Chronic Post-surgical PainCROPSNCT07629453
CROPS Study: Chronification of Post-Surgical Pain and Risk Assessment
A study testing Standard Multimodal Opioid-Based Analgesia and Regional Anesthesia-Based Analgesia in people with Chronic Post-surgical Pain and Acute Postoperative Pain, run by Kočan Ladislav.
Trial summary
Chronic post-surgical pain (CPSP) represents a major clinical problem associated with impaired functional recovery, reduced quality of life, prolonged opioid use, and increased healthcare utilization. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Chronic Post-surgical Pain, Acute Postoperative Pain, Cardiac Surgery
- What is being tested?
- Standard Multimodal Opioid-Based Analgesia and Regional Anesthesia-Based Analgesia
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 180 participants
- Where
- No sites listed yet
- Study dates
- 1 Sep 2026to 1 Jun 2029
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age ≥18 years
- Elective cardiac surgery requiring median sternotomy, including:
- coronary artery bypass grafting (CABG)
- aortic valve replacement or repair
- mitral valve replacement or repair
- ascending aorta surgery
Show all 10Show fewer
- Ability to understand study information
- Ability to provide written informed consent
- Expected postoperative hospital stay longer than 3 days
- Availability for follow-up at 1 week and 3 months after surgery
Who cannot join
- Emergency surgery
- Cognitive impairment preventing study participation
- Serious psychiatric illness interfering with study participation
- Language barrier preventing questionnaire completion
- Participation in another interventional study affecting pain outcomes
- Reoperation for postoperative bleeding
Show all 11Show fewer
- Severe chronic renal failure
- Allergy or contraindication to study medication or regional anesthesia techniques
- Pregnancy or breastfeeding
- Chronic opioid therapy exceeding 60 mg morphine equivalents daily
- Extensive emergency aortic surgery (e.g., Thoraflex implantation for acute aortic dissection)
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
Peter Kostič, MD PhD contact
About this study
Official title: Chronification of Post-Surgical Pain and Validation of a Novel Risk Assessment Tool: A Prospective Multicenter Randomized Controlled Trial
Chronic post-surgical pain (CPSP) represents a major clinical problem associated with impaired functional recovery, reduced quality of life, prolonged opioid use, and increased healthcare utilization. The mechanisms underlying pain chronification are multifactorial and involve complex interactions among surgical trauma, inflammatory responses, central sensitization, neuroimmune activation, and psychosocial risk factors.
The CROPS study (Chronification of Post-Surgical Pain and Risk Assessment) is a prospective multicenter randomized controlled trial designed to evaluate the impact of perioperative analgesic strategies on the development of chronic post-surgical pain and to validate a novel questionnaire-based pain chronification risk assessment tool in adult patients undergoing cardiac surgery.
Read more
Participants will be randomized to receive either standard multimodal opioid-based perioperative analgesia or regional anesthesia-based perioperative analgesia incorporating chest wall plane block techniques, including erector spinae plane block, paravertebral block, or PECS block, according to institutional practice.
The study will compare postoperative pain intensity, opioid consumption, postoperative recovery, postoperative complications, health-related quality of life, and the incidence of chronic post-surgical pain at 3 months after surgery. In parallel, the predictive performance of the pain chronification risk assessment questionnaire will be evaluated using discrimination and calibration analyses.
The study is conducted as an investigator-initiated academic collaboration between the East Slovakia Institute of Cardiovascular Diseases, Košice, Slovakia, and Uppsala University Hospital, Uppsala, Sweden.
Read the detailed description
Chronic post-surgical pain (CPSP) is a common and clinically significant complication following cardiac surgery and is associated with impaired functional recovery, reduced quality of life, prolonged opioid exposure, and increased healthcare utilization. Despite substantial advances in perioperative care, a considerable proportion of patients continue to experience persistent pain for months after surgery. The pathophysiology of CPSP is multifactorial and involves complex interactions among surgical tissue injury, peripheral and central sensitization, neuroinflammatory activation, altered pain modulation pathways, and psychosocial vulnerability factors.
Optimization of perioperative analgesia has been proposed as a strategy to reduce nociceptive input, attenuate perioperative stress responses, and potentially decrease the risk of pain chronification. Regional anesthesia techniques, particularly chest wall plane blocks, have demonstrated beneficial effects on acute postoperative pain control and opioid-sparing outcomes in cardiac surgery. However, their influence on long-term pain outcomes and the development of CPSP remains incompletely understood.
The CROPS study (Chronification of Post-Surgical Pain and Risk Assessment) is a prospective multicenter randomized controlled trial designed to evaluate the impact of perioperative analgesic strategies on postoperative recovery and chronic pain development in adult patients undergoing cardiac surgery. Participants will be randomized to receive either standard multimodal opioid-based perioperative analgesia or regional anesthesia-based perioperative analgesia incorporating chest wall plane block techniques, including erector spinae plane block, paravertebral block, or PECS block, according to institutional practice.
The study will compare postoperative pain intensity, opioid consumption, postoperative recovery parameters, postoperative complications, health-related quality of life, and the incidence of chronic post-surgical pain at 3 months after surgery. Particular emphasis will be placed on evaluating whether regional anesthesia-based analgesic strategies reduce perioperative opioid exposure and improve both short-term and long-term patient-centered outcomes.
In parallel, the study aims to validate a novel questionnaire-based pain chronification risk assessment tool intended to identify patients at increased risk of developing CPSP. Predictive performance of the questionnaire will be evaluated using receiver operating characteristic (ROC) analysis, including assessment of area under the curve (AUC), sensitivity, specificity, discrimination, and calibration performance.
The primary outcome measures are the incidence of chronic post-surgical pain at 3 months following surgery and the predictive accuracy of the pain chronification risk assessment questionnaire. Secondary outcomes include postoperative pain intensity, perioperative opioid consumption expressed as morphine milligram equivalents, postoperative nausea and vomiting, postoperative recovery parameters, respiratory complications, duration of mechanical ventilation, intensive care unit length of stay, hospital length of stay, postoperative complications, in-hospital mortality, and changes in quality-of-life and pain-related functional outcome measures.
The study is conducted as an investigator-initiated multicenter academic collaboration between the East Slovakia Institute of Cardiovascular Diseases, Košice, Slovakia, and Uppsala University Hospital, Uppsala, Sweden.
- Being tested
- Standard Multimodal Opioid-Based Analgesia, Regional Anesthesia-Based Analgesia
- Keywords
- chronic post-surgical pain, cardiac surgery, regional anesthesia, postoperative analgesia
- Medical subject headings
- Pain, Postoperative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Standard Multimodal Opioid-Based AnalgesiaProcedure or surgery
Standard perioperative pain management including opioid-based multimodal analgesia administered according to institutional cardiac surgery protocols.
Regional Anesthesia-Based AnalgesiaProcedure or surgery
Regional anesthesia-based perioperative analgesia including chest wall plane block techniques such as erector spinae plane block, PECS block, or paravertebral block in combination with multimodal analgesia during cardiac surgery.
| Study group | Role | What they receive |
|---|---|---|
| Standard Multimodal Opioid-Based Analgesia | Active comparator | Participants will receive standard multimodal opioid-based perioperative analgesia according to institutional cardiac surgery pain management protocols. Receives: Procedure: Standard Multimodal Opioid-Based Analgesia |
| Regional Anesthesia-Based Analgesia | Experimental | Participants will receive regional anesthesia-based perioperative analgesia including chest wall plane block techniques in combination with multimodal analgesia during cardiac surgery. Receives: Procedure: Regional Anesthesia-Based Analgesia |
What is being measured
The primary outcome is the main question the study is designed to answer.
Incidence of Chronic Post-Surgical Pain at 3 Months
Presence of chronic post-surgical pain assessed 3 months after surgery using the Brief Pain Inventory questionnaire and pain intensity evaluation.
Measured: 3 months after surgery
Secondary outcomes (12)
Postoperative Pain Intensity
Postoperative pain intensity assessed using the Visual Analogue Scale (VAS) ranging from 0 (no pain) to 10 (worst imaginable pain), assessed four times daily during the first postoperative week.
Measured: Postoperative days 1-7
Perioperative Opioid Consumption
Total perioperative and postoperative opioid consumption expressed as morphine milligram equivalents (MME).
Measured: Postoperative days 1-7
Brief Pain Inventory Score Changes
Changes in Brief Pain Inventory (BPI) questionnaire scores ranging from 0 to 10, where higher scores indicate worse pain severity and pain interference, assessed between baseline, postoperative week 1, and 3-month follow-up.
Measured: Baseline, 1 week, and 3 months after surgery
Validation of Pain Chronification Risk Assessment Questionnaire
Predictive performance of the questionnaire for chronic post-surgical pain development assessed using ROC analysis, sensitivity, and specificity.
Measured: Baseline assessment with 3-month follow-up
Quality of Life Assessment
Quality of life evaluated using the EuroQol 5-Dimension 5-Level questionnaire (EQ-5D-5L) and EQ Visual Analogue Scale (EQ-VAS), where higher scores indicate better health status.
Measured: Baseline and 3 months after surgery
Perioperative Vasopressor Requirement
Requirement for perioperative vasopressor support assessed by norepinephrine administration duration and cumulative dose during surgery and intensive care unit stay.
Measured: From surgery until postoperative day 7
Cardiopulmonary Bypass and Surgical Parameters
Operative and cardiopulmonary bypass parameters including duration of surgery, cardiopulmonary bypass time, and aortic cross-clamp time.
Measured: Intraoperative period
Duration of Mechanical Ventilation
Duration of postoperative mechanical ventilation measured in hours from ICU admission until successful extubation.
Measured: Postoperative period through day 7
Intensive Care Unit Length of Stay
Length of stay in the intensive care unit measured in days.
Measured: Up to 30 days after surgery
Hospital Length of Stay
Total postoperative hospital length of stay measured in days.
Measured: Up to 30 days after surgery
Postoperative Complications
Number of participants experiencing postoperative complications including respiratory, cardiovascular, neurological, infectious, or surgical complications.
Measured: Up to 30 days after surgery
In-Hospital Mortality
Number of participants who die during the index hospitalization.
Measured: Up to 30 days after surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Jun 2026
- Study start1 Sep 2026 (estimated)
- Primary completion1 Dec 2028 (estimated)
- Study completion1 Jun 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Chronic Post-surgical PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants undergoing elective cardiac surgery will be randomized in a parallel assignment design to receive either conventional multimodal opioid-based perioperative analgesia or regional anesthesia-based chest wall plane block techniques as part of perioperative pain management.
- Masking
- None (open label)
- Enrolment
- 180 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Kočan Ladislav
- Sponsor type
- University, hospital or other
- Collaborators
- East Slovakia Institute of Cardiovascular Diseases in Košice, Slovakia, Uppsala University Hospital
- Responsible party
- Sponsor-investigator, Kočan Ladislav, Pavol Jozef Safarik University
- Investigators
- Peter Kostic, MD, PhD, Study chair, Department of Heart and Lung Diseases, Unit for Cardiothoracic Surgery, Anesthesia and Intensive Care, Uppsala University Hospital, 751 85 Uppsala, Sweden
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07629453
- Sponsor's protocol ID
- CROPS-INT-RCT-2026
- Acronym
- CROPS
- Status last verified
- Jun 2026
- First submitted
- 17 May 2026
- Last updated
- 5 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data sharing has not yet been determined. Data sharing policies will be evaluated after study completion in accordance with institutional regulations, ethical approvals, and patient privacy requirements.
Publications
Martuliak I, Golubnitschaja O, Chvala L, Kapalla M, Ferencik M, Bubeliny M, Venglarcik M, Kocan L. Pain chronification risk assessment: advanced phenotyping and scoring for prediction and treatments tailored to individualized patient profile. EPMA J. 2024 Nov 15;15(4):739-750. doi: 10.1007/s13167-024-00383-3. eCollection 2024 Dec.
PubMed 39635026
Study at a glance
From the registry record, last updated by the sponsor on 5 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Chronification of Post-Surgical Pain and Validation of a Novel Risk Assessment Tool: A Prospective Multicenter Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07629453
- Acronym / sponsor ID
- CROPS / CROPS-INT-RCT-2026
- Keywords
- chronic post-surgical pain, cardiac surgery, regional anesthesia, postoperative analgesia
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 180 participants (estimated)
- Lead sponsor
- Kočan LadislavUniversity, hospital or other
- Collaborators
- East Slovakia Institute of Cardiovascular Diseases in Košice, Slovakia, Uppsala University Hospital
- Study start
- 1 Sep 2026 (estimated)
- Primary completion
- 1 Dec 2028 (estimated)
- Study completion
- 1 Jun 2029 (estimated)
- First posted
- 5 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Chronic post-surgical pain (CPSP) represents a major clinical problem associated with impaired functional recovery, reduced quality of life, prolonged opioid use, and increased healthcare utilization. The mechanisms underlying pain chronification are multifactorial and involve complex interactions among surgical trauma, inflammatory responses, central sensitization, neuroimmune activation, and psychosocial risk factors.
The CROPS study (Chronification of Post-Surgical Pain and Risk Assessment) is a prospective multicenter randomized controlled trial designed to evaluate the impact of perioperative analgesic strategies on the development of chronic post-surgical pain and to validate a novel questionnaire-based pain chronification risk assessment tool in adult patients undergoing cardiac surgery.
Participants will be randomized to receive either standard multimodal opioid-based perioperative analgesia or regional anesthesia-based perioperative analgesia incorporating chest wall plane block techniques, including erector spinae plane block, paravertebral block, or PECS block, according to institutional practice.
The study will compare postoperative pain intensity, opioid consumption, postoperative recovery, postoperative complications, health-related quality of life, and the incidence of chronic post-surgical pain at 3 months after surgery. In parallel, the predictive performance of the pain chronification risk assessment questionnaire will be evaluated using discrimination and calibration analyses.
The study is conducted as an investigator-initiated academic collaboration between the East Slovakia Institute of Cardiovascular Diseases, Košice, Slovakia, and Uppsala University Hospital, Uppsala, Sweden.
Detailed description
Chronic post-surgical pain (CPSP) is a common and clinically significant complication following cardiac surgery and is associated with impaired functional recovery, reduced quality of life, prolonged opioid exposure, and increased healthcare utilization. Despite substantial advances in perioperative care, a considerable proportion of patients continue to experience persistent pain for months after surgery. The pathophysiology of CPSP is multifactorial and involves complex interactions among surgical tissue injury, peripheral and central sensitization, neuroinflammatory activation, altered pain modulation pathways, and psychosocial vulnerability factors.
Optimization of perioperative analgesia has been proposed as a strategy to reduce nociceptive input, attenuate perioperative stress responses, and potentially decrease the risk of pain chronification. Regional anesthesia techniques, particularly chest wall plane blocks, have demonstrated beneficial effects on acute postoperative pain control and opioid-sparing outcomes in cardiac surgery. However, their influence on long-term pain outcomes and the development of CPSP remains incompletely understood.
The CROPS study (Chronification of Post-Surgical Pain and Risk Assessment) is a prospective multicenter randomized controlled trial designed to evaluate the impact of perioperative analgesic strategies on postoperative recovery and chronic pain development in adult patients undergoing cardiac surgery. Participants will be randomized to receive either standard multimodal opioid-based perioperative analgesia or regional anesthesia-based perioperative analgesia incorporating chest wall plane block techniques, including erector spinae plane block, paravertebral block, or PECS block, according to institutional practice.
The study will compare postoperative pain intensity, opioid consumption, postoperative recovery parameters, postoperative complications, health-related quality of life, and the incidence of chronic post-surgical pain at 3 months after surgery. Particular emphasis will be placed on evaluating whether regional anesthesia-based analgesic strategies reduce perioperative opioid exposure and improve both short-term and long-term patient-centered outcomes.
In parallel, the study aims to validate a novel questionnaire-based pain chronification risk assessment tool intended to identify patients at increased risk of developing CPSP. Predictive performance of the questionnaire will be evaluated using receiver operating characteristic (ROC) analysis, including assessment of area under the curve (AUC), sensitivity, specificity, discrimination, and calibration performance.
The primary outcome measures are the incidence of chronic post-surgical pain at 3 months following surgery and the predictive accuracy of the pain chronification risk assessment questionnaire. Secondary outcomes include postoperative pain intensity, perioperative opioid consumption expressed as morphine milligram equivalents, postoperative nausea and vomiting, postoperative recovery parameters, respiratory complications, duration of mechanical ventilation, intensive care unit length of stay, hospital length of stay, postoperative complications, in-hospital mortality, and changes in quality-of-life and pain-related functional outcome measures.
The study is conducted as an investigator-initiated multicenter academic collaboration between the East Slovakia Institute of Cardiovascular Diseases, Košice, Slovakia, and Uppsala University Hospital, Uppsala, Sweden.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Participants undergoing elective cardiac surgery will be randomized in a parallel assignment design to receive either conventional multimodal opioid-based perioperative analgesia or regional anesthesia-based chest wall plane block techniques as part of perioperative pain management.
| Arm | Type | Receives |
|---|---|---|
| Standard Multimodal Opioid-Based Analgesia | Active comparator | Procedure: Standard Multimodal Opioid-Based AnalgesiaParticipants will receive standard multimodal opioid-based perioperative analgesia according to institutional cardiac surgery pain management protocols. |
| Regional Anesthesia-Based Analgesia | Experimental | Procedure: Regional Anesthesia-Based AnalgesiaParticipants will receive regional anesthesia-based perioperative analgesia including chest wall plane block techniques in combination with multimodal analgesia during cardiac surgery. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (10 listed)
- Age ≥18 years
- Elective cardiac surgery requiring median sternotomy, including:
- coronary artery bypass grafting (CABG)
- aortic valve replacement or repair
- mitral valve replacement or repair
Key exclusion criteria (11 listed)
- Emergency surgery
- Cognitive impairment preventing study participation
- Serious psychiatric illness interfering with study participation
- Language barrier preventing questionnaire completion
- Participation in another interventional study affecting pain outcomes
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Standard Multimodal Opioid-Based AnalgesiaStandard perioperative pain management including opioid-based multimodal analgesia administered according to institutional cardiac surgery protocols. | Procedure or surgery | Standard Multimodal Opioid-Based Analgesia |
| Regional Anesthesia-Based AnalgesiaRegional anesthesia-based perioperative analgesia including chest wall plane block techniques such as erector spinae plane block, PECS block, or paravertebral block in combination with multimodal analgesia during cardiac surgery. | Procedure or surgery | Regional Anesthesia-Based Analgesia |
Primary outcome
Incidence of Chronic Post-Surgical Pain at 3 Months
Time frame: 3 months after surgery
Presence of chronic post-surgical pain assessed 3 months after surgery using the Brief Pain Inventory questionnaire and pain intensity evaluation.
12 secondary outcomes
Postoperative Pain Intensity
Time frame: Postoperative days 1-7
Perioperative Opioid Consumption
Time frame: Postoperative days 1-7
Brief Pain Inventory Score Changes
Time frame: Baseline, 1 week, and 3 months after surgery
Validation of Pain Chronification Risk Assessment Questionnaire
Time frame: Baseline assessment with 3-month follow-up
Quality of Life Assessment
Time frame: Baseline and 3 months after surgery
Perioperative Vasopressor Requirement
Time frame: From surgery until postoperative day 7
Cardiopulmonary Bypass and Surgical Parameters
Time frame: Intraoperative period
Duration of Mechanical Ventilation
Time frame: Postoperative period through day 7
Intensive Care Unit Length of Stay
Time frame: Up to 30 days after surgery
Hospital Length of Stay
Time frame: Up to 30 days after surgery
Postoperative Complications
Time frame: Up to 30 days after surgery
In-Hospital Mortality
Time frame: Up to 30 days after surgery
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Jun 2026.
- Results publication: PubMed 39635026Martuliak I, Golubnitschaja O, Chvala L, Kapalla M, Ferencik M, Bubeliny M, Venglarcik M, Kocan L. Pain chronification risk assessment: advanced phenotyping and scoring for prediction and treatments tailored to individualized patient profile. EPMA J. 2024 Nov 15;15(4):739-750. doi: 10.1007/s13167-024-00383-3. eCollection 2024 Dec.
- Individual participant dataSharing planned: No. Individual participant data sharing has not yet been determined. Data sharing policies will be evaluated after study completion in accordance with institutional regulations, ethical approvals, and patient privacy requirements.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Peter Kostič, MD PhD contact
Peter Kostic, MD, PhD study chair
Department of Heart and Lung Diseases, Unit for Cardiothoracic Surgery, Anesthesia and Intensive Care, Uppsala University Hospital, 751 85 Uppsala, Sweden
Questions about this trial
What is this clinical trial studying?
A study testing Standard Multimodal Opioid-Based Analgesia and Regional Anesthesia-Based Analgesia in people with Chronic Post-surgical Pain and Acute Postoperative Pain, run by Kočan Ladislav.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 10 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 5 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ladislav Kočan, assoc. prof, MD, PhD (+421557891110, lkocan@vusch.sk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Incidence of Chronic Post-Surgical Pain at 3 Months (time frame: 3 months after surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07629453, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Jun 2026.