Depressive Disorder, MajorPEPSYNCT07618208
Student Precarity and Psychiatry
An observational study of Depressive Disorder, Major and Generalized Anxiety Disorder, run by Assistance Publique - Hôpitaux de Paris.
Trial summary
Since the COVID-19 pandemic, mental health disorders have increased significantly, particularly among young people. In France, the proportion of young people aged 18 to 25 suffering from depression almost doubled between 2017 and 2021. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Depressive Disorder, Major, Generalized Anxiety Disorder, Suicidal Ideation
- What is being tested?
- Questionnaires
- How many people
- 45,000 participants
- Where
- No sites listed yet
- Study dates
- Sep 2026to Nov 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: All students enrolled at Paris Sciences et Lettres University or the Faculty of Health Sciences at Paris Cité University.
Who may be able to join
- Student enrolled at Paris Sciences et Lettres University (PSL, 17,000 students) or the Faculty of Health Sciences at Paris Cité University (UPC, 28,000 students),
- Aged 18 or over,
- Fluent in French,
- Affiliated to a health insurance.
Who cannot join
- Applicants under the age of 18,
- Not enrolled at PSL universities or the UPCS Faculty of Health,
- Insufficient level of French.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Impact of Precarity on the Emergence of Psychiatric Disorders and the Use of Care Among Students
Since the COVID-19 pandemic, mental health disorders have increased significantly, particularly among young people. In France, the proportion of young people aged 18 to 25 suffering from depression almost doubled between 2017 and 2021. This phenomenon particularly affects students, who are already identified as being at greater risk of mental health disorders than the general population. Medical students seem to be particularly vulnerable: in 2021, a national study showed very high rates of depression and suicidal thoughts in this population. The main factor associated with depression was the feeling of financial hardship.
Students often face multiple forms of insecurity. Financially, they have limited resources and struggle to cover their basic needs such as housing, food and healthcare. Socially, many experience significant isolation, particularly when they are away from their families or under pressure from their studies. All of this has a significant impact on their mental health. Unfortunately, many students do not seek help due to lack of time, resources, or awareness of support services. The 2021 study showed that only one-third of medical students suffering from depression received appropriate treatment.
Read more
The aim of our study is to assess the impact of precariousness on the onset of psychiatric disorders and on the use or non-use of healthcare services.
Our study will involve nearly 45,000 students from PSL and UPC universities. It is based on a longitudinal cohort (via questionnaires) over three years. The aim is to identify precisely the different aspects of student precariousness (housing, transport, isolation, economic difficulties, etc.) and their link with psychological distress. The study will measure the extent of the phenomenon and identify modifiable factors that could be targeted by preventive measures. The results will enable us to better target preventive measures and propose concrete solutions to improve students' well-being and promote their success.
Read the detailed description
The COVID-19 pandemic has led to an increase in depression, particularly among young people. The French health barometer, conducted every 4-5 years by Santé Publique France (SPF), found that the prevalence of major depressive episodes (MDE) among 18-25 year olds doubled (from 11.7% to 20.8%) between 2017 and 2021. There has also been an increase in suicidal thoughts and suicide attempts. Among students, data from the 2016 Student Life Observatory (OVE) found a higher prevalence of CDE and suicidal thoughts among students than in the general population of the same age. Among the factors associated with the risk of EDC, experiencing significant financial difficulties was the main one[4]. Among medical students, a national study conducted in 2021 found that the prevalence of depression and suicidal thoughts was much higher than in the general population of the same age. Financial difficulties were also the main factor associated with the risk of depression. Indeed, students are a population that is particularly vulnerable to precariousness due to several factors. Economically, they often have limited incomes, depending on parental support, insufficient grants or precarious jobs. This exposes them to difficulties in meeting their basic needs such as housing, food and healthcare. Socially, isolation can exacerbate their situation, especially when they are far from their family network or under pressure from their studies. In addition, high academic demands, combined with unstable living conditions, impact their mental health and can contribute to the development of psychiatric disorders, which often go untreated due to a lack of affordable and accessible resources. International students are even more vulnerable due to language and administrative barriers and limited access to local support services. This multidimensional precariousness highlights the need for comprehensive support for this population, even though students are unlikely to seek professional help. In the 2021 survey, only 32% of medical students suffering from depression received adequate care. If we want to improve the health of medical students, we must not only treat disorders, but also prevent them from occurring by helping students strive for a state of well-being. In terms of prevention, the Haute Autorité de Santé (HAS) distinguishes between three levels: primary prevention, which acts upstream of the disease (on risk factors); secondary prevention, which acts at an early stage of its development (screening); and tertiary prevention, which acts on complications and the risk of recurrence.
The objectives of the study are to identify and quantify the modifiable predictive and moderating factors explaining students' psychological distress that could give rise to (primary) prevention actions by studying the various components of precariousness (housing, transport, study conditions, social isolation, grants, etc.). It also aims to study the impact of the various components of precariousness on the use and non-use of healthcare (screening and treatment, secondary and tertiary prevention).
The data will be entered directly by participants on the SKEZIA platform (https://skezi.eu/) (a solution developed by SKEZI) co-founded by AP-HP and Paris-Cité University, and will be hosted on HDS-approved servers.
Main objective:
The objective is to explore the impact of precariousness on the risk of characterised depressive episodes and the use of healthcare among PSL students (17,000 students) and UPC health faculty students (28,000 students).
Primary outcome measure:
The study will assess the 12-month prevalence of:
- characterised depressive episodes (using the Composite International Diagnostic Interview Short-Form (CIDI-SF)) and suicidal ideation in the same way as SPF and OVE;
- use of healthcare services, which will be measured in a similar way to the OVE survey and the medical student survey.
Precariousness will be assessed by the question: 'Would you say that you are currently experiencing financial difficulties?'
Secondary objectives and evaluation criteria:
The secondary objectives are to :
- evaluate the prevalence of :
- anxiety, which will be assessed using the GAD7;
- eating disorders, which will be assessed using the SCOFF;
- alcohol addiction, which will be assessed using the AUDIT, and cannabis addiction, which will be assessed using the CAST;
- burnout, using the student version, which will be assessed using the MBI-SS for pre-clinical or healthcare students and the MBI-HSS for externs and residents,
- dropout, which will be assessed by a single question as in the CNA-CORE survey,
- insomnia, which will be measured by the Insomnia Severity Index (ISI),
- loneliness, which will be assessed using the UCLA 3 items,
- harassment,
- discriminatory treatment,
- and quality of life (WHOQOL);
- identify and quantify modifiable predictive and moderating factors explaining students' psychological distress that could lead to (primary) prevention measures = by studying the various components of precariousness (housing, transport, study conditions, social isolation, grants, etc.),
- study the impact of the various components of precariousness on the use and non-use of healthcare (screening and treatment, secondary and tertiary prevention). This will be assessed using questions on the renunciation of healthcare and its causes.
- Being tested
- Questionnaires
- Keywords
- Students, Depression, Use of care, Precarity
- Medical subject headings
- Depressive Disorder, Major, Generalized Anxiety Disorder, Suicidal Ideation, Depression
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
QuestionnairesOther
Questionnaires
| Study group | Role | What they receive |
|---|---|---|
| Health students | All students enrolled at the Faculty of Health Sciences of Paris Cité University Receives: Other: Questionnaires | |
| Non-health students | All students enrolled at Paris Sciences and Letters University Receives: Other: Questionnaires |
What is being measured
The primary outcome is the main question the study is designed to answer.
Composite International Diagnostic Interview Short-Form (CIDI-SF)
12-months prevalence Major Depressive Disorder and suicidal thoughts Composite International Diagnostic Interview Short-Form (CIDI-SF)
Measured: Day 0
Composite International Diagnostic Interview Short-Form (CIDI-SF)
12-months prevalence Major Depressive Disorder and suicidal thoughts Composite International Diagnostic Interview Short-Form (CIDI-SF)
Measured: 12 months
Use of care
Use of care service of care professional
Measured: Day 0
Use of care
Use of care service of care professional
Measured: 12 months
Precarity
Question "Would you say that you are currently experiencing financial difficulties?"
Measured: Day 0
Precarity
Question "Would you say that you are currently experiencing financial difficulties?"
Measured: 12 months
Secondary outcomes (37)
GAD7
Prevalence of anxiety
Measured: Day 0
GAD7
Prevalence of anxiety
Measured: 12 months
GAD7
Prevalence of anxiety
Measured: 24 months
SCOFF
Prevalence of Eating disorders
Measured: Day 0
SCOFF
Prevalence of Eating disorders
Measured: 12 months
SCOFF
Prevalence of Eating disorders
Measured: 24 months
AUDIT
Prevalence of Alcohol addiction
Measured: Day 0
AUDIT
Prevalence of Alcohol addiction
Measured: 12 months
AUDIT
Prevalence of Alcohol addiction
Measured: 24 months
CAST
Prevalence of cannabis addiction
Measured: Day 0
CAST
Prevalence of cannabis addiction
Measured: 12 months
CAST
Prevalence of cannabis addiction
Measured: 24 months
MBI-SS or MBI-HSS
Prevalence of Burnout using the student version : will be assessed using the MBI-SS for pre-clinical students or caregivers or Prevalence of Burnout using the student version : will be assessed using the MBI-HSS for externs and residents
Measured: Day 0
MBI-SS or MBI-HSS
Prevalence of Burnout using the student version : will be assessed using the MBI-SS for pre-clinical students or caregivers or Prevalence of Burnout using the student version : will be assessed using the MBI-HSS for externs and residents Time Frame: D0
Measured: 12 months
MBI-SS or MBI-HSS
Prevalence of Burnout using the student version : will be assessed using the MBI-SS for pre-clinical students or caregivers or Prevalence of Burnout using the student version : will be assessed using the MBI-HSS for externs and residents Time Frame: D0
Measured: 24 months
A single question as in the CNA-CORE survey
Prevalence of Dropout: will be assessed using a single question as in the CNA-CORE survey
Measured: Day 0
A single question as in the CNA-CORE survey
Prevalence of Dropout: will be assessed using a single question as in the CNA-CORE survey
Measured: 12 months
A single question as in the CNA-CORE survey
Prevalence of Dropout: will be assessed using a single question as in the CNA-CORE survey
Measured: 24 months
Insomnia Severity Index (ISI)
Prevalence of Insomnia
Measured: Day 0
Insomnia Severity Index (ISI)
Prevalence of Insomnia
Measured: 12 months
Insomnia Severity Index (ISI)
Prevalence of Insomnia
Measured: 24 months
UCLA 3 items
Prevalence of Loneliness
Measured: Day 0
UCLA 3 items
Prevalence of Loneliness
Measured: 12 months
UCLA 3 items
Prevalence of Loneliness
Measured: 24 months
Questions about harrassment
Harrassment
Measured: Day 0
Questions about harrassment
Harrassment
Measured: 12 months
Questions about harrassment
Harrassment
Measured: 24 months
Questions about discriminatory treatment
Discriminatory treatment
Measured: Day 0
Questions about discriminatory treatment
Discriminatory treatment
Measured: 12 months
Questions about discriminatory treatment
Discriminatory treatment
Measured: 24 months
WHOQOL
Quality of life
Measured: Day 0
WHOQOL
Quality of life
Measured: 12 months
WHOQOL
Quality of life
Measured: 24 months
Components of precariousness
Predictive and moderating factors = by studying the different components of precariousness (housing, transport, study conditions, social isolation, grants, etc.).
Measured: Day 0
Components of precariousness
Predictive and moderating factors = by studying the different components of precariousness (housing, transport, study conditions, social isolation, grants, etc.).
Measured: 12 months
Questions on the renunciation of healthcare and its causes.
Impact of the various components of precariousness on the use and non-use of healthcare will be assessed using questions on the renunciation of healthcare and its causes.
Measured: 12 months
Components of precariousness
Predictive and moderating factors = by studying the different components of precariousness (housing, transport, study conditions, social isolation, grants, etc.).
Measured: 24 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Jun 2026
- Study startSep 2026 (estimated)
- Primary completionSep 2028 (estimated)
- Study completionNov 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Depressive Disorder, MajorStudies of the same condition, open and under way.
- More trials run by Assistance Publique - Hôpitaux de ParisThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 45,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- Sponsor type
- University, hospital or other
- Collaborators
- Institut de Psychiatrie et Neurosciences de Paris (INSERM), URC-CIC Paris Descartes Necker Cochin
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07618208
- Sponsor's protocol ID
- APHP251300
- Other IDs
- N°IDRCB : 2025-A01968-41
- Acronym
- PEPSY
- Status last verified
- Jun 2026
- First submitted
- 4 Mar 2026
- Last updated
- 15 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Impact of Precarity on the Emergence of Psychiatric Disorders and the Use of Care Among Students
- ClinicalTrials.gov ID
- NCT07618208
- Acronym / sponsor ID
- PEPSY / APHP251300
- Keywords
- Students, Depression, Use of care, Precarity
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 45,000 participants (estimated)
- Lead sponsor
- Assistance Publique - Hôpitaux de ParisUniversity, hospital or other
- Collaborators
- Institut de Psychiatrie et Neurosciences de Paris (INSERM), URC-CIC Paris Descartes Necker Cochin
- Study start
- Sep 2026 (estimated)
- Primary completion
- Sep 2028 (estimated)
- Study completion
- Nov 2028 (estimated)
- First posted
- 1 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Since the COVID-19 pandemic, mental health disorders have increased significantly, particularly among young people. In France, the proportion of young people aged 18 to 25 suffering from depression almost doubled between 2017 and 2021. This phenomenon particularly affects students, who are already identified as being at greater risk of mental health disorders than the general population. Medical students seem to be particularly vulnerable: in 2021, a national study showed very high rates of depression and suicidal thoughts in this population. The main factor associated with depression was the feeling of financial hardship.
Students often face multiple forms of insecurity. Financially, they have limited resources and struggle to cover their basic needs such as housing, food and healthcare. Socially, many experience significant isolation, particularly when they are away from their families or under pressure from their studies. All of this has a significant impact on their mental health. Unfortunately, many students do not seek help due to lack of time, resources, or awareness of support services. The 2021 study showed that only one-third of medical students suffering from depression received appropriate treatment.
The aim of our study is to assess the impact of precariousness on the onset of psychiatric disorders and on the use or non-use of healthcare services.
Our study will involve nearly 45,000 students from PSL and UPC universities. It is based on a longitudinal cohort (via questionnaires) over three years. The aim is to identify precisely the different aspects of student precariousness (housing, transport, isolation, economic difficulties, etc.) and their link with psychological distress. The study will measure the extent of the phenomenon and identify modifiable factors that could be targeted by preventive measures. The results will enable us to better target preventive measures and propose concrete solutions to improve students' well-being and promote their success.
Detailed description
The COVID-19 pandemic has led to an increase in depression, particularly among young people. The French health barometer, conducted every 4-5 years by Santé Publique France (SPF), found that the prevalence of major depressive episodes (MDE) among 18-25 year olds doubled (from 11.7% to 20.8%) between 2017 and 2021. There has also been an increase in suicidal thoughts and suicide attempts. Among students, data from the 2016 Student Life Observatory (OVE) found a higher prevalence of CDE and suicidal thoughts among students than in the general population of the same age. Among the factors associated with the risk of EDC, experiencing significant financial difficulties was the main one[4]. Among medical students, a national study conducted in 2021 found that the prevalence of depression and suicidal thoughts was much higher than in the general population of the same age. Financial difficulties were also the main factor associated with the risk of depression. Indeed, students are a population that is particularly vulnerable to precariousness due to several factors. Economically, they often have limited incomes, depending on parental support, insufficient grants or precarious jobs. This exposes them to difficulties in meeting their basic needs such as housing, food and healthcare. Socially, isolation can exacerbate their situation, especially when they are far from their family network or under pressure from their studies. In addition, high academic demands, combined with unstable living conditions, impact their mental health and can contribute to the development of psychiatric disorders, which often go untreated due to a lack of affordable and accessible resources. International students are even more vulnerable due to language and administrative barriers and limited access to local support services. This multidimensional precariousness highlights the need for comprehensive support for this population, even though students are unlikely to seek professional help. In the 2021 survey, only 32% of medical students suffering from depression received adequate care. If we want to improve the health of medical students, we must not only treat disorders, but also prevent them from occurring by helping students strive for a state of well-being. In terms of prevention, the Haute Autorité de Santé (HAS) distinguishes between three levels: primary prevention, which acts upstream of the disease (on risk factors); secondary prevention, which acts at an early stage of its development (screening); and tertiary prevention, which acts on complications and the risk of recurrence.
The objectives of the study are to identify and quantify the modifiable predictive and moderating factors explaining students' psychological distress that could give rise to (primary) prevention actions by studying the various components of precariousness (housing, transport, study conditions, social isolation, grants, etc.). It also aims to study the impact of the various components of precariousness on the use and non-use of healthcare (screening and treatment, secondary and tertiary prevention).
The data will be entered directly by participants on the SKEZIA platform (https://skezi.eu/) (a solution developed by SKEZI) co-founded by AP-HP and Paris-Cité University, and will be hosted on HDS-approved servers.
Main objective:
The objective is to explore the impact of precariousness on the risk of characterised depressive episodes and the use of healthcare among PSL students (17,000 students) and UPC health faculty students (28,000 students).
Primary outcome measure:
The study will assess the 12-month prevalence of:
- characterised depressive episodes (using the Composite International Diagnostic Interview Short-Form (CIDI-SF)) and suicidal ideation in the same way as SPF and OVE;
- use of healthcare services, which will be measured in a similar way to the OVE survey and the medical student survey.
Precariousness will be assessed by the question: 'Would you say that you are currently experiencing financial difficulties?'
Secondary objectives and evaluation criteria:
The secondary objectives are to :
- evaluate the prevalence of :
- anxiety, which will be assessed using the GAD7;
- eating disorders, which will be assessed using the SCOFF;
- alcohol addiction, which will be assessed using the AUDIT, and cannabis addiction, which will be assessed using the CAST;
- burnout, using the student version, which will be assessed using the MBI-SS for pre-clinical or healthcare students and the MBI-HSS for externs and residents,
- dropout, which will be assessed by a single question as in the CNA-CORE survey,
- insomnia, which will be measured by the Insomnia Severity Index (ISI),
- loneliness, which will be assessed using the UCLA 3 items,
- harassment,
- discriminatory treatment,
- and quality of life (WHOQOL);
- identify and quantify modifiable predictive and moderating factors explaining students' psychological distress that could lead to (primary) prevention measures = by studying the various components of precariousness (housing, transport, study conditions, social isolation, grants, etc.),
- study the impact of the various components of precariousness on the use and non-use of healthcare (screening and treatment, secondary and tertiary prevention). This will be assessed using questions on the renunciation of healthcare and its causes.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Health students | – | Other: QuestionnairesAll students enrolled at the Faculty of Health Sciences of Paris Cité University |
| Non-health students | – | Other: QuestionnairesAll students enrolled at Paris Sciences and Letters University |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- All students enrolled at Paris Sciences et Lettres University or the Faculty of Health Sciences at Paris Cité University.
Key inclusion criteria (4 listed)
- Student enrolled at Paris Sciences et Lettres University (PSL, 17,000 students) or the Faculty of Health Sciences at Paris Cité University (UPC, 28,000 students),
- Aged 18 or over,
- Fluent in French,
- Affiliated to a health insurance.
Key exclusion criteria (3 listed)
- Applicants under the age of 18,
- Not enrolled at PSL universities or the UPCS Faculty of Health,
- Insufficient level of French.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| QuestionnairesQuestionnaires | Other | Health students, Non-health students |
Primary outcome
Composite International Diagnostic Interview Short-Form (CIDI-SF)
Time frame: Day 0
12-months prevalence Major Depressive Disorder and suicidal thoughts Composite International Diagnostic Interview Short-Form (CIDI-SF)
Composite International Diagnostic Interview Short-Form (CIDI-SF)
Time frame: 12 months
12-months prevalence Major Depressive Disorder and suicidal thoughts Composite International Diagnostic Interview Short-Form (CIDI-SF)
Use of care
Time frame: Day 0
Use of care service of care professional
Use of care
Time frame: 12 months
Use of care service of care professional
Precarity
Time frame: Day 0
Question "Would you say that you are currently experiencing financial difficulties?"
Precarity
Time frame: 12 months
Question "Would you say that you are currently experiencing financial difficulties?"
37 secondary outcomes
GAD7
Time frame: Day 0
GAD7
Time frame: 12 months
GAD7
Time frame: 24 months
SCOFF
Time frame: Day 0
SCOFF
Time frame: 12 months
SCOFF
Time frame: 24 months
AUDIT
Time frame: Day 0
AUDIT
Time frame: 12 months
AUDIT
Time frame: 24 months
CAST
Time frame: Day 0
CAST
Time frame: 12 months
CAST
Time frame: 24 months
MBI-SS or MBI-HSS
Time frame: Day 0
MBI-SS or MBI-HSS
Time frame: 12 months
MBI-SS or MBI-HSS
Time frame: 24 months
A single question as in the CNA-CORE survey
Time frame: Day 0
A single question as in the CNA-CORE survey
Time frame: 12 months
A single question as in the CNA-CORE survey
Time frame: 24 months
Insomnia Severity Index (ISI)
Time frame: Day 0
Insomnia Severity Index (ISI)
Time frame: 12 months
Insomnia Severity Index (ISI)
Time frame: 24 months
UCLA 3 items
Time frame: Day 0
UCLA 3 items
Time frame: 12 months
UCLA 3 items
Time frame: 24 months
Questions about harrassment
Time frame: Day 0
Questions about harrassment
Time frame: 12 months
Questions about harrassment
Time frame: 24 months
Questions about discriminatory treatment
Time frame: Day 0
Questions about discriminatory treatment
Time frame: 12 months
Questions about discriminatory treatment
Time frame: 24 months
WHOQOL
Time frame: Day 0
WHOQOL
Time frame: 12 months
WHOQOL
Time frame: 24 months
Components of precariousness
Time frame: Day 0
Components of precariousness
Time frame: 12 months
Questions on the renunciation of healthcare and its causes.
Time frame: 12 months
Components of precariousness
Time frame: 24 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Jun 2026.
- Individual participant dataSharing planned: No
Related trials for Depressive Disorder, Major
RecruitingPhase 2
Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders
Anxiety Disorders, Major Depressive Disorder
RecruitingPhase 2
Psilocybin-assisted Therapy for Comorbid Major Depressive Disorder and Alcohol Use Disorder
Major Depressive Disorder (MDD), Alcohol Use Disorder (AUD)
Recruiting
Defining Neurobiological Links Between Substance Use and Mental Illness
Major Depressive Disorder, Substance Use Disorder
RecruitingPhase 1
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
Healthy Volunteer, Major Depressive Disorder
Recruiting
Psychopharmacotherapy for Depressive Patients
Major Depressive Disorder
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
An observational study of Depressive Disorder, Major and Generalized Anxiety Disorder, run by Assistance Publique - Hôpitaux de Paris.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 15 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Cédric LEMOGNE, PR (00331 42 34 85 76, cedric.lemogne@aphp.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Composite International Diagnostic Interview Short-Form (CIDI-SF) (time frame: Day 0). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Jun 2026.