Dental ImplantEarly Bone LosNCT07625813
Early Bone Loss in Dental Implants
An observational study of Dental Implant and Marginal Bone Loss, run by Abant Izzet Baysal University at 1 site in Turkey (Türkiye).
Trial summary
This retrospective observational study aims to evaluate early marginal bone loss around dental implants using panoramic radiographs. Radiographic records of patients who underwent mandibular dental implant surgery and implant-supported prosthetic rehabilitation will be reviewed. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Dental Implant, Marginal Bone Loss
- How many people
- 256 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 Jan 2025to 15 Feb 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: The study population will consist of adult systemically healthy patients who underwent mandibular dental implant surgery and implant-supported prosthetic rehabilitation at Bolu Abant Izzet Baysal University Faculty of Dentistry between 2012 and 2025 and had suitable panoramic radiographs available for retrospective radiographic evaluation of marginal bone loss.
Who may be able to join
- Individuals older than 18 years
- Patients with mandibular dental implants
- Availability of panoramic radiographs obtained after implant surgery and after prosthetic loading
- Panoramic radiographs suitable for radiographic evaluation
- Visibility of the mandibular inferior cortex and mental foramen on panoramic radiographs
- Systemically healthy individuals
Who cannot join
- Low-quality panoramic radiographs
- Missing follow-up radiographs
- Presence of systemic diseases or conditions that may affect bone metabolism
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Faculty of Dentistry, Bolu Abant İzzet Baysal University, Department of Periodontics
Bolu, Central, 14100
About this study
Official title: Retrospective Evaluation of Early Bone Loss in Dental Implants
This retrospective observational study aims to evaluate early marginal bone loss around dental implants using panoramic radiographs. Radiographic records of patients who underwent mandibular dental implant surgery and implant-supported prosthetic rehabilitation will be reviewed. Marginal bone loss will be measured on the mesial and distal aspects of each implant at final restoration delivery and at follow-up periods after prosthetic loading. The study will also assess patient-, implant-, and prosthesis-related factors associated with marginal bone loss.
- Conditions
- Dental Implant, Marginal Bone Loss
- Keywords
- Dental implants, Early bone loss, Marginal bone loss, Peri-implant bone loss, Implant-supported prosthesis
- Medical subject headings
- Bone Diseases, Metabolic
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Dental Implant Patients | Patients with mandibular dental implants who had suitable panoramic radiographs for retrospective evaluation of marginal bone loss. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Marginal Bone Loss Over Time
Marginal bone loss will be assessed on panoramic radiographs by measuring the linear distance from the implant platform to the nearest supporting crestal bone on the mesial and distal aspects of each implant. Mesial, distal, and mean marginal bone loss values will be recorded in millimeters.
Measured: At final restoration delivery, 6 months, 18 months, and 60 months after prosthetic loading
Secondary outcomes (9)
Effect of implant length on mean marginal bone loss
The effect of implant length on mean marginal bone loss will be evaluated using regression analysis. Implant length will be recorded in millimeters from patient records and implant system information. Mean marginal bone loss will be calculated by averaging mesial and distal marginal bone loss measurements for each implant.
Measured: Up to 60 months after prosthetic loading
Effect of implant diameter on mean marginal bone loss
The effect of implant diameter on mean marginal bone loss will be evaluated using regression analysis. Implant diameter will be recorded in millimeters from patient records and implant system information. Mean marginal bone loss will be calculated by averaging mesial and distal marginal bone loss measurements for each implant.
Measured: Up to 60 months after prosthetic loading.
Effect of abutment height on mean marginal bone loss
The effect of abutment height on mean marginal bone loss will be evaluated using regression analysis. Abutment height will be recorded in millimeters from prosthetic records. Mean marginal bone loss will be calculated by averaging mesial and distal marginal bone loss measurements for each implant.
Measured: Up to 60 months after prosthetic loading.
Effect of implant-tooth distance on mean marginal bone loss
The effect of implant-tooth distance on mean marginal bone loss will be evaluated using regression analysis. Implant-tooth distance will be measured on panoramic radiographs as the horizontal distance between the implant and the adjacent natural tooth when applicable. Mean marginal bone loss will be calculated by averaging mesial and distal marginal bone loss measurements for each implant.
Measured: Up to 60 months after prosthetic loading.
Effect of implant-implant distance on mean marginal bone loss
The effect of implant-implant distance on mean marginal bone loss will be evaluated using regression analysis. Implant-implant distance will be measured on panoramic radiographs as the horizontal distance between adjacent implants when applicable. Mean marginal bone loss will be calculated by averaging mesial and distal marginal bone loss measurements for each implant.
Measured: Up to 60 months after prosthetic loading.
Effect of emergence profile angle on mean marginal bone loss
The effect of emergence profile angle on mean marginal bone loss will be evaluated using regression analysis. Emergence profile angle will be recorded in degrees when applicable. Mean marginal bone loss will be calculated by averaging mesial and distal marginal bone loss measurements for each implant.
Measured: Up to 60 months after prosthetic loading.
Mean marginal bone loss according to implant placement level
Mean marginal bone loss will be compared according to implant placement level. Implant placement level will be categorized as crestal, subcrestal, or supracrestal according to the vertical position of the implant platform relative to the crestal bone level. Mean marginal bone loss will be calculated by averaging mesial and distal marginal bone loss measurements for each implant.
Measured: Up to 60 months after prosthetic loading.
Mean marginal bone loss according to prosthetic restoration type
Mean marginal bone loss will be compared according to prosthetic restoration type. Prosthetic restoration type will be categorized according to the type of implant-supported prosthetic rehabilitation, including single crown, fixed partial prosthesis, splinted crowns, full-arch fixed restoration, or removable prosthesis. Mean marginal bone loss will be calculated by averaging mesial and distal marginal bone loss measurements for each implant.
Measured: Up to 60 months after prosthetic loading.
Mean marginal bone loss according to opposing arch condition
Mean marginal bone loss will be compared according to opposing arch condition. Opposing arch condition will be categorized according to the dentition or prosthetic status of the opposing arch. Mean marginal bone loss will be calculated by averaging mesial and distal marginal bone loss measurements for each implant.
Measured: Up to 60 months after prosthetic loading.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Jun 2026
- Study start15 Jan 2025
- Primary completion15 Jan 2026
- Study completion15 Feb 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Dental ImplantStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 256 participants (actual)
Sponsor and investigators
- Lead sponsor
- Abant Izzet Baysal University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Zeynep AKGÜL, Abant Izzet Baysal University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07625813
- Sponsor's protocol ID
- BAİBU-Perio-ZA-03
- Acronym
- Early Bone Los
- Status last verified
- Jun 2026
- First submitted
- 23 May 2026
- Last updated
- 4 Jun 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 4 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Retrospective Evaluation of Early Bone Loss in Dental Implants
- ClinicalTrials.gov ID
- NCT07625813
- Acronym / sponsor ID
- Early Bone Los / BAİBU-Perio-ZA-03
- Conditions
- Dental Implant, Marginal Bone Loss
- Keywords
- Dental implants, Early bone loss, Marginal bone loss, Peri-implant bone loss, Implant-supported prosthesis
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 256 participants (actual)
- Lead sponsor
- Abant Izzet Baysal UniversityUniversity, hospital or other
- Study start
- 15 Jan 2025 (actual)
- Primary completion
- 15 Jan 2026 (actual)
- Study completion
- 15 Feb 2026 (actual)
- First posted
- 4 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This retrospective observational study aims to evaluate early marginal bone loss around dental implants using panoramic radiographs. Radiographic records of patients who underwent mandibular dental implant surgery and implant-supported prosthetic rehabilitation will be reviewed. Marginal bone loss will be measured on the mesial and distal aspects of each implant at final restoration delivery and at follow-up periods after prosthetic loading. The study will also assess patient-, implant-, and prosthesis-related factors associated with marginal bone loss.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Dental Implant Patients | – | –Patients with mandibular dental implants who had suitable panoramic radiographs for retrospective evaluation of marginal bone loss. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- The study population will consist of adult systemically healthy patients who underwent mandibular dental implant surgery and implant-supported prosthetic rehabilitation at Bolu Abant Izzet Baysal University Faculty of Dentistry between 2012 and 2025 and had suitable panoramic radiographs available for retrospective radiographic evaluation of marginal bone loss.
Key inclusion criteria (6 listed)
- Individuals older than 18 years
- Patients with mandibular dental implants
- Availability of panoramic radiographs obtained after implant surgery and after prosthetic loading
- Panoramic radiographs suitable for radiographic evaluation
- Visibility of the mandibular inferior cortex and mental foramen on panoramic radiographs
Key exclusion criteria (3 listed)
- Low-quality panoramic radiographs
- Missing follow-up radiographs
- Presence of systemic diseases or conditions that may affect bone metabolism
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Change in Marginal Bone Loss Over Time
Time frame: At final restoration delivery, 6 months, 18 months, and 60 months after prosthetic loading
Marginal bone loss will be assessed on panoramic radiographs by measuring the linear distance from the implant platform to the nearest supporting crestal bone on the mesial and distal aspects of each implant. Mesial, distal, and mean marginal bone loss values will be recorded in millimeters.
9 secondary outcomes
Effect of implant length on mean marginal bone loss
Time frame: Up to 60 months after prosthetic loading
Effect of implant diameter on mean marginal bone loss
Time frame: Up to 60 months after prosthetic loading.
Effect of abutment height on mean marginal bone loss
Time frame: Up to 60 months after prosthetic loading.
Effect of implant-tooth distance on mean marginal bone loss
Time frame: Up to 60 months after prosthetic loading.
Effect of implant-implant distance on mean marginal bone loss
Time frame: Up to 60 months after prosthetic loading.
Effect of emergence profile angle on mean marginal bone loss
Time frame: Up to 60 months after prosthetic loading.
Mean marginal bone loss according to implant placement level
Time frame: Up to 60 months after prosthetic loading.
Mean marginal bone loss according to prosthetic restoration type
Time frame: Up to 60 months after prosthetic loading.
Mean marginal bone loss according to opposing arch condition
Time frame: Up to 60 months after prosthetic loading.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Jun 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Dental Implant and Marginal Bone Loss, run by Abant Izzet Baysal University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 4 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Marginal Bone Loss Over Time (time frame: At final restoration delivery, 6 months, 18 months, and 60 months after prosthetic loading). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Jun 2026.