StrokeNCT07578961
Combined Effects of Tactile Kinesthetic Stimulation With Neural Mobilization in Stroke Patients
A study testing Tactile kinesthetic stimulation with neural mobilization and kinesthetic therapy in people with Stroke, run by Riphah International University at 1 site in Pakistan.
Trial summary
Combined Effects of Tactile -kinesthetic stimulation with Neural mobilization on sensory and motor functions of upper limb in stroke patients Read more about this study
- Who is it for?
- Ages 45 to 65 years
- Conditions the study is for
- Stroke
- What is being tested?
- Tactile kinesthetic stimulation with neural mobilization and kinesthetic therapy
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 53 participants
- Where
- 1 sitePakistan
- Study dates
- 5 Apr 2025to 6 Jul 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 45 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age between 45 - 65 years
- Both gender Male and Female
- Diagnosed with chronic stroke stated as occurring 6 month to 12 month .
- Sensory impairment - loss of tactile and proprioception NSA ( < 7/12)
- Motor impairment - lack in full strength and coordination ( Brunnstrom >3)
- Scored 24 or higher on the Mini-Mental State Examination, indicating sufficient cognition to follow study instructions.
Who cannot join
- Severe cognitive or communication difficulties that would prevent meaningful involvement in therapy or testing.
- Comorbid conditions that impair upper-limb function, including arthritis, prior fractures, or similar disorders.
- Neurological conditions other than stroke that could interfere with study outcomes
- Engagement in any other rehabilitation program during the trial period.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Combined Effects of Tactile Kinesthetic Stimulation With Neural Mobilization on Sensory and Motor Functions of the Upper Limb in Stroke Patients
Combined Effects of Tactile -kinesthetic stimulation with Neural mobilization on sensory and motor functions of upper limb in stroke patients
Read the detailed description
Stroke ranks among the primary causes of lasting disability, frequently leaving the upper limb weak, numb, or clumsy and thereby curtailing daily independence and overall well-being. Although multiple therapy regimens appear helpful, research to date Meestal tests each method alone, obscuring how paired sensory and motor targets might accelerate recovery. The present study investigates combined the effect of tactile-kinesthetic input with neural mobilization against standard care, hypothesizing that the blend will produce broader gains in sensation and movement.
This randomized clinical trial will be conducted at Ittefaq Hospital (Trust) Lahore and Gulab Devi Chest Hospital Lahore over duration of 11 months. The sample size will be (53) participants. Participants which meet the inclusion criteria will be taken through non-probability convenience sampling technique, which will further be randomized through lottery method. Group A (27) participants will be assigned to combined tactile kinesthetic stimulation plus neural mobilization and Group B (27)participants will be assigned to conventional therapy. Data will be collected through different assessment tools, including Fugyl-Meyer Assessment for motor function, Nottingham Sensory Assessment Scale (NAS) for sensory function. Pre-interventions assessments will be conducted for both groups. The effects of the interventions will be measured at pre-treatment and post-treatment of 6 weeks. Data analysis will be performed by using SPSS 26 software.
- Conditions
- Stroke
- Being tested
- Tactile kinesthetic stimulation with neural mobilization, kinesthetic therapy
- Keywords
- Chronic stroke rehabilitation, neural mobilization, tactile kinesthetic stimulation, tactile therapy
- Medical subject headings
- Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Tactile kinesthetic stimulation with neural mobilizationOther
The therapist rests a light touch on the limb, applying only the weight of fingertips Soft, gliding strokes travel across the skin, delivered with the very tips of the fingers Pressure remains steadily upon targeted patches of tissue without sliding away Measured, rhythmical strokes creep up and down the length of the arm or leg Smooth silk, rough jute, coarse sponge, and other materials are brushed over the skin in turn.Slowly glide the median nerve by extending wrist and fingers while gently abducting the shoulder.
kinesthetic therapyOther
Median nerve mobilization: Slowly glide the median nerve by extending wrist and fingers while gently abducting the shoulder.
Ulnar nerve mobilization: Control elbow flexion and wrist extension while holding shoulder in slight abduction Radial nerve mobilization: Passively flex the wrist, pronate the forearm, and depress the shoulder to slide the radial nerve
| Study group | Role | What they receive |
|---|---|---|
| Combine effects of Tactile with neural of sensory and motor functions of upper limb stroke | Experimental | Tactile Kinesthetic with Neural Mobilization:
participants receive TKS WITH NM for 20 mins for 3 days per week for 4 weeks Receives: Other: Tactile kinesthetic stimulation with neural mobilization |
| Combine effects of Tactile with neural mobilization of sensory and motor functions of upper limb str | Active comparator | Tks With Nm receive 20 mins therapy for 3 days per week Receives: Other: kinesthetic therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
1.Fugl-Meyer Assessment (FMA)
The Fugl-Meyer Assessment (FMA) was developed specifically for stroke survivors and is a performance-based tool that gauges sensorimotor deficits in people living with hemiplegia. The FMA examines five key areas: voluntary motor control, sensory perception, balance, passive joint range of motion, and joint-related pain. Within this battery, the motor section commands the most attention; it rates movement, coordination, and reflex activity in the arms and legs, yielding a ceiling score of 100 points (66 for the arm and 34 for the leg).
Measured: baseline with 4 week
2.Nottingham Sensory Assessment (NSA)
The Nottingham Sensory Assessment, or NSA, provides clinicians with a standard method for mapping sensory loss after a stroke. Designed to examine both arms and legs, it centers on three core domains: touch, proprioception, and stereognosis. Within the protocol, practitioners test responses to light touch, gentle pressure, pinprick, temperature changes, and passive joint positioning. Because around half of all stroke survivors carry hidden somatosensory deficits that often impede movement, the tool is essential for early identification.
Measured: baseline with 4 week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 May 2026
- Study start5 Apr 2025
- Primary completion3 Jun 2026 (estimated)
- Study completion6 Jul 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for StrokeStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 53 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Sabiha Arshad, Ms, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07578961
- Sponsor's protocol ID
- REC/RCR&AHS/25/0216
- Status last verified
- May 2026
- First submitted
- 5 May 2026
- Last updated
- 11 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Battesha HHM, Wadee AN, Shafeek MM, Tawfick AM, Ibrahim HM. Maze Control Training on Kinesthetic Awareness in Patients with Stroke: A Randomized Controlled Trial. Rehabil Res Pract. 2022 Feb 24;2022:5063492. doi: 10.1155/2022/5063492. eCollection 2022.
PubMed 35251715Takahashi R, Koiwa M, Ide W, Okawada M, Akaboshi K, Kaneko F. Visually Induced Kinaesthetic Illusion Combined with Therapeutic Exercise for Patients with Chronic Stroke: A Pilot Study. J Rehabil Med. 2022 Apr 7;54:jrm00276. doi: 10.2340/jrm.v54.29.
PubMed 35266005Afzal MR, Pyo S, Oh MK, Park YS, Yoon J. Evaluating the effects of delivering integrated kinesthetic and tactile cues to individuals with unilateral hemiparetic stroke during overground walking. J Neuroeng Rehabil. 2018 Apr 16;15(1):33. doi: 10.1186/s12984-018-0372-0.
PubMed 29661237
Study at a glance
From the registry record, last updated by the sponsor on 11 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Combined Effects of Tactile Kinesthetic Stimulation With Neural Mobilization on Sensory and Motor Functions of the Upper Limb in Stroke Patients
- ClinicalTrials.gov ID
- NCT07578961
- Acronym / sponsor ID
- REC/RCR&AHS/25/0216
- Conditions
- Stroke
- Keywords
- Chronic stroke rehabilitation, neural mobilization, tactile kinesthetic stimulation, tactile therapy
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 53 participants (estimated)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 5 Apr 2025 (actual)
- Primary completion
- 3 Jun 2026 (estimated)
- Study completion
- 6 Jul 2026 (estimated)
- First posted
- 11 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Combined Effects of Tactile -kinesthetic stimulation with Neural mobilization on sensory and motor functions of upper limb in stroke patients
Detailed description
Stroke ranks among the primary causes of lasting disability, frequently leaving the upper limb weak, numb, or clumsy and thereby curtailing daily independence and overall well-being. Although multiple therapy regimens appear helpful, research to date Meestal tests each method alone, obscuring how paired sensory and motor targets might accelerate recovery. The present study investigates combined the effect of tactile-kinesthetic input with neural mobilization against standard care, hypothesizing that the blend will produce broader gains in sensation and movement.
This randomized clinical trial will be conducted at Ittefaq Hospital (Trust) Lahore and Gulab Devi Chest Hospital Lahore over duration of 11 months. The sample size will be (53) participants. Participants which meet the inclusion criteria will be taken through non-probability convenience sampling technique, which will further be randomized through lottery method. Group A (27) participants will be assigned to combined tactile kinesthetic stimulation plus neural mobilization and Group B (27)participants will be assigned to conventional therapy. Data will be collected through different assessment tools, including Fugyl-Meyer Assessment for motor function, Nottingham Sensory Assessment Scale (NAS) for sensory function. Pre-interventions assessments will be conducted for both groups. The effects of the interventions will be measured at pre-treatment and post-treatment of 6 weeks. Data analysis will be performed by using SPSS 26 software.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Combine effects of Tactile with neural of sensory and motor functions of upper limb stroke | Experimental | Other: Tactile kinesthetic stimulation with neural mobilizationTactile Kinesthetic with Neural Mobilization: participants receive TKS WITH NM for 20 mins for 3 days per week for 4 weeks |
| Combine effects of Tactile with neural mobilization of sensory and motor functions of upper limb str | Active comparator | Other: kinesthetic therapyTks With Nm receive 20 mins therapy for 3 days per week |
Who may qualify
- Ages
- 45 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Age between 45 - 65 years
- Both gender Male and Female
- Diagnosed with chronic stroke stated as occurring 6 month to 12 month .
- Sensory impairment - loss of tactile and proprioception NSA ( < 7/12)
- Motor impairment - lack in full strength and coordination ( Brunnstrom >3)
Key exclusion criteria (4 listed)
- Severe cognitive or communication difficulties that would prevent meaningful involvement in therapy or testing.
- Comorbid conditions that impair upper-limb function, including arthritis, prior fractures, or similar disorders.
- Neurological conditions other than stroke that could interfere with study outcomes
- Engagement in any other rehabilitation program during the trial period.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Tactile kinesthetic stimulation with neural mobilizationThe therapist rests a light touch on the limb, applying only the weight of fingertips Soft, gliding strokes travel across the skin, delivered with the very tips of the fingers Pressure remains steadily upon targeted patches of tissue without sliding away Measured, rhythmical strokes creep up and down the length of the arm or leg Smooth silk, rough jute, coarse sponge, and other materials are brushed over the skin in turn.Slowly glide the median nerve by extending wrist and fingers while gently abducting the shoulder. | Other | Combine effects of Tactile with neural of sensory and motor functions of upper limb stroke |
| kinesthetic therapyMedian nerve mobilization: Slowly glide the median nerve by extending wrist and fingers while gently abducting the shoulder. Ulnar nerve mobilization: Control elbow flexion and wrist extension while holding shoulder in slight abduction Radial nerve mobilization: Passively flex the wrist, pronate the forearm, and depress the shoulder to slide the radial nerve | Other | Combine effects of Tactile with neural mobilization of sensory and motor functions of upper limb str |
Primary outcome
1.Fugl-Meyer Assessment (FMA)
Time frame: baseline with 4 week
The Fugl-Meyer Assessment (FMA) was developed specifically for stroke survivors and is a performance-based tool that gauges sensorimotor deficits in people living with hemiplegia. The FMA examines five key areas: voluntary motor control, sensory perception, balance, passive joint range of motion, and joint-related pain. Within this battery, the motor section commands the most attention; it rates movement, coordination, and reflex activity in the arms and legs, yielding a ceiling score of 100 points (66 for the arm and 34 for the leg).
2.Nottingham Sensory Assessment (NSA)
Time frame: baseline with 4 week
The Nottingham Sensory Assessment, or NSA, provides clinicians with a standard method for mapping sensory loss after a stroke. Designed to examine both arms and legs, it centers on three core domains: touch, proprioception, and stereognosis. Within the protocol, practitioners test responses to light touch, gentle pressure, pinprick, temperature changes, and passive joint positioning. Because around half of all stroke survivors carry hidden somatosensory deficits that often impede movement, the tool is essential for early identification.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 May 2026.
- Background: PubMed 35251715Battesha HHM, Wadee AN, Shafeek MM, Tawfick AM, Ibrahim HM. Maze Control Training on Kinesthetic Awareness in Patients with Stroke: A Randomized Controlled Trial. Rehabil Res Pract. 2022 Feb 24;2022:5063492. doi: 10.1155/2022/5063492. eCollection 2022.
- Background: PubMed 35266005Takahashi R, Koiwa M, Ide W, Okawada M, Akaboshi K, Kaneko F. Visually Induced Kinaesthetic Illusion Combined with Therapeutic Exercise for Patients with Chronic Stroke: A Pilot Study. J Rehabil Med. 2022 Apr 7;54:jrm00276. doi: 10.2340/jrm.v54.29.
- Background: PubMed 29661237Afzal MR, Pyo S, Oh MK, Park YS, Yoon J. Evaluating the effects of delivering integrated kinesthetic and tactile cues to individuals with unilateral hemiparetic stroke during overground walking. J Neuroeng Rehabil. 2018 Apr 16;15(1):33. doi: 10.1186/s12984-018-0372-0.
- Individual participant dataSharing planned: No
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Web-Based Tele-Rehabilitation Using Action Observation and Mirror Therapy for Subacute Stroke: A Randomized Controlled Trial
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Sabiha Arshad, Ms principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Tactile kinesthetic stimulation with neural mobilization and kinesthetic therapy in people with Stroke, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 11 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
1.Fugl-Meyer Assessment (FMA) (time frame: baseline with 4 week). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07578961, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 May 2026.