Medial Meniscus Knee InjuryNCT07602985
Evaluation of Different Patterns PHMM Root Tears
An observational study of Medial Meniscus Knee Injury, run by Assiut University.
Trial summary
1. To evaluate and classify different morphological patterns of posterior horn medial meniscus root tears (PHMMRTs) and assess their correlation with clinical presentation, MRI findings, and arthroscopic features. 2. To determine the association between tear patterns and degree of meniscal extrusion. 3. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Medial Meniscus Knee Injury
- What is being tested?
- MRI
- Type of treatment
- Surgery or procedure
- How many people
- 30 participants
- Where
- No sites listed yet
- Study dates
- 1 Jun 2026to 1 Jul 2027
- How long will I take part?
- 4 Months
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: study population will include patients presenting to orthopedic surgery department at Assiut university
Who may be able to join
- Patients aged ≥18 years (no upper age limit, as PHMMRTs are prevalent in elderly population)
- Clinical suspicion of medial meniscal injury
- MRI-confirmed posterior horn medial meniscus root tear
- Patients undergoing diagnostic or therapeutic knee arthroscopy
Who cannot join
- Previous surgical intervention to the affected knee
- Lateral meniscus root tears
- Advanced knee osteoarthritis (Kellgren-Lawrence grade IV)
- Inflammatory or rheumatoid arthritis
- Acute ligamentous injuries requiring immediate surgical intervention
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Evaluation Of Different Patterns Of Posterior Horn Medial Meniscus Root Tears
- To evaluate and classify different morphological patterns of posterior horn medial meniscus root tears (PHMMRTs) and assess their correlation with clinical presentation, MRI findings, and arthroscopic features.
- To determine the association between tear patterns and degree of meniscal extrusion.
- To evaluate the relationship between tear patterns and articular cartilage degeneration.
- To identify predictors of specific tear patterns based on clinical and radiological findings
Read the detailed description
The medial meniscus posterior horn root plays a pivotal role in maintaining normal knee biomechanics by converting axial loads into circumferential hoop stresses. Injury to this structure leads to loss of meniscal function, increased tibiofemoral contact pressure, and accelerated degeneration of articular cartilage, resembling the biomechanical effects of total meniscectomy.
Posterior horn medial meniscus root tears (PHMMRTs) present with various morphological patterns, including radial tears, oblique tears, complex tears, and complete root avulsions. Each tear pattern has distinct clinical, radiological, and arthroscopic characteristics, which may influence management strategies and prognosis. Despite increasing recognition of these injuries, data correlating tear patterns with clinical presentation and imaging findings remain limited.
Despite increasing recognition of PHMMRTs, limited studies have comprehensively correlated different tear patterns with clinical, radiological, and arthroscopic findings in a single prospective cohort. This study aims to fill this gap and provide clinically applicable correlations that may guide decision-making and prognosis assessment
- Conditions
- Medial Meniscus Knee Injury
- Being tested
- MRI
- Keywords
- PHMM
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
MRIRadiation
all population should do MRI
What is being measured
The primary outcome is the main question the study is designed to answer.
different morphological patterns of posterior horn medial meniscus root tears.
Identification and distribution of different morphological patterns of posterior horn medial meniscus root tears Using Magnetic Resonance Imaging (MRI)
Measured: Baseline
Secondary outcomes (1)
Correlation between meniscal tear pattern and articular cartilage degeneration
Assessment of the correlation between MRI -defined meniscal tear pattern and grade of articular cartilage degeneration assessed using Outerbridge classification
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 May 2026
- Study start1 Jun 2026 (estimated)
- Primary completion1 Jun 2027 (estimated)
- Study completion1 Jul 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Medial Meniscus Knee InjuryStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 30 participants (estimated)
- Target duration
- 4 Months
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ahmed Gamal Mohamed Ahmed, Assiut University
- Investigators
- Islam Karam Karam Allah, A PROF, Study director
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07602985
- Sponsor's protocol ID
- PHMM Root Tears
- Status last verified
- May 2026
- First submitted
- 10 May 2026
- Last updated
- 22 May 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Lubowitz JH, Provencher MT, Poehling GG. Arthroscopy Techniques achieves PubMed Central citation, yet knee and shoulder outcome failures represent a challenge, and a presidential address prepares us for adversity. Arthroscopy. 2013 Sep;29(9):1461-2. doi: 10.1016/j.arthro.2013.06.012. No abstract available.
PubMed 23992981Zhu JW, Zheng HL, Wang TF, Zhou ZY, Lei L, Guo XJ, Chen YX, Duan GQ. Global Research Trends on Medial Meniscus Posterior Root Tear: A 20-Year Bibliometric Analysis. J Multidiscip Healthc. 2025 Oct 9;18:6595-6605. doi: 10.2147/JMDH.S541028. eCollection 2025.
PubMed 41099059
Study at a glance
From the registry record, last updated by the sponsor on 22 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation Of Different Patterns Of Posterior Horn Medial Meniscus Root Tears
- ClinicalTrials.gov ID
- NCT07602985
- Acronym / sponsor ID
- PHMM Root Tears
- Conditions
- Medial Meniscus Knee Injury
- Keywords
- PHMM
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 1 Jun 2026 (estimated)
- Primary completion
- 1 Jun 2027 (estimated)
- Study completion
- 1 Jul 2027 (estimated)
- First posted
- 22 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
- To evaluate and classify different morphological patterns of posterior horn medial meniscus root tears (PHMMRTs) and assess their correlation with clinical presentation, MRI findings, and arthroscopic features.
- To determine the association between tear patterns and degree of meniscal extrusion.
- To evaluate the relationship between tear patterns and articular cartilage degeneration.
- To identify predictors of specific tear patterns based on clinical and radiological findings
Detailed description
The medial meniscus posterior horn root plays a pivotal role in maintaining normal knee biomechanics by converting axial loads into circumferential hoop stresses. Injury to this structure leads to loss of meniscal function, increased tibiofemoral contact pressure, and accelerated degeneration of articular cartilage, resembling the biomechanical effects of total meniscectomy.
Posterior horn medial meniscus root tears (PHMMRTs) present with various morphological patterns, including radial tears, oblique tears, complex tears, and complete root avulsions. Each tear pattern has distinct clinical, radiological, and arthroscopic characteristics, which may influence management strategies and prognosis. Despite increasing recognition of these injuries, data correlating tear patterns with clinical presentation and imaging findings remain limited.
Despite increasing recognition of PHMMRTs, limited studies have comprehensively correlated different tear patterns with clinical, radiological, and arthroscopic findings in a single prospective cohort. This study aims to fill this gap and provide clinically applicable correlations that may guide decision-making and prognosis assessment
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 4 Months
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- study population will include patients presenting to orthopedic surgery department at Assiut university
Key inclusion criteria (4 listed)
- Patients aged ≥18 years (no upper age limit, as PHMMRTs are prevalent in elderly population)
- Clinical suspicion of medial meniscal injury
- MRI-confirmed posterior horn medial meniscus root tear
- Patients undergoing diagnostic or therapeutic knee arthroscopy
Key exclusion criteria (5 listed)
- Previous surgical intervention to the affected knee
- Lateral meniscus root tears
- Advanced knee osteoarthritis (Kellgren-Lawrence grade IV)
- Inflammatory or rheumatoid arthritis
- Acute ligamentous injuries requiring immediate surgical intervention
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| MRIall population should do MRI | Radiation | – |
Primary outcome
different morphological patterns of posterior horn medial meniscus root tears.
Time frame: Baseline
Identification and distribution of different morphological patterns of posterior horn medial meniscus root tears Using Magnetic Resonance Imaging (MRI)
1 secondary outcome
Correlation between meniscal tear pattern and articular cartilage degeneration
Time frame: Baseline
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 May 2026.
- Background: PubMed 23992981Lubowitz JH, Provencher MT, Poehling GG. Arthroscopy Techniques achieves PubMed Central citation, yet knee and shoulder outcome failures represent a challenge, and a presidential address prepares us for adversity. Arthroscopy. 2013 Sep;29(9):1461-2. doi: 10.1016/j.arthro.2013.06.012. No abstract available.
- Results publication: PubMed 41099059Zhu JW, Zheng HL, Wang TF, Zhou ZY, Lei L, Guo XJ, Chen YX, Duan GQ. Global Research Trends on Medial Meniscus Posterior Root Tear: A 20-Year Bibliometric Analysis. J Multidiscip Healthc. 2025 Oct 9;18:6595-6605. doi: 10.2147/JMDH.S541028. eCollection 2025.
- Individual participant dataSharing planned: Undecided
Related trials for Medial Meniscus Knee Injury
Recruiting
Hemi-tibial Plateau Osteotomy Combined With Arthroscopic Repair for Medial Meniscus Posterior Root Tears in Varus Knees
Knee Osteoarthristis, Meniscus Injury
Not yet recruitingObservational study
A Study on Different Treatments for Knee Osteoarthritis Caused by Damaged Roots of the Medial Meniscus.
Osteoarthritis, Meniscus Lesion
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Islam Karam Karam Allah, A PROF study director
Questions about this trial
What is this clinical trial studying?
An observational study of Medial Meniscus Knee Injury, run by Assiut University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 22 May 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ahmed Gamal Ahmed sayed, orthopedic resident (+201003663138, ggemi800@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
different morphological patterns of posterior horn medial meniscus root tears. (time frame: Baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07602985, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 May 2026.