Coronary Artery DiseaseNCT07619664
High-Intensity Interval Training vs Moderate-Intensity Continuous Training in Phase II Cardiac Rehabilitation
A study testing High-Intensity Interval Training and Moderate-Intensity Continuous Training in people with Coronary Artery Disease, run by Riphah International University at 1 site in Pakistan.
Trial summary
This randomized controlled trial aims to compare the effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) in patients undergoing Phase II cardiac rehabilitation after coronary artery disease or post-angioplasty. Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- Coronary Artery Disease
- What is being tested?
- High-Intensity Interval Training and Moderate-Intensity Continuous Training
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 66 participants
- Where
- 1 sitePakistan
- Study dates
- Jun 2026to Aug 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Adults aged 18-60 years.
- Diagnosed with stable coronary artery disease confirmed by angiography, stress testing, or echocardiography.
- Left ventricular ejection fraction ≥45%.
- Functional NYHA Class I or II.
- Medically cleared by a cardiologist to participate in exercise (including recent ECG or stress test if necessary).
- Lightly active lifestyle prior to study (not involved in structured exercise programs).
Who cannot join
- Unstable angina or recent myocardial infarction (within the past 6 weeks).
- Uncontrolled hypertension (systolic BP >180 mmHg or diastolic BP >110 mmHg).
- Severe valvular heart disease, arrhythmias, or left ventricular dysfunction (EF <35%).
- Musculoskeletal disorders (e.g., severe osteoarthritis, recent fractures, or surgeries) preventing safe participation in exercise.
- Neurological disorders affecting mobility or safe exercise (e.g., stroke, Parkinson's disease).
- Uncontrolled diabetes mellitus (HbA1c >9% or recent hypoglycemia).
- Any other condition judged by the investigator to make participation unsafe.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site
Ch Pervaiz Elahi institute of cardiology Multan.
Multan, Punjab Province, 60000
Arjumand Bano, MS-CPPT, 03059551883, arjumand.bano@riphah.edu.pk
ALISHBA JAVED, MS-CPPT
About this study
Official title: Effects of High-Intensity Interval Training vs Moderate-Intensity Continuous Training on Ejection Fraction, Functional Capacity, and Lipid Profiles in Phase II Cardiac Rehabilitation
This randomized controlled trial aims to compare the effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) in patients undergoing Phase II cardiac rehabilitation after coronary artery disease or post-angioplasty. A total of 66 participants will be randomly allocated into two groups: HIIT (n=33) and MICT (n=33). The intervention will be conducted 3 times per week using treadmill-based exercise protocols under heart rate monitoring. Primary outcomes include changes in left ventricular ejection fraction, functional capacity measured by 6-minute walk test, and lipid profile parameters before and after intervention. Secondary assessment includes health-related quality of life (HRQoL). The study aims to determine which exercise modality provides superior cardiovascular and functional improvement in stable cardiac patients during supervised rehabilitation.
Read the detailed description
This randomized controlled trial will compare the effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) in patients undergoing Phase II cardiac rehabilitation after stable coronary artery disease or post-angioplasty. A total of 66 participants will be randomly assigned into two groups.
The HIIT group will perform treadmill-based interval exercise 3 times per week at 85-95% heart rate reserve with active recovery periods, while the MICT group will perform continuous treadmill exercise at 65-75% heart rate reserve for 30-45 minutes.
Primary outcomes include left ventricular ejection fraction (echocardiography), functional capacity (6-minute walk test), and lipid profile (LDL, HDL, triglycerides, total cholesterol) measured before and after intervention. Health-related quality of life (HRQoL) will also be assessed. The study aims to determine which exercise protocol produces greater improvement in cardiac and functional outcomes.
- Conditions
- Coronary Artery Disease
- Being tested
- High-Intensity Interval Training, Moderate-Intensity Continuous Training
- Keywords
- Cardiac Rehabilitation ,High-Intensity Interval Training
- Medical subject headings
- Coronary Artery Disease
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
High-Intensity Interval TrainingBehavioural
Also called HIIT
Participants will perform supervised treadmill-based high-intensity interval training 3 times per week. Each session includes 10 minutes warm-up, 4 intervals of 4 minutes at 85-95% heart rate reserve, 4 minutes active recovery at 50-60% heart rate reserve, followed by 5 minutes cool-down.
Moderate-Intensity Continuous TrainingBehavioural
Also called MICT
Participants will perform supervised treadmill-based continuous exercise 3 times per week at 65-75% heart rate reserve for 30-45 minutes, including warm-up and cool-down periods.
| Study group | Role | What they receive |
|---|---|---|
| High-Intensity Interval Training (HIIT) | Experimental | Participants will perform supervised treadmill-based high-intensity interval training 3 sessions per week, including 10-minute warm-up, 4 intervals of 4 minutes at 85-95% heart rate reserve, 4-minute active recovery at 50-60% heart rate reserve, followed by 5-minute cool-down. Receives: Behavioral: High-Intensity Interval Training |
| Moderate-Intensity Continuous Training (MICT) | Active comparator | Participants will perform supervised treadmill-based continuous exercise 3 sessions per week at 65-75% heart rate reserve for 30-45 minutes, with warm-up and cool-down periods. Receives: Behavioral: Moderate-Intensity Continuous Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Left Ventricular Ejection Fraction
Assessment of left ventricular ejection fraction using echocardiography to determine changes in cardiac function after intervention.
Measured: Baseline and at 12 weeks after intervention
Functional Capacity
Functional capacity will be measured by 6-minute walk test to evaluate distance covered during exercise tolerance assessment
Measured: Baseline and at 12 weeks after intervention
Secondary outcomes (1)
Lipid Profile
Laboratory measurement of total cholesterol, LDL, HDL, and triglycerides to assess metabolic changes after exercise intervention.
Measured: Baseline and at 12 weeks after intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Jun 2026
- Study startJun 2026 (estimated)
- Primary completionAug 2026 (estimated)
- Study completionAug 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Coronary Artery DiseaseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomly assigned into two parallel groups: one group will receive High-Intensity Interval Training (HIIT) and the other group will receive Moderate-Intensity Continuous Training (MICT). Both groups will receive supervised treadmill-based exercise interventions during Phase II cardiac rehabilitation, and outcomes will be compared before and after intervention.
- Masking
- None (open label)
- Enrolment
- 66 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Arjumand Bano, MSPT, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07619664
- Sponsor's protocol ID
- REC/RCR & AHS/25/0320
- Status last verified
- Jun 2026
- First submitted
- 2 Apr 2026
- Last updated
- 2 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 2 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of High-Intensity Interval Training vs Moderate-Intensity Continuous Training on Ejection Fraction, Functional Capacity, and Lipid Profiles in Phase II Cardiac Rehabilitation
- ClinicalTrials.gov ID
- NCT07619664
- Acronym / sponsor ID
- REC/RCR & AHS/25/0320
- Conditions
- Coronary Artery Disease
- Keywords
- Cardiac Rehabilitation ,High-Intensity Interval Training
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 66 participants (estimated)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- Jun 2026 (estimated)
- Primary completion
- Aug 2026 (estimated)
- Study completion
- Aug 2026 (estimated)
- First posted
- 2 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial aims to compare the effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) in patients undergoing Phase II cardiac rehabilitation after coronary artery disease or post-angioplasty. A total of 66 participants will be randomly allocated into two groups: HIIT (n=33) and MICT (n=33). The intervention will be conducted 3 times per week using treadmill-based exercise protocols under heart rate monitoring. Primary outcomes include changes in left ventricular ejection fraction, functional capacity measured by 6-minute walk test, and lipid profile parameters before and after intervention. Secondary assessment includes health-related quality of life (HRQoL). The study aims to determine which exercise modality provides superior cardiovascular and functional improvement in stable cardiac patients during supervised rehabilitation.
Detailed description
This randomized controlled trial will compare the effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) in patients undergoing Phase II cardiac rehabilitation after stable coronary artery disease or post-angioplasty. A total of 66 participants will be randomly assigned into two groups.
The HIIT group will perform treadmill-based interval exercise 3 times per week at 85-95% heart rate reserve with active recovery periods, while the MICT group will perform continuous treadmill exercise at 65-75% heart rate reserve for 30-45 minutes.
Primary outcomes include left ventricular ejection fraction (echocardiography), functional capacity (6-minute walk test), and lipid profile (LDL, HDL, triglycerides, total cholesterol) measured before and after intervention. Health-related quality of life (HRQoL) will also be assessed. The study aims to determine which exercise protocol produces greater improvement in cardiac and functional outcomes.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Participants will be randomly assigned into two parallel groups: one group will receive High-Intensity Interval Training (HIIT) and the other group will receive Moderate-Intensity Continuous Training (MICT). Both groups will receive supervised treadmill-based exercise interventions during Phase II cardiac rehabilitation, and outcomes will be compared before and after intervention.
| Arm | Type | Receives |
|---|---|---|
| High-Intensity Interval Training (HIIT) | Experimental | Behavioral: High-Intensity Interval TrainingParticipants will perform supervised treadmill-based high-intensity interval training 3 sessions per week, including 10-minute warm-up, 4 intervals of 4 minutes at 85-95% heart rate reserve, 4-minute active recovery at 50-60% heart rate reserve, followed by 5-minute cool-down. |
| Moderate-Intensity Continuous Training (MICT) | Active comparator | Behavioral: Moderate-Intensity Continuous TrainingParticipants will perform supervised treadmill-based continuous exercise 3 sessions per week at 65-75% heart rate reserve for 30-45 minutes, with warm-up and cool-down periods. |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Adults aged 18-60 years.
- Diagnosed with stable coronary artery disease confirmed by angiography, stress testing, or echocardiography.
- Left ventricular ejection fraction ≥45%.
- Functional NYHA Class I or II.
- Medically cleared by a cardiologist to participate in exercise (including recent ECG or stress test if necessary).
Key exclusion criteria (7 listed)
- Unstable angina or recent myocardial infarction (within the past 6 weeks).
- Uncontrolled hypertension (systolic BP >180 mmHg or diastolic BP >110 mmHg).
- Severe valvular heart disease, arrhythmias, or left ventricular dysfunction (EF <35%).
- Musculoskeletal disorders (e.g., severe osteoarthritis, recent fractures, or surgeries) preventing safe participation in exercise.
- Neurological disorders affecting mobility or safe exercise (e.g., stroke, Parkinson's disease).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| High-Intensity Interval TrainingAlso: HIITParticipants will perform supervised treadmill-based high-intensity interval training 3 times per week. Each session includes 10 minutes warm-up, 4 intervals of 4 minutes at 85-95% heart rate reserve, 4 minutes active recovery at 50-60% heart rate reserve, followed by 5 minutes cool-down. | Behavioural | High-Intensity Interval Training (HIIT) |
| Moderate-Intensity Continuous TrainingAlso: MICTParticipants will perform supervised treadmill-based continuous exercise 3 times per week at 65-75% heart rate reserve for 30-45 minutes, including warm-up and cool-down periods. | Behavioural | Moderate-Intensity Continuous Training (MICT) |
Primary outcome
Left Ventricular Ejection Fraction
Time frame: Baseline and at 12 weeks after intervention
Assessment of left ventricular ejection fraction using echocardiography to determine changes in cardiac function after intervention.
Functional Capacity
Time frame: Baseline and at 12 weeks after intervention
Functional capacity will be measured by 6-minute walk test to evaluate distance covered during exercise tolerance assessment
1 secondary outcome
Lipid Profile
Time frame: Baseline and at 12 weeks after intervention
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Jun 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Arjumand Bano, MSPT principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing High-Intensity Interval Training and Moderate-Intensity Continuous Training in people with Coronary Artery Disease, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 2 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Muhammad Iqbal Tariq, Phd* (333826752, iqbal.tariq@riphah.edu.pk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Left Ventricular Ejection Fraction (time frame: Baseline and at 12 weeks after intervention). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Jun 2026.