CognitionNCT07606469
Human Neural Correlates of Multi-Timescale Inference
An observational study of Cognition and Brain Activity, run by University of Colorado, Boulder at 1 site in United States.
Trial summary
Adult epilepsy patients who are undergoing intracranial monitoring will participate in a simple behavioral task during the clinical recording period. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Cognition, Brain Activity
- What is being tested?
- Decision-making task and eye tracking
- Type of treatment
- Lifestyle or therapy programme
- How many people
- 30 participants
- Where
- 1 siteUnited States
- Study dates
- 15 Jun 2026to 30 Jun 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Epilepsy patients with intractable seizures who are undergoing clinical continuous intracranial recordings of the brain's electrical activity to assess the seizure focus location.
Who may be able to join
- Epilepsy patients undergoing intracranial electrode monitoring for uncontrolled seizures.
- no lesions identified in the participants' brains
- capable of giving consent
Who cannot join
- seizure activity during task recording
- electrodes in regions of interest are identified to be the seizure focus
- task performance outside of the normal range as determined from online studies with healthy participants
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site
University of Colorado Anschutz
Aurora, Colorado, 80045
About this study
Official title: Neuronal Mechanisms of Human Cognition
Adult epilepsy patients who are undergoing intracranial monitoring will participate in a simple behavioral task during the clinical recording period.
Read the detailed description
The investigators will analyze recorded neural activity, eye movements, and behavioral responses from epilepsy patients undergoing intracranial monitoring with clinically-relevant microelectrodes in hippocampus that perform a decision-making task. The participants will perform 1 session of the task during their monitoring period. Behavioral responses will be fit to inference models to identify strategies subjects use, and neural recordings (neuronal firing and low frequency activity) will be correlated with task features by comparing results to those produced by randomized (bootstrapped) data. Neural activity and corresponding behavioral strategies for each participant will be used to refine theoretical recurrent neural network models of hippocampal engagement in multi-timescale inference.
- Conditions
- Cognition, Brain Activity
- Being tested
- Decision-making task, eye tracking
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Decision-making taskBehavioural
Patients will be asked to play a decision-making game in which they hear a tone and must identify its source.
eye trackingBehavioural
Patients will have simultaneous eye-tracking performed while playing the decision-making game
| Study group | Role | What they receive |
|---|---|---|
| Flexible Decision Making Task | Not described Receives: Behavioral: Decision-making task; Behavioral: eye tracking |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pupil size changes with respect to task features
pupil size will be measured with a portable eye-tracking device and correlated with task features
Measured: continuous recording during task, up to 30 minutes
Behavioral Responses
Patient selects one of two choices on each trial using the computer keyboard
Measured: Approximately 10 seconds per trial, up to 30 minutes total
Intracranial electrode recordings to measure changes in brain activity during decision making
Intracranial neural recordings from patients who are implanted with electrodes for clinical purposes tha take place during the decision-making task
Measured: duration of the task, approximately 30 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 May 2026
- Study start15 Jun 2026 (estimated)
- Primary completion1 Aug 2027 (estimated)
- Study completion30 Jun 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for CognitionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Other
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Colorado, Boulder
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Tahra Eissa, University of Colorado, Denver
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07606469
- Sponsor's protocol ID
- 25-1284
- Other IDs
- R00NS127855
- Status last verified
- May 2026
- First submitted
- 11 May 2026
- Last updated
- 26 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Given that these are patients, the investigators cannot directly share their identifiable information without conflicting with HIPAA compliance
Study at a glance
From the registry record, last updated by the sponsor on 26 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Neuronal Mechanisms of Human Cognition
- ClinicalTrials.gov ID
- NCT07606469
- Acronym / sponsor ID
- 25-1284
- Conditions
- Cognition, Brain Activity
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- University of Colorado, BoulderUniversity, hospital or other
- Study start
- 15 Jun 2026 (estimated)
- Primary completion
- 1 Aug 2027 (estimated)
- Study completion
- 30 Jun 2028 (estimated)
- First posted
- 26 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Adult epilepsy patients who are undergoing intracranial monitoring will participate in a simple behavioral task during the clinical recording period.
Detailed description
The investigators will analyze recorded neural activity, eye movements, and behavioral responses from epilepsy patients undergoing intracranial monitoring with clinically-relevant microelectrodes in hippocampus that perform a decision-making task. The participants will perform 1 session of the task during their monitoring period. Behavioral responses will be fit to inference models to identify strategies subjects use, and neural recordings (neuronal firing and low frequency activity) will be correlated with task features by comparing results to those produced by randomized (bootstrapped) data. Neural activity and corresponding behavioral strategies for each participant will be used to refine theoretical recurrent neural network models of hippocampal engagement in multi-timescale inference.
Study design
- Observational model
- Case only
- Time perspective
- Other
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Flexible Decision Making Task | – | Behavioral: Decision-making task, Behavioral: eye tracking |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Epilepsy patients with intractable seizures who are undergoing clinical continuous intracranial recordings of the brain's electrical activity to assess the seizure focus location.
Key inclusion criteria (3 listed)
- Epilepsy patients undergoing intracranial electrode monitoring for uncontrolled seizures.
- no lesions identified in the participants' brains
- capable of giving consent
Key exclusion criteria (3 listed)
- seizure activity during task recording
- electrodes in regions of interest are identified to be the seizure focus
- task performance outside of the normal range as determined from online studies with healthy participants
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Decision-making taskPatients will be asked to play a decision-making game in which they hear a tone and must identify its source. | Behavioural | Flexible Decision Making Task |
| eye trackingPatients will have simultaneous eye-tracking performed while playing the decision-making game | Behavioural | Flexible Decision Making Task |
Primary outcome
Pupil size changes with respect to task features
Time frame: continuous recording during task, up to 30 minutes
pupil size will be measured with a portable eye-tracking device and correlated with task features
Behavioral Responses
Time frame: Approximately 10 seconds per trial, up to 30 minutes total
Patient selects one of two choices on each trial using the computer keyboard
Intracranial electrode recordings to measure changes in brain activity during decision making
Time frame: duration of the task, approximately 30 minutes
Intracranial neural recordings from patients who are implanted with electrodes for clinical purposes tha take place during the decision-making task
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 May 2026.
- Individual participant dataSharing planned: No. Given that these are patients, the investigators cannot directly share their identifiable information without conflicting with HIPAA compliance
Related trials for Cognition
Recruiting
Telehealth-Adapted Compensatory Training and Intervention for Cognition
MCI, Mild Cognitive Impairment
Active, not recruitingPhase 2
Effect of Equol Supplementation on Arterial Stiffness and Cognition in Healthy Volunteers
Arterial Stiffness, White Matter Lesions
Recruiting
Neurobehavioral Changes Following Spaceflight Stressors
Stressor, Individual, Alcohol Impairment
RecruitingPhase 4
Testing Healthy Participants for Drowsiness After Single Dosing of Two Different Doses of Muscle Relaxer
Healthy Participants
RecruitingPhase 1
PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)
Alzheimer s Disease, Mild Cognitive Impairment
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Cognition and Brain Activity, run by University of Colorado, Boulder at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 26 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Tahra Eissa ((303) 492-6974, tahra.eissa@cuanschutz.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pupil size changes with respect to task features (time frame: continuous recording during task, up to 30 minutes). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 May 2026.