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Adhesive CapsulitisNCT07588087

Effect of Adding Latissimus Dorsi Myofascial Release to Scapular Proprioceptive Neuromuscular Facilitation on Pain, Disability, and Range of Motion in Adhesive Capsulitis

A study testing Myofascial release+ Scapular Proprioceptive Neuromuscular Facilitation (PNF) hold-relax technique and Scapular PNF hold-relax only in people with Adhesive Capsulitis, run by Ibadat International University, Islamabad at 1 site in Pakistan.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

This randomized controlled trial aims to compare the effects of scapular proprioceptive neuromuscular facilitation (PNF) alone versus PNF combined with latissimus dorsi myofascial release on pain, range of motion, and functional disability in patients with stage II adhesive capsulitis; a condition characterized by… Read more about this study

Who is it for?
Ages 35 to 70 years
Conditions the study is for
Adhesive Capsulitis
What is being tested?
Myofascial release+ Scapular Proprioceptive Neuromuscular Facilitation (PNF) hold-relax technique and Scapular PNF hold-relax only
Could I receive a placebo?
No, everyone receives an active treatment
How many people
58 participants
Where
1 sitePakistan
Study dates
5 Apr 2026to 8 Jun 2026
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 35 to 70 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • 1. Age between 35 and 70 years.
  • Both male and female participants.
  • Stiffening (Stage II) phase of frozen shoulder.
  • Pain intensity ≥ 4/10 on NPRS during shoulder movement.
  • Unilateral shoulder involvement.
  • Presence of capsular pattern:ER > ABD > IR limitation
Show all 9Show fewer
  • Apley's Scratch Test
  • Limited both ROMs
  • Symptom duration between 3 and 9 months.(Di Mascio et al., 2024)

Who cannot join

  • Secondary adhesive capsulitis due to trauma or surgery
  • History of shoulder fracture or dislocation.
  • Bilateral frozen shoulder.
  • Active systemic inflammatory or neurological disease
  • Recent intra-articular corticosteroid injection (within last 3 months)
  • Current anticoagulation therapy or bleeding disorders.
  • Pregnant females.

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Hufsa Naseer, DPT, MS-PT MSK contact

+3095166821

hufsanaseer@gmail.com

Fatima Amjad, DPT, MS-PT Sports, PHD Scholar contact

+3330940975

Fatima.amjad@uipt.iiui.edu.pk

Pakistan1 site, 1 recruiting
  • • Ibadat international hospital • Shaafi international hospital • South East hospital • Fauji Foundation hospital

    Islamabad, Punjab Province, 44000

    Hufsa Naseer, DPT, MS-PT MSK, 03095166821, hufsanaseer@gmail.com

    Fatima Amjad, DPT, MS-PT MSK Sports, PHD, +923330940975, Fatima.amjad@uipt.iiui.edu.pk

    Recruiting

Other trials in Pakistan

About this study

Official title: Effect of Adding Latissimus Dorsi Myofascial Release to Scapular Proprioceptive Neuromuscular Facilitation on Pain, Disability, and Range of Motion in Adhesive Capsulitis: A Randomized Controlled Trial

This randomized controlled trial aims to compare the effects of scapular proprioceptive neuromuscular facilitation (PNF) alone versus PNF combined with latissimus dorsi myofascial release on pain, range of motion, and functional disability in patients with stage II adhesive capsulitis; a condition characterized by capsular stiffness, pain, and restricted shoulder mobility, with outcomes assessed using NPRS, goniometry, and SPADI over a 6-week intervention period.

Read the detailed description

Participants diagnosed with stage II adhesive capsulitis will be randomly allocated into two groups. The experimental group will receive latissimus dorsi myofascial release combined with scapular proprioceptive neuromuscular facilitation (PNF) hold-relax technique, while the control group will receive scapular PNF hold-relax technique only. Both interventions will be administered for 6 weeks, with 3 sessions per week. Outcome measures will include Numeric Pain Rating Scale (NPRS) for pain intensity, goniometry for shoulder range of motion, latissimus dorsi length test for muscle tightness, and Shoulder Pain and Disability Index (SPADI) for functional disability. Data will be analyzed using IBM SPSS version 26.

Being tested
Myofascial release+ Scapular Proprioceptive Neuromuscular Facilitation (PNF) hold-relax technique, Scapular PNF hold-relax only
Medical subject headings
Bursitis

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Myofascial release+ Scapular Proprioceptive Neuromuscular Facilitation (PNF) hold-relax techniqueOther

    Participants in the experimental group will receive a combination of latissimus dorsi myofascial release (MFR) and scapular proprioceptive neuromuscular facilitation (PNF) using the hold-relax technique. Myofascial release will be applied to the latissimus dorsi muscle with the patient positioned in side-lying (affected side up) or supine with the shoulder in flexion. The therapist will apply slow, sustained pressure along the posterior axillary fold and lateral border of the scapula, following the muscle fibers toward the thoracolumbar fascia. The technique will include sustained pressure, longitudinal gliding, and passive shoulder elevation until a tissue resistance barrier is reached. Each stretch will be maintained for 90-120 seconds, with a total MFR duration of approximately 10-15 minutes per session.

    Following MFR, scapular PNF will be performed using the posterior elevation to anterior depression pattern. The hold-relax technique will involve isometric contractions of 5-7 seco

  • Scapular PNF hold-relax onlyOther

    Participants in the control group will receive scapular proprioceptive neuromuscular facilitation (PNF) using the hold-relax technique without the addition of myofascial release. The intervention will follow the scapular posterior elevation to anterior depression pattern. Each repetition will include an isometric contraction lasting 5-7 seconds followed by a passive stretch of 10-15 seconds. A total of 3 sets with 5 repetitions per set will be performed in each session, with an overall duration of approximately 20 minutes.

    In addition, a hot pack will be applied to the affected area for 10-15 minutes prior to the exercise session to promote muscle relaxation. Treatment sessions will be conducted three times per week for a duration of 6 weeks.

Study groups in NCT07588087
Study groupRoleWhat they receive
Latissimus dorsi myofascial release and Scapular PNF hold-relax technique. ( Experimental)ExperimentalReceived latissimus dorsi myofascial release (10-15 minutes, sustained pressure with 90-120 sec holds) combined with scapular PNF hold-relax (posterior elevation-anterior depression pattern; 3 sets × 5 reps, 5-7 sec contraction, 10-15 sec stretch).
Receives: Other: Myofascial release+ Scapular Proprioceptive Neuromuscular Facilitation (PNF) hold-relax technique
Scapular PNF hold-relax only (control)Active comparatorReceived scapular PNF hold-relax only (same pattern and dosage: 3 sets × 5 reps, 5-7 sec contraction, 10-15 sec stretch),
Receives: Other: Scapular PNF hold-relax only

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Pain Intensity

    Numeric Pain rating scale(NPRS) will be used. It is the numeric version of visual analogue scale used to assess the intensity of pain. The 11-point numeric scale ranges from '0' representing one pain extreme (e.g. "no pain") to '10' representing the other pain extreme. it has moderate to excellent reliability and good validity

    Measured: baseline to 6 weeks

  2. Shoulder Range of Motion (ROM)

    Measured using a universal goniometer. Shoulder flexion, abduction, external rotation, and internal rotation will be assessed at baseline and at 6 weeks.

    Measured: baseline to 6 weeks

  3. Latissimus Dorsi Length Test

    It is used to check the tightness of latissimus dorsi muscle. The patient is in supine lying with knees bend and back flattened to the floor, arm elevated overhead. if there is tightness of this muscle person's unable to flexed his arm by 180° and compensated by arching its back also with the help of goniometer measurement starts with axis at the humeral head , stationary arm midline to the body and moveable arm parallel to the longitudinal axis of the humerus a normal full length muscle allows the arms to touch the table while shortened muscle not allow them to touch the table.

    Measured: baseline to 6 weeks

  4. Shoulder Pain and Disability Index (SPADI)

    The Shoulder Pain and Disability Index (SPADI) is a self-administered questionnaire used to assess pain and functional disability associated with shoulder conditions. It consists of 13 items divided into two subscales: pain (5 items) and disability (8 items). Each item is scored on a scale from 0 to 10, where 0 indicates no pain or difficulty and 10 indicates the worst pain or maximum difficulty. The total score is calculated by averaging the scores of both subscales and converting them into a percentage ranging from 0 to 100, with higher scores indicating greater pain and disability.

    Measured: baseline to 6 weeks

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted14 May 2026
  2. Study start5 Apr 2026
  3. Primary completion6 Jun 2026 (estimated)
  4. Study completion8 Jun 2026 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Model description
Two-arm parallel group randomized controlled trial
Masking
Single blind
Who is masked
Outcomes assessor
Enrolment
58 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07588087
Sponsor's protocol ID
IIUI/RERC/ADT/2026/04/287
Status last verified
May 2026
First submitted
2 May 2026
Last updated
14 May 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • Teoli D, Sanvictores T, An J. SWOT Analysis. 2023 Sep 4. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK537302/

    PubMed 30725987
  • Su S, Guo Y, Parnitzke B, Poerio T, Derosa J. A Voltage-Controlled Strategy for Modular Shono-Type Amination. J Am Chem Soc. 2024 Oct 23;146(42):28663-28668. doi: 10.1021/jacs.4c12520. Epub 2024 Oct 14.

    PubMed 39401528
  • Elnaggar RK, Elbanna MF, Mahmoud WS, Alqahtani BA. Plyometric exercises: subsequent changes of weight-bearing symmetry, muscle strength and walking performance in children with unilateral cerebral palsy. J Musculoskelet Neuronal Interact. 2019 Dec 1;19(4):507-515.

    PubMed 31789302
  • Roach KE, Budiman-Mak E, Songsiridej N, Lertratanakul Y. Development of a shoulder pain and disability index. Arthritis Care Res. 1991 Dec;4(4):143-9.

    PubMed 11188601
  • Page MJ, Green S, Kramer S, Johnston RV, McBain B, Chau M, Buchbinder R. Manual therapy and exercise for adhesive capsulitis (frozen shoulder). Cochrane Database Syst Rev. 2014 Aug 26;2014(8):CD011275. doi: 10.1002/14651858.CD011275.

    PubMed 25157702
  • Fehd HM, Seiffert AE. Looking at the center of the targets helps multiple object tracking. J Vis. 2010 Apr 28;10(4):19.1-13. doi: 10.1167/10.4.19.

    PubMed 20465338
  • Harnett G, Collins M. Nursing in rural, remote and isolated settings: a literature review. Rural Remote Health. 2023 Jan;23(1):8159. doi: 10.22605/RRH8159. Epub 2023 Jan 10.

    PubMed 36802815
  • Khaled N, Kalbarczyk A, Zavala E, Rahman A, de Boer M, Chakraborty B, Rahman H, Ali H, Haque R, Ayesha K, Siddiqua TJ, Afsana K, Christian P, Thorne-Lyman AL. A formative study of the sociocultural influences on dietary behaviours during pregnancy in rural Bangladesh. Matern Child Nutr. 2024 Oct;20 Suppl 6(Suppl 6):e13713. doi: 10.1111/mcn.13713. Epub 2024 Aug 30.

    PubMed 39212336
  • Zhang W, Xia K, Feng Z, Qin Y, Zhou Y, Feng G, Zhu H, Yao Q. Tomato plant growth promotion and drought tolerance conferred by three arbuscular mycorrhizal fungi is mediated by lipid metabolism. Plant Physiol Biochem. 2024 Mar;208:108478. doi: 10.1016/j.plaphy.2024.108478. Epub 2024 Feb 28.

    PubMed 38430785
  • Thayaparan T, Petrovic RM, Achkova DY, Zabinski T, Davies DM, Klampatsa A, Parente-Pereira AC, Whilding LM, van der Stegen SJ, Woodman N, Sheaff M, Cochran JR, Spicer JF, Maher J. CAR T-cell immunotherapy of MET-expressing malignant mesothelioma. Oncoimmunology. 2017 Aug 14;6(12):e1363137. doi: 10.1080/2162402X.2017.1363137. eCollection 2017.

    PubMed 29209570
  • Ahearn N, McCann PA, Tasker A, Sarangi PP. The influence of rotator cuff pathology on functional outcome in total shoulder replacement. Int J Shoulder Surg. 2013 Oct;7(4):127-31. doi: 10.4103/0973-6042.123509.

    PubMed 24403759

Questions about this trial

What is this clinical trial studying?

A study testing Myofascial release+ Scapular Proprioceptive Neuromuscular Facilitation (PNF) hold-relax technique and Scapular PNF hold-relax only in people with Adhesive Capsulitis, run by Ibadat International University, Islamabad at 1 site in Pakistan.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 9 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 14 May 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Hufsa Naseer, DPT, MS-PT MSK (+3095166821, hufsanaseer@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Pain Intensity (time frame: baseline to 6 weeks). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07588087, which also lists 11 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 May 2026.

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