Peritoneal DialysisCAPER-PDNCT07634211
Combined Aerobic and Resistance Exercise in Peritoneal Dialysis Patients
A study testing Combined Aerobic and Resistance Exercise in people with Peritoneal Dialysis, run by Dilek GİBYELİ GENEK at 1 site in Turkey (Türkiye).
Trial summary
The goal of this randomized controlled trial was to learn whether a combined aerobic and resistance exercise program could improve physical function and muscle health in people receiving peritoneal dialysis. Researchers compared an exercise group with a control group to evaluate the effects of regular exercise. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Peritoneal Dialysis
- What is being tested?
- Combined Aerobic and Resistance Exercise
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 36 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jul 2022to 30 Sep 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults aged 18 years or older
- Receiving peritoneal dialysis for at least 6 months
- Ability to sit and stand independently
Who cannot join
- Myocardial infarction within the previous 6 months
- History of cardiac surgery
- Uncontrolled hypertension
- Pericardial or pleural effusion
- Aortic stenosis
- Active lower extremity amputation, prosthesis, or fracture
Show all 9Show fewer
- History of osteoporotic fractures
- Regular participation in sports or structured exercise
- Advanced cognitive impairment
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Mugla Sitki Kocman University Faculty of Medicine, Mugla Training and Research Hospital
Muğla, Muğla, 48000
About this study
Official title: Combined Aerobic and Resistance Exercise in Peritoneal Dialysis Patients: A Randomized Controlled Trial
The goal of this randomized controlled trial was to learn whether a combined aerobic and resistance exercise program could improve physical function and muscle health in people receiving peritoneal dialysis. Researchers compared an exercise group with a control group to evaluate the effects of regular exercise.
The main questions the study aimed to answer were:
Read more
- Can regular exercise improve physical performance and muscle strength in people receiving peritoneal dialysis?
- Can regular exercise improve body composition and blood markers related to muscle health?
Before the exercise program, participants completed a one-month training period to learn the exercises and practice them safely.
Participants in the exercise group:
- Performed combined aerobic and resistance exercises for 8 weeks
- Completed assessments before and after the exercise program
Participants in the control group:
- Continued their usual care
- Completed assessments before and after the study period
Read the detailed description
People receiving peritoneal dialysis often experience reduced physical function, muscle weakness, and changes in body composition. This randomized controlled trial evaluated the effects of a combined aerobic and resistance exercise program in adults receiving peritoneal dialysis.
Before the intervention, participants completed a one-month training and adaptation period to learn the exercises and ensure safe participation. Participants were then assigned to either an exercise group or a control group. The exercise group performed a structured combined aerobic and resistance exercise program for 8 weeks, while the control group continued usual care.
Researchers evaluated physical performance, muscle strength, body composition, and blood markers related to muscle health before and after the intervention period. The study aimed to determine whether regular exercise could improve physical function and muscle health in people receiving peritoneal dialysis.
- Conditions
- Peritoneal Dialysis
- Being tested
- Combined Aerobic and Resistance Exercise
- Keywords
- Peritoneal Dialysis, exercise, Physical Performance, Muscle Strength, Body Composition
- Medical subject headings
- Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Combined Aerobic and Resistance ExerciseBehavioural
Participants performed a structured combined aerobic and resistance exercise program for 8 weeks. Before the intervention period, participants completed a one-month training and adaptation phase to learn the exercises and ensure safe participation. The exercise program aimed to improve physical performance, muscle strength, and muscle health in people receiving peritoneal dialysis.
| Study group | Role | What they receive |
|---|---|---|
| exercise group | Experimental | Participants performed a combined aerobic and resistance exercise program for 8 weeks. Receives: Behavioral: Combined Aerobic and Resistance Exercise |
| control group | No intervention | Participants continued their usual care during the study period without a structured exercise program. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Physical Performance
Changes in physical performance assessed using the 6-minute walk test after 8 weeks of combined aerobic and resistance exercise.
Measured: Baseline and after 8 weeks of intervention
Changes in right handgrip strength
Changes in right handgrip strength measured in kilograms after 8 weeks of combined aerobic and resistance exercise.
Measured: Baseline and after 8 weeks of intervention
Changes in left handgrip strength
Changes in left handgrip strength measured in kilograms after 8 weeks of combined aerobic and resistance exercise.
Measured: Baseline and after 8 weeks of intervention
Changes in leg strength
Changes in lower extremity muscle strength measured using a leg and back dynamometer after 8 weeks of combined aerobic and resistance exercise.
Measured: Baseline and after 8 weeks of intervention
Secondary outcomes (7)
Changes in flexibility
Changes in flexibility assessed using the Modified Back-Saver Sit-and-Reach Test after 8 weeks of combined aerobic and resistance exercise.
Measured: Baseline and after 8 weeks of intervention
Changes in Fat Tissue Index (FTI)
Changes in Fat Tissue Index measured by by bioimpedance spectroscopy after 8 weeks of combined aerobic and resistance exercise.
Measured: Baseline and after 8 weeks of intervention
Changes in Lean Tissue Index (LTI)
Changes in Lean Tissue Index measured by by bioimpedance spectroscopy after 8 weeks of combined aerobic and resistance exercise.
Measured: Baseline and after 8 weeks of intervention
Changes in serum IGF-1 levels
Changes in serum insulin-like growth factor-1 (IGF-1) levels after 8 weeks of combined aerobic and resistance exercise.
Measured: Baseline and after 8 weeks of intervention
Changes in serum ACTH levels
Changes in serum adrenocorticotropic hormone (ACTH) levels after 8 weeks of combined aerobic and resistance exercise.
Measured: Baseline and after 8 weeks of intervention
Changes in serum myostatin levels
Changes in serum myostatin levels after 8 weeks of combined aerobic and resistance exercise.
Measured: Baseline and after 8 weeks of intervention
Changes in serum irisin levels
Changes in serum irisin levels after 8 weeks of combined aerobic and resistance exercise.
Measured: Baseline and after 8 weeks of intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Jun 2026
- Study start1 Jul 2022
- Primary completion30 Sep 2022
- Study completion30 Sep 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Peritoneal DialysisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants were assigned to either an exercise group or a control group and followed in parallel throughout the study period
- Masking
- None (open label)
- Enrolment
- 36 participants (actual)
Sponsor and investigators
- Lead sponsor
- Dilek GİBYELİ GENEK
- Sponsor type
- University, hospital or other
- Collaborators
- Muğla Sıtkı Koçman University
- Responsible party
- Sponsor-investigator, Dilek GİBYELİ GENEK, Muğla Sıtkı Koçman University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07634211
- Sponsor's protocol ID
- PD-EX-2022
- Other IDs
- Ethics Approval 9/XVI-2022
- Acronym
- CAPER-PD
- Status last verified
- Jun 2026
- First submitted
- 11 May 2026
- Last updated
- 8 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared to protect participant privacy and confidentiality.
Publications
Lu Y, Wang Y, Lu Q. Effects of Exercise on Muscle Fitness in Dialysis Patients: A Systematic Review and Meta-Analysis. Am J Nephrol. 2019;50(4):291-302. doi: 10.1159/000502635. Epub 2019 Sep 3.
PubMed 31480056Heiwe S, Jacobson SH. Exercise training for adults with chronic kidney disease. Cochrane Database Syst Rev. 2011 Oct 5;2011(10):CD003236. doi: 10.1002/14651858.CD003236.pub2.
PubMed 21975737Uchiyama K, Washida N, Morimoto K, Muraoka K, Kasai T, Yamaki K, Miyashita K, Wakino S, Itoh H. Home-based Aerobic Exercise and Resistance Training in Peritoneal Dialysis Patients: A Randomized Controlled Trial. Sci Rep. 2019 Feb 22;9(1):2632. doi: 10.1038/s41598-019-39074-9.
PubMed 30796338
Study at a glance
From the registry record, last updated by the sponsor on 8 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Combined Aerobic and Resistance Exercise in Peritoneal Dialysis Patients: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07634211
- Acronym / sponsor ID
- CAPER-PD / PD-EX-2022
- Conditions
- Peritoneal Dialysis
- Keywords
- Peritoneal Dialysis, exercise, Physical Performance, Muscle Strength, Body Composition
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 36 participants (actual)
- Lead sponsor
- Dilek GİBYELİ GENEKUniversity, hospital or other
- Collaborators
- Muğla Sıtkı Koçman University
- Study start
- 1 Jul 2022 (actual)
- Primary completion
- 30 Sep 2022 (actual)
- Study completion
- 30 Sep 2022 (actual)
- First posted
- 8 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this randomized controlled trial was to learn whether a combined aerobic and resistance exercise program could improve physical function and muscle health in people receiving peritoneal dialysis. Researchers compared an exercise group with a control group to evaluate the effects of regular exercise.
The main questions the study aimed to answer were:
- Can regular exercise improve physical performance and muscle strength in people receiving peritoneal dialysis?
- Can regular exercise improve body composition and blood markers related to muscle health?
Before the exercise program, participants completed a one-month training period to learn the exercises and practice them safely.
Participants in the exercise group:
- Performed combined aerobic and resistance exercises for 8 weeks
- Completed assessments before and after the exercise program
Participants in the control group:
- Continued their usual care
- Completed assessments before and after the study period
Detailed description
People receiving peritoneal dialysis often experience reduced physical function, muscle weakness, and changes in body composition. This randomized controlled trial evaluated the effects of a combined aerobic and resistance exercise program in adults receiving peritoneal dialysis.
Before the intervention, participants completed a one-month training and adaptation period to learn the exercises and ensure safe participation. Participants were then assigned to either an exercise group or a control group. The exercise group performed a structured combined aerobic and resistance exercise program for 8 weeks, while the control group continued usual care.
Researchers evaluated physical performance, muscle strength, body composition, and blood markers related to muscle health before and after the intervention period. The study aimed to determine whether regular exercise could improve physical function and muscle health in people receiving peritoneal dialysis.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Participants were assigned to either an exercise group or a control group and followed in parallel throughout the study period
| Arm | Type | Receives |
|---|---|---|
| exercise group | Experimental | Behavioral: Combined Aerobic and Resistance ExerciseParticipants performed a combined aerobic and resistance exercise program for 8 weeks. |
| control group | No intervention | –Participants continued their usual care during the study period without a structured exercise program. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Adults aged 18 years or older
- Receiving peritoneal dialysis for at least 6 months
- Ability to sit and stand independently
Key exclusion criteria (9 listed)
- Myocardial infarction within the previous 6 months
- History of cardiac surgery
- Uncontrolled hypertension
- Pericardial or pleural effusion
- Aortic stenosis
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Combined Aerobic and Resistance ExerciseParticipants performed a structured combined aerobic and resistance exercise program for 8 weeks. Before the intervention period, participants completed a one-month training and adaptation phase to learn the exercises and ensure safe participation. The exercise program aimed to improve physical performance, muscle strength, and muscle health in people receiving peritoneal dialysis. | Behavioural | exercise group |
Primary outcome
Physical Performance
Time frame: Baseline and after 8 weeks of intervention
Changes in physical performance assessed using the 6-minute walk test after 8 weeks of combined aerobic and resistance exercise.
Changes in right handgrip strength
Time frame: Baseline and after 8 weeks of intervention
Changes in right handgrip strength measured in kilograms after 8 weeks of combined aerobic and resistance exercise.
Changes in left handgrip strength
Time frame: Baseline and after 8 weeks of intervention
Changes in left handgrip strength measured in kilograms after 8 weeks of combined aerobic and resistance exercise.
Changes in leg strength
Time frame: Baseline and after 8 weeks of intervention
Changes in lower extremity muscle strength measured using a leg and back dynamometer after 8 weeks of combined aerobic and resistance exercise.
7 secondary outcomes
Changes in flexibility
Time frame: Baseline and after 8 weeks of intervention
Changes in Fat Tissue Index (FTI)
Time frame: Baseline and after 8 weeks of intervention
Changes in Lean Tissue Index (LTI)
Time frame: Baseline and after 8 weeks of intervention
Changes in serum IGF-1 levels
Time frame: Baseline and after 8 weeks of intervention
Changes in serum ACTH levels
Time frame: Baseline and after 8 weeks of intervention
Changes in serum myostatin levels
Time frame: Baseline and after 8 weeks of intervention
Changes in serum irisin levels
Time frame: Baseline and after 8 weeks of intervention
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Jun 2026.
- Background: PubMed 31480056Lu Y, Wang Y, Lu Q. Effects of Exercise on Muscle Fitness in Dialysis Patients: A Systematic Review and Meta-Analysis. Am J Nephrol. 2019;50(4):291-302. doi: 10.1159/000502635. Epub 2019 Sep 3.
- Background: PubMed 21975737Heiwe S, Jacobson SH. Exercise training for adults with chronic kidney disease. Cochrane Database Syst Rev. 2011 Oct 5;2011(10):CD003236. doi: 10.1002/14651858.CD003236.pub2.
- Background: PubMed 30796338Uchiyama K, Washida N, Morimoto K, Muraoka K, Kasai T, Yamaki K, Miyashita K, Wakino S, Itoh H. Home-based Aerobic Exercise and Resistance Training in Peritoneal Dialysis Patients: A Randomized Controlled Trial. Sci Rep. 2019 Feb 22;9(1):2632. doi: 10.1038/s41598-019-39074-9.
- Individual participant dataSharing planned: No. Individual participant data will not be shared to protect participant privacy and confidentiality.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Combined Aerobic and Resistance Exercise in people with Peritoneal Dialysis, run by Dilek GİBYELİ GENEK at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Physical Performance (time frame: Baseline and after 8 weeks of intervention). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07634211, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Jun 2026.