Cerebral PalsyNCT07574996
Effects of Multimodal Neuro Rehabilitation on Cortical Activity and Muscle Syenergy in Spastic Cerebral Palsy
A study testing Active Anodal Transcranial Direct Current Stimulation (tDCS) + Task-Oriented Training, Active Anodal Transcranial Direct Current Stimulation + Virtual Reality and Conventional Physiotherapy in people with Cerebral Palsy, run by Riphah International University.
Trial summary
To determine the effects of tDCS in conjunction with task-oriented training (TOT) and virtual reality (VR) as compared with sham stimulation and conventional physiotherapy on cortical activity and muscle synergy. Read more about this study
- Who is it for?
- Ages 6 to 18 years
- Conditions the study is for
- Cerebral Palsy
- What is being tested?
- Active Anodal Transcranial Direct Current Stimulation (tDCS) + Task-Oriented Training, Active Anodal Transcranial Direct Current Stimulation + Virtual Reality and Conventional Physiotherapy
- Type of treatment
- Medical device
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 150 participants
- Where
- No sites listed yet
- Study dates
- 1 Jun 2026to 14 Jan 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 6 to 18 years
- All sexes
- No healthy volunteers
- Child, Adult
Who may be able to join
- Children aged 6-18 years.
- Neurologist-confirmed spastic cerebral palsy.
- GMFCS Levels I-III (mild to moderate motor impairment).
- Ability to understand and follow simple instructions.
- Medically stable (no planned major surgery; no recent adjustment of medications affecting cortical excitability).
- Parental/guardian written informed consent and child assent.
Who cannot join
- Active uncontrolled epilepsy or history of seizure in the last year.
- Metal implants in the head or implanted medical/electrical devices (e.g., cochlear implants, ventriculoperitoneal shunts, pacemakers).
- Significant visual or auditory impairments that would interfere with task performance.
- Severe behavioral or cognitive difficulties that would prevent safe application of tDCS or training tasks.
- Currently taking medications known to significantly alter cortical excitability (e.g., benzodiazepines, antiepileptics) if dosage is unstable.
- Participation in other experimental neurorehabilitation or brain stimulation interventions within the last 6 months.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
- To determine the effects of tDCS in conjunction with task-oriented training (TOT) and virtual reality (VR) as compared with sham stimulation and conventional physiotherapy on cortical activity and muscle synergy.
- To determine the retention effects of tDCS in conjunction with task-oriented training (TOT) and virtual reality (VR) as compared with sham stimulation and conventional physiotherapy on cortical activity and muscle synergy, one-month follow-up across the five groups.
Read the detailed description
- To determine the effects of tDCS in conjunction with task-oriented training (TOT) and virtual reality (VR) as compared with sham stimulation and conventional physiotherapy on
- gross motor function, gait, balance, mobility, dexterity, and spasticity.
- executive functions
- self-esteem.
- Conditions
- Cerebral Palsy
- Being tested
- Active Anodal Transcranial Direct Current Stimulation (tDCS) + Task-Oriented Training, Sham Active Anodal Transcranial Direct Current Stimulation + Task-Oriented Training, Active Anodal Transcranial Direct Current Stimulation + Virtual Reality, Sham Active Anodal Transcranial Direct Current Stimulation + Virtual Reality, Conventional Physiotherapy
- Keywords
- Spastic Cerebral Palsy, Pediatric Neurorehabilitation, Transcranial direct current stimulation, Task-oriented training, Virtual reality, Conventional Physiotherapy, Cortical Activity, Muscle synergy
- Medical subject headings
- Cerebral Palsy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Active Anodal Transcranial Direct Current Stimulation (tDCS) + Task-Oriented TrainingDevice
Active anodal transcranial direct current stimulation is delivered using a certified tDCS device at a low, safe intensity according to pediatric guidelines. Stimulation is applied to the scalp for approximately 20 minutes per session and is delivered concurrently with task-oriented training. Task-oriented activities individualized to motor deficits, emphasizing:
- Functional reaching
- Grasp-release tasks
- Bilateral coordination
- Balance and postural activities
- Each session includes 10-15 task circuits, progressing from simple to complex tasks based on child performance.
Sham Active Anodal Transcranial Direct Current Stimulation + Task-Oriented TrainingDevice
Sham stimulation will mimic active tDCS for the first 30 seconds (ramp up/down) and then deliver no current for the remainder of the session, ensuring blinding. TOT protocol is identical to Group 1.
Active Anodal Transcranial Direct Current Stimulation + Virtual RealityDevice
Active anodal transcranial direct current stimulation is delivered using a certified tDCS device at a low, safe intensity according to pediatric guidelines. Stimulation is applied to the scalp for approximately 20 minutes per session and is delivered concurrently with Virtual Reality. System: Pediatric upper-limb and balance VR rehabilitation system Activities: Interactive tasks including
- reaching,
- stepping,
- virtual object manipulation,
- coordination games.
- Session duration: 30 to 40 minutes Difficulty automatically progresses based on performance metrics (speed, accuracy, movement amplitude)
Sham Active Anodal Transcranial Direct Current Stimulation + Virtual RealityDevice
Sham stimulation will mimic active tDCS for the first 30 seconds (ramp up/down) and then deliver no current for the remainder of the session, ensuring blinding. VR protocol identical to Group 3
Conventional PhysiotherapyOther
- Stretching of spastic muscle groups
- Strengthening exercises for weak muscle groups
- Balance and gait training
- Functional mobility practice
- Session duration: 45 minutes. Delivered by a trained pediatric physiotherapist following standard clinical guidelines.
| Study group | Role | What they receive |
|---|---|---|
| Group A: Active Anodal Transcranial direct current stimulation + Task-Oriented Training | Experimental | Participants receive active anodal transcranial direct current stimulation (tDCS) applied concurrently with task-oriented training. Receives: Device: Active Anodal Transcranial Direct Current Stimulation (tDCS) + Task-Oriented Training |
| Sham Transcranial direct current stimulation + Task-Oriented Training | Sham comparator | Participants receive sham (inactive) transcranial direct current stimulation combined with task-oriented training. Receives: Device: Sham Active Anodal Transcranial Direct Current Stimulation + Task-Oriented Training |
| Active Anodal Transcranial direct current stimulation + Virtual Reality Therapy | Experimental | Participants receive active anodal transcranial direct current stimulation (tDCS) combined with virtual reality based rehabilitation. Receives: Device: Active Anodal Transcranial Direct Current Stimulation + Virtual Reality |
| Sham Transcranial direct current stimulation + Virtual Reality Therapy | Sham comparator | Participants receive sham (inactive) transcranial direct current stimulation combined with virtual reality based rehabilitation. Receives: Device: Sham Active Anodal Transcranial Direct Current Stimulation + Virtual Reality |
| Conventional Physiotherapy | Active comparator | Participants receive conventional physiotherapy based on standard clinical practice for spastic cerebral palsy. Receives: Other: Conventional Physiotherapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Cortical Activity
Quantitative electroencephalography (EEG) parameters to assess changes in brain activity specifically cortical activity. EEG data will be recorded using a 14-channel system with electrodes placed according to the international 10-20 system, ensuring adequate spatial coverage of relevant cortical regions. Resting-state EEG will be obtained under eyes-open and eyes-closed conditions (5 minutes each) to evaluate baseline neural activity. At the event-related potentials (ERPs) cortical activity will be recorded during cognitive tasks such as oddball or Go/No-Go paradigms. Primary outcomes will include changes in power spectral density across standard frequency bands and alterations in ERP components (P3, N2, P2) in terms of amplitude and latency.
Measured: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
Change in Muscle Synergy Patterns
The outcome measures for this clinical trial will include quantitative electromyography (EMG) parameters and muscle synergy analysis to evaluate neuromuscular function. Surface EMG signals will be recorded from key upper and lower limb muscles, including tibialis anterior, gastrocnemius medialis, soleus, rectus femoris, vastus lateralis, biceps femoris, semitendinosus, gluteus medius, flexor carpi radialis, extensor carpi radialis, biceps brachii, triceps brachii, deltoid, and first dorsal interosseous, at a sampling rate of ≥1000-2000 Hz following SENIAM guidelines for electrode placement. Primary outcomes will include normalized EMG amplitude and temporal activation patterns during functional tasks, processed band-pass filtering (20-450 Hz), rectification, and envelope smoothing. Muscle activity will be normalized using the maximum voluntary contraction (MVC) or peak-amplitude methods. Secondary outcomes will include muscle synergy characteristics derived using a non-negative matrix
Measured: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
Measure Gross Motor Function children.
GMFM-66 focusing on functional movements such as lying, sitting, standing, and walking.
Measured: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
Measures balance in children.
Balance will be evaluated using the Pediatric Balance Scale (PBS; Children's Modified Berg, 14 items scored 0-4).
Measured: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
Assesses walking speed in children
Walking ability will be assessed using the 10-Meter Walk Test (10MWT) to calculate gait speed (m/s)
Measured: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
Assesses mobility and balance in children
Timed Up and Go (TUG): Assesses mobility and balance. (get out of a chair, walk three meters, turn, come back, and sit); time in seconds, average of two trials.
Measured: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
Measures balance and reach ability in children
Functional Reach Test (FRT): Measures balance and reach ability. Two to three attempts are recorded in centimeters for the standard forward reach distance.
Measured: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
Assesses manual dexterity in children
Box \& Block Test (BBT): Assesses manual dexterity. The number of 1-inch cubes moved over the partition in 60 seconds, tested independently for each hand, and one practice trial was used to measure the standard BBT.
Measured: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
Measures spasticity and muscle tone in children
Modified Tardieu Scale (MTS): Measures spasticity and muscle tone. Joint specific passive stretches are carried out at predetermined speeds (V1, V2, V3)
Measured: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
Measures functional performance and disability in children.
Pediatric Evaluation of Disability Inventory (PEDI / PEDI-CAT): Measures functional performance and disability. record functional skills, caregiver support, and changes in self-care, mobility, and social function
Measured: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
Assesses the child's self-esteem
Rosenberg Self-Esteem Scale (Child Version): Assesses the child's self-esteem. 10-item, 4-point Likert scale; total score represents overall self-esteem
Measured: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 May 2026
- Study start1 Jun 2026 (estimated)
- Primary completion18 Nov 2027 (estimated)
- Study completion14 Jan 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cerebral PalsyStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- This is a prospective, randomized, double-blind, parallel-group interventional study with five treatment arms. Eligible participants are randomly assigned in a 1:1:1:1:1 ratio to one of five rehabilitation interventions. These include task-oriented training or virtual reality-based therapy delivered with either active or sham transcranial direct current stimulation (tDCS), as well as a conventional physiotherapy group. Randomization is performed using a computer-generated blocked allocation sequence with variable block sizes to ensure balanced group assignment. Parallel-group allocation is maintained throughout the study, with participants receiving only the intervention assigned at enrollment. Blinding is applied to participants, caregivers, therapists, and outcome assessors for the brain stimulation condition. Outcome assessments are conducted at baseline, immediately after the intervention period, and at one-month follow-up to evaluate both immediate and retention effects.
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 150 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Qamar Mehmood, PhD, Study chair, Riphah international univestyWaqar Ahmed Awan, PhD, Study chair, Riphah International UniversityRiafat Mehmood, PhD*, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07574996
- Sponsor's protocol ID
- PhD/011109
- Status last verified
- May 2026
- First submitted
- 17 Feb 2026
- Last updated
- 8 May 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 8 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Multimodal Neuro Rehabilitation on Cortical Activity and Muscle Syenergy in Spastic Cerebral Palsy
- ClinicalTrials.gov ID
- NCT07574996
- Acronym / sponsor ID
- PhD/011109
- Conditions
- Cerebral Palsy
- Keywords
- Spastic Cerebral Palsy, Pediatric Neurorehabilitation, Transcranial direct current stimulation, Task-oriented training, Virtual reality, Conventional Physiotherapy, Cortical Activity, Muscle synergy
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 150 participants (estimated)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 1 Jun 2026 (estimated)
- Primary completion
- 18 Nov 2027 (estimated)
- Study completion
- 14 Jan 2028 (estimated)
- First posted
- 8 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
- To determine the effects of tDCS in conjunction with task-oriented training (TOT) and virtual reality (VR) as compared with sham stimulation and conventional physiotherapy on cortical activity and muscle synergy.
- To determine the retention effects of tDCS in conjunction with task-oriented training (TOT) and virtual reality (VR) as compared with sham stimulation and conventional physiotherapy on cortical activity and muscle synergy, one-month follow-up across the five groups.
Detailed description
- To determine the effects of tDCS in conjunction with task-oriented training (TOT) and virtual reality (VR) as compared with sham stimulation and conventional physiotherapy on
- gross motor function, gait, balance, mobility, dexterity, and spasticity.
- executive functions
- self-esteem.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 5
- Model description
- This is a prospective, randomized, double-blind, parallel-group interventional study with five treatment arms. Eligible participants are randomly assigned in a 1:1:1:1:1 ratio to one of five rehabilitation interventions. These include task-oriented training or virtual reality-based therapy delivered with either active or sham transcranial direct current stimulation (tDCS), as well as a conventional physiotherapy group. Randomization is performed using a computer-generated blocked allocation sequence with variable block sizes to ensure balanced group assignment. Parallel-group allocation is maintained throughout the study, with participants receiving only the intervention assigned at enrollment. Blinding is applied to participants, caregivers, therapists, and outcome assessors for the brain stimulation condition. Outcome assessments are conducted at baseline, immediately after the intervention period, and at one-month follow-up to evaluate both immediate and retention effects.
| Arm | Type | Receives |
|---|---|---|
| Group A: Active Anodal Transcranial direct current stimulation + Task-Oriented Training | Experimental | Device: Active Anodal Transcranial Direct Current Stimulation (tDCS) + Task-Oriented TrainingParticipants receive active anodal transcranial direct current stimulation (tDCS) applied concurrently with task-oriented training. |
| Sham Transcranial direct current stimulation + Task-Oriented Training | Sham comparator | Device: Sham Active Anodal Transcranial Direct Current Stimulation + Task-Oriented TrainingParticipants receive sham (inactive) transcranial direct current stimulation combined with task-oriented training. |
| Active Anodal Transcranial direct current stimulation + Virtual Reality Therapy | Experimental | Device: Active Anodal Transcranial Direct Current Stimulation + Virtual RealityParticipants receive active anodal transcranial direct current stimulation (tDCS) combined with virtual reality based rehabilitation. |
| Sham Transcranial direct current stimulation + Virtual Reality Therapy | Sham comparator | Device: Sham Active Anodal Transcranial Direct Current Stimulation + Virtual RealityParticipants receive sham (inactive) transcranial direct current stimulation combined with virtual reality based rehabilitation. |
| Conventional Physiotherapy | Active comparator | Other: Conventional PhysiotherapyParticipants receive conventional physiotherapy based on standard clinical practice for spastic cerebral palsy. |
Who may qualify
- Ages
- 6 to 18 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
Key inclusion criteria (6 listed)
- Children aged 6-18 years.
- Neurologist-confirmed spastic cerebral palsy.
- GMFCS Levels I-III (mild to moderate motor impairment).
- Ability to understand and follow simple instructions.
- Medically stable (no planned major surgery; no recent adjustment of medications affecting cortical excitability).
Key exclusion criteria (6 listed)
- Active uncontrolled epilepsy or history of seizure in the last year.
- Metal implants in the head or implanted medical/electrical devices (e.g., cochlear implants, ventriculoperitoneal shunts, pacemakers).
- Significant visual or auditory impairments that would interfere with task performance.
- Severe behavioral or cognitive difficulties that would prevent safe application of tDCS or training tasks.
- Currently taking medications known to significantly alter cortical excitability (e.g., benzodiazepines, antiepileptics) if dosage is unstable.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Active Anodal Transcranial Direct Current Stimulation (tDCS) + Task-Oriented TrainingActive anodal transcranial direct current stimulation is delivered using a certified tDCS device at a low, safe intensity according to pediatric guidelines. Stimulation is applied to the scalp for approximately 20 minutes per session and is delivered concurrently with task-oriented training. Task-oriented activities individualized to motor deficits, emphasizing: * Functional reaching * Grasp-release tasks * Bilateral coordination * Balance and postural activities * Each session includes 10-15 task circuits, progressing from simple to complex tasks based on child performance. | Device | Group A: Active Anodal Transcranial direct current stimulation + Task-Oriented Training |
| Sham Active Anodal Transcranial Direct Current Stimulation + Task-Oriented TrainingSham stimulation will mimic active tDCS for the first 30 seconds (ramp up/down) and then deliver no current for the remainder of the session, ensuring blinding. TOT protocol is identical to Group 1. | Device | Sham Transcranial direct current stimulation + Task-Oriented Training |
| Active Anodal Transcranial Direct Current Stimulation + Virtual RealityActive anodal transcranial direct current stimulation is delivered using a certified tDCS device at a low, safe intensity according to pediatric guidelines. Stimulation is applied to the scalp for approximately 20 minutes per session and is delivered concurrently with Virtual Reality. System: Pediatric upper-limb and balance VR rehabilitation system Activities: Interactive tasks including * reaching, * stepping, * virtual object manipulation, * coordination games. * Session duration: 30 to 40 minutes Difficulty automatically progresses based on performance metrics (speed, accuracy, movement amplitude) | Device | Active Anodal Transcranial direct current stimulation + Virtual Reality Therapy |
| Sham Active Anodal Transcranial Direct Current Stimulation + Virtual RealitySham stimulation will mimic active tDCS for the first 30 seconds (ramp up/down) and then deliver no current for the remainder of the session, ensuring blinding. VR protocol identical to Group 3 | Device | Sham Transcranial direct current stimulation + Virtual Reality Therapy |
| Conventional Physiotherapy* Stretching of spastic muscle groups * Strengthening exercises for weak muscle groups * Balance and gait training * Functional mobility practice * Session duration: 45 minutes. Delivered by a trained pediatric physiotherapist following standard clinical guidelines. | Other | Conventional Physiotherapy |
Primary outcome
Change in Cortical Activity
Time frame: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
Quantitative electroencephalography (EEG) parameters to assess changes in brain activity specifically cortical activity. EEG data will be recorded using a 14-channel system with electrodes placed according to the international 10-20 system, ensuring adequate spatial coverage of relevant cortical regions. Resting-state EEG will be obtained under eyes-open and eyes-closed conditions (5 minutes each) to evaluate baseline neural activity. At the event-related potentials (ERPs) cortical activity will be recorded during cognitive tasks such as oddball or Go/No-Go paradigms. Primary outcomes will include changes in power spectral density across standard frequency bands and alterations in ERP components (P3, N2, P2) in terms of amplitude and latency.
Change in Muscle Synergy Patterns
Time frame: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
The outcome measures for this clinical trial will include quantitative electromyography (EMG) parameters and muscle synergy analysis to evaluate neuromuscular function. Surface EMG signals will be recorded from key upper and lower limb muscles, including tibialis anterior, gastrocnemius medialis, soleus, rectus femoris, vastus lateralis, biceps femoris, semitendinosus, gluteus medius, flexor carpi radialis, extensor carpi radialis, biceps brachii, triceps brachii, deltoid, and first dorsal interosseous, at a sampling rate of ≥1000-2000 Hz following SENIAM guidelines for electrode placement. Primary outcomes will include normalized EMG amplitude and temporal activation patterns during functional tasks, processed band-pass filtering (20-450 Hz), rectification, and envelope smoothing. Muscle activity will be normalized using the maximum voluntary contraction (MVC) or peak-amplitude methods. Secondary outcomes will include muscle synergy characteristics derived using a non-negative matrix
Measure Gross Motor Function children.
Time frame: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
GMFM-66 focusing on functional movements such as lying, sitting, standing, and walking.
Measures balance in children.
Time frame: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
Balance will be evaluated using the Pediatric Balance Scale (PBS; Children's Modified Berg, 14 items scored 0-4).
Assesses walking speed in children
Time frame: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
Walking ability will be assessed using the 10-Meter Walk Test (10MWT) to calculate gait speed (m/s)
Assesses mobility and balance in children
Time frame: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
Timed Up and Go (TUG): Assesses mobility and balance. (get out of a chair, walk three meters, turn, come back, and sit); time in seconds, average of two trials.
Measures balance and reach ability in children
Time frame: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
Functional Reach Test (FRT): Measures balance and reach ability. Two to three attempts are recorded in centimeters for the standard forward reach distance.
Assesses manual dexterity in children
Time frame: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
Box \& Block Test (BBT): Assesses manual dexterity. The number of 1-inch cubes moved over the partition in 60 seconds, tested independently for each hand, and one practice trial was used to measure the standard BBT.
Measures spasticity and muscle tone in children
Time frame: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
Modified Tardieu Scale (MTS): Measures spasticity and muscle tone. Joint specific passive stretches are carried out at predetermined speeds (V1, V2, V3)
Measures functional performance and disability in children.
Time frame: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
Pediatric Evaluation of Disability Inventory (PEDI / PEDI-CAT): Measures functional performance and disability. record functional skills, caregiver support, and changes in self-care, mobility, and social function
Assesses the child's self-esteem
Time frame: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
Rosenberg Self-Esteem Scale (Child Version): Assesses the child's self-esteem. 10-item, 4-point Likert scale; total score represents overall self-esteem
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 May 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Qamar Mehmood, PhD study chair
Riphah international univesty
Waqar Ahmed Awan, PhD study chair
Riphah International University
Riafat Mehmood, PhD* principal investigator
Riphah International University
Questions about this trial
What is this clinical trial studying?
A study testing Active Anodal Transcranial Direct Current Stimulation (tDCS) + Task-Oriented Training, Active Anodal Transcranial Direct Current Stimulation + Virtual Reality and Conventional Physiotherapy in people with Cerebral Palsy, run by Riphah International University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 8 May 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Riafat Mehmood, PhD* (0333551063, riafat.mehmood@riphah.edu.pk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Cortical Activity (time frame: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up). The study lists 11 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 May 2026.