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Parkinson s DiseaseNCT07610031

Trunk Control Exercises and Mirror Therapy on Balance and Posture in Parkinson's Disease

A study testing Mirror therapy in people with Parkinson s Disease, run by University of Lahore at 1 site in Pakistan.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

Parkinson's disease (PD) is movement disorder of the nervous system that worsens over time. As nerve cells (neurons) in parts of the brain weaken or are damaged or die, people may begin to notice problems with movement, tremor, stiffness in the limbs or the trunk of the body, or impaired balance. Read more about this study

Who is it for?
Ages 50 to 70 years
Conditions the study is for
Parkinson s Disease
What is being tested?
Mirror therapy
Could I receive a placebo?
No, everyone receives an active treatment
How many people
36 participants
Where
1 sitePakistan
Study dates
22 Dec 2024to 20 Jun 2026
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 50 to 70 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • • 50-70 age(Bomasang-Layno et al., 2015)
  • Both genders (Bomasang-Layno et al., 2015)
  • Patient with grade 1,2,3 Parkinsonism (according to Hoehn and Yahr scale)
  • Patient taking fixed dose of medicines
  • No cognitive impairment (according to Mini-Mental scale 24-30 scoring) (Capecci et al., 2014)
  • The patient was able to get out of chairs and beds without assistance (Hoffmann et al., 2016).
  • Individuals without significant dyskinesias or "on-off" periods.(Lötzke et al., 2015)

Who cannot join

  • • Patient having any recent episode of epilepsy(Bomasang-Layno et al., 2015)
  • Patient has had any recent trauma. (Hong et al., 2009)
  • Individuals free from chronic diseases such as unstable cardiovascular disease that could compromise their safety during training or testing (Hoffmann et al., 2016).

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Pakistan1 site, 1 recruiting
  • Nimra Nadeem

    Lahore, Punjab Province, 54000

    Hafiza Sana Ashraf, MS-MSK, 03224866794, sana.ashraf@uipt.uol.edu.pk

    Muhammad Asim Arif, MS-MSK, PhD*, 03216597727, asim.arif@uol.edu.pk

    Recruiting

Other trials in Pakistan

About this study

Official title: Effects of Trunk Control Exercises and Mirror Therapy on Balance and Posture in Patients With Parkinson's Disease

Parkinson's disease (PD) is movement disorder of the nervous system that worsens over time. As nerve cells (neurons) in parts of the brain weaken or are damaged or die, people may begin to notice problems with movement, tremor, stiffness in the limbs or the trunk of the body, or impaired balance. As these symptoms become more obvious, people may have difficulty walking, talking, or completing other simple tasks. Not everyone with one or more of these symptoms has PD, as the symptoms appear in other diseases as well.

Both non-modifiable (age, gender) and modifiable risk factors such as occupation, exposure to pesticides, and depression have an association with PD. Several studies have suggested that Parkinson disease is more common in men. The MT mechanism is based on the concept of visual illusion. The movement of the non-paretic part in front of the mirror (reflective side) is perceived as that of the paretic body part (hidden beside the mirror). MT allows an individual to have an experience of normal movement, even for the severely paralyzed limb. In addition, wherever other rehabilitation methods fail to induce normal movements without any compensation, MT may act as a foundation step for further motor therapy. The perception of movement illusion, a neuropsychological phenomenon may induce neural activation of the lesioned brain and enhance associated motor recovery. Therefore the aim of this study is to compare the effects of truck control exercise program and mirror therapy on balance and postural instability in patients with Parkinson's disease.

Read the detailed description

Parkinson's disease (PD) is movement disorder of the nervous system that worsens over time. As nerve cells (neurons) in parts of the brain weaken or are damaged or die, people may begin to notice problems with movement, tremor, stiffness in the limbs or the trunk of the body, or impaired balance. As these symptoms become more obvious, people may have difficulty walking, talking, or completing other simple tasks. Not everyone with one or more of these symptoms has PD, as the symptoms appear in other diseases as well. Both non-modifiable (age, gender) and modifiable risk factors such as occupation, exposure to pesticides, and depression have an association with PD. Several studies have suggested that Parkinson disease is more common in men. The MT mechanism is based on the concept of visual illusion. The movement of the non-paretic part in front of the mirror (reflective side) is perceived as that of the paretic body part (hidden beside the mirror). MT allows an individual to have an experience of normal movement, even for the severely paralyzed limb. In addition, wherever other rehabilitation methods fail to induce normal movements without any compensation, MT may act as a foundation step for further motor therapy. The perception of movement illusion, a neuropsychological phenomenon may induce neural activation of the lesioned brain and enhance associated motor recovery. Therefore the aim of this study is to compare the effects of truck control exercise program and mirror therapy on balance and postural instability in patients with Parkinson's disease.

Screening: Patients will be screened to meet inclusion criteria. The consent form will be taken from patients then patients will be randomly allocated into two groups (28 in each group). Patients fulfilling the inclusion criteria will be randomly divided into experimental and control groups using the computer software. The study will be single-blinded. The assessor will be unaware of the treatment given to both groups. Data will be collected at baseline and then at the end of the sixth week. Before applying intervention, Berg Balance scale will be used to measure level of balance and goniometer will be used to measure two-dimensional angular deviations between the pelvis and the upper part of the trunk.

Being tested
Trunk control exercise, Mirror therapy
Medical subject headings
Parkinson Disease

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Trunk control exerciseOther

    The participants will complete balance exercises which targeted their feedforward along with feedback postural reflexes. The exercise program will include three different groups of tasks: self-destabilizing movements such as rolling on the toes and bouncing a ball while walking as well as external destabilization tasks like balancing on foam surfaces and therapist-performed perturbations and coordinated arm movements during walking. The patients will undergo ten specific movements per session and medical staff raised the exercise difficulty level as they made improvement. The principal investigator will provide verbal instruction together with physical help if required.

  • Mirror therapyOther

    In this, each patient will be instructed to keep the affected limb in static position. The limb will be in the position of hip 90°, knee 90°, and ankle 90° for the short-sitting posture and in the position of hip 90°, knee 0°, and ankle neutral in the long-sitting posture. The position of the limb was ensured from time to time. The repetition will be modulated to complete the maximum time of each session. Weight bearing in standing (extended knee) 2-3 minutes, Weight bearing in standing on inclined wedge 2-3 minutes. Movements using associated reactions 10 repetitions, Knee flexion control in prone position 10 repetitions, Active-assistive movement using activities (medicinal ball, rocker board, pedocycle, jogger) for hip (flexion), knee (flexion-extension) and ankle (ankle dorsi flexion-plantar flexion) in sitting position 10 repetitions for each.

Study groups in NCT07610031
Study groupRoleWhat they receive
Trunk control exerciseExperimentalThe participants will complete balance exercises which targeted their feedforward along with feedback postural reflexes. The exercise program will include three different groups of tasks: self-destabilizing movements such as rolling on the toes and bouncing a ball while walking as well as external destabilization tasks like balancing on foam surfaces and therapist-performed perturbations and coordinated arm movements during walking. The patients will undergo ten specific movements per session and medical staff raised the exercise difficulty level as they made improvement. The principal investigator will provide verbal instruction together with physical help if required.
Receives: Other: Trunk control exercise; Other: Mirror therapy
Mirror therapyExperimentalIn this, each patient will be instructed to keep the affected limb in static position. The limb will be in the position of hip 90°, knee 90°, and ankle 90° for the short-sitting posture and in the position of hip 90°, knee 0°, and ankle neutral in the long-sitting posture. The position of the limb was ensured from time to time. The repetition will be modulated to complete the maximum time of each session. Weight bearing in standing (extended knee) 2-3 minutes, Weight bearing in standing on inclined wedge 2-3 minutes. Movements using associated reactions 10 repetitions, Knee flexion control in prone position 10 repetitions, Active-assistive movement using activities (medicinal ball, rocker board, pedocycle, jogger) for hip (flexion), knee (flexion-extension) and ankle (ankle dorsi flexion-plantar flexion) in sitting position 10 repetitions for each.
Receives: Other: Trunk control exercise; Other: Mirror therapy

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Berg Balance Scale:

    Using a series of pre-established exercises, the Berg Balance Scale (BBS) evaluates a patient's objective ability-or lack thereof-to maintain balance (Lima et al., 2018). The fourteen things on the list are assessed on a five-point ordinal scale, with 0 being the lowest degree of function and 4 the greatest level. Completing the list takes approximately twenty minutes. It excludes the gait analysis. (Louie \& Eng, 2018).

    Measured: 12 weeks

Secondary outcomes (1)
  1. Unified Parkinson's Disease Rating Scale (UPDRS-PG):

    The Unified Parkinson's Disease Rating Scale (UPDRS-PG) posture and gait sub-scores were used to assess postural stability and gait problems. It is divided into four pieces. Each part has many points: zero for normal or no problems, one for minor problems, two for moderate problems, three for major problems, and four for severe problems.(Shen \& Mak, 2015).

    Measured: 12 weeks

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted27 May 2026
  2. Study start22 Dec 2024
  3. Primary completion15 Jun 2026 (estimated)
  4. Study completion20 Jun 2026 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Double blind
Who is masked
Participant, Outcomes assessor
Enrolment
36 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07610031
Sponsor's protocol ID
REC-UOL-/343/08/24
Status last verified
Dec 2025
First submitted
8 Sep 2025
Last updated
27 May 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • Lopez-Liria R, Vega-Tirado S, Valverde-Martinez MA, Calvache-Mateo A, Martinez-Martinez AM, Rocamora-Perez P. Efficacy of Specific Trunk Exercises in the Balance Dysfunction of Patients with Parkinson's Disease: A Systematic Review and Meta-Analysis. Sensors (Basel). 2023 Feb 6;23(4):1817. doi: 10.3390/s23041817.

    PubMed 36850413
  • Hubble RP, Silburn PA, Naughton GA, Cole MH. Trunk Exercises Improve Balance in Parkinson Disease: A Phase II Randomized Controlled Trial. J Neurol Phys Ther. 2019 Apr;43(2):96-105. doi: 10.1097/NPT.0000000000000258.

    PubMed 30883497
  • Aarsland D, Batzu L, Halliday GM, Geurtsen GJ, Ballard C, Ray Chaudhuri K, Weintraub D. Parkinson disease-associated cognitive impairment. Nat Rev Dis Primers. 2021 Jul 1;7(1):47. doi: 10.1038/s41572-021-00280-3.

    PubMed 34210995
  • Bonassi G, Pelosin E, Ogliastro C, Cerulli C, Abbruzzese G, Avanzino L. Mirror Visual Feedback to Improve Bradykinesia in Parkinson's Disease. Neural Plast. 2016;2016:8764238. doi: 10.1155/2016/8764238. Epub 2016 Aug 1.

    PubMed 27563470
  • Gandolfi M, Tinazzi M, Magrinelli F, Busselli G, Dimitrova E, Polo N, Manganotti P, Fasano A, Smania N, Geroin C. Four-week trunk-specific exercise program decreases forward trunk flexion in Parkinson's disease: A single-blinded, randomized controlled trial. Parkinsonism Relat Disord. 2019 Jul;64:268-274. doi: 10.1016/j.parkreldis.2019.05.006. Epub 2019 May 3.

    PubMed 31097299

Questions about this trial

What is this clinical trial studying?

A study testing Mirror therapy in people with Parkinson s Disease, run by University of Lahore at 1 site in Pakistan.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 7 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 27 May 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Ishaq Ahmed, PHD (0334 4066 463, ishaq.ahmed@uipt.uol.edu.pk), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Berg Balance Scale: (time frame: 12 weeks). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07610031, which also lists 5 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 May 2026.

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