Knee Arthroplasty, TotalSWB_PoCNCT07572292
Proof of Concept for Simulating Static Weight-bearing Exercises in the Supine Position
A study testing Static supine weight bearing CT in people with Knee Arthroplasty, Total and Healthy Participants, run by Vrije Universiteit Brussel.
Trial summary
This project evaluates a new weight-bearing CT method to later improve early detection of implant migration after knee arthroplasty. This method aims to allow patients to apply a controlled load during CT scanning, simulating standing conditions with real-time feedback. The study has two phases. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Knee Arthroplasty, Total, Healthy Participants
- What is being tested?
- Static supine weight bearing CT
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 15 participants
- Where
- No sites listed yet
- Study dates
- 1 May 2026to 31 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Healthy participants
- Patients with TKA
Who cannot join
- neurological conditions
- acute trauma
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Validation and Evaluation of a Static Supine Weight-Bearing Computed Tomography Method to Enable Detection of Implant Migration After Knee Arthroplasty
This project evaluates a new weight-bearing CT method to later improve early detection of implant migration after knee arthroplasty.
This method aims to allow patients to apply a controlled load during CT scanning, simulating standing conditions with real-time feedback.
Read more
The study has two phases. First, in healthy volunteers, biomechanical loading during prone simulated weight-bearing will be compared with a standard standing squat to validate the method. Second, in arthroplasty patients, standard radiographs will be compared with loaded and unloaded WBCT scans.
Patients will not deviate from the standard plan of care. The CT images are additions to the standard RX images and are not intended for diagnostic purposes to the patient.
The aim is to determine whether this method opens the door for more accurate and earlier detection of implant migration than current clinical imaging in the future, potentially improving long-term outcomes after knee arthroplasty.
- Conditions
- Knee Arthroplasty, Total, Healthy Participants
- Being tested
- Static supine weight bearing CT
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Static supine weight bearing CTDiagnostic test
Static supine weight bearing CT in addition to standard care RX
| Study group | Role | What they receive |
|---|---|---|
| Knee Arthroplasty | Experimental | Patients with Knee Arthroplasty Receives: Diagnostic Test: Static supine weight bearing CT |
What is being measured
The primary outcome is the main question the study is designed to answer.
Validation of static supine weight bearing against standing weight bearing using kinematic parameters
Comparison of lower-limb and trunk joint kinematics between static supine weight-bearing and standing weight-bearing conditions in healthy subjects using marker-based motion capture.
Unit of Measure: Degrees (°)
Measured: 1 year
Validation of static supine weight bearing against standing weight bearing using kinetic parameters
Comparison of ground reaction forces and joint moments between static supine weight-bearing and standing weight-bearing conditions in healthy subjects using force plate measurements.
Unit of Measure: Newtons (N) and Newton-meters (Nm)
Measured: 1 Year
Validation of static supine weight bearing against standing weight bearing using muscle activation
Comparison of lower-limb muscle activation patterns between static supine weight-bearing and standing weight-bearing conditions in healthy subjects using surface electromyography.
Unit of Measure: Percentage of maximum voluntary contraction (%MVC)
Measured: 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 May 2026
- Study start1 May 2026 (estimated)
- Primary completion31 Oct 2026 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Knee Arthroplasty, TotalStudies of the same condition, open and under way.
- More trials run by Vrije Universiteit BrusselThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 15 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Vrije Universiteit Brussel
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07572292
- Sponsor's protocol ID
- 26015_SWB_PoC
- Acronym
- SWB_PoC
- Status last verified
- Jan 2026
- First submitted
- 23 Jan 2026
- Last updated
- 7 May 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 7 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Validation and Evaluation of a Static Supine Weight-Bearing Computed Tomography Method to Enable Detection of Implant Migration After Knee Arthroplasty
- ClinicalTrials.gov ID
- NCT07572292
- Acronym / sponsor ID
- SWB_PoC / 26015_SWB_PoC
- Conditions
- Knee Arthroplasty, Total, Healthy Participants
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 15 participants (estimated)
- Lead sponsor
- Vrije Universiteit BrusselUniversity, hospital or other
- Study start
- 1 May 2026 (estimated)
- Primary completion
- 31 Oct 2026 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 7 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This project evaluates a new weight-bearing CT method to later improve early detection of implant migration after knee arthroplasty.
This method aims to allow patients to apply a controlled load during CT scanning, simulating standing conditions with real-time feedback.
The study has two phases. First, in healthy volunteers, biomechanical loading during prone simulated weight-bearing will be compared with a standard standing squat to validate the method. Second, in arthroplasty patients, standard radiographs will be compared with loaded and unloaded WBCT scans.
Patients will not deviate from the standard plan of care. The CT images are additions to the standard RX images and are not intended for diagnostic purposes to the patient.
The aim is to determine whether this method opens the door for more accurate and earlier detection of implant migration than current clinical imaging in the future, potentially improving long-term outcomes after knee arthroplasty.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Knee Arthroplasty | Experimental | Diagnostic Test: Static supine weight bearing CTPatients with Knee Arthroplasty |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- Healthy participants
- Patients with TKA
Key exclusion criteria (2 listed)
- neurological conditions
- acute trauma
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Static supine weight bearing CTStatic supine weight bearing CT in addition to standard care RX | Diagnostic test | Knee Arthroplasty |
Primary outcome
Validation of static supine weight bearing against standing weight bearing using kinematic parameters
Time frame: 1 year
Comparison of lower-limb and trunk joint kinematics between static supine weight-bearing and standing weight-bearing conditions in healthy subjects using marker-based motion capture. Unit of Measure: Degrees (°)
Validation of static supine weight bearing against standing weight bearing using kinetic parameters
Time frame: 1 Year
Comparison of ground reaction forces and joint moments between static supine weight-bearing and standing weight-bearing conditions in healthy subjects using force plate measurements. Unit of Measure: Newtons (N) and Newton-meters (Nm)
Validation of static supine weight bearing against standing weight bearing using muscle activation
Time frame: 1 year
Comparison of lower-limb muscle activation patterns between static supine weight-bearing and standing weight-bearing conditions in healthy subjects using surface electromyography. Unit of Measure: Percentage of maximum voluntary contraction (%MVC)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 May 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing Static supine weight bearing CT in people with Knee Arthroplasty, Total and Healthy Participants, run by Vrije Universiteit Brussel.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 7 May 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Nicolas Van Vlasselaer, Master (555-5555, nicolas.van.vlasselaer@vub.be), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Validation of static supine weight bearing against standing weight bearing using kinematic parameters (time frame: 1 year). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 May 2026.