Deep Bite MalocclusionMOPsNCT07566676
Maxillary Incisor Intrusion Using Utility Arch Assisted With Micro-osteoperforations
A study testing Micro-osteoperforations and Utility arch in people with Deep Bite Malocclusion and Intrusion of Tooth, run by Al-Azhar University at 1 site in Egypt.
Trial summary
Study will be directed to evaluate the dentoalveolar changes following maxillary incisor intrusion using utility arch assisted with micro-osteoperforations in deep bite cases. Read more about this study
- Who is it for?
- Ages 15 to 25 years
- Conditions the study is for
- Deep Bite Malocclusion, Intrusion of Tooth, Orthodontic Tooth Movement
- What is being tested?
- Micro-osteoperforations and Utility arch
- Type of treatment
- Medical device, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 18 participants
- Where
- 1 siteEgypt
- Study dates
- May 2026to Jun 2029
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 15 to 25 years
- All sexes
- No healthy volunteers
- Child, Adult
Who may be able to join
- Patients age between 15-25 years.
- Patients with overbite ≥ 4 mm.
- All permanent teeth erupted (excluding 3rd molars).
- No previous orthodontic treatment.
- Patients with good oral hygiene and good periodontal health.
Who cannot join
- Skeletal discrepancies.
- Missing maxillary anterior teeth or any kind of tooth/root shape anomaly.
- Patients with root resorption or impacted canines.
- Previous history of orthodontic treatment.
- Systemic disease interferes with orthodontic tooth movement.
- History of trauma affecting the maxillary incisors.
- Poor oral hygiene or periodontally compromised patient.
- Endodontically treated upper anterior teeth.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Hussein N.I Al khalifa, Professor, Vice Dean (Phd) contact
Egypt1 site, 1 recruiting
- Recruiting
Faculty of Dental Medicine (Boys), Al-Azhar University
Cairo, Nasr City, 4434103
Taha S.S Hossameldin, MSc Candidate, +201096667923, tahahossameldin.3.209@azhar.edu.eg
Hussein N.I Al khalifa, Professor, Vice Dean (Phd), +201090302704, HusseinAlkhalifa.209@azhar.edu.eg
About this study
Official title: Evaluation of Dentoalveolar Changes Following Maxillary Incisor Intrusion Using Utility Arch Assisted With Micro-osteoperforations in Deep Bite Cases: A Randomized Clinical Trial
Study will be directed to evaluate the dentoalveolar changes following maxillary incisor intrusion using utility arch assisted with micro-osteoperforations in deep bite cases.
Read the detailed description
Micro-osteoperforations (MOPs) are a new, simple, and minimally invasive technique to accelerate tooth movement. The biologic mechanism behind MOPs is to increase the cytokine expression that leads to increased bone resorption, the catabolic phase of tooth movement, in the direction of tooth movement. Transmucosal holes in cortical bone are made to trigger bone remodeling changes for faster tooth movement and decrease root resotption.
- Being tested
- Micro-osteoperforations, Utility arch
- Medical subject headings
- Root Resorption
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Micro-osteoperforationsProcedure or surgery
Also called MOPs
Using utility arch with micro-osteoperforations (MOPs). The biologic mechanism behind MOPs is to increase the cytokine expression that leads to increase bone resorption and the catabolic phase of tooth movement in the direction of tooth movement. Transmucosal holes in cortical bone are made to trigger bone remodeling changes for faster tooth movement at the apices above maxillary incisors to evaluate the amount of movement and amount of root resorption.
Utility archDevice
Patients will receive utility arch for intrusion of maxillary incisors without micro-osteoperforations.
| Study group | Role | What they receive |
|---|---|---|
| Maxillary incisor intrusion with utility arch assisted with micro-osteoperforations. | Experimental | Using Ricketts utility arch in the maxillary arch inside the molar tubes bypassing premolars and canines to engage inside the four incisors brackets with application of micro-osteoperforations above the apices of maxillary incisors. Receives: Procedure: Micro-osteoperforations |
| Maxillary incisor intrusion with utility arch without micro-osteoperforations | Active comparator | Using Ricketts utility arch in the maxillary arch inside the molar tubes bypassing premolars and canines to engage inside the four incisors brackets without application of micro-osteoperforations. Receives: Device: Utility arch |
What is being measured
The primary outcome is the main question the study is designed to answer.
Amount of root resorption
Measured: Up to 6 months or correction of deep bite
Marginal bone level changes
Measured: Up to 6 months or correction of deep bite
Secondary outcomes (1)
Amount of intrusion of maxillary incisors
Measured: Up to 6 months or correction of deep bite
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 May 2026
- Study startMay 2026 (estimated)
- Primary completionJun 2028 (estimated)
- Study completionJun 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Deep Bite MalocclusionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 18 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Al-Azhar University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Taha Saad Said Hossameldin, Al-Azhar University
- Investigators
- Hussein N.I Al khalifa, Professor, Vice Dean (Phd), Study director, Faculty of Dental medicine (Boys), Al-Azhar University, Cairo, EgyptRaafat E. Mohamed, Prof, Head of Department (Phd), Study director, Faculty of Dental medicine (Boys), Al-Azhar University, Cairo, Egypt
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07566676
- Sponsor's protocol ID
- 1333/833
- Acronym
- MOPs
- Status last verified
- Apr 2026
- First submitted
- 24 Apr 2026
- Last updated
- 5 May 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Data will not be shared due to privacy considerations.
Study at a glance
From the registry record, last updated by the sponsor on 5 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of Dentoalveolar Changes Following Maxillary Incisor Intrusion Using Utility Arch Assisted With Micro-osteoperforations in Deep Bite Cases: A Randomized Clinical Trial
- ClinicalTrials.gov ID
- NCT07566676
- Acronym / sponsor ID
- MOPs / 1333/833
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 18 participants (estimated)
- Lead sponsor
- Al-Azhar UniversityUniversity, hospital or other
- Study start
- May 2026 (estimated)
- Primary completion
- Jun 2028 (estimated)
- Study completion
- Jun 2029 (estimated)
- First posted
- 5 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Study will be directed to evaluate the dentoalveolar changes following maxillary incisor intrusion using utility arch assisted with micro-osteoperforations in deep bite cases.
Detailed description
Micro-osteoperforations (MOPs) are a new, simple, and minimally invasive technique to accelerate tooth movement. The biologic mechanism behind MOPs is to increase the cytokine expression that leads to increased bone resorption, the catabolic phase of tooth movement, in the direction of tooth movement. Transmucosal holes in cortical bone are made to trigger bone remodeling changes for faster tooth movement and decrease root resotption.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Maxillary incisor intrusion with utility arch assisted with micro-osteoperforations. | Experimental | Procedure: Micro-osteoperforationsUsing Ricketts utility arch in the maxillary arch inside the molar tubes bypassing premolars and canines to engage inside the four incisors brackets with application of micro-osteoperforations above the apices of maxillary incisors. |
| Maxillary incisor intrusion with utility arch without micro-osteoperforations | Active comparator | Device: Utility archUsing Ricketts utility arch in the maxillary arch inside the molar tubes bypassing premolars and canines to engage inside the four incisors brackets without application of micro-osteoperforations. |
Who may qualify
- Ages
- 15 to 25 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
Key inclusion criteria (5 listed)
- Patients age between 15-25 years.
- Patients with overbite ≥ 4 mm.
- All permanent teeth erupted (excluding 3rd molars).
- No previous orthodontic treatment.
- Patients with good oral hygiene and good periodontal health.
Key exclusion criteria (8 listed)
- Skeletal discrepancies.
- Missing maxillary anterior teeth or any kind of tooth/root shape anomaly.
- Patients with root resorption or impacted canines.
- Previous history of orthodontic treatment.
- Systemic disease interferes with orthodontic tooth movement.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Micro-osteoperforationsAlso: MOPsUsing utility arch with micro-osteoperforations (MOPs). The biologic mechanism behind MOPs is to increase the cytokine expression that leads to increase bone resorption and the catabolic phase of tooth movement in the direction of tooth movement. Transmucosal holes in cortical bone are made to trigger bone remodeling changes for faster tooth movement at the apices above maxillary incisors to evaluate the amount of movement and amount of root resorption. | Procedure or surgery | Maxillary incisor intrusion with utility arch assisted with micro-osteoperforations. |
| Utility archPatients will receive utility arch for intrusion of maxillary incisors without micro-osteoperforations. | Device | Maxillary incisor intrusion with utility arch without micro-osteoperforations |
Primary outcome
Amount of root resorption
Time frame: Up to 6 months or correction of deep bite
Marginal bone level changes
Time frame: Up to 6 months or correction of deep bite
1 secondary outcome
Amount of intrusion of maxillary incisors
Time frame: Up to 6 months or correction of deep bite
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 May 2026.
- Individual participant dataSharing planned: No. Data will not be shared due to privacy considerations.
Related trials for Deep Bite Malocclusion
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Maxillary Arch Distalization With Infrazygomatic Crest Miniscrews for Class II Malocclusion
Class II Malocclusion
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Treatment of Mild Class II Malocclusion in Adult Patients With Clear Aligners Versus Fixed Multibracket Therapy
Malocclusion, Class II Malocclusion
Enrolling by invitationObservational study
Long-term Stability of Treatment With the Twin Block Appliance
Malocclusion, Angle Class II, Overbite (Excessive) Horizontal
Active, not recruitingObservational study
Comparative Evaluation of Functional and Aesthetic Outcomes of Box and Mini-Wing Genioplasty Techniques
Class II Malocclusion, Dentofacial Deformities
Active, not recruiting
Modified Versus Clear Twin Block for Skeletal Class II Malocclusion
Skeletal Class II Malocclusion
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Hussein N.I Al khalifa, Professor, Vice Dean (Phd) contact
Hussein N.I Al khalifa, Professor, Vice Dean (Phd) study director
Faculty of Dental medicine (Boys), Al-Azhar University, Cairo, Egypt
Raafat E. Mohamed, Prof, Head of Department (Phd) study director
Faculty of Dental medicine (Boys), Al-Azhar University, Cairo, Egypt
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Micro-osteoperforations and Utility arch in people with Deep Bite Malocclusion and Intrusion of Tooth, run by Al-Azhar University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 5 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Taha S.S Hossameldin, MSc Candidate (+201096667923, tahahossameldin.3.209@azhar.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Amount of root resorption (time frame: Up to 6 months or correction of deep bite). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 May 2026.