Thyroid CancerPMRT-ThyCaNCT07623005
Progressive Muscle Relaxation for Pain and Quality of Life in Thyroid Cancer
A study testing Progressive Muscle Relaxation Technique and Range of Motion and Stretching Exercises in people with Thyroid Cancer, run by University of Faisalabad at 1 site in Pakistan.
Trial summary
Thyroid cancer patients often experience pain and reduced quality of life during chemotherapy. This randomized controlled trial will evaluate whether Progressive Muscle Relaxation (PMR) exercises, added to routine range-of-motion exercises, reduce pain and improve quality of life compared to range-of-motion exercises… Read more about this study
- Who is it for?
- Ages 30 to 50 years
- Conditions the study is for
- Thyroid Cancer
- What is being tested?
- Progressive Muscle Relaxation Technique and Range of Motion and Stretching Exercises
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 32 participants
- Where
- 1 sitePakistan
- Study dates
- 1 Jan 2026to 15 May 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 50 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Histologically confirmed thyroid cancer (Stage I-III)
- Age 30-50 years
- Moderate pain (NPRS score 3-7)
- Baseline FACT-G score ≥80%
- Undergoing chemotherapy (1-3 sessions completed)
- History of lobectomy or thyroidectomy
- Provided written informed consent
Who cannot join
- Comorbidities (cardiomyopathy, respiratory disorders, severe mental illness)
- Recent fractures or surgeries
- Unable to comprehend or follow instructions
- Currently practicing PMR or any other relaxation therapy
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
The University of Faisalabad
Faisalābad, Punjab Province, 3800
About this study
Official title: Effectiveness of Progressive Muscle Relaxation Technique on Pain and Quality of Life in Thyroid Cancer Patients: A Randomized Controlled Trial
Thyroid cancer patients often experience pain and reduced quality of life during chemotherapy. This randomized controlled trial will evaluate whether Progressive Muscle Relaxation (PMR) exercises, added to routine range-of-motion exercises, reduce pain and improve quality of life compared to range-of-motion exercises alone. Thirty-two thyroid cancer patients randomly assigned to either the PMR group or the control group. Pain measured by using the Numeric Pain Rating Scale (NPRS) and quality of life using the FACT-G questionnaire before and after a 4-5 day intervention. The study compared changes between groups.
Read the detailed description
This is a single-center, parallel-group, randomized controlled trial to be conducted at PINUM Cancer Hospital, Faisalabad, Pakistan. A total of 32 patients with histologically confirmed thyroid cancer (Stage I-III) undergoing chemotherapy (1-3 sessions) will be enrolled. Inclusion criteria: age 30-50 years, moderate pain (NPRS 3-7), baseline FACT-G score ≥80%, history of lobectomy or thyroidectomy. Exclusion criteria: comorbidities (cardiomyopathy, respiratory disorders, severe mental illness), recent fractures or surgeries, inability to follow instructions, current practice of relaxation therapies. Participants will be randomly allocated 1:1 using an online random number generator into two groups. Experimental group (n=16): Progressive Muscle Relaxation Technique (PMRT) once daily for 4-5 consecutive days, each session 20-40 minutes, targeting head/neck, shoulders, arms/hands, lower back/hips, calves/thighs, and feet/toes. Each movement involves deep inhalation, tensing for 10-20 seconds, then exhalation with relaxation. Control group (n=16): gentle range-of-motion and stretching exercises of same frequency and duration. Outcomes: pain (NPRS, 0-10) and quality of life (FACT-G, 4 subscales) measured at baseline and post-intervention. Normality of data assessed by using Shapiro-Wilk test. Between-group comparisons is performed by using Mann-Whitney U test, and within-group pre-post comparisons using Wilcoxon signed-rank test. No adverse events are anticipated. After study completion, results will be submitted separately in the Results Module.
- Conditions
- Thyroid Cancer
- Being tested
- Progressive Muscle Relaxation Technique, Range of Motion and Stretching Exercises
- Keywords
- Progressive Muscle Relaxation, Pain, Quality of Life
- Medical subject headings
- Thyroid Neoplasms, Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Progressive Muscle Relaxation TechniqueBehavioural
Participants were guided through sequential tensing and relaxing of six muscle groups: head/neck, shoulders/upper back, arms/hands, lower back/hips, calves/thighs, and feet/toes. For each group, they inhaled deeply and tensed muscles for 10-20 seconds, then exhaled slowly while relaxing completely. Each session lasted 20-40 minutes, once daily for 4-5 consecutive days. Sessions were conducted by a trained physiotherapist in a quiet hospital room.
Range of Motion and Stretching ExercisesOther
Participants performed gentle range-of-motion (ROM) and stretching exercises for the same muscle groups (head/neck, shoulders, arms, lower back, legs, feet), without the tensing-relaxation component of PMR. Each session lasted 20-40 minutes, once daily for 4-5 consecutive days, supervised by the same physiotherapist.
| Study group | Role | What they receive |
|---|---|---|
| PMR + ROM | Experimental | Participants received once-daily Progressive Muscle Relaxation Technique (PMRT) plus range-of-motion (ROM) exercises for 4-5 consecutive days, 20-40 minutes per session. Receives: Behavioral: Progressive Muscle Relaxation Technique; Other: Range of Motion and Stretching Exercises |
| ROM | Active comparator | Participants received only gentle range-of-motion (ROM) and stretching exercises, once daily for 4-5 consecutive days, 20-40 minutes per session. Receives: Other: Range of Motion and Stretching Exercises |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Pain Intensity
Pain intensity measured using the Numeric Pain Rating Scale (NPRS), an 11-point scale from 0 (no pain) to 10 (worst possible pain). Higher scores indicate worse pain.
Measured: Baseline (day 1) and post-intervention (day 4-5)
Change in Quality of Life
Quality of life measured using the Functional Assessment of Cancer Therapy - General (FACT-G), a 27-item questionnaire covering physical, social/family, emotional, and functional well-being. Higher scores indicate better quality of life.
Measured: Baseline (day 1) and post-intervention (day 4-5)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Jun 2026
- Study start1 Jan 2026
- Primary completion1 Apr 2026
- Study completion15 May 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Thyroid CancerStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 32 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Faisalabad
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Dr. Marium Zafar, University of Faisalabad
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07623005
- Sponsor's protocol ID
- TUF/EIRB/ 206 /26
- Acronym
- PMRT-ThyCa
- Status last verified
- May 2026
- First submitted
- 23 May 2026
- Last updated
- 3 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 3 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effectiveness of Progressive Muscle Relaxation Technique on Pain and Quality of Life in Thyroid Cancer Patients: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07623005
- Acronym / sponsor ID
- PMRT-ThyCa / TUF/EIRB/ 206 /26
- Conditions
- Thyroid Cancer
- Keywords
- Progressive Muscle Relaxation, Pain, Quality of Life
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 32 participants (actual)
- Lead sponsor
- University of FaisalabadUniversity, hospital or other
- Study start
- 1 Jan 2026 (actual)
- Primary completion
- 1 Apr 2026 (actual)
- Study completion
- 15 May 2026 (actual)
- First posted
- 3 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Thyroid cancer patients often experience pain and reduced quality of life during chemotherapy. This randomized controlled trial will evaluate whether Progressive Muscle Relaxation (PMR) exercises, added to routine range-of-motion exercises, reduce pain and improve quality of life compared to range-of-motion exercises alone. Thirty-two thyroid cancer patients randomly assigned to either the PMR group or the control group. Pain measured by using the Numeric Pain Rating Scale (NPRS) and quality of life using the FACT-G questionnaire before and after a 4-5 day intervention. The study compared changes between groups.
Detailed description
This is a single-center, parallel-group, randomized controlled trial to be conducted at PINUM Cancer Hospital, Faisalabad, Pakistan. A total of 32 patients with histologically confirmed thyroid cancer (Stage I-III) undergoing chemotherapy (1-3 sessions) will be enrolled. Inclusion criteria: age 30-50 years, moderate pain (NPRS 3-7), baseline FACT-G score ≥80%, history of lobectomy or thyroidectomy. Exclusion criteria: comorbidities (cardiomyopathy, respiratory disorders, severe mental illness), recent fractures or surgeries, inability to follow instructions, current practice of relaxation therapies. Participants will be randomly allocated 1:1 using an online random number generator into two groups. Experimental group (n=16): Progressive Muscle Relaxation Technique (PMRT) once daily for 4-5 consecutive days, each session 20-40 minutes, targeting head/neck, shoulders, arms/hands, lower back/hips, calves/thighs, and feet/toes. Each movement involves deep inhalation, tensing for 10-20 seconds, then exhalation with relaxation. Control group (n=16): gentle range-of-motion and stretching exercises of same frequency and duration. Outcomes: pain (NPRS, 0-10) and quality of life (FACT-G, 4 subscales) measured at baseline and post-intervention. Normality of data assessed by using Shapiro-Wilk test. Between-group comparisons is performed by using Mann-Whitney U test, and within-group pre-post comparisons using Wilcoxon signed-rank test. No adverse events are anticipated. After study completion, results will be submitted separately in the Results Module.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| PMR + ROM | Experimental | Behavioral: Progressive Muscle Relaxation Technique, Other: Range of Motion and Stretching ExercisesParticipants received once-daily Progressive Muscle Relaxation Technique (PMRT) plus range-of-motion (ROM) exercises for 4-5 consecutive days, 20-40 minutes per session. |
| ROM | Active comparator | Other: Range of Motion and Stretching ExercisesParticipants received only gentle range-of-motion (ROM) and stretching exercises, once daily for 4-5 consecutive days, 20-40 minutes per session. |
Who may qualify
- Ages
- 30 to 50 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (7 listed)
- Histologically confirmed thyroid cancer (Stage I-III)
- Age 30-50 years
- Moderate pain (NPRS score 3-7)
- Baseline FACT-G score ≥80%
- Undergoing chemotherapy (1-3 sessions completed)
Key exclusion criteria (4 listed)
- Comorbidities (cardiomyopathy, respiratory disorders, severe mental illness)
- Recent fractures or surgeries
- Unable to comprehend or follow instructions
- Currently practicing PMR or any other relaxation therapy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Progressive Muscle Relaxation TechniqueParticipants were guided through sequential tensing and relaxing of six muscle groups: head/neck, shoulders/upper back, arms/hands, lower back/hips, calves/thighs, and feet/toes. For each group, they inhaled deeply and tensed muscles for 10-20 seconds, then exhaled slowly while relaxing completely. Each session lasted 20-40 minutes, once daily for 4-5 consecutive days. Sessions were conducted by a trained physiotherapist in a quiet hospital room. | Behavioural | PMR + ROM |
| Range of Motion and Stretching ExercisesParticipants performed gentle range-of-motion (ROM) and stretching exercises for the same muscle groups (head/neck, shoulders, arms, lower back, legs, feet), without the tensing-relaxation component of PMR. Each session lasted 20-40 minutes, once daily for 4-5 consecutive days, supervised by the same physiotherapist. | Other | PMR + ROM, ROM |
Primary outcome
Change in Pain Intensity
Time frame: Baseline (day 1) and post-intervention (day 4-5)
Pain intensity measured using the Numeric Pain Rating Scale (NPRS), an 11-point scale from 0 (no pain) to 10 (worst possible pain). Higher scores indicate worse pain.
Change in Quality of Life
Time frame: Baseline (day 1) and post-intervention (day 4-5)
Quality of life measured using the Functional Assessment of Cancer Therapy - General (FACT-G), a 27-item questionnaire covering physical, social/family, emotional, and functional well-being. Higher scores indicate better quality of life.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Jun 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Progressive Muscle Relaxation Technique and Range of Motion and Stretching Exercises in people with Thyroid Cancer, run by University of Faisalabad at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Pain Intensity (time frame: Baseline (day 1) and post-intervention (day 4-5)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Jun 2026.