Duchene Muscular DystrophyNCT07581743
How Can Different Forms of Strengthening Exercises Affect the Muscular Tissue and Its Chemical Markers in Children With Duchenne Muscular Dystrophy
A study testing strengthening exercises, Low-Intensity Exercise Protocol and traditional physical therapy program in people with Duchene Muscular Dystrophy, run by Cairo University at 1 site in Egypt.
Trial summary
The treatment of patients diagnosed with DMD needs to be multidisciplinary, judicious, and always focused on the patient's well-being. Physiotherapy and occupational therapy are very often standard care. Read more about this study
- Who is it for?
- Ages 6 to 10 years
- Conditions the study is for
- Duchene Muscular Dystrophy
- What is being tested?
- strengthening exercises, Low-Intensity Exercise Protocol and traditional physical therapy program
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 45 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jun 2026to 1 Sep 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 6 to 10 years
- All sexes
- No healthy volunteers
- Child
Who may be able to join
- DD,
- aging from 6 To 10
Who cannot join
- able to understand order
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Different Forms of Strengthening Exercises and Chemical Markers in Children With Duchenne Muscular Dystrophy
The treatment of patients diagnosed with DMD needs to be multidisciplinary, judicious, and always focused on the patient's well-being. Physiotherapy and occupational therapy are very often standard care. Physiotherapy is regarded as crucial for the success of treatment, since it has achieved good results in the short term, such as maintaining the autonomy of these individuals . Physical activity is another method that has been used to treat DMD. Studies have used physical exercise in individuals with DMD in order to decrease muscle deterioration, muscle contractures, and bone fractures, and to increase the time of functional independence
- Conditions
- Duchene Muscular Dystrophy
- Being tested
- strengthening exercises, Low-Intensity Exercise Protocol, traditional physical therapy program
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
strengthening exercisesOther
Concentric strengthening exercises: involves the muscle producing tension and shortening to move a load Isometric strengthening exercises: occurs when a muscle produces tension without a change in muscle length. Isometric contractions involve sarcomere shortening and increasing muscle tension, but do not move a load Eccentric strengthening exercises: occurs when the muscle tension produced is less than the load and a muscle lengthens while under tension
Low-Intensity Exercise ProtocolOther
The children were trained 3 times per week for 8 weeks on a treadmill without inclination, with speed and time programmed and adapted for this purpose. The length of each training activity was 30 min (Andersen et al. 2013; Markert et al. 2012). The children were acclimated to the treadmill for 7 days before the beginning of the training program, with a speed of 4 m/min, in order to minimize the stress caused by the different environment.
traditional physical therapy programOther
traditional physical therapy program to improve strength
| Study group | Role | What they receive |
|---|---|---|
| Strengthening exercises | Experimental | Not described Receives: Other: strengthening exercises |
| Low-Intensity Exercise | Experimental | Not described Receives: Other: Low-Intensity Exercise Protocol |
| Control group | Active comparator | Not described Receives: Other: traditional physical therapy program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Creatine-kinase (CK)
Measured: 8 weeks
Six-minute walk test
Measured: 8 weeks
Muscle strength
Measured: 8 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 May 2026
- Study start1 Jun 2026 (estimated)
- Primary completion15 Aug 2026 (estimated)
- Study completion1 Sep 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Duchene Muscular DystrophyStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 45 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Reham Saeed Alsakhawi, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07581743
- Sponsor's protocol ID
- PUA0320234303090
- Status last verified
- May 2026
- First submitted
- 6 May 2026
- Last updated
- 12 May 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 12 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Different Forms of Strengthening Exercises and Chemical Markers in Children With Duchenne Muscular Dystrophy
- ClinicalTrials.gov ID
- NCT07581743
- Acronym / sponsor ID
- PUA0320234303090
- Conditions
- Duchene Muscular Dystrophy
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 45 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 1 Jun 2026 (estimated)
- Primary completion
- 15 Aug 2026 (estimated)
- Study completion
- 1 Sep 2026 (estimated)
- First posted
- 12 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The treatment of patients diagnosed with DMD needs to be multidisciplinary, judicious, and always focused on the patient's well-being. Physiotherapy and occupational therapy are very often standard care. Physiotherapy is regarded as crucial for the success of treatment, since it has achieved good results in the short term, such as maintaining the autonomy of these individuals . Physical activity is another method that has been used to treat DMD. Studies have used physical exercise in individuals with DMD in order to decrease muscle deterioration, muscle contractures, and bone fractures, and to increase the time of functional independence
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Strengthening exercises | Experimental | Other: strengthening exercises |
| Low-Intensity Exercise | Experimental | Other: Low-Intensity Exercise Protocol |
| Control group | Active comparator | Other: traditional physical therapy program |
Who may qualify
- Ages
- 6 to 10 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child
Key inclusion criteria (2 listed)
- DD,
- aging from 6 To 10
Key exclusion criteria (1 listed)
- able to understand order
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| strengthening exercisesConcentric strengthening exercises: involves the muscle producing tension and shortening to move a load Isometric strengthening exercises: occurs when a muscle produces tension without a change in muscle length. Isometric contractions involve sarcomere shortening and increasing muscle tension, but do not move a load Eccentric strengthening exercises: occurs when the muscle tension produced is less than the load and a muscle lengthens while under tension | Other | Strengthening exercises |
| Low-Intensity Exercise ProtocolThe children were trained 3 times per week for 8 weeks on a treadmill without inclination, with speed and time programmed and adapted for this purpose. The length of each training activity was 30 min (Andersen et al. 2013; Markert et al. 2012). The children were acclimated to the treadmill for 7 days before the beginning of the training program, with a speed of 4 m/min, in order to minimize the stress caused by the different environment. | Other | Low-Intensity Exercise |
| traditional physical therapy programtraditional physical therapy program to improve strength | Other | Control group |
Primary outcome
Creatine-kinase (CK)
Time frame: 8 weeks
Six-minute walk test
Time frame: 8 weeks
Muscle strength
Time frame: 8 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 May 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing strengthening exercises, Low-Intensity Exercise Protocol and traditional physical therapy program in people with Duchene Muscular Dystrophy, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 12 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Reham Alsakhawi (00966504182628, rsm211_pt@cu.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Creatine-kinase (CK) (time frame: 8 weeks). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 May 2026.