Dentin HypersensitivityNCT07622043
Effectiveness of Two Different Desensitizing Dental Varnishes
A study testing Fluoride-containing varnish and Fluoride-free varnish in people with Dentin Hypersensitivity and Dentin Desensitizing Agents, run by Ivoclar Vivadent AG at 1 site in Liechtenstein.
Trial summary
Dental varnishes are commonly used to relieve dentin hypersensitivity by forming a protective film that occludes dentinal tubules and reduces fluid flow. This clinical investigation aims to compare the desensitizing effect of a fluoride containing varnish with a fluoride free placebo varnish. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Dentin Hypersensitivity, Dentin Desensitizing Agents
- What is being tested?
- Fluoride-containing varnish and Fluoride-free varnish
- Type of treatment
- Medical device
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 66 participants
- Where
- 1 siteLiechtenstein
- Study dates
- 13 Jul 2026to Aug 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Informed Consent signed by the subject
- Age: 18-65 years
- Hypersensitivity assessment scale ≥ Grade 2 in
- two non-neighboring teeth in different quadrants
- The affected teeth are/have: vital, caries-free, received no restorations within the last month
- No change in medication anticipated over the next 3 months (e.g. due to upcoming surgery etc.)
Who cannot join
- Contraindications and limitations of the MD as described in the instructions for use.
- Known hypersensitivity or allergy to the device material (especially acrylates, mint flavouring)
- Pregnant or other vulnerable subjects
- Participants with severe systemic disease
- Enrolment of employees of the dental clinic of Ivoclar Vivadent AG
- Recent change in medication concerning Analgesics, NSAIDs, psychotropic drugs, other medications that may alter pain perception
Show all 11Show fewer
- Intake of analgesics prior to appointment
- Professional desensitizing therapy in the last 3 months
- Bleaching procedures in the last 4 weeks
- Confounding dental conditions at test sites: defective or extensive restorations, abutment teeth for prostheses, recent restorations, pulpitis/periapical pathology.
- Current or recent use of desensitizing toothpastes or mouthrinses (i.e. products specifically marketed for the treatment of dentin hypersensitivity) within 4 weeks prior to enrolment
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Liechtenstein1 site, 1 recruiting
- Recruiting
Internal Clinic Ivoclar Vivadent AG
Schaan, 9494
Lydia Eberhard, Dr. med. dent., +423 238 6136, Lydia.Eberhard@ivoclar.com
About this study
Official title: Effectiveness of Two Different Desensitizing Dental Varnishes: A Prospective, Randomized Split Mouth Clinical Investigation
Dental varnishes are commonly used to relieve dentin hypersensitivity by forming a protective film that occludes dentinal tubules and reduces fluid flow. This clinical investigation aims to compare the desensitizing effect of a fluoride containing varnish with a fluoride free placebo varnish. Primary and secondary objectives include evaluating short and long term reductions in dentinal hypersensitivity, assessing patient reported outcomes and daily experiences, and monitoring the varnish's tolerability and safety.
- Being tested
- Fluoride-containing varnish, Fluoride-free varnish
- Medical subject headings
- Dentin Sensitivity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Fluoride-containing varnishDevice
A fluoride-containing varnish is applied to a tooth that is hypersensitive.
Fluoride-free varnishDevice
A fluoride-free varnish is applied to a tooth that is hypersensitive.
| Study group | Role | What they receive |
|---|---|---|
| Fluoride-containing varnish | Experimental | A fluoride-containing varnish is applied to a tooth that is hypersensitive. Receives: Device: Fluoride-containing varnish |
| Fluoride-free varnish | Placebo comparator | A fluoride-free varnish is applied to a tooth that is hypersensitive. Receives: Device: Fluoride-free varnish |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change of dentin hypersensitivity
assessed by patient response to an air stimulus using a pain scale (grades 0-4, lower scores mean a better outcome)
Measured: 1 week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Jun 2026
- Study start13 Jul 2026
- Primary completionApr 2027 (estimated)
- Study completionAug 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Dentin HypersensitivityStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- split-mouth design: 2 hypersensitive teeth are treated per participant (test and control treatment in the same patient)
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 66 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ivoclar Vivadent AG
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07622043
- Sponsor's protocol ID
- OTCS 524967700
- Status last verified
- Aug 2026
- First submitted
- 27 May 2026
- Last updated
- 20 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effectiveness of Two Different Desensitizing Dental Varnishes: A Prospective, Randomized Split Mouth Clinical Investigation
- ClinicalTrials.gov ID
- NCT07622043
- Acronym / sponsor ID
- OTCS 524967700
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 66 participants (estimated)
- Lead sponsor
- Ivoclar Vivadent AGIndustry (pharma, biotech, devices)
- Study start
- 13 Jul 2026 (actual)
- Primary completion
- Apr 2027 (estimated)
- Study completion
- Aug 2027 (estimated)
- First posted
- 2 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Dental varnishes are commonly used to relieve dentin hypersensitivity by forming a protective film that occludes dentinal tubules and reduces fluid flow. This clinical investigation aims to compare the desensitizing effect of a fluoride containing varnish with a fluoride free placebo varnish. Primary and secondary objectives include evaluating short and long term reductions in dentinal hypersensitivity, assessing patient reported outcomes and daily experiences, and monitoring the varnish's tolerability and safety.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
- Model description
- split-mouth design: 2 hypersensitive teeth are treated per participant (test and control treatment in the same patient)
| Arm | Type | Receives |
|---|---|---|
| Fluoride-containing varnish | Experimental | Device: Fluoride-containing varnishA fluoride-containing varnish is applied to a tooth that is hypersensitive. |
| Fluoride-free varnish | Placebo comparator | Device: Fluoride-free varnishA fluoride-free varnish is applied to a tooth that is hypersensitive. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Informed Consent signed by the subject
- Age: 18-65 years
- Hypersensitivity assessment scale ≥ Grade 2 in
- two non-neighboring teeth in different quadrants
- The affected teeth are/have: vital, caries-free, received no restorations within the last month
Key exclusion criteria (11 listed)
- Contraindications and limitations of the MD as described in the instructions for use.
- Known hypersensitivity or allergy to the device material (especially acrylates, mint flavouring)
- Pregnant or other vulnerable subjects
- Participants with severe systemic disease
- Enrolment of employees of the dental clinic of Ivoclar Vivadent AG
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Fluoride-containing varnishA fluoride-containing varnish is applied to a tooth that is hypersensitive. | Device | Fluoride-containing varnish |
| Fluoride-free varnishA fluoride-free varnish is applied to a tooth that is hypersensitive. | Device | Fluoride-free varnish |
Primary outcome
Change of dentin hypersensitivity
Time frame: 1 week
assessed by patient response to an air stimulus using a pain scale (grades 0-4, lower scores mean a better outcome)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Aug 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Fluoride-containing varnish and Fluoride-free varnish in people with Dentin Hypersensitivity and Dentin Desensitizing Agents, run by Ivoclar Vivadent AG at 1 site in Liechtenstein.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 20 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Liechtenstein. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change of dentin hypersensitivity (time frame: 1 week). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Aug 2026.