AgingNCT07568951
Impact of Force Control of Hip Abductor Muscles in Healthy Adults and Individuals With Parkinson's Disease
An observational study of Aging and Parkinson's Disease (PD), run by Chang Gung Memorial Hospital at 2 sites in Taiwan.
Trial summary
Both aging and Parkinson's disease (PD) negatively affect postural control and increase the risk of falls, with frontal plane balance being particularly challenging for these populations. Read more about this study
- Who is it for?
- Ages 20 to 85 yearsHealthy volunteers can take part
- Conditions the study is for
- Aging, Parkinson's Disease (PD)
- What is being tested?
- Age and Parkinson's disease (PD)
- How many people
- 210 participants
- Where
- 2 sitesTaiwan
- Study dates
- 1 Aug 2023to 31 Jul 2029
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 85 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: This study recruits healthy elderly individuals, healthy middle-aged individuals, healthy young individuals, and individuals with PD.
Who may be able to join
- 20 to 39 years (young), 40 to 59 years (young), and 60-85 years (old)
- generally in good health
- able to walk 10 m independently
- able to follow all instructions
- clinical diagnosis of idiopathic PD
- Hoehn and Yahr stages 1 to 3
Show all 9Show fewer
- stable anti-PD medications
- able to walk 10 m independently
- able to follow all instructions
Who cannot join
- neurologic, psychiatric, immune, integumentary, and musculoskeletal diseases or disorders which might influence this study
- any pain over the lower extremities
- uncontrolled cardiovascular diseases
- unable to provide informed consent.
- PD
- psychiatric, immune, integumentary, and musculoskeletal diseases or disorders which might influence this study
Show all 10Show fewer
- neurological conditions other than PD
- any pain over the lower extremities
- uncontrolled cardiovascular diseases
- unable to provide informed consent.
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Taiwan2 sites, 2 recruiting
- Recruiting
Chang Gung Memorial Hospital
Taoyuan
Chu-Ling Yen, 886-3-2118800 ext. 3059, clyen@mail.cgu.edu.tw
- Recruiting
Chang Gung University
Taoyuan
Chu-Ling Yen, 886-3-2118800 ext. 3059, clyen@mail.cgu.edu.tw
About this study
Official title: Impact of Force Control of Hip Abductor Muscles on Postural Control in Middle-aged and Older Adults and Individuals With Parkinson's Disease
Both aging and Parkinson's disease (PD) negatively affect postural control and increase the risk of falls, with frontal plane balance being particularly challenging for these populations. While previous studies have mainly focused on sagittal plane balance, the contribution of hip abductor muscles remains unclear, especially regarding their force production and control abilities. Therefore, this study aims to investigate hip abductor muscle force production and force control, and to examine whether these factors are associated with postural control, gait, and balance performance in individuals across different ages and those with PD.
Read the detailed description
Both aging and Parkinson's disease (PD) negatively affect postural control and increase the risk of falls, with frontal plane balance being particularly challenging for these populations. Previous studies have mainly focused on sagittal plane balance and have identified the important roles of ankle plantar flexors and knee extensors; however, the contribution of hip abductor muscles-key muscles for frontal plane stability-remains unclear, particularly in terms of their force production and control abilities. Therefore, this study aims to investigate hip abductor muscle force production and force control, and to examine whether these factors are associated with postural control, gait, and balance performance in individuals across different ages and those with PD. Healthy young, middle-aged, and older adults will be recruited from the community, and individuals with PD will be recruited from the Department of Neurology. Healthy participants must be in good health, able to walk independently, demonstrate normal cognitive function, and provide informed consent, while those with neurological, cardiovascular, musculoskeletal, or other conditions affecting motor performance will be excluded. For individuals with PD, inclusion criteria will be a clinical diagnosis of idiopathic PD, Hoehn and Yahr stages 1 to 3, stable anti-PD medication use, and the ability to follow instructions and walk at least 10 m. Exclusion criteria will include psychiatric, immune, integumentary, or musculoskeletal disorders, neurological conditions other than PD, lower extremity pain, uncontrolled cardiovascular disease, or inability to provide informed consent. All participants will undergo a one-time assessment, including maximal voluntary isometric contraction, force steadiness, postural control, and gait performance.
Surface electromyography will be used to assess neuromuscular function, postural control will be evaluated using a force plate under multiple standing conditions, and gait parameters will be measured at both comfortable and fast walking speeds. Statistical analyses will be conducted using ANOVA to examine group differences.
- Conditions
- Aging, Parkinson's Disease (PD)
- Being tested
- Age, Parkinson's disease (PD)
- Keywords
- Old, Parkinson's disease, muscle force, force steadiness, balance, gait performance
- Medical subject headings
- Parkinson Disease
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
AgeOther
We compare the young, middle-aged, and old groups
Parkinson's disease (PD)Other
We compare the healthy group and PD group.
| Study group | Role | What they receive |
|---|---|---|
| Healthy people | General healthy adults Receives: Other: Age; Other: Parkinson's disease (PD) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Maximal force
The maximal force of lower extremity muscles
Measured: Baseline
Rate of torque development
The ability to rapidly generate muscle force
Measured: Baseline
Force steadiness
The ability to maintain a constant force output during a submaximal contraction
Measured: Baseline
Walking speed
The time taken by participants to walk a standardized distance
Measured: Baseline
Step Length
The linear distance between the two ankles, typically expressed in centimeter(cm).
Measured: Baseline
Cadence
The number of steps taken per minute (SPM)
Measured: Baseline
Single Support Time
The duration within the gait cycle when only one foot is in contact with the ground, typically measured in seconds or as a percentage of the total gait cycle.
Measured: Baseline
Double Support Time
The portion of the gait cycle where both feet are in contact with the ground, indicating the transition phase between steps, expressed as a percentage of the gait cycle or in seconds.
Measured: Baseline
Swing Time
The portion of the gait cycle where the foot is not in contact with the ground, moving forward to the next step. It is usually expressed as a percentage of the total gait cycle or in seconds.
Measured: Baseline
Center of Pressure (COP) Velocity in Balance Tasks
The speed at which the COP moves, calculated over the duration of the balance task. Higher velocities may reflect more dynamic balance adjustments or instability. Unit：millimeter per second(mm/s)
Measured: Baseline
Center of Pressure (COP) Area in Balance Tasks
The area covered by the COP trajectory during the balance task, providing an estimate of the sway envelope. A larger area might indicate poorer balance control. Unit：square millimeter(mm^2)
Measured: Baseline
Timed Up-and-Go Test
Tthe time an individual takes to stand up from a chair, walk 3 meters, turn around, walk back, and sit down.
Measured: Baseline
Four Square Step Test
Participants will be required to perform four square step test by changing directions while stepping forward, sideway, and backward over a low obstacle as fast as possible.
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 May 2026
- Study start1 Aug 2023
- Primary completion31 Jul 2029 (estimated)
- Study completion31 Jul 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AgingStudies of the same condition, open and under way.
- More trials run by Chang Gung Memorial HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 210 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Chang Gung Memorial Hospital
- Sponsor type
- University, hospital or other
- Collaborators
- Chang Gung University
- Responsible party
- Principal investigator, Chu-Ling Yen, Chang Gung University
- Investigators
- Chu-Ling Yen, Principal investigator, Chang Gung University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07568951
- Sponsor's protocol ID
- 202202289A3
- Status last verified
- May 2026
- First submitted
- 25 Apr 2026
- Last updated
- 8 May 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 8 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Impact of Force Control of Hip Abductor Muscles on Postural Control in Middle-aged and Older Adults and Individuals With Parkinson's Disease
- ClinicalTrials.gov ID
- NCT07568951
- Acronym / sponsor ID
- 202202289A3
- Conditions
- Aging, Parkinson's Disease (PD)
- Keywords
- Old, Parkinson's disease, muscle force, force steadiness, balance, gait performance
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 210 participants (estimated)
- Lead sponsor
- Chang Gung Memorial HospitalUniversity, hospital or other
- Collaborators
- Chang Gung University
- Study start
- 1 Aug 2023 (actual)
- Primary completion
- 31 Jul 2029 (estimated)
- Study completion
- 31 Jul 2029 (estimated)
- First posted
- 6 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Both aging and Parkinson's disease (PD) negatively affect postural control and increase the risk of falls, with frontal plane balance being particularly challenging for these populations. While previous studies have mainly focused on sagittal plane balance, the contribution of hip abductor muscles remains unclear, especially regarding their force production and control abilities. Therefore, this study aims to investigate hip abductor muscle force production and force control, and to examine whether these factors are associated with postural control, gait, and balance performance in individuals across different ages and those with PD.
Detailed description
Both aging and Parkinson's disease (PD) negatively affect postural control and increase the risk of falls, with frontal plane balance being particularly challenging for these populations. Previous studies have mainly focused on sagittal plane balance and have identified the important roles of ankle plantar flexors and knee extensors; however, the contribution of hip abductor muscles-key muscles for frontal plane stability-remains unclear, particularly in terms of their force production and control abilities. Therefore, this study aims to investigate hip abductor muscle force production and force control, and to examine whether these factors are associated with postural control, gait, and balance performance in individuals across different ages and those with PD. Healthy young, middle-aged, and older adults will be recruited from the community, and individuals with PD will be recruited from the Department of Neurology. Healthy participants must be in good health, able to walk independently, demonstrate normal cognitive function, and provide informed consent, while those with neurological, cardiovascular, musculoskeletal, or other conditions affecting motor performance will be excluded. For individuals with PD, inclusion criteria will be a clinical diagnosis of idiopathic PD, Hoehn and Yahr stages 1 to 3, stable anti-PD medication use, and the ability to follow instructions and walk at least 10 m. Exclusion criteria will include psychiatric, immune, integumentary, or musculoskeletal disorders, neurological conditions other than PD, lower extremity pain, uncontrolled cardiovascular disease, or inability to provide informed consent. All participants will undergo a one-time assessment, including maximal voluntary isometric contraction, force steadiness, postural control, and gait performance.
Surface electromyography will be used to assess neuromuscular function, postural control will be evaluated using a force plate under multiple standing conditions, and gait parameters will be measured at both comfortable and fast walking speeds. Statistical analyses will be conducted using ANOVA to examine group differences.
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Healthy people | – | Other: Age, Other: Parkinson's disease (PD)General healthy adults |
Who may qualify
- Ages
- 20 to 85 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- This study recruits healthy elderly individuals, healthy middle-aged individuals, healthy young individuals, and individuals with PD.
Key inclusion criteria (9 listed)
- 20 to 39 years (young), 40 to 59 years (young), and 60-85 years (old)
- generally in good health
- able to walk 10 m independently
- able to follow all instructions
- clinical diagnosis of idiopathic PD
Key exclusion criteria (10 listed)
- neurologic, psychiatric, immune, integumentary, and musculoskeletal diseases or disorders which might influence this study
- any pain over the lower extremities
- uncontrolled cardiovascular diseases
- unable to provide informed consent.
- PD
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| AgeWe compare the young, middle-aged, and old groups | Other | Healthy people |
| Parkinson's disease (PD)We compare the healthy group and PD group. | Other | Healthy people |
Primary outcome
Maximal force
Time frame: Baseline
The maximal force of lower extremity muscles
Rate of torque development
Time frame: Baseline
The ability to rapidly generate muscle force
Force steadiness
Time frame: Baseline
The ability to maintain a constant force output during a submaximal contraction
Walking speed
Time frame: Baseline
The time taken by participants to walk a standardized distance
Step Length
Time frame: Baseline
The linear distance between the two ankles, typically expressed in centimeter(cm).
Cadence
Time frame: Baseline
The number of steps taken per minute (SPM)
Single Support Time
Time frame: Baseline
The duration within the gait cycle when only one foot is in contact with the ground, typically measured in seconds or as a percentage of the total gait cycle.
Double Support Time
Time frame: Baseline
The portion of the gait cycle where both feet are in contact with the ground, indicating the transition phase between steps, expressed as a percentage of the gait cycle or in seconds.
Swing Time
Time frame: Baseline
The portion of the gait cycle where the foot is not in contact with the ground, moving forward to the next step. It is usually expressed as a percentage of the total gait cycle or in seconds.
Center of Pressure (COP) Velocity in Balance Tasks
Time frame: Baseline
The speed at which the COP moves, calculated over the duration of the balance task. Higher velocities may reflect more dynamic balance adjustments or instability. Unit：millimeter per second(mm/s)
Center of Pressure (COP) Area in Balance Tasks
Time frame: Baseline
The area covered by the COP trajectory during the balance task, providing an estimate of the sway envelope. A larger area might indicate poorer balance control. Unit：square millimeter(mm^2)
Timed Up-and-Go Test
Time frame: Baseline
Tthe time an individual takes to stand up from a chair, walk 3 meters, turn around, walk back, and sit down.
Four Square Step Test
Time frame: Baseline
Participants will be required to perform four square step test by changing directions while stepping forward, sideway, and backward over a low obstacle as fast as possible.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 May 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Chu-Ling Yen principal investigator
Chang Gung University
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Aging and Parkinson's Disease (PD), run by Chang Gung Memorial Hospital at 2 sites in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 8 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Chu-Ling Yen (886-3-2118800 ext. 3059, clyen@mail.cgu.edu.tw), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Maximal force (time frame: Baseline). The study lists 13 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 May 2026.