Morbid ObesityC-MACNCT07636746
Interaction Between Head/Neck Position and C-MAC Blade Geometry on Videolaryngoscopic Intubation in Morbidly Obese Patients: A Randomized Controlled Trial
A study testing Sniffing position and using MAC blade., Ramped position and MAC Blade and videolaryngoscopy in people with Morbid Obesity, run by Ain Shams University at 1 site in Egypt.
Trial summary
This study aims to explore the effect of head/neck position (sniffing vs ramped) and C-MAC blade geometry (MAC vs D-blade) on intubation in morbidly obese patients. The patients will be randomized into 4 groups: 1. S MAC: Sniffing + MAC blade. 2. R MAC: Ramped + MAC blade. 3. S D-blade: Sniffing + D-blade. 4. Read more about this study
- Who is it for?
- Ages 18 to 70 years
- Conditions the study is for
- Morbid Obesity
- What is being tested?
- Sniffing position and using MAC blade., Ramped position and MAC Blade and videolaryngoscopy
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 140 participants
- Where
- 1 siteEgypt
- Study dates
- 17 Apr 2026to 1 Nov 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age 18-70 years.
- BMI ≥ 40 kg/m².
- ASA physical status III - IV.
- Elective surgery requiring intubation.
- Informed consent obtained.
Who cannot join
- Anticipated difficult airway unrelated to obesity.
- Cervical spine pathology.
- Pregnancy.
- Emergency surgery.
- High aspiration risk.
- OSA requiring CPAP >15 cmH₂O.
- Need for awake intubation.
Trial locations and contacts
1 site in 1 country.
About this study
This study aims to explore the effect of head/neck position (sniffing vs ramped) and C-MAC blade geometry (MAC vs D-blade) on intubation in morbidly obese patients.
The patients will be randomized into 4 groups:
- S MAC: Sniffing + MAC blade.
- R MAC: Ramped + MAC blade.
- S D-blade: Sniffing + D-blade.
- R D-blade: Ramped + D-blade.
- Conditions
- Morbid Obesity
- Being tested
- Sniffing position and using MAC blade., Ramped position and MAC Blade, videolaryngoscopy, videolaryngosopy
- Medical subject headings
- Obesity, Morbid
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Sniffing position and using MAC blade.Device
Machintosch blade will be used in intubating patient in sniffing position
Ramped position and MAC BladeDevice
MAC blade will be used in intubating patient in ramped postion
videolaryngoscopyDevice
D-blade will be used in intubating patient in sniffing position
videolaryngosopyDevice
D-blade will be used in intubating patient in Ramped position
| Study group | Role | What they receive |
|---|---|---|
| S MAC: Sniffing + MAC blade. | Active comparator | the patient will be positioned in sniffing position and MAC blade will be used in intubation Receives: Device: Sniffing position and using MAC blade. |
| Ramped position and using MAC blade. | Active comparator | the patient will be positioned in Ramped position and MAC blade will be used in intubation Receives: Device: Ramped position and MAC Blade |
| S D-blade: Sniffing + D-blade. | Active comparator | the patient will be positioned in sniffing position and D-blade will be used in intubation Receives: Device: videolaryngoscopy |
| R D-blade: Ramped + D-blade. | Active comparator | the patient will be positioned in Ramped position and D-blade willbe used in intubation Receives: Device: videolaryngosopy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Intubation time (seconds), from blade insertion to confirmed placement via capnography.
Intubation time (seconds), from blade insertion to confirmed placement via capnography.
Measured: seconds
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Jun 2026
- Study start17 Apr 2026
- Primary completion20 Sep 2026 (estimated)
- Study completion1 Nov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Morbid ObesityStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 140 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ain Shams University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- fagr fathy abdo, Medical Doctorate, Principal investigator, Ain Shams University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07636746
- Sponsor's protocol ID
- FMASU R81/2026
- Acronym
- C-MAC
- Status last verified
- Apr 2026
- First submitted
- 4 Jun 2026
- Last updated
- 9 Jun 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 9 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Interaction Between Head/Neck Position and C-MAC Blade Geometry on Videolaryngoscopic Intubation in Morbidly Obese Patients: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07636746
- Acronym / sponsor ID
- C-MAC / FMASU R81/2026
- Conditions
- Morbid Obesity
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 140 participants (estimated)
- Lead sponsor
- Ain Shams UniversityUniversity, hospital or other
- Study start
- 17 Apr 2026 (actual)
- Primary completion
- 20 Sep 2026 (estimated)
- Study completion
- 1 Nov 2026 (estimated)
- First posted
- 9 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to explore the effect of head/neck position (sniffing vs ramped) and C-MAC blade geometry (MAC vs D-blade) on intubation in morbidly obese patients.
The patients will be randomized into 4 groups:
- S MAC: Sniffing + MAC blade.
- R MAC: Ramped + MAC blade.
- S D-blade: Sniffing + D-blade.
- R D-blade: Ramped + D-blade.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| S MAC: Sniffing + MAC blade. | Active comparator | Device: Sniffing position and using MAC blade.the patient will be positioned in sniffing position and MAC blade will be used in intubation |
| Ramped position and using MAC blade. | Active comparator | Device: Ramped position and MAC Bladethe patient will be positioned in Ramped position and MAC blade will be used in intubation |
| S D-blade: Sniffing + D-blade. | Active comparator | Device: videolaryngoscopythe patient will be positioned in sniffing position and D-blade will be used in intubation |
| R D-blade: Ramped + D-blade. | Active comparator | Device: videolaryngosopythe patient will be positioned in Ramped position and D-blade willbe used in intubation |
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Age 18-70 years.
- BMI ≥ 40 kg/m².
- ASA physical status III - IV.
- Elective surgery requiring intubation.
- Informed consent obtained.
Key exclusion criteria (7 listed)
- Anticipated difficult airway unrelated to obesity.
- Cervical spine pathology.
- Pregnancy.
- Emergency surgery.
- High aspiration risk.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Sniffing position and using MAC blade.Machintosch blade will be used in intubating patient in sniffing position | Device | S MAC: Sniffing + MAC blade. |
| Ramped position and MAC BladeMAC blade will be used in intubating patient in ramped postion | Device | Ramped position and using MAC blade. |
| videolaryngoscopyD-blade will be used in intubating patient in sniffing position | Device | S D-blade: Sniffing + D-blade. |
| videolaryngosopyD-blade will be used in intubating patient in Ramped position | Device | R D-blade: Ramped + D-blade. |
Primary outcome
Intubation time (seconds), from blade insertion to confirmed placement via capnography.
Time frame: seconds
Intubation time (seconds), from blade insertion to confirmed placement via capnography.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Jun 2026.
- Individual participant dataSharing planned: Yes
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
fagr fathy abdo, Medical Doctorate principal investigator
Ain Shams University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Sniffing position and using MAC blade., Ramped position and MAC Blade and videolaryngoscopy in people with Morbid Obesity, run by Ain Shams University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 9 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Intubation time (seconds), from blade insertion to confirmed placement via capnography. (time frame: seconds). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Jun 2026.