Visual Field DefectBRIGHTNCT07635329
Home-based Vision Rehabilitation Guided by Brain Imaging
A study testing High-level perceptual learning-based training and Low-level perceptual learning-based training in people with Visual Field Defect and Stroke, run by Georgetown University at 1 site in United States.
Trial summary
The BRIGHT (Behavioral Rehabilitation Through Image-Guided Home-based Training) study aims to evaluate the effectiveness of image-guided, home-based perceptual training at improving visual performance in individuals with visual field loss. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Visual Field Defect, Stroke, Hemianopia Homonymous
- What is being tested?
- High-level perceptual learning-based training and Low-level perceptual learning-based training
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 100 participants
- Where
- 1 siteUnited States
- Study dates
- 23 Jul 2026to 31 Mar 2030
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- At least 18 years of age.
- Capable of providing informed consent and complying with study procedures.
- Unilateral or bilateral focal brain damage causing visual field loss.
- At least three months post-stroke or traumatic brain injury, or a stable brain tumor within the past year.
- Eligible for MRI based on standard safety screening.
Who cannot join
- Severe neurological or psychiatric conditions unrelated to the focal lesion that may interfere with study participation or data interpretation.
- Current or recent (within the past 6 months) drug or alcohol abuse or addiction as defined by DSM-5.
- Ocular disease or disorder.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Georgetown University Medical Center
Washington D.C., District of Columbia, 20057
Tina Liu, PhD, 202-784-9949, vpplab@georgetown.edu
Tina Liu, PhD
About this study
Official title: Behavioral Rehabilitation Through Image-Guided Home-based Training
The BRIGHT (Behavioral Rehabilitation Through Image-Guided Home-based Training) study aims to evaluate the effectiveness of image-guided, home-based perceptual training at improving visual performance in individuals with visual field loss.
Using a prospective, crossover design, BRIGHT combines visual behavioral testing, neuroimaging, and a home-based intervention. It aims to 1) identify neural pathways that support training-induced visual plasticity; and 2) compare the efficacy of different types of visual training delivered in a home-based setting.
- Conditions
- Visual Field Defect, Stroke, Hemianopia Homonymous, Quadrantanopia, Cortical Blindness, Visual Field Defect, Peripheral
- Being tested
- High-level perceptual learning-based training, Low-level perceptual learning-based training
- Keywords
- neuroplasticity, stroke, vision, TBI, brain tumor
- Medical subject headings
- Stroke, Hemianopsia, Blindness, Cortical, Brain Injuries, Traumatic, Brain Neoplasms
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
High-level perceptual learning-based trainingBehavioural
Behavioral intervention consisting of repeated computerized visual discrimination tasks targeting higher-order visual processing
Low-level perceptual learning-based trainingBehavioural
behavioral intervention consisting of repeated computerized visual discrimination tasks targeting low-level visual processing
| Study group | Role | What they receive |
|---|---|---|
| Perceptual learning-based training using high-level visual stimuli | Experimental | A 3 week at-home online perceptual learning-based training using high-level visual stimuli. Receives: Behavioral: High-level perceptual learning-based training |
| Perceptual learning-based training using low-level visual stimuli | Active comparator | A 3 week at-home online perceptual learning-based training using low-level visual stimuli. Receives: Behavioral: Low-level perceptual learning-based training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in high-level perceptual discrimination performance
Change in performance on an online computerized high-level perceptual discrimination task. Participants complete a computerized high-level perceptual discrimination task during a 3-week training period (5 days per week). Task difficulty is adaptively adjusted using a 3-up/1-down staircase procedure to estimate perceptual discrimination thresholds corresponding to approximately 75% accuracy.
Measured: Week 2-4 or Week 7-9 of the study (depending on the order)
Change in low-level perceptual discrimination performance
Change in performance on an online computerized low-level perceptual discrimination task. Participants complete a computerized high-level perceptual discrimination task during a 3-week training period (5 days per week). Task difficulty is adaptively adjusted using a 3-up/1-down staircase procedure to estimate perceptual discrimination thresholds corresponding to approximately 75% accuracy.
Measured: Week 2-4 or Week 7-9 of the study (depending on the order)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Jun 2026
- Study start23 Jul 2026
- Primary completion31 Mar 2030 (estimated)
- Study completion31 Mar 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Visual Field DefectStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- Study Procedures Week 1: Pre-intervention visual assessment and functional magnetic resonance imaging (fMRI) scan (in-person study visit). Weeks 2-4: Participants complete at-home, online perceptual learning training using either low-level or high-level visual stimuli. End of Week 4: Online assessment to evaluate the spatial transfer of training effects. Weeks 5-6: Washout period to minimize potential carryover effects. Weeks 7-9: Participants complete the alternate at-home, online perceptual learning training condition (low-level or high-level visual stimuli). End of Week 9: Second online assessment to evaluate the spatial transfer of training effects. Week 10 (Final Visit): Post-intervention visual assessment and fMRI scan (in-person study visit). Approximately Week 24: Follow-up visual assessment and fMRI scan (in-person study visit). The timing of study visits and training sessions may be adjusted as needed to accommodate participants' health status or scheduling needs.
- Masking
- None (open label)
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Georgetown University
- Sponsor type
- University, hospital or other
- Collaborators
- American Heart Association
- Responsible party
- Principal investigator, Tong (Tina) Liu, Georgetown University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07635329
- Sponsor's protocol ID
- STUDY00010314
- Other IDs
- 26CDA1590827
- Acronym
- BRIGHT
- Status last verified
- Sep 2026
- First submitted
- 3 Jun 2026
- Last updated
- 14 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 14 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Behavioral Rehabilitation Through Image-Guided Home-based Training
- ClinicalTrials.gov ID
- NCT07635329
- Acronym / sponsor ID
- BRIGHT / STUDY00010314
- Conditions
- Visual Field Defect, Stroke, Hemianopia Homonymous, Quadrantanopia, Cortical Blindness, Visual Field Defect, Peripheral
- Keywords
- neuroplasticity, stroke, vision, TBI, brain tumor
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Georgetown UniversityUniversity, hospital or other
- Collaborators
- American Heart Association
- Study start
- 23 Jul 2026 (actual)
- Primary completion
- 31 Mar 2030 (estimated)
- Study completion
- 31 Mar 2030 (estimated)
- First posted
- 9 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The BRIGHT (Behavioral Rehabilitation Through Image-Guided Home-based Training) study aims to evaluate the effectiveness of image-guided, home-based perceptual training at improving visual performance in individuals with visual field loss.
Using a prospective, crossover design, BRIGHT combines visual behavioral testing, neuroimaging, and a home-based intervention. It aims to 1) identify neural pathways that support training-induced visual plasticity; and 2) compare the efficacy of different types of visual training delivered in a home-based setting.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Study Procedures Week 1: Pre-intervention visual assessment and functional magnetic resonance imaging (fMRI) scan (in-person study visit). Weeks 2-4: Participants complete at-home, online perceptual learning training using either low-level or high-level visual stimuli. End of Week 4: Online assessment to evaluate the spatial transfer of training effects. Weeks 5-6: Washout period to minimize potential carryover effects. Weeks 7-9: Participants complete the alternate at-home, online perceptual learning training condition (low-level or high-level visual stimuli). End of Week 9: Second online assessment to evaluate the spatial transfer of training effects. Week 10 (Final Visit): Post-intervention visual assessment and fMRI scan (in-person study visit). Approximately Week 24: Follow-up visual assessment and fMRI scan (in-person study visit). The timing of study visits and training sessions may be adjusted as needed to accommodate participants' health status or scheduling needs.
| Arm | Type | Receives |
|---|---|---|
| Perceptual learning-based training using high-level visual stimuli | Experimental | Behavioral: High-level perceptual learning-based trainingA 3 week at-home online perceptual learning-based training using high-level visual stimuli. |
| Perceptual learning-based training using low-level visual stimuli | Active comparator | Behavioral: Low-level perceptual learning-based trainingA 3 week at-home online perceptual learning-based training using low-level visual stimuli. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- At least 18 years of age.
- Capable of providing informed consent and complying with study procedures.
- Unilateral or bilateral focal brain damage causing visual field loss.
- At least three months post-stroke or traumatic brain injury, or a stable brain tumor within the past year.
- Eligible for MRI based on standard safety screening.
Key exclusion criteria (3 listed)
- Severe neurological or psychiatric conditions unrelated to the focal lesion that may interfere with study participation or data interpretation.
- Current or recent (within the past 6 months) drug or alcohol abuse or addiction as defined by DSM-5.
- Ocular disease or disorder.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| High-level perceptual learning-based trainingBehavioral intervention consisting of repeated computerized visual discrimination tasks targeting higher-order visual processing | Behavioural | Perceptual learning-based training using high-level visual stimuli |
| Low-level perceptual learning-based trainingbehavioral intervention consisting of repeated computerized visual discrimination tasks targeting low-level visual processing | Behavioural | Perceptual learning-based training using low-level visual stimuli |
Primary outcome
Change in high-level perceptual discrimination performance
Time frame: Week 2-4 or Week 7-9 of the study (depending on the order)
Change in performance on an online computerized high-level perceptual discrimination task. Participants complete a computerized high-level perceptual discrimination task during a 3-week training period (5 days per week). Task difficulty is adaptively adjusted using a 3-up/1-down staircase procedure to estimate perceptual discrimination thresholds corresponding to approximately 75% accuracy.
Change in low-level perceptual discrimination performance
Time frame: Week 2-4 or Week 7-9 of the study (depending on the order)
Change in performance on an online computerized low-level perceptual discrimination task. Participants complete a computerized high-level perceptual discrimination task during a 3-week training period (5 days per week). Task difficulty is adaptively adjusted using a 3-up/1-down staircase procedure to estimate perceptual discrimination thresholds corresponding to approximately 75% accuracy.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Sep 2026.
- Individual participant dataSharing planned: Undecided
Related trials for Visual Field Defect
Active, not recruitingObservational study
Glaucoma, Visual Field Loss, and Their Association With Life Space in Older Adults
Primary Open Angle Glaucoma
Active, not recruitingObservational study
Impact of Glaucoma and Visual Field Loss on Life Space
Primary Open-angle Glaucoma
Active, not recruiting
Statistical Learning as a Novel Intervention for Cortical Blindness
Stroke, Ischemic, Hemianopia, Homonymous
Recruiting
Vision Improvement Through Behavioral Rehabilitation And Neuroplasticity Training
Visual Field Defect, Stroke
Not yet recruiting
Virtual Reality-based Perceptual Learning Therapy for Visually Impaired Population
Visual Field Defects
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing High-level perceptual learning-based training and Low-level perceptual learning-based training in people with Visual Field Defect and Stroke, run by Georgetown University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 14 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Tina Liu, PhD (2027849920, tina.liu@georgetown.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in high-level perceptual discrimination performance (time frame: Week 2-4 or Week 7-9 of the study (depending on the order)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Sep 2026.