Menstrual CycleEEMDO-MCNCT07581067
Eccentric Exercise, Muscle Damage, and Oxygen Uptake Across Menstrual Cycle Phases
A study testing Isokinetic eccentric exercise using knee extensors of the right lower limb and Isokinetic eccentric exercise using knee extensors of the left lower limb in people with Menstrual Cycle and Exercise Performance Impairment, run by National and Kapodistrian University of Athens at 1 site in Greece.
Trial summary
The existing literature examining the effect of female sex hormones across the phases of the menstrual cycle on muscle microdamage and oxygen uptake is limited. The protective role of estrogens against muscle microdamage is supported by findings from some studies; however, it is questioned by others. Read more about this study
- Who is it for?
- Ages 18 to 28 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Menstrual Cycle, Exercise Performance Impairment
- What is being tested?
- Isokinetic eccentric exercise using knee extensors of the right lower limb and Isokinetic eccentric exercise using knee extensors of the left lower limb
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 12 participants
- Where
- 1 siteGreece
- Study dates
- 15 May 2025to 22 Jan 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 28 years
- Women only
- Healthy volunteers accepted
- Adult
Who may be able to join
- No known medical history
- Not receiving any medication or dietary supplementation.
- Stable menstrual cycle
Who cannot join
- Pathological conditions the last month before enrolment in the study
- Low limb injury the past 4 months
- Unstable menstrual cycle
Trial locations and contacts
1 site in 1 country.
Greece1 site
Department of Physical Educaiton and Sport Science
Dafni, Attica, 17234
About this study
Official title: The Effect of Eccentric Exercise on Biomarkers of Exercise Induced Muscle Damage and Oxygen Uptake: Differences Between Phases of the Menstrual Cycle
The existing literature examining the effect of female sex hormones across the phases of the menstrual cycle on muscle microdamage and oxygen uptake is limited. The protective role of estrogens against muscle microdamage is supported by findings from some studies; however, it is questioned by others. The aim of the present study was to investigate the effect of eccentric exercise on biomarkers of muscle microdamage and on oxygen uptake during two phases of the menstrual cycle in healthy premenopausal women.
- Conditions
- Menstrual Cycle, Exercise Performance Impairment
- Being tested
- Isokinetic eccentric exercise using knee extensors of the right lower limb, Isokinetic eccentric exercise using knee extensors of the left lower limb
- Keywords
- Eccentric exercise, Exercise induced muscle damage
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Isokinetic eccentric exercise using knee extensors of the right lower limbOther
Isokinetic eccentric exercise consisted of 10 min at 40% of maximal voluntary contractions, followed by 2 min maximal intensity muscle effort
Isokinetic eccentric exercise using knee extensors of the left lower limbOther
Isokinetic eccentric exercise consisted of 10 min at 40% of maximal voluntary contractions, followed by 2 min maximal intensity muscle effort
| Study group | Role | What they receive |
|---|---|---|
| Eccentric exercise | Experimental | A group of female subjects performed an exercise with one leg and an exercise with the other leg, separated by 2 weeks. Before and 2 days after the exercise sessions, performance was assessed. Receives: Other: Isokinetic eccentric exercise using knee extensors of the right lower limb; Other: Isokinetic eccentric exercise using knee extensors of the left lower limb |
What is being measured
The primary outcome is the main question the study is designed to answer.
Maximal isometric torque
maximal performance during 5 sec isometric knee extensors contraction, assessed pre and 48 h post eccentric exercise
Measured: From enrollment to the end of the intervention at 2 weeks
Delayed onset muscle soreness
Palpation of the muscle belly, performed pre and 48h post eccentric exercise
Measured: From enrollment to the end of intervention at 2 weeks
Oxygen consumption
During the isokinetic eccentric exercise, participants were attached to a gas analyser for continuously measuring oxygen consumption.
Measured: From enrollment to the end of the intervention at 2 weeks
Duration of the isokinetic exercise
The total duration of exercise performed on the isokinetic dynamometer was recorded
Measured: From enrollment to the end of intervention at 2 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 May 2026
- Study start15 May 2025
- Primary completion5 Aug 2025
- Study completion22 Jan 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Menstrual CycleStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 12 participants (actual)
Sponsor and investigators
- Lead sponsor
- National and Kapodistrian University of Athens
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Vassilis Paschalis, National and Kapodistrian University of Athens
- Investigators
- Vassilis Paschalis, PhD, Principal investigator, National and Kapodistrian University of Athens
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07581067
- Sponsor's protocol ID
- 1723/19-12-2024
- Acronym
- EEMDO-MC
- Status last verified
- May 2026
- First submitted
- 6 May 2026
- Last updated
- 15 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Eccentric Exercise on Biomarkers of Exercise Induced Muscle Damage and Oxygen Uptake: Differences Between Phases of the Menstrual Cycle
- ClinicalTrials.gov ID
- NCT07581067
- Acronym / sponsor ID
- EEMDO-MC / 1723/19-12-2024
- Conditions
- Menstrual Cycle, Exercise Performance Impairment
- Keywords
- Eccentric exercise, Exercise induced muscle damage
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 12 participants (actual)
- Lead sponsor
- National and Kapodistrian University of AthensUniversity, hospital or other
- Study start
- 15 May 2025 (actual)
- Primary completion
- 5 Aug 2025 (actual)
- Study completion
- 22 Jan 2026 (actual)
- First posted
- 12 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The existing literature examining the effect of female sex hormones across the phases of the menstrual cycle on muscle microdamage and oxygen uptake is limited. The protective role of estrogens against muscle microdamage is supported by findings from some studies; however, it is questioned by others. The aim of the present study was to investigate the effect of eccentric exercise on biomarkers of muscle microdamage and on oxygen uptake during two phases of the menstrual cycle in healthy premenopausal women.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Eccentric exercise | Experimental | Other: Isokinetic eccentric exercise using knee extensors of the right lower limb, Other: Isokinetic eccentric exercise using knee extensors of the left lower limbA group of female subjects performed an exercise with one leg and an exercise with the other leg, separated by 2 weeks. Before and 2 days after the exercise sessions, performance was assessed. |
Who may qualify
- Ages
- 18 to 28 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- No known medical history
- Not receiving any medication or dietary supplementation.
- Stable menstrual cycle
Key exclusion criteria (3 listed)
- Pathological conditions the last month before enrolment in the study
- Low limb injury the past 4 months
- Unstable menstrual cycle
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Isokinetic eccentric exercise using knee extensors of the right lower limbIsokinetic eccentric exercise consisted of 10 min at 40% of maximal voluntary contractions, followed by 2 min maximal intensity muscle effort | Other | Eccentric exercise |
| Isokinetic eccentric exercise using knee extensors of the left lower limbIsokinetic eccentric exercise consisted of 10 min at 40% of maximal voluntary contractions, followed by 2 min maximal intensity muscle effort | Other | Eccentric exercise |
Primary outcome
Maximal isometric torque
Time frame: From enrollment to the end of the intervention at 2 weeks
maximal performance during 5 sec isometric knee extensors contraction, assessed pre and 48 h post eccentric exercise
Delayed onset muscle soreness
Time frame: From enrollment to the end of intervention at 2 weeks
Palpation of the muscle belly, performed pre and 48h post eccentric exercise
Oxygen consumption
Time frame: From enrollment to the end of the intervention at 2 weeks
During the isokinetic eccentric exercise, participants were attached to a gas analyser for continuously measuring oxygen consumption.
Duration of the isokinetic exercise
Time frame: From enrollment to the end of intervention at 2 weeks
The total duration of exercise performed on the isokinetic dynamometer was recorded
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 May 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Vassilis Paschalis, PhD principal investigator
National and Kapodistrian University of Athens
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Isokinetic eccentric exercise using knee extensors of the right lower limb and Isokinetic eccentric exercise using knee extensors of the left lower limb in people with Menstrual Cycle and Exercise Performance Impairment, run by National and Kapodistrian University of Athens at 1 site in Greece.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 15 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Greece. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Maximal isometric torque (time frame: From enrollment to the end of the intervention at 2 weeks). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 May 2026.