.
- Background: PubMed 16394910Miller RS, Morris JA Jr, Diaz JJ Jr, Herring MB, May AK. Complications after 344 damage-control open celiotomies. J Trauma. 2005 Dec;59(6):1365-71; discussion 1371-4. doi: 10.1097/01.ta.0000196004.49422.af.
- Background: PubMed 24921201van Brunschot S, Schut AJ, Bouwense SA, Besselink MG, Bakker OJ, van Goor H, Hofker S, Gooszen HG, Boermeester MA, van Santvoort HC; Dutch Pancreatitis Study Group. Abdominal compartment syndrome in acute pancreatitis: a systematic review. Pancreas. 2014 Jul;43(5):665-74. doi: 10.1097/MPA.0000000000000108.
- WSACSLink provided by the sponsor.
- Individual participant dataSharing planned: No. The IPD is available to investigators and can be shared with appropriate requests.
Related trials for Abdominal Hypertension
Not yet recruitingObservational study
Intra-Abdominal Pressure, Respiratory Mechanics, and Ventilator Liberation After Emergency Major Laparotomy
Intra-Abdominal Hypertension, Respiratory Mechanics
Not yet recruitingObservational study
Cumulative Intra-Abdominal Pressure Burden and Acute Kidney Injury After Emergency Abdominal Surgery
Acute Kidney Injury, Intra-Abdominal Hypertension
Not yet recruiting
Post-exercise Blood Pressure With Inorganic Nitrate
Obese Individuals, Central Adiposity
RecruitingObservational study
Intra-Abdominal Pressure Changes During Continuous Renal Replacement Therapy in Critically Ill Patients
Intra-Abdominal Hypertension, Critical Illness
Recruiting
Culturally Adapted Dietary Clinical Trial in PR
Diabetes Mellitus, Type 2, Obesity
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Prashant Nasa, MD principal investigator
The Royal Wolverhampton NHS Trust Wolverhampton, UK
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Abdominal Hypertension and Abdominal Compartment Syndrome, run by Medical University of Lublin at 1 site in Poland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 0 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 4 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Poland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Level of consensus on definitions of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) (time frame: 3-6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07563842, which also lists 27 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 May 2026.