Lichen PlanusLP-NOSENCT07570706
Mucosal and Nasal Involvement and Their Correlation With Smell and Taste Functions in Lichen Planus Patients
An observational study of Lichen Planus, run by Istanbul Training and Research Hospital at 1 site in Turkey (Türkiye).
Trial summary
This study investigates smell and taste function in patients diagnosed with lichen planus, a chronic inflammatory condition affecting the skin and mucous membranes. Adults aged 18-65 with lichen planus participated in taste and smell tests. Read more about this study
- Who is it for?
- Ages 18 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Lichen Planus
- What is being tested?
- Grup 1 - Lichen Planus Patients Intervention Name: Taste and Smell Testing, Oral and Nasal Examination, Nasal Endoscopy Intervention Description: Participants undergo taste and smell testing to assess
- Type of treatment
- Pill or oral medicine
- How many people
- 88 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jan 2026to 2 Apr 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: The study includes adults aged 18-65 years with a clinical diagnosis of lichen planus, as well as healthy volunteers without lichen planus. Participants were assessed for smell and taste function, and the patient group also underwent oral and nasal mucosal examinations, including nasal endoscopy. Both male and female participants were included.
Who may be able to join
- Age 18-65 years Clinically diagnosed with lichen planus (patient group) Healthy individuals without lichen planus (control group) Willing and able to provide informed consent
Who cannot join
- Nasal septum deviation Nasal polyposis, congenital olfactory dysfunction, chronic rhinosinusitis, or allergic rhinitis History of head trauma History of nasal or paranasal surgery Psychiatric or neurological disorders (e.g., Parkinson's disease, Alzheimer's disease) Persistent loss of smell following COVID-19 infection Pregnancy or breastfeeding
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
S.B.U. Istanbul Training and Research Hospital
Istanbul, Istanbul, 34098
About this study
Official title: Correlation of Mucosal and Nasal Involvement With Smell and Taste Functions in Patients With Lichen Planus
This study investigates smell and taste function in patients diagnosed with lichen planus, a chronic inflammatory condition affecting the skin and mucous membranes.
Adults aged 18-65 with lichen planus participated in taste and smell tests. Oral and nasal examinations were performed to check for mucosal involvement, and nasal endoscopy was used to further evaluate nasal involvement.
Read more
A healthy control group of similar age also underwent taste and smell tests to compare results with the lichen planus patients.
The study aims to better understand how lichen planus affects smell and taste, which may help improve patient care. Participation is voluntary, and all information collected will be kept confidential.
Read the detailed description
The study aims to evaluate the impact of lichen planus on olfactory and gustatory functions in adults aged 18-65. Participants with lichen planus underwent taste and smell testing, oral and nasal mucosal examinations, and nasal endoscopy to detect potential mucosal involvement. A matched healthy control group also completed taste and smell tests to provide comparative data. This design allows the assessment of whether mucosal involvement in lichen planus correlates with changes in taste and smell, which may contribute to better clinical understanding and management of the disease.
- Conditions
- Lichen Planus
- Being tested
- Grup 1 - Lichen Planus Patients Intervention Name: Taste and Smell Testing, Oral and Nasal Examination, Nasal Endoscopy Intervention Description: Participants undergo taste and smell testing to assess
- Keywords
- Lichen Planus, Taste Function, Smell Function, Olfactory Testing, Gustatory Testing, Nasal Endoscopy, Oral Mucosa, Nasal Mucosa, Mucosal Involvement, Healthy Controls
- Medical subject headings
- Lichen Planus
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Grup 1 - Lichen Planus Patients Intervention Name: Taste and Smell Testing, Oral and Nasal Examination, Nasal Endoscopy Intervention Description: Participants undergo taste and smell testing to assessOther
Group 1 - Lichen Planus Patients:
Participants undergo taste and smell testing to assess sensory function, oral and nasal examinations to evaluate mucosal involvement, and nasal endoscopy for detailed nasal assessment.
Group 2 - Healthy Controls:
Participants undergo taste and smell testing to provide comparative data for the lichen planus group.
| Study group | Role | What they receive |
|---|---|---|
| Group 1- Lichen Planus Patients | Participants undergo taste and smell testing, oral and nasal examinations, and nasal endoscopy to assess mucosal involvement. Receives: Other: Grup 1 - Lichen Planus Patients Intervention Name: Taste and Smell Testing, Oral and Nasal Examination, Nasal Endoscopy Intervention Description: Participants undergo taste and smell testing to assess | |
| Group 2 - Healthy Controls | Participants undergo taste and smell testing to provide comparative data with the lichen planus group. Receives: Other: Grup 1 - Lichen Planus Patients Intervention Name: Taste and Smell Testing, Oral and Nasal Examination, Nasal Endoscopy Intervention Description: Participants undergo taste and smell testing to assess |
What is being measured
The primary outcome is the main question the study is designed to answer.
Smell and Taste Function
Participants underwent standardized smell (olfactory) and taste (gustatory) tests to assess sensory function. Tests were performed on both lichen planus patients and healthy controls to compare results and evaluate the impact of mucosal involvement on smell and taste function.
Time Frame: Single visit assessment
Measured: Day 1
Smell and taste function in patients with lichen planus
Participants underwent standardized smell (olfactory) and taste (gustatory) tests to assess sensory function. Tests were performed on both lichen planus patients and healthy controls to compare results and evaluate the impact of mucosal involvement on smell and taste function.
Measured: Day 1
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 May 2026
- Study start1 Jan 2026
- Primary completion20 Mar 2026
- Study completion2 Apr 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Lichen PlanusStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Enrolment
- 88 participants (actual)
Sponsor and investigators
- Lead sponsor
- Istanbul Training and Research Hospital
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Yasemin Bolat Eren, Istanbul Training and Research Hospital
- Investigators
- Yasemin Bolat Eren, MD, Principal investigator, S.B.U. Istanbul Eğitim ve Araştırma Hastanesi, Dermatology Department
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07570706
- Sponsor's protocol ID
- LP-Nasal-2026-01
- Other IDs
- LP-NOSE
- Acronym
- LP-NOSE
- Status last verified
- Apr 2026
- First submitted
- 9 Apr 2026
- Last updated
- 6 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data (IPD) will not be shared due to privacy and confidentiality considerations for study participants.
Study at a glance
From the registry record, last updated by the sponsor on 6 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Correlation of Mucosal and Nasal Involvement With Smell and Taste Functions in Patients With Lichen Planus
- ClinicalTrials.gov ID
- NCT07570706
- Acronym / sponsor ID
- LP-NOSE / LP-Nasal-2026-01
- Conditions
- Lichen Planus
- Keywords
- Lichen Planus, Taste Function, Smell Function, Olfactory Testing, Gustatory Testing, Nasal Endoscopy, Oral Mucosa, Nasal Mucosa
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 88 participants (actual)
- Lead sponsor
- Istanbul Training and Research HospitalOther government
- Study start
- 1 Jan 2026 (actual)
- Primary completion
- 20 Mar 2026 (actual)
- Study completion
- 2 Apr 2026 (actual)
- First posted
- 6 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study investigates smell and taste function in patients diagnosed with lichen planus, a chronic inflammatory condition affecting the skin and mucous membranes.
Adults aged 18-65 with lichen planus participated in taste and smell tests. Oral and nasal examinations were performed to check for mucosal involvement, and nasal endoscopy was used to further evaluate nasal involvement.
A healthy control group of similar age also underwent taste and smell tests to compare results with the lichen planus patients.
The study aims to better understand how lichen planus affects smell and taste, which may help improve patient care. Participation is voluntary, and all information collected will be kept confidential.
Detailed description
The study aims to evaluate the impact of lichen planus on olfactory and gustatory functions in adults aged 18-65. Participants with lichen planus underwent taste and smell testing, oral and nasal mucosal examinations, and nasal endoscopy to detect potential mucosal involvement. A matched healthy control group also completed taste and smell tests to provide comparative data. This design allows the assessment of whether mucosal involvement in lichen planus correlates with changes in taste and smell, which may contribute to better clinical understanding and management of the disease.
Study design
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group 1- Lichen Planus Patients | – | Other: Grup 1 - Lichen Planus Patients Intervention Name: Taste and Smell Testing, Oral and Nasal Examination, Nasal Endoscopy Intervention Description: Participants undergo taste and smell testing to assessParticipants undergo taste and smell testing, oral and nasal examinations, and nasal endoscopy to assess mucosal involvement. |
| Group 2 - Healthy Controls | – | Other: Grup 1 - Lichen Planus Patients Intervention Name: Taste and Smell Testing, Oral and Nasal Examination, Nasal Endoscopy Intervention Description: Participants undergo taste and smell testing to assessParticipants undergo taste and smell testing to provide comparative data with the lichen planus group. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- The study includes adults aged 18-65 years with a clinical diagnosis of lichen planus, as well as healthy volunteers without lichen planus. Participants were assessed for smell and taste function, and the patient group also underwent oral and nasal mucosal examinations, including nasal endoscopy. Both male and female participants were included.
Key inclusion criteria (1 listed)
- Age 18-65 years Clinically diagnosed with lichen planus (patient group) Healthy individuals without lichen planus (control group) Willing and able to provide informed consent
Key exclusion criteria (1 listed)
- Nasal septum deviation Nasal polyposis, congenital olfactory dysfunction, chronic rhinosinusitis, or allergic rhinitis History of head trauma History of nasal or paranasal surgery Psychiatric or neurological disorders (e.g., Parkinson's disease, Alzheimer's disease) Persistent loss of smell following COVID-19 infection Pregnancy or breastfeeding
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Grup 1 - Lichen Planus Patients Intervention Name: Taste and Smell Testing, Oral and Nasal Examination, Nasal Endoscopy Intervention Description: Participants undergo taste and smell testing to assessGroup 1 - Lichen Planus Patients: Participants undergo taste and smell testing to assess sensory function, oral and nasal examinations to evaluate mucosal involvement, and nasal endoscopy for detailed nasal assessment. Group 2 - Healthy Controls: Participants undergo taste and smell testing to provide comparative data for the lichen planus group. | Other | Group 1- Lichen Planus Patients, Group 2 - Healthy Controls |
Primary outcome
Smell and Taste Function
Time frame: Day 1
Participants underwent standardized smell (olfactory) and taste (gustatory) tests to assess sensory function. Tests were performed on both lichen planus patients and healthy controls to compare results and evaluate the impact of mucosal involvement on smell and taste function. Time Frame: Single visit assessment
Smell and taste function in patients with lichen planus
Time frame: Day 1
Participants underwent standardized smell (olfactory) and taste (gustatory) tests to assess sensory function. Tests were performed on both lichen planus patients and healthy controls to compare results and evaluate the impact of mucosal involvement on smell and taste function.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 May 2026.
- Individual participant dataSharing planned: No. Individual participant data (IPD) will not be shared due to privacy and confidentiality considerations for study participants.
Related trials for Lichen Planus
RecruitingObservational study
Salivary IL-8 and Serum IL-6 as Biomarkers for Oral Potentially Malignant Disorders in Smokers and Never-Smokers
Oral Potentially Malignant Disorders, Oral Lichen Planus
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Curcumin-mediated Photodynamic Therapy Versus Photobiomodulation in the Treatment of Oral Erosive Lichen Planus
Oral Lichen Planus
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Adherence to Topical and Systemic Medications Among Symptomatic Oral Lichen Planus Patients: A Pilot Randomized Clinical Trial
Degree of Adherence of Symptomatic OLP Patients to Their Medications
RecruitingPhase 2
A Study to Assess the Efficacy and Safety of GIA632 Across a Range of Doses in Participants With Moderate to Severe Cutaneous Lichen Planus
Cutaneous Lichen Planus
RecruitingPhase 2
Upadacitinib in Adult Patients With Erosive Mucosal Lichen Planus and Lichen Planopilaris: a Prospective Multicenter Randomized Placebo-controlled Study.
Lichen Penis Planus
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Yasemin Bolat Eren, MD principal investigator
S.B.U. Istanbul Eğitim ve Araştırma Hastanesi, Dermatology Department
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Lichen Planus, run by Istanbul Training and Research Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Smell and Taste Function (time frame: Day 1). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 May 2026.