Diode Laser TherapyPhase 3PeriodontologyNCT07602738
Evaluation of Liquorice Nanogel Versus Diode Laser as an Adjunctive Treatment for Patients With Periodontitis Stage Ⅲ.
A Phase 3 study testing Liquorice Nanogel and diode laser in people with Diode Laser Therapy and Periodontal Disease, run by Al-Azhar University at 1 site in Egypt.
Trial summary
Evaluation of the effect of liquorice nanogel versus diode laser on periodontitis stage Ⅲ clinically and microbiologically by molecular analysis of porphyromonas gingivalis using real time PCR. Read more about this study
- Who is it for?
- Ages 18 to 50 years
- Conditions the study is for
- Diode Laser Therapy, Periodontal Disease, Liquorice Nanogel
- What is being tested?
- Liquorice Nanogel and diode laser
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 27 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jul 2025to 1 Apr 2026
- Phase
- Phase 3
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Patient had Periodontitis stage III with pocket depth ≥ 6mm; indicated for periodontal surgery or CAL ≥ 5mm.
- Patient agreed to the surgical procedure and clinical trial.
- Age ranged between 18-50 years old.
Who cannot join
- 1: No previous drug was taken affecting bone metabolism. 2- Smoking. 3- Pregnant women and women with menopause. 4- Patients with psychological problems . 5- Patients with abnormal habits. 6- Patients with medical conditions as Diabetes or Hypertension.
Trial locations and contacts
1 site in 1 country.
About this study
Evaluation of the effect of liquorice nanogel versus diode laser on periodontitis stage Ⅲ clinically and microbiologically by molecular analysis of porphyromonas gingivalis using real time PCR.
Read the detailed description
Quantitative analysis technique using real time pcr (polymerase chain reaction) was done to detect presence of porphyromonas gingivalis. Pocket depth (PD), Plaque index (PI), gingival index (GI) and Clinical attachment level (CAL) were measured before work and after 3 months postoperatively.
Analysis was made from gingival crevicular fluid samples of the patients using gutta percha paper points.
- Conditions
- Diode Laser Therapy, Periodontal Disease, Liquorice Nanogel
- Being tested
- Liquorice Nanogel, diode laser
- Keywords
- Liquorice Nanogel, Diode Laser, Real time pcr, P.gingivalis, 16s gene
- Medical subject headings
- Periodontal Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Liquorice NanogelDrug
Real Time pcr was chosen to detect 16s gene concentration for porphyromonas gingivalis bacteria that is specific for Periodontitis Stage 3.
diode laserDrug
Real time Pcr was used to detect gene concentration 16s specific for porphyromonas gingivalis
| Study group | Role | What they receive |
|---|---|---|
| control group | Experimental | no drug was added to control group Receives: Drug: Liquorice Nanogel; Drug: diode laser |
| Liquorice Nanogel | Experimental | 10% Liquorice was prepared in nanogel concentrate Receives: Drug: Liquorice Nanogel; Drug: diode laser |
| Diode laser | Experimental | Epic X 0.9watt device was used Receives: Drug: Liquorice Nanogel; Drug: diode laser |
What is being measured
The primary outcome is the main question the study is designed to answer.
Quantitative analysis using real time pcr
Measured: 3 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 May 2026
- Study start1 Jul 2025
- Primary completion28 Sep 2025
- Study completion1 Apr 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Diode Laser TherapyStudies of the same condition, open and under way.
- More trials run by Al-Azhar UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 3
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Patient had Periodontitis stage III with pocket depth ≥ 6mm; indicated for periodontal surgery or CAL ≥ 5mm , Patient agreed to the surgical procedure and clinical trial, Age ranged between 18-50 years old. No previous drug was taken affecting bone metabolism , No Smokers Pregnant women and women with menopause were excluded. Patients with psychological problems were excluded. Patients with abnormal habits were excluded . Patients with medical conditions as Diabetes or Hypertension were excluded.
- Masking
- Single blind
- Who is masked
- Investigator
- Enrolment
- 27 participants (actual)
Sponsor and investigators
- Lead sponsor
- Al-Azhar University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Alaa Yousri Mohamed, Al-Azhar University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07602738
- Sponsor's protocol ID
- P-ME-24-10
- Acronym
- Periodontology
- Status last verified
- May 2026
- First submitted
- 12 May 2026
- Last updated
- 29 Sep 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 29 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of Liquorice Nanogel Versus Diode Laser as an Adjunctive Treatment for Patients With Periodontitis Stage Ⅲ.
- ClinicalTrials.gov ID
- NCT07602738
- Acronym / sponsor ID
- Periodontology / P-ME-24-10
- Conditions
- Diode Laser Therapy, Periodontal Disease, Liquorice Nanogel
- Keywords
- Liquorice Nanogel, Diode Laser, Real time pcr, P.gingivalis, 16s gene
- Phase
- Phase 3
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 27 participants (actual)
- Lead sponsor
- Al-Azhar UniversityUniversity, hospital or other
- Study start
- 1 Jul 2025 (actual)
- Primary completion
- 28 Sep 2025 (actual)
- Study completion
- 1 Apr 2026 (actual)
- First posted
- 22 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Evaluation of the effect of liquorice nanogel versus diode laser on periodontitis stage Ⅲ clinically and microbiologically by molecular analysis of porphyromonas gingivalis using real time PCR.
Detailed description
Quantitative analysis technique using real time pcr (polymerase chain reaction) was done to detect presence of porphyromonas gingivalis. Pocket depth (PD), Plaque index (PI), gingival index (GI) and Clinical attachment level (CAL) were measured before work and after 3 months postoperatively.
Analysis was made from gingival crevicular fluid samples of the patients using gutta percha paper points.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (investigator)
- Number of arms
- 3
- Model description
- Patient had Periodontitis stage III with pocket depth ≥ 6mm; indicated for periodontal surgery or CAL ≥ 5mm , Patient agreed to the surgical procedure and clinical trial, Age ranged between 18-50 years old. No previous drug was taken affecting bone metabolism , No Smokers Pregnant women and women with menopause were excluded. Patients with psychological problems were excluded. Patients with abnormal habits were excluded . Patients with medical conditions as Diabetes or Hypertension were excluded.
| Arm | Type | Receives |
|---|---|---|
| control group | Experimental | Drug: Liquorice Nanogel, Drug: diode laserno drug was added to control group |
| Liquorice Nanogel | Experimental | Drug: Liquorice Nanogel, Drug: diode laser10% Liquorice was prepared in nanogel concentrate |
| Diode laser | Experimental | Drug: Liquorice Nanogel, Drug: diode laserEpic X 0.9watt device was used |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Patient had Periodontitis stage III with pocket depth ≥ 6mm; indicated for periodontal surgery or CAL ≥ 5mm.
- Patient agreed to the surgical procedure and clinical trial.
- Age ranged between 18-50 years old.
Key exclusion criteria (1 listed)
- 1: No previous drug was taken affecting bone metabolism. 2- Smoking. 3- Pregnant women and women with menopause. 4- Patients with psychological problems . 5- Patients with abnormal habits. 6- Patients with medical conditions as Diabetes or Hypertension.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Liquorice NanogelReal Time pcr was chosen to detect 16s gene concentration for porphyromonas gingivalis bacteria that is specific for Periodontitis Stage 3. | Drug | Diode laser, Liquorice Nanogel, control group |
| diode laserReal time Pcr was used to detect gene concentration 16s specific for porphyromonas gingivalis | Drug | Diode laser, Liquorice Nanogel, control group |
Primary outcome
Quantitative analysis using real time pcr
Time frame: 3 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Sep 2026.
- Individual participant dataSharing planned: Undecided
Related trials for Diode Laser Therapy
Not yet recruiting
Recurrent Aphthous Stomatitis Management in Children Using Diode Laser 980 Nanometer Versus Hyaluronic Acid Gel (RCT)
Apthous Ulcer
Recruiting
Effect of Ultrasonic and Diode Laser Activated Irrigation on Postoperative Pain Following Root Canal Treatment
Symptomatic Irreversible Pulpitis and Symptomatic Apical Periodontitis
Not yet recruiting
Adjunctive Diode Laser Therapy for Peri-Implant Mucositis
Peri-implant Mucositis
Not yet recruiting
Diode Laser 635 nm and 810 nm Photodynamic Therapy as Adjuncts to Non-Surgical Periodontal Treatment
Periodontitis
Recruiting
Diode Laser Versus LED for Maxillary Canine Retraction in Orthodontic Patients
Malocclusion Class I
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 3 study testing Liquorice Nanogel and diode laser in people with Diode Laser Therapy and Periodontal Disease, run by Al-Azhar University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 29 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Quantitative analysis using real time pcr (time frame: 3 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Sep 2026.