Mental FatigueNCT07620860
Muscular Fatigue vs. Mental Fatigue on Balance, Proprioception and Reaction Time
A study testing Mental Fatigue Protocol, Upper Extremity Fatigue Protocol and Lower Extremity Fatigue Protocol in people with Mental Fatigue and Muscular Fatigue, run by Istinye University at 1 site in Turkey (Türkiye).
Trial summary
This study aims to understand how different types of fatigue affect balance and reaction time, proprioception, and fine motor in healthy young adults. Fatigue is a common experience in daily life and can arise from physical activity or prolonged mental effort. Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Mental Fatigue, Muscular Fatigue
- What is being tested?
- Mental Fatigue Protocol, Upper Extremity Fatigue Protocol and Lower Extremity Fatigue Protocol
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 71 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 11 Nov 2025to 8 Jul 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Being between 18 and 35 years of age
- Self-reporting good general health status
- Not having any physician-diagnosed medical condition
- Not using any assistive device or orthotic insoles
Who cannot join
- History of neurological disorders affecting balance (e.g., stroke, Parkinson's disease, multiple sclerosis, vestibular disorders)
- Current or recent (within the past 6 months) lower extremity or spinal injury
- Current lower extremity pain
- Uncontrolled cardiovascular disease
- Uncorrected visual impairment affecting balance
- Current pregnancy
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Istinye University Research and Application Center (ISUFIZYOTEM)
Istanbul
About this study
Official title: Comparison of the Effects of Extremity Fatigue and Mental Fatigue on Balance, Proprioception and Reaction Time
This study aims to understand how different types of fatigue affect balance and reaction time, proprioception, and fine motor in healthy young adults. Fatigue is a common experience in daily life and can arise from physical activity or prolonged mental effort. The study seeks to determine whether fatigue of the upper body, lower body, or mental fatigue from cognitively demanding tasks can negatively affect balance and reaction time, proprioception, and fine motor abilities.
To examine this, participants will undergo controlled fatigue protocols designed to tire specific parts of the body or the mind. the Upper body fatigue will be induced through repeated maximal push-up sets performed until the participant can no longer maintain proper form. Lower body fatigue will be created through repeated maximal 1-minute squat jump sets, with participants touching a low box to ensure standardized depth and proper movement. Mental fatigue will be induced using a 20-minute computer-based cognitive task that alternates between the 2-back working memory task and the numerical Stroop task. These tasks are designed to require continuous attention, mental effort, and inhibitory control. Each type of fatigue will be induced independently, and participants' performance will be measured before and after each fatigue protocol.
Read more
Following fatigue induction, participants will complete a series of tests designed to assess balance and reaction time, proprioception, and fine motor abilities. This includes both static and dynamic postural tasks, as well as reaction time and proprioceptive accuracy assessments. By evaluating these measures before and after fatigue, the study will determine how different forms of physical and mental fatigue impact postural stability, sensory processing, and precise motor control.
The study addresses the question: "Do upper body fatigue, lower body fatigue, or mental fatigue reduce balance and reaction time, proprioception, and fine motor performance in healthy young adults?" The hypothesis is that each form of fatigue upper body, lower body, or mental-will meaningfully impair balance and reaction time, proprioception, and fine motor performance compared to non-fatigued conditions.
- Conditions
- Mental Fatigue, Muscular Fatigue
- Being tested
- Mental Fatigue Protocol, Upper Extremity Fatigue Protocol, Lower Extremity Fatigue Protocol
- Keywords
- fatigue, reaction time, balance, cognitive
- Medical subject headings
- Mental Fatigue, Fatigue
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Mental Fatigue ProtocolOther
Mental Fatigue will be created by administering a continuous 20-minute computerized cognitive protocol composed of four consecutive 5-minute blocks without rest. The 2-back task (5 minutes) and the numerical Stroop task (5 minutes) will each be performed twice in alternating order. The sustained and repeated working memory and inhibitory control demands are intended to induce progressive cognitive load and mental fatigue.
Upper Extremity Fatigue ProtocolOther
The upper extremity fatigue will be created by requiring participants to perform consecutive sets of push-ups until task failure. Push-ups will be executed according to standardized ACSM guidelines, and repetitions will be recorded. Participants will first complete one maximal set to exhaustion, followed by a 1-minute rest period and a second maximal set. If performance in the second set exceeds 60% of the initial repetition count, additional sets will be performed after 1-minute recovery intervals. This sequence will continue until the participant's performance declines below 60% of the previous set, at which point neuromuscular fatigue will be considered achieved.
Lower Extremity Fatigue ProtocolOther
The lower extremity fatigue will be created by requiring participants to perform repeated 1-minute sets of maximal squat jumps until exhaustion. During each jump, participants will execute countermovement jumps and touch a low box with their hips to ensure standardized depth, under researcher supervision for proper technique. After completing an initial 1-minute maximal set, total jump count will be recorded. Following a 1-minute recovery period, a second 1-minute maximal set will be performed. If performance in the second set exceeds 60% of the first set's total repetitions, additional 1-minute sets will be completed after 1-minute rest intervals. This procedure will continue until jump performance declines below 60% of the previous set, at which point neuromuscular fatigue will be considered achieved.
| Study group | Role | What they receive |
|---|---|---|
| Upper Extremity Fatigue | Experimental | Not described Receives: Other: Upper Extremity Fatigue Protocol |
| Lower Extremity Fatigue | Experimental | Not described Receives: Other: Lower Extremity Fatigue Protocol |
| Mental Fatigue | Experimental | Not described Receives: Other: Mental Fatigue Protocol |
What is being measured
The primary outcome is the main question the study is designed to answer.
Y Balance Test (YBT)
The assessment will be performed using a standard YBT kit, which includes a central stance platform and three measurement tapes extending in the anterior (ANT), posteromedial (PM), and posterolateral (PL) directions.
Participants will stand barefoot on their dominant leg on the central platform. While maintaining balance and keeping the stance foot stationary, they will reach as far as possible in each of the three directions with the contralateral leg to push a reach indicator. To ensure maximum performance, three trials will be conducted for each direction, and the best score (maximum reach distance) will be recorded for analysis.
Measured: Day 1
BlazePod Reaction System for Lower Extremity
Four pods will be arranged in a square configuration at a distance equal to the participant's leg length. Participants stand barefoot in the center on one leg for 30 seconds. They must tap the illuminated pods with their raised foot as quickly as possible without the raised foot touching the ground more than once.
Measured: Day 1
BlazePod Reaction System for Upper Extremity
Four pods will be arranged in a rectangular layout (91 cm long and 30 cm wide), with two pods on each side. The protocol follows the same principles as the lower extremity test. Performance is measured by the total number of "hits" and the average RT between responses.
Measured: Day 1
Secondary outcomes (3)
Ruler Drop Reaction Test
The Ruler Drop Reaction Test will be performed using a standard 30-centimeter ruler to assess simple visual reaction time. The protocol requires the participant to sit parallel to a table with the elbow flexed at 90° and resting on the surface. The dominant hand will be extended, with the thumb and index finger positioned at the 0 cm mark without touching the ruler. The researcher will hold the ruler vertically, aligning the zero point with the top of the participant's thumb and index finger, and release it without warning. The participant will attempt to catch the ruler as quickly as possible. The distance the ruler falls (in centimeters) will be measured from the 0 cm mark to the top of the participant's thumb. Three trials will be conducted for both the dominant and non-dominant hands, and the best performance (shortest distance) will be used for data analysis.
Measured: Day 1
Purdue Pegboard Test (PPT)
The Purdue Pegboard Test (PPT) will be utilized to evaluate fine motor skills and the coordinated movement of the hands, fingers, and arms. Participants will sit comfortably in front of the pegboard to perform four distinct batteries, where the score for each section is determined by the number of items successfully placed or assembled within the allotted time. The first and second sections involve individual pin placement for 30 seconds using the dominant and non-dominant hands respectively; the third section requires simultaneous bimanual pin placement for 30 seconds; and the final section tests the ability to assemble pins, collars, and washers using both hands over a 60-second duration.
Measured: Day 1
Joint Position Sense Test (JPS Test)
To ensure measurement precision, fixed anatomical landmarks-the greater trochanter, the lateral knee joint space, and the lateral malleolus-will be marked. At the start of the test, the participant will be positioned with the knee and hip joints at 90°. The researcher will passively move the participant's leg to a target angle of 45° flexion. After holding this position briefly, the leg will be returned to the starting position. Participants will be blindfolded to eliminate visual feedback. They will then be asked to actively reproduce the target angle. The absolute difference between the target angle and the actively reproduced angle will be recorded as the test score.
Measured: Day 1
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Jun 2026
- Study start11 Nov 2025
- Primary completion8 Jul 2026
- Study completion8 Jul 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Mental FatigueStudies of the same condition, open and under way.
- More trials run by Istinye UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Investigator
- Enrolment
- 71 participants (actual)
Sponsor and investigators
- Lead sponsor
- Istinye University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Çiçek Günday, Istinye University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07620860
- Sponsor's protocol ID
- ISU-25-099
- Status last verified
- Jul 2026
- First submitted
- 31 Mar 2026
- Last updated
- 9 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 9 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of the Effects of Extremity Fatigue and Mental Fatigue on Balance, Proprioception and Reaction Time
- ClinicalTrials.gov ID
- NCT07620860
- Acronym / sponsor ID
- ISU-25-099
- Conditions
- Mental Fatigue, Muscular Fatigue
- Keywords
- fatigue, reaction time, balance, cognitive
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 71 participants (actual)
- Lead sponsor
- Istinye UniversityUniversity, hospital or other
- Study start
- 11 Nov 2025 (actual)
- Primary completion
- 8 Jul 2026 (actual)
- Study completion
- 8 Jul 2026 (actual)
- First posted
- 2 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to understand how different types of fatigue affect balance and reaction time, proprioception, and fine motor in healthy young adults. Fatigue is a common experience in daily life and can arise from physical activity or prolonged mental effort. The study seeks to determine whether fatigue of the upper body, lower body, or mental fatigue from cognitively demanding tasks can negatively affect balance and reaction time, proprioception, and fine motor abilities.
To examine this, participants will undergo controlled fatigue protocols designed to tire specific parts of the body or the mind. the Upper body fatigue will be induced through repeated maximal push-up sets performed until the participant can no longer maintain proper form. Lower body fatigue will be created through repeated maximal 1-minute squat jump sets, with participants touching a low box to ensure standardized depth and proper movement. Mental fatigue will be induced using a 20-minute computer-based cognitive task that alternates between the 2-back working memory task and the numerical Stroop task. These tasks are designed to require continuous attention, mental effort, and inhibitory control. Each type of fatigue will be induced independently, and participants' performance will be measured before and after each fatigue protocol.
Following fatigue induction, participants will complete a series of tests designed to assess balance and reaction time, proprioception, and fine motor abilities. This includes both static and dynamic postural tasks, as well as reaction time and proprioceptive accuracy assessments. By evaluating these measures before and after fatigue, the study will determine how different forms of physical and mental fatigue impact postural stability, sensory processing, and precise motor control.
The study addresses the question: "Do upper body fatigue, lower body fatigue, or mental fatigue reduce balance and reaction time, proprioception, and fine motor performance in healthy young adults?" The hypothesis is that each form of fatigue upper body, lower body, or mental-will meaningfully impair balance and reaction time, proprioception, and fine motor performance compared to non-fatigued conditions.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (investigator)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Upper Extremity Fatigue | Experimental | Other: Upper Extremity Fatigue Protocol |
| Lower Extremity Fatigue | Experimental | Other: Lower Extremity Fatigue Protocol |
| Mental Fatigue | Experimental | Other: Mental Fatigue Protocol |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Being between 18 and 35 years of age
- Self-reporting good general health status
- Not having any physician-diagnosed medical condition
- Not using any assistive device or orthotic insoles
Key exclusion criteria (6 listed)
- History of neurological disorders affecting balance (e.g., stroke, Parkinson's disease, multiple sclerosis, vestibular disorders)
- Current or recent (within the past 6 months) lower extremity or spinal injury
- Current lower extremity pain
- Uncontrolled cardiovascular disease
- Uncorrected visual impairment affecting balance
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Mental Fatigue ProtocolMental Fatigue will be created by administering a continuous 20-minute computerized cognitive protocol composed of four consecutive 5-minute blocks without rest. The 2-back task (5 minutes) and the numerical Stroop task (5 minutes) will each be performed twice in alternating order. The sustained and repeated working memory and inhibitory control demands are intended to induce progressive cognitive load and mental fatigue. | Other | Mental Fatigue |
| Upper Extremity Fatigue ProtocolThe upper extremity fatigue will be created by requiring participants to perform consecutive sets of push-ups until task failure. Push-ups will be executed according to standardized ACSM guidelines, and repetitions will be recorded. Participants will first complete one maximal set to exhaustion, followed by a 1-minute rest period and a second maximal set. If performance in the second set exceeds 60% of the initial repetition count, additional sets will be performed after 1-minute recovery intervals. This sequence will continue until the participant's performance declines below 60% of the previous set, at which point neuromuscular fatigue will be considered achieved. | Other | Upper Extremity Fatigue |
| Lower Extremity Fatigue ProtocolThe lower extremity fatigue will be created by requiring participants to perform repeated 1-minute sets of maximal squat jumps until exhaustion. During each jump, participants will execute countermovement jumps and touch a low box with their hips to ensure standardized depth, under researcher supervision for proper technique. After completing an initial 1-minute maximal set, total jump count will be recorded. Following a 1-minute recovery period, a second 1-minute maximal set will be performed. If performance in the second set exceeds 60% of the first set's total repetitions, additional 1-minute sets will be completed after 1-minute rest intervals. This procedure will continue until jump performance declines below 60% of the previous set, at which point neuromuscular fatigue will be considered achieved. | Other | Lower Extremity Fatigue |
Primary outcome
Y Balance Test (YBT)
Time frame: Day 1
The assessment will be performed using a standard YBT kit, which includes a central stance platform and three measurement tapes extending in the anterior (ANT), posteromedial (PM), and posterolateral (PL) directions. Participants will stand barefoot on their dominant leg on the central platform. While maintaining balance and keeping the stance foot stationary, they will reach as far as possible in each of the three directions with the contralateral leg to push a reach indicator. To ensure maximum performance, three trials will be conducted for each direction, and the best score (maximum reach distance) will be recorded for analysis.
BlazePod Reaction System for Lower Extremity
Time frame: Day 1
Four pods will be arranged in a square configuration at a distance equal to the participant's leg length. Participants stand barefoot in the center on one leg for 30 seconds. They must tap the illuminated pods with their raised foot as quickly as possible without the raised foot touching the ground more than once.
BlazePod Reaction System for Upper Extremity
Time frame: Day 1
Four pods will be arranged in a rectangular layout (91 cm long and 30 cm wide), with two pods on each side. The protocol follows the same principles as the lower extremity test. Performance is measured by the total number of "hits" and the average RT between responses.
3 secondary outcomes
Ruler Drop Reaction Test
Time frame: Day 1
Purdue Pegboard Test (PPT)
Time frame: Day 1
Joint Position Sense Test (JPS Test)
Time frame: Day 1
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Jul 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Mental Fatigue Protocol, Upper Extremity Fatigue Protocol and Lower Extremity Fatigue Protocol in people with Mental Fatigue and Muscular Fatigue, run by Istinye University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 9 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Y Balance Test (YBT) (time frame: Day 1). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Jul 2026.