Geriatric DiseasesThyroid dysfunNCT07606560
Thyroid Dysfunction in Elderly
An observational study of Geriatric Diseases, run by Assiut University.
Trial summary
Thyroid dysfunction in elderly Read more about this study
- Who is it for?
- Ages 60 years and olderHealthy volunteers can take part
- Conditions the study is for
- Geriatric Diseases
- How many people
- 187 participants
- Where
- No sites listed yet
- Study dates
- 1 Aug 2026to 30 Nov 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Older adult patients aged 60 years or older attending the internal medicine, family medicine, and Geriatric department, both males and females.
inclusion criteria: Older adult patients aged 60 years or older attending the internal medicine, family medicine, and Geriatric department, both males and females.
exclusion criteria: patients previously diagnosed with thyroid dysfunction or currently receiving thyroid related treatment, patients with a history of thyroid malignancy, or with end stage organ failure
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Thyroid Dysfunction and it's Association With Comorbidities and Polypharmacy Among Older Adults in a Tertiary Care Hospital, Assiut_Egypt
Thyroid dysfunction in elderly
Read the detailed description
Thyroid dysfunction is a common endocrine disorder among older adults, with prevalence increasing due to age-related physiological changes and the high burden of chronic diseases (1).
It is estimated that 20-30% of individuals aged 60 years and above have some form of thyroid dysfunction, particularly hypothyroidism (2).
Aging affects thyroid hormone secretion, metabolism, and tissue responsiveness, which may alter thyroid function tests even in the absence of overt disease (3).
In elderly patients, thyroid disorders often present with nonspecific or atypical manifestations such as fatigue, cognitive decline, and weight changes, leading to underdiagnosis (4).
Subclinical thyroid dysfunction is also highly prevalent and frequently detected incidentally (5).
Older adults commonly suffer from multiple comorbidities involving different organ systems, which complicates both clinical presentation and interpretation of thyroid function tests (6).
Thyroid dysfunction has been associated with adverse outcomes, including cardiovascular disease, atrial fibrillation, and increased mortality (7).
Polypharmacy is highly prevalent in this population, with many patients receiving five or more medications concurrently (8).
Several drugs can interfere with thyroid function or its laboratory assessment (9).
Despite the clinical importance of this issue, limited data are available in our locality regarding the combined effect of comorbidities and polypharmacy on thyroid function in older adults. Therefore, this study aims to investigate this association.
- Conditions
- Geriatric Diseases
- Keywords
- geriatric, thyroid dysfunction, polypharmacy
What is being measured
The primary outcome is the main question the study is designed to answer.
prevalence of thyroid dysfunction in older adult patients
prevalence of thyroid dysfunction in older adult patients in Assiut university hospitals geriatric patients
Measured: at baseline
assess association between comorbidities and polypharmacy on thyroid function among older adult patients
assess association between comorbidities and polypharmacy on thyroid function among older adult patients
Measured: at baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 May 2026
- Study start1 Aug 2026 (estimated)
- Primary completion1 Aug 2026 (estimated)
- Study completion30 Nov 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Geriatric DiseasesStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case crossover
- Time perspective
- Prospective
- Enrolment
- 187 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Marwa Abd Ellatif Ahmed Mohamed, Assiut University
- Investigators
- Soheir Mostafa Kasim, Professor, Study director, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07606560
- Sponsor's protocol ID
- Thyroid Dysfunction in Elderly
- Acronym
- Thyroid dysfun
- Status last verified
- May 2026
- First submitted
- 19 May 2026
- Last updated
- 26 May 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 26 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Thyroid Dysfunction and it's Association With Comorbidities and Polypharmacy Among Older Adults in a Tertiary Care Hospital, Assiut_Egypt
- ClinicalTrials.gov ID
- NCT07606560
- Acronym / sponsor ID
- Thyroid dysfun / Thyroid Dysfunction in Elderly
- Conditions
- Geriatric Diseases
- Keywords
- geriatric, thyroid dysfunction, polypharmacy
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 187 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 1 Aug 2026 (estimated)
- Primary completion
- 1 Aug 2026 (estimated)
- Study completion
- 30 Nov 2027 (estimated)
- First posted
- 26 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Thyroid dysfunction in elderly
Detailed description
Thyroid dysfunction is a common endocrine disorder among older adults, with prevalence increasing due to age-related physiological changes and the high burden of chronic diseases (1).
It is estimated that 20-30% of individuals aged 60 years and above have some form of thyroid dysfunction, particularly hypothyroidism (2).
Aging affects thyroid hormone secretion, metabolism, and tissue responsiveness, which may alter thyroid function tests even in the absence of overt disease (3).
In elderly patients, thyroid disorders often present with nonspecific or atypical manifestations such as fatigue, cognitive decline, and weight changes, leading to underdiagnosis (4).
Subclinical thyroid dysfunction is also highly prevalent and frequently detected incidentally (5).
Older adults commonly suffer from multiple comorbidities involving different organ systems, which complicates both clinical presentation and interpretation of thyroid function tests (6).
Thyroid dysfunction has been associated with adverse outcomes, including cardiovascular disease, atrial fibrillation, and increased mortality (7).
Polypharmacy is highly prevalent in this population, with many patients receiving five or more medications concurrently (8).
Several drugs can interfere with thyroid function or its laboratory assessment (9).
Despite the clinical importance of this issue, limited data are available in our locality regarding the combined effect of comorbidities and polypharmacy on thyroid function in older adults. Therefore, this study aims to investigate this association.
Study design
- Observational model
- Case crossover
- Time perspective
- Prospective
Who may qualify
- Ages
- 60 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Older adult patients aged 60 years or older attending the internal medicine, family medicine, and Geriatric department, both males and females.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
prevalence of thyroid dysfunction in older adult patients
Time frame: at baseline
prevalence of thyroid dysfunction in older adult patients in Assiut university hospitals geriatric patients
assess association between comorbidities and polypharmacy on thyroid function among older adult patients
Time frame: at baseline
assess association between comorbidities and polypharmacy on thyroid function among older adult patients
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 May 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Soheir Mostafa Kasim, Professor study director
Assiut University
Questions about this trial
What is this clinical trial studying?
An observational study of Geriatric Diseases, run by Assiut University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 26 May 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Marwa Ahmed Ahmed, Assistant Lecturer (01094504225, mero.doctor9090@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
prevalence of thyroid dysfunction in older adult patients (time frame: at baseline). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 May 2026.