ColonoscopyNCT07608120
Electrolyte Beverage Combined With Polyethylene Glycol for Colonoscopy Bowel Preparation
A study testing PEG With Water, PEG With Low-dose Electrolyte Beverage and PEG With Medium-dose Electrolyte Beverage in people with Colonoscopy and Bowel Preparation Solutions, run by Nanfang Hospital, Southern Medical University at 1 site in China.
Trial summary
This randomized controlled trial aims to evaluate the effects of different ratios of electrolyte beverage and water combined with polyethylene glycol (PEG) on bowel preparation quality before colonoscopy. Read more about this study
- Who is it for?
- Ages 18 to 75 yearsHealthy volunteers can take part
- Conditions the study is for
- Colonoscopy, Bowel Preparation Solutions, Colorectal Cancer Screening
- What is being tested?
- PEG With Water, PEG With Low-dose Electrolyte Beverage and PEG With Medium-dose Electrolyte Beverage
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 405 participants
- Where
- 1 siteChina
- Study dates
- 18 May 2026to 31 May 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Adults aged 18-75 years scheduled to undergo elective colonoscopy
- Meet the standard clinical indications for colonoscopy;
- Able to understand and comply with the bowel preparation procedure and complete oral polyethylene glycol (PEG) intake as required;
- Able to comply with study-related data collection and follow-up;
- Provide written informed consent voluntarily.
Who cannot join
- Previously diagnosed colorectal cancer, intestinal obstruction, or suspected intestinal obstruction;
- Active gastrointestinal bleeding or a definite history of gastrointestinal bleeding within the past 4 weeks (including melena, hematochezia, or hematemesis);
- Severe renal insufficiency, decompensated heart failure, significant electrolyte imbalance, or other conditions unsuitable for PEG bowel preparation;
- Known allergy to polyethylene glycol or components of the electrolyte beverage used in the study;
- Pregnant or breastfeeding women;
- Any other condition considered by the investigators to make the participant unsuitable for the study.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
China1 site, 1 recruiting
- Recruiting
Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong
Aimin Li, +86 13580317630, lam0725@163.com
About this study
Official title: Randomized Controlled Trial of Different Ratios of Electrolyte Beverage and Water Combined With Polyethylene Glycol on Bowel Preparation Quality and Ingestion Rhythm Before Colonoscopy
This randomized controlled trial aims to evaluate the effects of different ratios of electrolyte beverage and water combined with polyethylene glycol (PEG) on bowel preparation quality before colonoscopy. Participants undergoing elective colonoscopy will be randomly assigned to one of three bowel preparation regimens: PEG prepared with water only, PEG prepared with a low ratio of electrolyte beverage and water, or PEG prepared with a medium ratio of electrolyte beverage and water. The primary outcome is adequate bowel preparation assessed by the Boston Bowel Preparation Scale (BBPS). Secondary outcomes include bowel preparation completion rate, tolerability, adverse events, repeat colonoscopy rate, adenoma detection rate, and ingestion rhythm characteristics during bowel preparation. This study also aims to explore whether electrolyte beverage-assisted bowel preparation may improve bowel cleansing quality by influencing participants' ingestion rhythm and adherence during PEG intake.
- Being tested
- PEG With Water, PEG With Low-dose Electrolyte Beverage, PEG With Medium-dose Electrolyte Beverage
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
PEG With WaterOther
Polyethylene glycol (PEG) prepared with water only for bowel preparation before colonoscopy.
PEG With Low-dose Electrolyte BeverageOther
Polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:3 ratio for bowel preparation before colonoscopy.
PEG With Medium-dose Electrolyte BeverageOther
Polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:1 ratio for bowel preparation before colonoscopy.
| Study group | Role | What they receive |
|---|---|---|
| Water Group | Active comparator | Participants receive polyethylene glycol (PEG) prepared with water only for bowel preparation before colonoscopy. Receives: Other: PEG With Water |
| Low-dose Electrolyte Beverage Group | Experimental | Participants receive polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:3 ratio for bowel preparation before colonoscopy. Receives: Other: PEG With Low-dose Electrolyte Beverage |
| Medium-dose Electrolyte Beverage Group | Experimental | Participants receive polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:1 ratio for bowel preparation before colonoscopy. Receives: Other: PEG With Medium-dose Electrolyte Beverage |
What is being measured
The primary outcome is the main question the study is designed to answer.
Adequate Bowel Preparation Rate
Adequate bowel preparation is defined as a total Boston Bowel Preparation Scale (BBPS) score ≥6 with each colonic segment score ≥2 during colonoscopy.
Measured: At the time of colonoscopy on Day 1
Secondary outcomes (3)
Total Boston Bowel Preparation Scale Score
Total Boston Bowel Preparation Scale (BBPS) score assessed during colonoscopy.
Measured: At the time of colonoscopy on Day 1
Bowel Preparation Completion Rate
Proportion of participants who complete the planned polyethylene glycol bowel preparation within 60 minutes.
Measured: During bowel preparation within 1 hour before colonoscopy on Day 1
Adverse Event Rate
Incidence of adverse events during bowel preparation, including nausea, vomiting, abdominal distension, abdominal pain, dizziness, and fatigue.
Measured: During bowel preparation within 1 hour before colonoscopy on Day 1
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 May 2026
- Study start18 May 2026
- Primary completion31 Jan 2027 (estimated)
- Study completion31 May 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for ColonoscopyStudies of the same condition, open and under way.
- More trials run by Nanfang Hospital, Southern Medical UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 405 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Nanfang Hospital, Southern Medical University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07608120
- Sponsor's protocol ID
- NFEC-2026-307
- Status last verified
- May 2026
- First submitted
- 18 May 2026
- Last updated
- 27 May 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Randomized Controlled Trial of Different Ratios of Electrolyte Beverage and Water Combined With Polyethylene Glycol on Bowel Preparation Quality and Ingestion Rhythm Before Colonoscopy
- ClinicalTrials.gov ID
- NCT07608120
- Acronym / sponsor ID
- NFEC-2026-307
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 405 participants (estimated)
- Lead sponsor
- Nanfang Hospital, Southern Medical UniversityUniversity, hospital or other
- Study start
- 18 May 2026 (actual)
- Primary completion
- 31 Jan 2027 (estimated)
- Study completion
- 31 May 2027 (estimated)
- First posted
- 27 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial aims to evaluate the effects of different ratios of electrolyte beverage and water combined with polyethylene glycol (PEG) on bowel preparation quality before colonoscopy. Participants undergoing elective colonoscopy will be randomly assigned to one of three bowel preparation regimens: PEG prepared with water only, PEG prepared with a low ratio of electrolyte beverage and water, or PEG prepared with a medium ratio of electrolyte beverage and water. The primary outcome is adequate bowel preparation assessed by the Boston Bowel Preparation Scale (BBPS). Secondary outcomes include bowel preparation completion rate, tolerability, adverse events, repeat colonoscopy rate, adenoma detection rate, and ingestion rhythm characteristics during bowel preparation. This study also aims to explore whether electrolyte beverage-assisted bowel preparation may improve bowel cleansing quality by influencing participants' ingestion rhythm and adherence during PEG intake.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Water Group | Active comparator | Other: PEG With WaterParticipants receive polyethylene glycol (PEG) prepared with water only for bowel preparation before colonoscopy. |
| Low-dose Electrolyte Beverage Group | Experimental | Other: PEG With Low-dose Electrolyte BeverageParticipants receive polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:3 ratio for bowel preparation before colonoscopy. |
| Medium-dose Electrolyte Beverage Group | Experimental | Other: PEG With Medium-dose Electrolyte BeverageParticipants receive polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:1 ratio for bowel preparation before colonoscopy. |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Adults aged 18-75 years scheduled to undergo elective colonoscopy
- Meet the standard clinical indications for colonoscopy;
- Able to understand and comply with the bowel preparation procedure and complete oral polyethylene glycol (PEG) intake as required;
- Able to comply with study-related data collection and follow-up;
- Provide written informed consent voluntarily.
Key exclusion criteria (6 listed)
- Previously diagnosed colorectal cancer, intestinal obstruction, or suspected intestinal obstruction;
- Active gastrointestinal bleeding or a definite history of gastrointestinal bleeding within the past 4 weeks (including melena, hematochezia, or hematemesis);
- Severe renal insufficiency, decompensated heart failure, significant electrolyte imbalance, or other conditions unsuitable for PEG bowel preparation;
- Known allergy to polyethylene glycol or components of the electrolyte beverage used in the study;
- Pregnant or breastfeeding women;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| PEG With WaterPolyethylene glycol (PEG) prepared with water only for bowel preparation before colonoscopy. | Other | Water Group |
| PEG With Low-dose Electrolyte BeveragePolyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:3 ratio for bowel preparation before colonoscopy. | Other | Low-dose Electrolyte Beverage Group |
| PEG With Medium-dose Electrolyte BeveragePolyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:1 ratio for bowel preparation before colonoscopy. | Other | Medium-dose Electrolyte Beverage Group |
Primary outcome
Adequate Bowel Preparation Rate
Time frame: At the time of colonoscopy on Day 1
Adequate bowel preparation is defined as a total Boston Bowel Preparation Scale (BBPS) score ≥6 with each colonic segment score ≥2 during colonoscopy.
3 secondary outcomes
Total Boston Bowel Preparation Scale Score
Time frame: At the time of colonoscopy on Day 1
Bowel Preparation Completion Rate
Time frame: During bowel preparation within 1 hour before colonoscopy on Day 1
Adverse Event Rate
Time frame: During bowel preparation within 1 hour before colonoscopy on Day 1
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 May 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing PEG With Water, PEG With Low-dose Electrolyte Beverage and PEG With Medium-dose Electrolyte Beverage in people with Colonoscopy and Bowel Preparation Solutions, run by Nanfang Hospital, Southern Medical University at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 27 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Aimin Li (+86 13580317630, lam0725@163.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Adequate Bowel Preparation Rate (time frame: At the time of colonoscopy on Day 1). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 May 2026.