Diplegic Cerebral PalsyNCT07568808
Core Stabilization and Kinesthetic Training in Diplegic CP
A study testing Core Stabilization Exercises and Kinesthetic Training in people with Diplegic Cerebral Palsy and Diaplegia, run by University of Lahore at 1 site in Pakistan.
Trial summary
This randomized controlled trial aimed to compare the effects of core stabilization exercises (CSE) and kinesthetic training (KT) on postural control in children with spastic diplegic cerebral palsy (GMFCS Level III), aged 4-8 years. Read more about this study
- Who is it for?
- Ages 5 to 12 years
- Conditions the study is for
- Diplegic Cerebral Palsy, Diaplegia
- What is being tested?
- Core Stabilization Exercises and Kinesthetic Training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 32 participants
- Where
- 1 sitePakistan
- Study dates
- 8 Aug 2025to 10 Apr 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 5 to 12 years
- All sexes
- No healthy volunteers
- Child
Who may be able to join
- Spastic diplegic CP
- GMFCS Level III
- Age range: 4 to 8 years
- Must have verbal communication
- Ability to follow verbal commands
Who cannot join
- Severe cognitive impairment
- History of epilepsy or seizures in the past 3 months.
- Children with progressive neurological or genetic disorders (e.g., muscular dystrophy).
- Any acute respiratory infection or chronic pulmonary disease
- Any visual or auditory impairments
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
Sehat Medical Complex, Pediatric Rehabilitation Department, ULTH.
Lahore, Punjab Province, 42000
About this study
Official title: Comparative Effects of Core Stabilization Exercises and Kinesthetic Training in Diplegic Cerebral Palsy
This randomized controlled trial aimed to compare the effects of core stabilization exercises (CSE) and kinesthetic training (KT) on postural control in children with spastic diplegic cerebral palsy (GMFCS Level III), aged 4-8 years. Cerebral palsy was recognized as a non-progressive neurological disorder that affects movement, posture, and motor function, often leading to impaired balance, reduced trunk control, and decreased functional independence. Postural instability was identified as a key concern in diplegic CP, and effective rehabilitation strategies were considered essential to improve mobility and daily functioning. Core stabilization exercises focused on strengthening deep trunk muscles to enhance stability and alignment, whereas kinesthetic training emphasized proprioceptive awareness and neuromuscular coordination to improve movement accuracy and balance. Although both interventions had shown benefits individually, their comparative effectiveness remained unclear.
A total of 32 participants were recruited using purposive sampling and were randomly assigned into two groups: CSE (n=16) and KT (n=16). Both groups received conventional physiotherapy for 15 minutes followed by 30 minutes of their respective interventions, three times per week for 12 weeks. Outcome assessment was conducted at baseline, mid-intervention (6 weeks), and post-intervention (12 weeks) using the Pediatric Berg Balance Scale (PBBS) to evaluate static and dynamic balance. Data were analyzed using SPSS, applying paired t-tests for within-group comparisons and independent t-tests for between-group analysis, with significance set at p < 0.05. This study aimed to determine the more effective intervention for improving balance and functional outcomes, thereby supporting evidence-based clinical practice in pediatric rehabilitation.
A total of 32 participants will be recruited using purposive sampling and randomly assigned into two groups: CSE (n=16) and KT (n=16). Both groups will receive conventional physiotherapy for 15 minutes followed by 30 minutes of their respective interventions, three times per week for 12 weeks. Outcome assessment will be conducted at baseline, mid-intervention (6 weeks), and post-intervention (12 weeks) using the Pediatric Berg Balance Scale (PBBS) to evaluate static and dynamic balance. Data will be analyzed using SPSS, applying paired t-tests for within-group comparisons and independent t-tests for between-group analysis, with significance set at p < 0.05. This study aims to determine the more effective intervention for improving balance and functional outcomes, thereby supporting evidence-based clinical practice in pediatric rehabilitation.
Read the detailed description
This randomized controlled trial was conducted to compare the effects of core stabilization exercises (CSE) and kinesthetic training (KT) on postural control in children diagnosed with spastic diplegic cerebral palsy classified at Gross Motor Function Classification System (GMFCS) Level III, aged between 4 and 8 years. Children within this classification typically demonstrated limitations in independent mobility and required assistive devices for ambulation, with notable impairments in trunk control and balance.
Postural instability in this population was identified as a major contributor to functional limitations, affecting activities such as sitting, standing, and transitional movements. Impaired trunk stability and reduced proprioceptive input were considered key factors influencing balance deficits. Therefore, targeted interventions focusing on trunk control and sensory-motor integration were explored to enhance postural regulation and functional independence.
Core stabilization exercises were implemented with the aim of improving activation, strength, and endurance of deep trunk musculature, including the transversus abdominis, multifidus, and pelvic stabilizers. These exercises emphasized controlled movements, alignment, and postural symmetry in various positions such as supine, sitting, and supported standing. Progression was based on the child's ability to maintain stability with reduced external support.
Kinesthetic training was designed to enhance proprioceptive awareness, joint position sense, and neuromuscular coordination. Activities included weight-shifting, balance challenges on stable and unstable surfaces, guided movement tasks, and functional reaching exercises. The intervention focused on improving the child's ability to perceive and adjust body position in space, thereby facilitating better motor control and balance responses.
Participants were recruited through purposive sampling from pediatric rehabilitation settings and were randomly allocated into two intervention groups using a simple randomization method. Each group consisted of 16 participants. Both groups received a standardized conventional physiotherapy program to ensure consistency in baseline care. This included stretching of spastic muscle groups, range-of-motion exercises, and facilitation of functional movements.
Following conventional therapy, participants underwent their assigned intervention (CSE or KT) for 30 minutes per session. The intervention was delivered three times per week over a period of 12 weeks. Sessions were supervised by trained physiotherapists to ensure adherence, safety, and appropriate progression of exercises.
Outcome measures were recorded at three time points: baseline (prior to intervention), mid-intervention (6 weeks), and post-intervention (12 weeks). Postural control and balance were assessed using the Pediatric Berg Balance Scale (PBBS), a validated tool for measuring both static and dynamic balance in pediatric populations. The scale included functional tasks such as sitting, standing, reaching, turning, and transferring, with scores reflecting the child's level of independence and stability.
Data were analyzed using statistical software. Within-group comparisons were performed to assess changes over time, while between-group comparisons were conducted to determine differences in effectiveness between the two interventions. Statistical significance was set at p < 0.05.
The findings of this study were intended to provide evidence regarding the relative effectiveness of core stabilization versus kinesthetic training in improving balance in children with spastic diplegic cerebral palsy. The results were expected to contribute to clinical decision-making and support the development of targeted rehabilitation protocols aimed at enhancing functional outcomes and quality of life in this population.
- Conditions
- Diplegic Cerebral Palsy, Diaplegia
- Being tested
- Core Stabilization Exercises, Kinesthetic Training
- Keywords
- core stability, kinesthetic, peadetric, cerebral palsy, diaplegia
- Medical subject headings
- Cerebral Palsy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Core Stabilization ExercisesOther
A 4-week exercise program focusing on deep abdominal and back muscles. Sessions are 45 minutes each, 3 times per week. Exercises include The Plank (front and side), Bird-Dog, and Dead Bug. Progression will be managed by increasing hold times and repetitions as the patient's stability improves.
Kinesthetic TrainingOther
A 4-week sensory-motor training program designed to improve proprioception and balance. Sessions are 45 minutes each, 3 times per week. Activities include single-limb standing, weight shifting on stable and unstable surfaces (like foam pads), and coordinated limb movements to enhance joint position sense and postural control.
| Study group | Role | What they receive |
|---|---|---|
| Core Stabilization Group | Experimental | Participants in this group received a core stabilization exercise program focusing on deep abdominal and back muscles. The protocol included the plank, bird-dog, and dead bug exercises, which were performed three times per week for four weeks. Receives: Other: Core Stabilization Exercises |
| Kinesthetic Training Group | Experimental | Participants in this group underwent kinesthetic training aimed at improving proprioception and joint position sense. This included weight-shifting and balance activities on stable and unstable surfaces, which were performed three times per week for four weeks. Receives: Other: Kinesthetic Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Balance Control is measured using the PBBS to evaluate both static and dynamic postural stability.
The Pediatric Berg Balance Scale (PBBS) is a standardized clinical assessment used to measure functional balance and postural control in children with motor challenges. It consists of 14 distinct tasks that mimic activities of daily living, including the ability to sit and stand without support, transfer between chairs, reach forward, and pick up objects from the floor. Each task is evaluated on a 5-point scale ranging from 0 to 4, where a higher score reflects a greater level of independence and stability. With a maximum total score of 56, the PBBS serves as a reliable tool for tracking a child's progress over time and determining the effectiveness of therapeutic interventions. In this clinical trial, the scale is utilized at baseline, week 6, and week 12 to provide a clear quantitative record of the participant's balance improvements.
Measured: 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 May 2026
- Study start8 Aug 2025
- Primary completion9 Mar 2026
- Study completion10 Apr 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Diplegic Cerebral PalsyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 32 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Lahore
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Nabisha Yaseen, University of Lahore
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07568808
- Sponsor's protocol ID
- UOL/IREB/25/12/0035.
- Status last verified
- Apr 2026
- First submitted
- 28 Apr 2026
- Last updated
- 6 May 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Eliasson AC, Krumlinde-Sundholm L, Rosblad B, Beckung E, Arner M, Ohrvall AM, Rosenbaum P. The Manual Ability Classification System (MACS) for children with cerebral palsy: scale development and evidence of validity and reliability. Dev Med Child Neurol. 2006 Jul;48(7):549-54. doi: 10.1017/S0012162206001162.
PubMed 16780622Akay T, Murray AJ. Relative Contribution of Proprioceptive and Vestibular Sensory Systems to Locomotion: Opportunities for Discovery in the Age of Molecular Science. Int J Mol Sci. 2021 Feb 2;22(3):1467. doi: 10.3390/ijms22031467.
PubMed 33540567
Study at a glance
From the registry record, last updated by the sponsor on 6 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Effects of Core Stabilization Exercises and Kinesthetic Training in Diplegic Cerebral Palsy
- ClinicalTrials.gov ID
- NCT07568808
- Acronym / sponsor ID
- UOL/IREB/25/12/0035.
- Conditions
- Diplegic Cerebral Palsy, Diaplegia
- Keywords
- core stability, kinesthetic, peadetric, cerebral palsy, diaplegia
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 32 participants (actual)
- Lead sponsor
- University of LahoreUniversity, hospital or other
- Study start
- 8 Aug 2025 (actual)
- Primary completion
- 9 Mar 2026 (actual)
- Study completion
- 10 Apr 2026 (actual)
- First posted
- 6 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial aimed to compare the effects of core stabilization exercises (CSE) and kinesthetic training (KT) on postural control in children with spastic diplegic cerebral palsy (GMFCS Level III), aged 4-8 years. Cerebral palsy was recognized as a non-progressive neurological disorder that affects movement, posture, and motor function, often leading to impaired balance, reduced trunk control, and decreased functional independence. Postural instability was identified as a key concern in diplegic CP, and effective rehabilitation strategies were considered essential to improve mobility and daily functioning. Core stabilization exercises focused on strengthening deep trunk muscles to enhance stability and alignment, whereas kinesthetic training emphasized proprioceptive awareness and neuromuscular coordination to improve movement accuracy and balance. Although both interventions had shown benefits individually, their comparative effectiveness remained unclear.
A total of 32 participants were recruited using purposive sampling and were randomly assigned into two groups: CSE (n=16) and KT (n=16). Both groups received conventional physiotherapy for 15 minutes followed by 30 minutes of their respective interventions, three times per week for 12 weeks. Outcome assessment was conducted at baseline, mid-intervention (6 weeks), and post-intervention (12 weeks) using the Pediatric Berg Balance Scale (PBBS) to evaluate static and dynamic balance. Data were analyzed using SPSS, applying paired t-tests for within-group comparisons and independent t-tests for between-group analysis, with significance set at p < 0.05. This study aimed to determine the more effective intervention for improving balance and functional outcomes, thereby supporting evidence-based clinical practice in pediatric rehabilitation.
A total of 32 participants will be recruited using purposive sampling and randomly assigned into two groups: CSE (n=16) and KT (n=16). Both groups will receive conventional physiotherapy for 15 minutes followed by 30 minutes of their respective interventions, three times per week for 12 weeks. Outcome assessment will be conducted at baseline, mid-intervention (6 weeks), and post-intervention (12 weeks) using the Pediatric Berg Balance Scale (PBBS) to evaluate static and dynamic balance. Data will be analyzed using SPSS, applying paired t-tests for within-group comparisons and independent t-tests for between-group analysis, with significance set at p < 0.05. This study aims to determine the more effective intervention for improving balance and functional outcomes, thereby supporting evidence-based clinical practice in pediatric rehabilitation.
Detailed description
This randomized controlled trial was conducted to compare the effects of core stabilization exercises (CSE) and kinesthetic training (KT) on postural control in children diagnosed with spastic diplegic cerebral palsy classified at Gross Motor Function Classification System (GMFCS) Level III, aged between 4 and 8 years. Children within this classification typically demonstrated limitations in independent mobility and required assistive devices for ambulation, with notable impairments in trunk control and balance.
Postural instability in this population was identified as a major contributor to functional limitations, affecting activities such as sitting, standing, and transitional movements. Impaired trunk stability and reduced proprioceptive input were considered key factors influencing balance deficits. Therefore, targeted interventions focusing on trunk control and sensory-motor integration were explored to enhance postural regulation and functional independence.
Core stabilization exercises were implemented with the aim of improving activation, strength, and endurance of deep trunk musculature, including the transversus abdominis, multifidus, and pelvic stabilizers. These exercises emphasized controlled movements, alignment, and postural symmetry in various positions such as supine, sitting, and supported standing. Progression was based on the child's ability to maintain stability with reduced external support.
Kinesthetic training was designed to enhance proprioceptive awareness, joint position sense, and neuromuscular coordination. Activities included weight-shifting, balance challenges on stable and unstable surfaces, guided movement tasks, and functional reaching exercises. The intervention focused on improving the child's ability to perceive and adjust body position in space, thereby facilitating better motor control and balance responses.
Participants were recruited through purposive sampling from pediatric rehabilitation settings and were randomly allocated into two intervention groups using a simple randomization method. Each group consisted of 16 participants. Both groups received a standardized conventional physiotherapy program to ensure consistency in baseline care. This included stretching of spastic muscle groups, range-of-motion exercises, and facilitation of functional movements.
Following conventional therapy, participants underwent their assigned intervention (CSE or KT) for 30 minutes per session. The intervention was delivered three times per week over a period of 12 weeks. Sessions were supervised by trained physiotherapists to ensure adherence, safety, and appropriate progression of exercises.
Outcome measures were recorded at three time points: baseline (prior to intervention), mid-intervention (6 weeks), and post-intervention (12 weeks). Postural control and balance were assessed using the Pediatric Berg Balance Scale (PBBS), a validated tool for measuring both static and dynamic balance in pediatric populations. The scale included functional tasks such as sitting, standing, reaching, turning, and transferring, with scores reflecting the child's level of independence and stability.
Data were analyzed using statistical software. Within-group comparisons were performed to assess changes over time, while between-group comparisons were conducted to determine differences in effectiveness between the two interventions. Statistical significance was set at p < 0.05.
The findings of this study were intended to provide evidence regarding the relative effectiveness of core stabilization versus kinesthetic training in improving balance in children with spastic diplegic cerebral palsy. The results were expected to contribute to clinical decision-making and support the development of targeted rehabilitation protocols aimed at enhancing functional outcomes and quality of life in this population.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Core Stabilization Group | Experimental | Other: Core Stabilization ExercisesParticipants in this group received a core stabilization exercise program focusing on deep abdominal and back muscles. The protocol included the plank, bird-dog, and dead bug exercises, which were performed three times per week for four weeks. |
| Kinesthetic Training Group | Experimental | Other: Kinesthetic TrainingParticipants in this group underwent kinesthetic training aimed at improving proprioception and joint position sense. This included weight-shifting and balance activities on stable and unstable surfaces, which were performed three times per week for four weeks. |
Who may qualify
- Ages
- 5 to 12 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child
Key inclusion criteria (5 listed)
- Spastic diplegic CP
- GMFCS Level III
- Age range: 4 to 8 years
- Must have verbal communication
- Ability to follow verbal commands
Key exclusion criteria (5 listed)
- Severe cognitive impairment
- History of epilepsy or seizures in the past 3 months.
- Children with progressive neurological or genetic disorders (e.g., muscular dystrophy).
- Any acute respiratory infection or chronic pulmonary disease
- Any visual or auditory impairments
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Core Stabilization ExercisesA 4-week exercise program focusing on deep abdominal and back muscles. Sessions are 45 minutes each, 3 times per week. Exercises include The Plank (front and side), Bird-Dog, and Dead Bug. Progression will be managed by increasing hold times and repetitions as the patient's stability improves. | Other | Core Stabilization Group |
| Kinesthetic TrainingA 4-week sensory-motor training program designed to improve proprioception and balance. Sessions are 45 minutes each, 3 times per week. Activities include single-limb standing, weight shifting on stable and unstable surfaces (like foam pads), and coordinated limb movements to enhance joint position sense and postural control. | Other | Kinesthetic Training Group |
Primary outcome
Balance Control is measured using the PBBS to evaluate both static and dynamic postural stability.
Time frame: 6 months
The Pediatric Berg Balance Scale (PBBS) is a standardized clinical assessment used to measure functional balance and postural control in children with motor challenges. It consists of 14 distinct tasks that mimic activities of daily living, including the ability to sit and stand without support, transfer between chairs, reach forward, and pick up objects from the floor. Each task is evaluated on a 5-point scale ranging from 0 to 4, where a higher score reflects a greater level of independence and stability. With a maximum total score of 56, the PBBS serves as a reliable tool for tracking a child's progress over time and determining the effectiveness of therapeutic interventions. In this clinical trial, the scale is utilized at baseline, week 6, and week 12 to provide a clear quantitative record of the participant's balance improvements.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 May 2026.
- Background: PubMed 16780622Eliasson AC, Krumlinde-Sundholm L, Rosblad B, Beckung E, Arner M, Ohrvall AM, Rosenbaum P. The Manual Ability Classification System (MACS) for children with cerebral palsy: scale development and evidence of validity and reliability. Dev Med Child Neurol. 2006 Jul;48(7):549-54. doi: 10.1017/S0012162206001162.
- Background: PubMed 33540567Akay T, Murray AJ. Relative Contribution of Proprioceptive and Vestibular Sensory Systems to Locomotion: Opportunities for Discovery in the Age of Molecular Science. Int J Mol Sci. 2021 Feb 2;22(3):1467. doi: 10.3390/ijms22031467.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Core Stabilization Exercises and Kinesthetic Training in people with Diplegic Cerebral Palsy and Diaplegia, run by University of Lahore at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Balance Control is measured using the PBBS to evaluate both static and dynamic postural stability. (time frame: 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07568808, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 May 2026.