COPD (Chronic Obstructive Pulmonary Disease)ISTrainingCOPDNCT07605117
Isoinertial Training in Patients With COPD
A study testing Isoinertial training in people with COPD (Chronic Obstructive Pulmonary Disease), run by Universidad Manuela Beltrán at 2 sites in Colombia.
Trial summary
Isoinertial training is emerging as a potentially effective strategy to improve strength and functionality in older people diagnosed with chronic obstructive pulmonary disease (COPD), due to its influence on muscle mass and neuromuscular efficiency. Read more about this study
- Who is it for?
- Ages 50 to 80 years
- Conditions the study is for
- COPD (Chronic Obstructive Pulmonary Disease)
- What is being tested?
- Isoinertial training
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 2 sitesColombia
- Study dates
- 7 May 2026to 27 Jul 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- People between 50 - 80 years of age diagnosed with moderate or severe COPD
- No acute exacerbations in the last 4 weeks
- Sufficient functional capacity to exercise
- Signed informed consent
Who cannot join
- Presence of neurological, musculoskeletal, or cardiovascular diseases that significantly limit exercise performance or compromise participant safety; including uncontrolled hypertension, recent myocardial infarction, unstable angina, severe osteoarthritis, stroke sequelae, or Parkinson's disease.
- Contraindications to exercise participation according to medical evaluation.
- Recent surgeries in the past 3 months
- Simultaneous participation in other exercise programs
- Cognitive disorders
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Colombia2 sites, 2 recruiting
- Recruiting
Universidad Manuela Beltrán
Bogotá, Bogotá, DC, 110231
David Murcia-Lesmes, PhD
Edwin Fernando Gutiérrez-Reyes, MSc
- Recruiting
Pulsar Unidad de Neumologia y Rehabilitación Pulmonar
Ibague, Ibagué, 730006
About this study
Official title: Effect of Isoinertial Training on Muscle Strength and Functional Capacity in Patients With Chronic Obstructive Pulmonary Disease (COPD): A Randomized Controlled Clinical Trial
Isoinertial training is emerging as a potentially effective strategy to improve strength and functionality in older people diagnosed with chronic obstructive pulmonary disease (COPD), due to its influence on muscle mass and neuromuscular efficiency. COPD is characterized by systemic alterations, including peripheral muscle dysfunction; which contributes to patient functional limitation, and reduces patients' quality of life. Isoinertial training may improve the physiological response to effort, and also promote functional performance in this population. Hence, the aim of this study is to evaluate the effect of an isoinertial training program on muscle strength and functional capacity in patients with COPD during an 8-week intervention.
Read the detailed description
To assess the effects of an isoinertial training programme on muscle strength and functional capacity in older people diagnosed with chronic obstructive pulmonary disease (COPD), in a randomized controlled clinical trial. Thirty participants diagnosed with moderate to severe COPD, over 50 years (50% men, 50% women), will be included to analyze possible differences in the training response compared to the control group. Participants will sign the informed consent and randomly assign to the intervention or control group. The intervention consists in a supervised isoinertial training program, while the control group will continue with the usual pulmonary rehabilitation program. Patients will be subjected to an initial assessment that include the application of tests of functional capacity, muscle strength, as well as clinical parameters and sociodemographic characteristics. The intervention will last 8 weeks, with a frequency of 2 to 3 sessions per week. The training program will include exercises aimed at strengthening the upper and lower limbs, using a isoinertial device with controlled load progression.
- Being tested
- Isoinertial training, Traditional rehabilitation (control group)
- Keywords
- Muscle Strength, Functional Capacity, Pulmonary Rehabilitation, Interventional study, Adults, Exercise, Flywheel training, Lung Disease
- Medical subject headings
- Pulmonary Disease, Chronic Obstructive, Motor Activity, Lung Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Isoinertial trainingDevice
Supervised isoinertial training:
- Participants will perform a supervised isoinertial training program during 8 weeks of follow-up
- The intervention will have a frequency of 2 to 3 weekly sessions
- The program will include exercises aimed at strengthening the upper and lower limbs using a isoinertial device
- The training load will be progressive to each participant and adjusted according to the individual response.
- The program will be carried out in combination with usual pulmonary rehabilitation care.
Traditional rehabilitation (control group)Other
Traditional treatment (control group)
- Participants involved in the usual pulmonary rehabilitation program during 8 weeks with a frequency of 2-3 sessions per week.
- This program includes low- to moderate-intensity aerobic exercise, joint mobility activities and general strengthening exercises using conventional resources according to the clinic's rehabilitation protocol.
- No isoinertial training
| Study group | Role | What they receive |
|---|---|---|
| Supervised isoinertial training | Experimental | Participants will perform a supervised isoinertial training program during 8 weeks of follow-up Receives: Device: Isoinertial training |
| Traditional rehabilitation | Active comparator | Participants involved in the usual pulmonary rehabilitation program
* The usual recommendations for physical activity and clinical follow-up will be maintained
* No isoinertial training Receives: Other: Traditional rehabilitation (control group) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in upper limb muscle strength using the Hand Grip Test (HGT)
Manual grip strength will be evaluated by dynamometry, as an indicator of peripheral muscle strength in patients with COPD.
Measured: Baseline and 8-week follow-up
Change in functional capacity by 6-minute walk test (6MWT)
The distance covered for 6 minutes will be evaluated as an indicator of exercise tolerance and functional capacity.
Measured: Baseline and 8-week follow-up
Lower limb functional performance
The number of repetitions performed in 30 seconds will be recorded as an indicator of functional strength-endurance in the lower limbs
Measured: Baseline and 8-week follow-up
Change in functional mobility using the Timed Up and Go Test (TUG)
The time needed to get up from a chair, walk, turn and sit down again will be measured, as an indicator of mobility and functional risk.
Measured: Baseline and 8-week follow-up
Change in muscle quality index (MQI)
Muscle quality will be estimated using the MQI, which evaluates the muscle power of the lower limbs considering leg length, body mass, gravitational acceleration and time required to complete 10 sit-to-stand repetitions
Measured: Baseline and 8-week follow-up
Secondary outcomes (6)
Change in functional performance using 5 Times Sit-to-Stand Test (5STS)
Time required to perform 5 repetitions of standing and sitting will be measured, as a complementary indicator of lower limb function
Measured: Baseline and 8-week follow-up
Change in health-related quality of life through The Saint George's Respiratory Questionnaire (SGRQ)
The SGRQ will be applied to assess the symptoms, activity and impact of the respiratory disease. This score ranges from 0 to 100 points, a higher score indicates poor health.
Measured: Baseline and 8-week follow-up
Changes in Body Mass Index (BMI)
Body mass index (BMI) will be assessed to characterize participants' anthropometric status. BMI will be calculated as body weight divided by height squared and expressed in kilograms per square meter (kg/m^2).
Measured: Baseline and 8-week follow-up
Changes in heart rate
Heart rate (bpm) will be measured using an automatic monitor
Measured: Baseline and 8-week follow-up
Changes in blood pressure
Diastolic and systolic blood pressure (mmHg) will be measured using a blood pressure monitor
Measured: Baseline and 8-week follow-up
Changes in oxygen saturation (SpO2)
Oxygen saturation (Percentage, %) will be measured using an oximeter.
Measured: Baseline and 8 week follow-up
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 May 2026
- Study start7 May 2026 (estimated)
- Primary completion25 Jul 2026 (estimated)
- Study completion27 Jul 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for COPD (Chronic Obstructive Pulmonary Disease)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Universidad Manuela Beltrán
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, David Murcia-Lesmes, PhD, Universidad Manuela Beltrán
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07605117
- Sponsor's protocol ID
- DCTAFD24 23
- Acronym
- ISTrainingCOPD
- Status last verified
- May 2026
- First submitted
- 5 May 2026
- Last updated
- 29 May 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Data availability to external researchers is restricted to related project proposals upon request to the PI.
Study at a glance
From the registry record, last updated by the sponsor on 29 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Isoinertial Training on Muscle Strength and Functional Capacity in Patients With Chronic Obstructive Pulmonary Disease (COPD): A Randomized Controlled Clinical Trial
- ClinicalTrials.gov ID
- NCT07605117
- Acronym / sponsor ID
- ISTrainingCOPD / DCTAFD24 23
- Keywords
- Muscle Strength, Functional Capacity, Pulmonary Rehabilitation, Interventional study, Adults, Exercise, Flywheel training, Lung Disease
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Universidad Manuela BeltránUniversity, hospital or other
- Study start
- 7 May 2026 (estimated)
- Primary completion
- 25 Jul 2026 (estimated)
- Study completion
- 27 Jul 2026 (estimated)
- First posted
- 22 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Isoinertial training is emerging as a potentially effective strategy to improve strength and functionality in older people diagnosed with chronic obstructive pulmonary disease (COPD), due to its influence on muscle mass and neuromuscular efficiency. COPD is characterized by systemic alterations, including peripheral muscle dysfunction; which contributes to patient functional limitation, and reduces patients' quality of life. Isoinertial training may improve the physiological response to effort, and also promote functional performance in this population. Hence, the aim of this study is to evaluate the effect of an isoinertial training program on muscle strength and functional capacity in patients with COPD during an 8-week intervention.
Detailed description
To assess the effects of an isoinertial training programme on muscle strength and functional capacity in older people diagnosed with chronic obstructive pulmonary disease (COPD), in a randomized controlled clinical trial. Thirty participants diagnosed with moderate to severe COPD, over 50 years (50% men, 50% women), will be included to analyze possible differences in the training response compared to the control group. Participants will sign the informed consent and randomly assign to the intervention or control group. The intervention consists in a supervised isoinertial training program, while the control group will continue with the usual pulmonary rehabilitation program. Patients will be subjected to an initial assessment that include the application of tests of functional capacity, muscle strength, as well as clinical parameters and sociodemographic characteristics. The intervention will last 8 weeks, with a frequency of 2 to 3 sessions per week. The training program will include exercises aimed at strengthening the upper and lower limbs, using a isoinertial device with controlled load progression.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Supervised isoinertial training | Experimental | Device: Isoinertial trainingParticipants will perform a supervised isoinertial training program during 8 weeks of follow-up |
| Traditional rehabilitation | Active comparator | Other: Traditional rehabilitation (control group)Participants involved in the usual pulmonary rehabilitation program * The usual recommendations for physical activity and clinical follow-up will be maintained * No isoinertial training |
Who may qualify
- Ages
- 50 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- People between 50 - 80 years of age diagnosed with moderate or severe COPD
- No acute exacerbations in the last 4 weeks
- Sufficient functional capacity to exercise
- Signed informed consent
Key exclusion criteria (5 listed)
- Presence of neurological, musculoskeletal, or cardiovascular diseases that significantly limit exercise performance or compromise participant safety; including uncontrolled hypertension, recent myocardial infarction, unstable angina, severe osteoarthritis, stroke sequelae, or Parkinson's disease.
- Contraindications to exercise participation according to medical evaluation.
- Recent surgeries in the past 3 months
- Simultaneous participation in other exercise programs
- Cognitive disorders
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Isoinertial trainingSupervised isoinertial training: * Participants will perform a supervised isoinertial training program during 8 weeks of follow-up * The intervention will have a frequency of 2 to 3 weekly sessions * The program will include exercises aimed at strengthening the upper and lower limbs using a isoinertial device * The training load will be progressive to each participant and adjusted according to the individual response. * The program will be carried out in combination with usual pulmonary rehabilitation care. | Device | Supervised isoinertial training |
| Traditional rehabilitation (control group)Traditional treatment (control group) * Participants involved in the usual pulmonary rehabilitation program during 8 weeks with a frequency of 2-3 sessions per week. * This program includes low- to moderate-intensity aerobic exercise, joint mobility activities and general strengthening exercises using conventional resources according to the clinic's rehabilitation protocol. * No isoinertial training | Other | Traditional rehabilitation |
Primary outcome
Change in upper limb muscle strength using the Hand Grip Test (HGT)
Time frame: Baseline and 8-week follow-up
Manual grip strength will be evaluated by dynamometry, as an indicator of peripheral muscle strength in patients with COPD.
Change in functional capacity by 6-minute walk test (6MWT)
Time frame: Baseline and 8-week follow-up
The distance covered for 6 minutes will be evaluated as an indicator of exercise tolerance and functional capacity.
Lower limb functional performance
Time frame: Baseline and 8-week follow-up
The number of repetitions performed in 30 seconds will be recorded as an indicator of functional strength-endurance in the lower limbs
Change in functional mobility using the Timed Up and Go Test (TUG)
Time frame: Baseline and 8-week follow-up
The time needed to get up from a chair, walk, turn and sit down again will be measured, as an indicator of mobility and functional risk.
Change in muscle quality index (MQI)
Time frame: Baseline and 8-week follow-up
Muscle quality will be estimated using the MQI, which evaluates the muscle power of the lower limbs considering leg length, body mass, gravitational acceleration and time required to complete 10 sit-to-stand repetitions
6 secondary outcomes
Change in functional performance using 5 Times Sit-to-Stand Test (5STS)
Time frame: Baseline and 8-week follow-up
Change in health-related quality of life through The Saint George's Respiratory Questionnaire (SGRQ)
Time frame: Baseline and 8-week follow-up
Changes in Body Mass Index (BMI)
Time frame: Baseline and 8-week follow-up
Changes in heart rate
Time frame: Baseline and 8-week follow-up
Changes in blood pressure
Time frame: Baseline and 8-week follow-up
Changes in oxygen saturation (SpO2)
Time frame: Baseline and 8 week follow-up
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 May 2026.
- Individual participant dataSharing planned: No. Data availability to external researchers is restricted to related project proposals upon request to the PI.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Isoinertial training in people with COPD (Chronic Obstructive Pulmonary Disease), run by Universidad Manuela Beltrán at 2 sites in Colombia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 29 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Colombia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact David Murcia-Lesmes, PhD (+571 5460600, david.murcia@docentes.umb.edu.co), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in upper limb muscle strength using the Hand Grip Test (HGT) (time frame: Baseline and 8-week follow-up). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 May 2026.