Dental AnesthesiaMRI and LANCT07602686
MRI and Local Anesthesia
A study testing ddMRI in people with Dental Anesthesia, run by University of Minnesota at 1 site in United States.
Trial summary
The purpose of this research is to investigate the utility of using dental-dedicated MRI as a measurement tool to observe and evaluate the administration of local anesthesia in dental patients. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Dental Anesthesia
- What is being tested?
- ddMRI
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 102 participants
- Where
- 1 siteUnited States
- Study dates
- 15 Dec 2026to 1 Jul 2029
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adult age 18 or older
- Health status of American Society of Anesthesiologists (ASA) class 1 or 2
- Able to provide informed consent
- Able to appear in person at OMRIC on the days indicated for the study
Who cannot join
- ASA class 3 or higher
- Pregnant patients
- Taking any medication that would affect pain perception or interact with local anesthetic
- Allergic/history of adverse reaction to local anesthetic or any component in the local anesthetic
- Paresthesia in the area of innervation of Cranial Nerve V3
- Active infection or abscess in the oral and maxillofacial region
Show all 12Show fewer
- History of temporomandibular disorder, maximum incisal opening less than 15mm
- History of recent dental trauma (within the past 6 months)
- Dental hypersensitivity
- Claustrophobia and/or conditions of anxiety or motion disorder (for MRI purposes)
- Metallic, electronic, or magnetic implants or devices classified as MR Unsafe or Conditional by the American College of Radiology
- Unable to give informed consent
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site
University of Minnesota
Minneapolis, Minnesota, 55455
Rachel Uppgaard, DDS, FACS, 612-209-9176, uppg0003@umn.edu
About this study
Official title: MRI Evaluation of Local Anesthesia Administration
The purpose of this research is to investigate the utility of using dental-dedicated MRI as a measurement tool to observe and evaluate the administration of local anesthesia in dental patients.
- Conditions
- Dental Anesthesia
- Being tested
- ddMRI
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ddMRIDevice
Dental MRI imaging
| Study group | Role | What they receive |
|---|---|---|
| ddMRI scanning | Experimental | The ddMRI will take place after anesthesia administration. The ddMRI will allow researchers to see and measure the distribution of the local anesthetic, as well as the the area of the local anesthetic and the intensity on MRI. Receives: Device: ddMRI |
What is being measured
The primary outcome is the main question the study is designed to answer.
Patient reported sensation - 5min
Minimum value: No numbness Maximum value: Numb High scores mean a successful outcome for the block.
Measured: 5 minutes after the nerve block
Patient reported sensation - 1 hour
Minimum value: No numbness Maximum value: Numb High scores mean a successful outcome for the block.
Measured: within 1 hour of the nerve block
Ability to sense light touch
binary scale. Options are yes or no
Measured: within 1 hour of the nerve block
Ability to sense pressure
Minimum value: 1.65 Maximum value: 6.65 Low scores mean that the participant can sense more, and that the block was less effective
Measured: within 1 hour of the nerve block
Ability to sense direction of touch (only if can sense VonFrey fibers)
Patient reports direction of sensation (up/down/right/left). This is scored 5 times per site
Measured: within 1 hour of the nerve block
Ability to distinguish sharp versus dull (only if can sense VonFrey fibers)
Patient reports sharp versus dull sensation. This is scored 5 times per site
Measured: within 1 hour of the nerve block
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 May 2026
- Study start15 Dec 2026 (estimated)
- Primary completion1 Jul 2029 (estimated)
- Study completion1 Jul 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Dental AnesthesiaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 102 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Minnesota
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Rachel Uppgaard, DDS, FACS, Principal investigator, University of Minnesota
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07602686
- Sponsor's protocol ID
- STUDY00025764
- Acronym
- MRI and LA
- Status last verified
- Sep 2026
- First submitted
- 30 Apr 2026
- Last updated
- 10 Sep 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 10 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- MRI Evaluation of Local Anesthesia Administration
- ClinicalTrials.gov ID
- NCT07602686
- Acronym / sponsor ID
- MRI and LA / STUDY00025764
- Conditions
- Dental Anesthesia
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 102 participants (estimated)
- Lead sponsor
- University of MinnesotaUniversity, hospital or other
- Study start
- 15 Dec 2026 (estimated)
- Primary completion
- 1 Jul 2029 (estimated)
- Study completion
- 1 Jul 2029 (estimated)
- First posted
- 22 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this research is to investigate the utility of using dental-dedicated MRI as a measurement tool to observe and evaluate the administration of local anesthesia in dental patients.
Study design
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| ddMRI scanning | Experimental | Device: ddMRIThe ddMRI will take place after anesthesia administration. The ddMRI will allow researchers to see and measure the distribution of the local anesthetic, as well as the the area of the local anesthetic and the intensity on MRI. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Adult age 18 or older
- Health status of American Society of Anesthesiologists (ASA) class 1 or 2
- Able to provide informed consent
- Able to appear in person at OMRIC on the days indicated for the study
Key exclusion criteria (12 listed)
- ASA class 3 or higher
- Pregnant patients
- Taking any medication that would affect pain perception or interact with local anesthetic
- Allergic/history of adverse reaction to local anesthetic or any component in the local anesthetic
- Paresthesia in the area of innervation of Cranial Nerve V3
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ddMRIDental MRI imaging | Device | ddMRI scanning |
Primary outcome
Patient reported sensation - 5min
Time frame: 5 minutes after the nerve block
Minimum value: No numbness Maximum value: Numb High scores mean a successful outcome for the block.
Patient reported sensation - 1 hour
Time frame: within 1 hour of the nerve block
Minimum value: No numbness Maximum value: Numb High scores mean a successful outcome for the block.
Ability to sense light touch
Time frame: within 1 hour of the nerve block
binary scale. Options are yes or no
Ability to sense pressure
Time frame: within 1 hour of the nerve block
Minimum value: 1.65 Maximum value: 6.65 Low scores mean that the participant can sense more, and that the block was less effective
Ability to sense direction of touch (only if can sense VonFrey fibers)
Time frame: within 1 hour of the nerve block
Patient reports direction of sensation (up/down/right/left). This is scored 5 times per site
Ability to distinguish sharp versus dull (only if can sense VonFrey fibers)
Time frame: within 1 hour of the nerve block
Patient reports sharp versus dull sensation. This is scored 5 times per site
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Sep 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Rachel Uppgaard, DDS, FACS principal investigator
University of Minnesota
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing ddMRI in people with Dental Anesthesia, run by University of Minnesota at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 10 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Rachel Uppgaard, DDS, FACS (612-209-9176, uppg0003@umn.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Patient reported sensation - 5min (time frame: 5 minutes after the nerve block). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Sep 2026.