Physical PerformanceFOOTBALL-TCPNCT07580248
Effects of Supplementation on Performance in Football Players
A study testing Taurine and Caffeine and Taurine, Caffeine, and Phosphatidylserine in people with Physical Performance and Cognitive Performance, run by Krzysztof Mizera at 1 site in Poland.
Trial summary
This study investigated the effects of short-term supplementation with taurine, caffeine, and phosphatidylserine on physical and cognitive performance in professional male football players. Read more about this study
- Who is it for?
- Ages 19 to 32 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Physical Performance, Cognitive Performance
- What is being tested?
- Taurine and Caffeine and Taurine, Caffeine, and Phosphatidylserine
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 81 participants
- Where
- 1 sitePoland
- Study dates
- 25 Mar 2025to 5 Apr 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 19 to 32 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Male professional football (soccer) players
- Age 19-32 years
- Currently participating in regular team training (4-5 sessions per week)
- Medically cleared for participation in high-intensity physical activity
- Provided written informed consent
Who cannot join
- Current injury or musculoskeletal condition affecting performance
- Chronic disease or medical condition
- Use of medications that may affect physical or cognitive performance
- Regular use of dietary supplements or caffeine prior to the study period
- Smoking or alcohol consumption
- Failure to comply with study procedures
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of Combined Taurine, Caffeine, and Phosphatidylserine Supplementation on Physical and Cognitive Performance in Professional Male Football Players
This study investigated the effects of short-term supplementation with taurine, caffeine, and phosphatidylserine on physical and cognitive performance in professional male football players. Eighty-one players were randomly assigned to one of three groups: placebo, taurine plus caffeine, or taurine plus caffeine combined with phosphatidylserine. Supplementation was administered for 10 days, with a final dose taken 60 minutes before a standardized 105-minute football training session.
Primary and secondary outcomes included sprint performance, reaction time, GPS-derived locomotor variables, and technical and tactical performance indicators. The aim of the study was to evaluate whether combined multi-ingredient supplementation could improve performance and attenuate fatigue-related declines under match-like conditions.
Read the detailed description
This randomized, placebo-controlled, single-blind study evaluated the effects of combined supplementation with taurine, caffeine, and phosphatidylserine on physical and cognitive performance in professional male football players.
Eighty-one participants aged 19-32 years were randomly assigned to one of three groups: placebo (lactose), taurine plus caffeine (1500 mg taurine + 200 mg caffeine), or taurine plus caffeine plus phosphatidylserine (1500 mg taurine + 150 mg caffeine + 300 mg phosphatidylserine daily for 10 days). All participants completed a 10-day supplementation period, followed by a standardized 105-minute football training session.
Outcome measures included sprint performance (30 m sprint time), reaction time (visual and auditory), GPS-derived variables (total distance, sprint activity, speed, accelerations, and decelerations), and technical and tactical performance indicators assessed by coaching staff and video analysis.
The study was conducted under controlled environmental conditions and in accordance with standardized training procedures. Data were analyzed using analysis of variance (ANOVA) with post hoc testing. The aim was to determine whether multi-ingredient supplementation could enhance performance and reduce fatigue-related declines in a football-specific setting.
- Conditions
- Physical Performance, Cognitive Performance
- Being tested
- Placebo, Taurine and Caffeine, Taurine, Caffeine, and Phosphatidylserine
- Keywords
- taurine, caffeine, phosphatidylserine, football, reaction time, sprint performance
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
PlaceboOther
Placebo (lactose) administered daily for 10 days
Taurine and CaffeineDietary supplement
Taurine 1500 mg and caffeine 200 mg administered daily for 10 days
Taurine, Caffeine, and PhosphatidylserineDietary supplement
Taurine 1500 mg, caffeine 150 mg, and phosphatidylserine 300 mg administered daily for 10 days
| Study group | Role | What they receive |
|---|---|---|
| Placebo | Placebo comparator | Participants received a placebo (lactose) daily for 10 days. Receives: Other: Placebo |
| Taurine + Caffeine | Experimental | Participants received taurine (1500 mg) and caffeine (200 mg) daily for 10 days. Receives: Dietary Supplement: Taurine and Caffeine |
| Taurine + Caffeine + PS | Experimental | Participants received taurine (1500 mg), caffeine (150 mg), and phosphatidylserine (300 mg) daily for 10 days. Receives: Dietary Supplement: Taurine, Caffeine, and Phosphatidylserine |
What is being measured
The primary outcome is the main question the study is designed to answer.
30 m sprint time (seconds)
Time to complete a 30 meter sprint under standardized conditions, expressed in seconds; calculated as the mean of valid trials.
Measured: Day 10 (final training session following supplementation)
Secondary outcomes (5)
Reaction time (visual and auditory)
Visual and auditory reaction time measured using standardized computerized reaction time tests (e.g., validated software-based assessment tools), expressed as mean response time in seconds across valid trials.
Measured: Day 10 (post-supplementation)
Total distance (meters)
Total distance covered during the standardized training session, measured using GPS tracking devices (e.g., 10 Hz GPS units), expressed in meters.
Measured: Day 10 (during standardized training session)
Running speed (m/s)
Mean running speed during the standardized training session, measured using GPS tracking devices (e.g., 10 Hz GPS units), expressed in meters per second.
Measured: Day 10 (during standardized training session)
Sprint count (number)
Total number of sprint efforts recorded during the standardized training session using GPS tracking devices.
Measured: Day 10 (during standardized training session)
High-speed running distance (meters)
Distance covered at high-speed running thresholds during the standardized training session, measured using GPS tracking and expressed in meters.
Measured: Day 10 (during standardized training session)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 May 2026
- Study start25 Mar 2025
- Primary completion5 Apr 2025
- Study completion5 Apr 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Physical PerformanceStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants were randomly assigned to one of three parallel groups: placebo, taurine plus caffeine, or taurine plus caffeine combined with phosphatidylserine. Each participant received only one intervention throughout the study.
- Masking
- Double blind
- Who is masked
- Participant, Care provider
- Enrolment
- 81 participants (actual)
Sponsor and investigators
- Lead sponsor
- Krzysztof Mizera
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Krzysztof Mizera, Vizja University in Warsaw
- Investigators
- Krzysztof Maciej MIZERA, PhD, Principal investigator, 1. Vizja University in Warsaw, Faculty of Medical Sciences and Health Sciences, 01-143 Warsaw, Poland
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07580248
- Sponsor's protocol ID
- MIZERA-2025-FOOTBALL-RCT
- Acronym
- FOOTBALL-TCP
- Status last verified
- May 2026
- First submitted
- 28 Apr 2026
- Last updated
- 26 May 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be publicly available due to confidentiality restrictions related to professional athletes. Data may be available from the corresponding author upon reasonable request.
Study at a glance
From the registry record, last updated by the sponsor on 26 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Combined Taurine, Caffeine, and Phosphatidylserine Supplementation on Physical and Cognitive Performance in Professional Male Football Players
- ClinicalTrials.gov ID
- NCT07580248
- Acronym / sponsor ID
- FOOTBALL-TCP / MIZERA-2025-FOOTBALL-RCT
- Conditions
- Physical Performance, Cognitive Performance
- Keywords
- taurine, caffeine, phosphatidylserine, football, reaction time, sprint performance
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 81 participants (actual)
- Lead sponsor
- Krzysztof MizeraUniversity, hospital or other
- Study start
- 25 Mar 2025 (actual)
- Primary completion
- 5 Apr 2025 (actual)
- Study completion
- 5 Apr 2025 (actual)
- First posted
- 12 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study investigated the effects of short-term supplementation with taurine, caffeine, and phosphatidylserine on physical and cognitive performance in professional male football players. Eighty-one players were randomly assigned to one of three groups: placebo, taurine plus caffeine, or taurine plus caffeine combined with phosphatidylserine. Supplementation was administered for 10 days, with a final dose taken 60 minutes before a standardized 105-minute football training session.
Primary and secondary outcomes included sprint performance, reaction time, GPS-derived locomotor variables, and technical and tactical performance indicators. The aim of the study was to evaluate whether combined multi-ingredient supplementation could improve performance and attenuate fatigue-related declines under match-like conditions.
Detailed description
This randomized, placebo-controlled, single-blind study evaluated the effects of combined supplementation with taurine, caffeine, and phosphatidylserine on physical and cognitive performance in professional male football players.
Eighty-one participants aged 19-32 years were randomly assigned to one of three groups: placebo (lactose), taurine plus caffeine (1500 mg taurine + 200 mg caffeine), or taurine plus caffeine plus phosphatidylserine (1500 mg taurine + 150 mg caffeine + 300 mg phosphatidylserine daily for 10 days). All participants completed a 10-day supplementation period, followed by a standardized 105-minute football training session.
Outcome measures included sprint performance (30 m sprint time), reaction time (visual and auditory), GPS-derived variables (total distance, sprint activity, speed, accelerations, and decelerations), and technical and tactical performance indicators assessed by coaching staff and video analysis.
The study was conducted under controlled environmental conditions and in accordance with standardized training procedures. Data were analyzed using analysis of variance (ANOVA) with post hoc testing. The aim was to determine whether multi-ingredient supplementation could enhance performance and reduce fatigue-related declines in a football-specific setting.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, care provider)
- Number of arms
- 3
- Model description
- Participants were randomly assigned to one of three parallel groups: placebo, taurine plus caffeine, or taurine plus caffeine combined with phosphatidylserine. Each participant received only one intervention throughout the study.
| Arm | Type | Receives |
|---|---|---|
| Placebo | Placebo comparator | Other: PlaceboParticipants received a placebo (lactose) daily for 10 days. |
| Taurine + Caffeine | Experimental | Dietary Supplement: Taurine and CaffeineParticipants received taurine (1500 mg) and caffeine (200 mg) daily for 10 days. |
| Taurine + Caffeine + PS | Experimental | Dietary Supplement: Taurine, Caffeine, and PhosphatidylserineParticipants received taurine (1500 mg), caffeine (150 mg), and phosphatidylserine (300 mg) daily for 10 days. |
Who may qualify
- Ages
- 19 to 32 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Male professional football (soccer) players
- Age 19-32 years
- Currently participating in regular team training (4-5 sessions per week)
- Medically cleared for participation in high-intensity physical activity
- Provided written informed consent
Key exclusion criteria (6 listed)
- Current injury or musculoskeletal condition affecting performance
- Chronic disease or medical condition
- Use of medications that may affect physical or cognitive performance
- Regular use of dietary supplements or caffeine prior to the study period
- Smoking or alcohol consumption
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| PlaceboPlacebo (lactose) administered daily for 10 days | Other | Placebo |
| Taurine and CaffeineTaurine 1500 mg and caffeine 200 mg administered daily for 10 days | Dietary supplement | Taurine + Caffeine |
| Taurine, Caffeine, and PhosphatidylserineTaurine 1500 mg, caffeine 150 mg, and phosphatidylserine 300 mg administered daily for 10 days | Dietary supplement | Taurine + Caffeine + PS |
Primary outcome
30 m sprint time (seconds)
Time frame: Day 10 (final training session following supplementation)
Time to complete a 30 meter sprint under standardized conditions, expressed in seconds; calculated as the mean of valid trials.
5 secondary outcomes
Reaction time (visual and auditory)
Time frame: Day 10 (post-supplementation)
Total distance (meters)
Time frame: Day 10 (during standardized training session)
Running speed (m/s)
Time frame: Day 10 (during standardized training session)
Sprint count (number)
Time frame: Day 10 (during standardized training session)
High-speed running distance (meters)
Time frame: Day 10 (during standardized training session)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 May 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be publicly available due to confidentiality restrictions related to professional athletes. Data may be available from the corresponding author upon reasonable request.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Krzysztof Maciej MIZERA, PhD principal investigator
1. Vizja University in Warsaw, Faculty of Medical Sciences and Health Sciences, 01-143 Warsaw, Poland
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Taurine and Caffeine and Taurine, Caffeine, and Phosphatidylserine in people with Physical Performance and Cognitive Performance, run by Krzysztof Mizera at 1 site in Poland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 26 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Poland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
30 m sprint time (seconds) (time frame: Day 10 (final training session following supplementation)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 May 2026.